Major interaction on record — check this product against your medications before combining. Check your meds →
Dietary supplement

Aloe Vera 500 mg with Yucca Ingredients & Drug Interactions

by herbscience

Aloe Vera 500 mg with Yucca label
See full label image
Other (e.g. Tea Bag) Category: Botanical
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Aloe Vera 500 mg with Yucca against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Aloe Vera 500 mg with Yucca is a dietary supplement by herbscience with 2 active ingredients. Its ingredients are commonly taken for minor burns and skin irritation, wound healing, constipation.Based on those ingredients, 461 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Aloe Extract Blend. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Aloe Vera 500 mg with Yucca by herbscience

Ask about any prescription or over-the-counter medication and we check it for interactions with Aloe Vera 500 mg with Yucca by herbscience — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Aloe Vera 500 mg with Yucca by herbscience

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 12, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 1 of its 3 active ingredients.
  • “Aloe Extract Blend” is a proprietary blend — the label gives one combined amount (500 mg) without saying how much of each component you get.

This product contains 3 active ingredients: an aloe extract blend (which includes aloe vera listed twice in the formulation), and yucca. Aloe vera is the gel and latex from the aloe plant — the gel is the clear inner part, and the latex is the yellow substance just under the plant's skin.

Yucca is a plant extract used traditionally for various purposes. The product also contains several inactive ingredients — dicalcium phosphate, microcrystalline cellulose, maltodextrin, croscarmellose sodium, stearic acid, silica, magnesium stearate, and pharmaceutical glaze — which are fillers, binders, and capsule materials.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded its ingredients' overall clinical evidence instead.

Moderate

Some clinical evidence supports its ingredients for:

  • Acne via Aloe Possibly Effective
  • Burns via Aloe Possibly Effective
  • Constipation via Aloe Possibly Effective
  • Diabetes via Aloe Possibly Effective
  • Obesity via Aloe Possibly Effective
Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredients' overall clinical evidence instead.
  • On file: Acne — rated "Possibly Effective" (Aloe) (Natural Medicines).
  • On file: Burns — rated "Possibly Effective" (Aloe) (Natural Medicines).
  • On file: Constipation — rated "Possibly Effective" (Aloe) (Natural Medicines).
  • On file: Diabetes — rated "Possibly Effective" (Aloe) (Natural Medicines).
  • On file: Obesity — rated "Possibly Effective" (Aloe) (Natural Medicines).

Aloe vera is possibly effective for acne, obesity, diabetes, psoriasis, burns, and constipation, according to the evidence we have on file. For yucca, the evidence isn't established — we hold insufficient data to say whether it works for bleeding, joint pain, or dandruff.

The evidence, ingredient by ingredient Aloe Yucca

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Aloe gel applied to skin is generally well tolerated, but oral aloe latex — the part that comes from inside the plant's skin — can cause serious side effects. When taken by mouth, aloe commonly causes abdominal pain, cramps, and diarrhea.

Long-term use or overuse can lead to more serious problems: severe potassium loss (hypokalemia), muscle weakness, irregular heartbeat, and pigment spots in the intestines (pseudomelanosis coli), though those spots usually go away once you stop taking aloe. The safety data advises against aloe by mouth during pregnancy because the latex may trigger uterine contractions and act as a strong laxative.

The same applies to breastfeeding — there isn't enough safety information, and the laxative effects are a concern. For yucca, there isn't enough safety information available, so it's best avoided during pregnancy and breastfeeding.

Side effects, ingredient by ingredient Aloe Yucca

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 1 of the 2 matched ingredients can interact with medications — Aloe.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications; heart-rhythm medications.
  • For scale: 461 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take this product, check with your pharmacist if you're on digoxin (a heart medication) — this is the highest-risk interaction. Also double-check if you take blood thinners or antiplatelet drugs like warfarin or aspirin, diabetes medications, water pills (diuretics), other stimulant laxatives, or any drug your liver metabolizes.

No interactions are documented for yucca.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence behind its ingredients' uses. Major medication interactions have been identified, and safety information is well characterized.

Aloe vera may help with several conditions, but it's not for everyone — especially if you take heart, blood-thinning, or diabetes medications. Yucca's benefits aren't well established.

Talk to your pharmacist before starting, particularly if you're on any prescription drugs.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 3 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Mar 23, 2012.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Aloe Vera 500 mg with Yucca, straight from the product label.

Brand herbscience
Barcode (UPC) 035046041625
Net contents 60 Caplet(s)
Market status On market
Date entered into DSLD Mar 23, 2012
DSLD ID 7094
Product type Botanical
Supplement form Other (e.g. Tea Bag)
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Aloe Vera 500 mg with Yucca by herbscience, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Caplet(s)
Maximum serving Sizes:
4 Caplet(s)
UPC/BARCODE
035046041625
IngredientAmount% DV
Aloe Extract Blend500 mg--
Aloe vera0 NP--
Aloe vera0 NP--
Yucca50 mg--

Other ingredients: Dicalcium Phosphate, Microcrystalline Cellulose, Maltodextrin, Croscarmellose Sodium, Stearic Acid, Silica, Magnesium Stearate, Pharmaceutical Glaze

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Precautions

WARNING: This product contains aloe vera. Read and follow directions carefully. Do not use if you have or develop diarrhea, loose stools or abdominal pain. Consult your physician if you have frequent diarrhea.

If you are pregnant, nursing, taking medication or have a medical condition, consult your physician before using this product.

Keep out of reach of children.

Do not use if seal is broken.

Storage

Protect from heat, light and moisture.

Seals/Symbols

(symbol) BLUEPRINT BOTANICALS(TM)

FDA Statement of Identity

herbal supplement

Formula

Aloe Vera 500 mg with yucca in a whole herb base

Suggested/Recommended/Usage/Directions

DIRECTIONS: Take two to four caplets daily as a dietary supplement or as recommended by a healthcare professional.

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Brand IP Statement(s)

(C) Copyright 1998 Windmill Consumer Products(TM)

BLUEPRINT BOTANICALS(TM)

At herbscience(TM), we have found a way to combine high technology with age-old herbal tradition. The Blueprint Botanicals(TM) system begins with select herbs gathered from all over the world. Pre-tested, using advanced analytical methods, our herbal extracts are patiently concentrated utilizing time-tested methods. Once we have attained the highly standardized levels recommended by leading herbalists, our finished products are packaged and double-sealed for optimal freshness. This is your assurance of potency and purity. Blueprint Botanicals(TM) for herbscience(TM)- Perfecting the Science of Nature(TM).

General

TC# 54120602 ITEM# N4162

General Statements

support DIGESTIVE FUNCTION

STANDARDIZED-FULL POTENCY

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Aloe Vera 500 mg with Yucca by herbscience label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Aloe Vera 500 mg with Yucca label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Aloe Vera 500 mg with Yucca by herbscience

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Caplet(s) Dosage formOther (e.g. Tea Bag) Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Aloe Extract Blend

Interacts with
461 drugs
500 mg per serving

Aloe vera gel is widely used on the skin for minor burns and irritation, and some research suggests it may help. Aloe latex (the yellow part) is a str...

Aloe Extract Blend monograph & interactions

Yucca

No known
interactions
50 mg per serving

Yucca is a desert plant traditionally used for joint pain, arthritis, and digestion, and it contains compounds called saponins thought to have anti-in...

Yucca monograph & interactions

Other (inactive) ingredients: Dicalcium Phosphate, Microcrystalline Cellulose, Maltodextrin, Croscarmellose Sodium, Stearic Acid, Silica, Magnesium Stearate, Pharmaceutical Glaze. These complete the product’s ingredient list but are not active constituents.

Interaction report

Aloe Vera 500 mg with Yucca by herbscience Drug Interactions

Want to check YOUR meds against Aloe Vera 500 mg with Yucca?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
461Drugs
1 Major 304 Moderate 156 Minor

Ingredients driving the most interactions

Aloe Extract Blend 461

Individual Drug Interactions

The ingredients in Aloe Vera 500 mg with Yucca interact with 461 drugs. Click any drug to see the details.

1 of the 2 ingredients in Aloe Vera 500 mg with Yucca interact with drugs. Each result below shows which ingredient is responsible. Aloe Extract Blend

Each ingredient & the kinds of drugs it affects

For each ingredient in Aloe Vera 500 mg with Yucca with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Aloe Extract Blend7 drug types · 461 drugs

Digoxin (Lanoxin)

Theoretically, aloe latex might increase the risk of adverse effects when taken with cardiac glycosides.
Overuse of aloe latex can increase the risk of adverse effects from cardiac glycoside drugs, such as digoxin, due to potassium depletion. Overuse of aloe, along with cardiac glycoside drugs, can increase the risk of toxicity.

Likelihood Probable Evidence D
Anticoagulant/Antiplatelet Drugs

Theoretically, aloe gel might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
In vitro research shows that aloe gel can inhibit platelet aggregation. This inhibition was greater than that seen with celecoxib, but less than that seen with aspirin.

Likelihood Possible Evidence D
Antidiabetes Drugs

Aloe might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Preliminary clinical research suggests aloe gel might lower blood glucose levels and have additive effects when used with antidiabetes drugs. Monitor blood glucose levels closely.

Likelihood Possible Evidence D
Diuretic Drugs

Theoretically, aloe latex might increase the risk of hypokalemia when taken with diuretic drugs.
Overuse of aloe latex might compound diuretic-induced potassium loss, increasing the risk of hypokalemia.

Likelihood Possible Evidence D
Stimulant Laxatives

Theoretically, aloe latex might increase the risk for fluid and electrolyte loss when taken with stimulant laxatives.
Due to cathartic laxative effects of aloe latex, concomitant use with other stimulant laxatives might compound fluid and electrolyte loss.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Theoretically, aloe latex might increase the risk of bleeding when taken with warfarin.
Aloe latex has stimulant laxative effects. In some people aloe latex can cause diarrhea. Diarrhea can increase the effects of warfarin, increase international normalized ratio (INR), and increase the risk of bleeding. Advise patients who take warfarin not to take excessive amounts of aloe vera.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, aloe might decrease the levels and clinical effects of CYP1A2 substrates.
In vitro research shows that aloe extract induces CYP1A2 enzymes.

Likelihood Possible Evidence D
Aloe Extract Blend full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Aloe Vera 500 mg with Yucca, from the product label.

herbscience

See all herbscience products
Name
Windmill Consumer Products
City
West Caldwell
State
NJ
ZipCode
07006
Pharmacist Counseling Corner

Aloe Vera 500 mg with Yucca by herbscience: Common Questions

Does Aloe Vera 500 mg with Yucca by herbscience interact with any medications?
Yes. Based on its ingredients, Aloe Vera 500 mg with Yucca has a known interaction with 461 medications, including 1 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Aloe Vera 500 mg with Yucca contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this while pregnant or breastfeeding?
No. The safety data advises against oral aloe during pregnancy — the latex may trigger uterine contractions and cause strong laxative effects. During breastfeeding, there isn't enough safety information, and the laxative effects are a concern. Talk to your doctor or pharmacist for personalized advice.
What's the difference between aloe gel and aloe latex?
Aloe gel is the clear inner part of the plant leaf — it's generally well tolerated when applied to skin. Aloe latex is the yellow substance just under the plant's skin and is taken by mouth in this product — it has stronger laxative effects and a higher risk of side effects, especially with long-term or high-dose use.
What are the most common side effects?
When taken by mouth, aloe latex may cause abdominal pain, cramps, and diarrhea. Long-term overuse can lead to potassium loss, muscle weakness, and irregular heartbeat. If applied to skin, aloe may cause burning, redness, itching, or contact dermatitis in sensitive people.
Will this help my constipation?
Aloe vera is possibly effective for constipation, and its laxative action is one reason. However, it's not meant for long-term use — overuse can cause serious electrolyte imbalances. Talk to your pharmacist about whether this is right for you.
Is yucca proven to work?
We don't have enough evidence to say whether yucca works for bleeding, joint pain, or dandruff. The evidence is classified as insufficient, so its benefits aren't established in our data.
Are there any fillers in this product?
Yes. The product contains several inactive ingredients used as fillers, binders, and capsule materials: dicalcium phosphate, microcrystalline cellulose, maltodextrin, croscarmellose sodium, stearic acid, silica, magnesium stearate, and pharmaceutical glaze.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Aloe Vera 500 mg with Yucca is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Aloe Vera 500 mg with Yucca label
Go deeper

The Full Monographs Behind Aloe Vera 500 mg with Yucca’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Aloe

Interacts with 461 drugs

Aloe vera gel is widely used on the skin for minor burns and irritation, and some research suggests it may help. Aloe latex (the yellow part) is a strong laxative that can cause cramping and...

Read the full Aloe monograph → Herb & supplement monograph

Yucca

Yucca is a desert plant traditionally used for joint pain, arthritis, and digestion, and it contains compounds called saponins thought to have anti-inflammatory effects. Human evidence for t...

Read the full Yucca monograph →
Sources

Sources & How We Checked

Aloe Vera 500 mg with Yucca's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 44 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Aloe 41 references
  1. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
  2. Wichtl MW. Herbal Drugs and Phytopharmaceuticals. Ed. N.M. Bisset. Stuttgart: Medpharm GmbH Scientific Publishers, 1994.
  3. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
  4. Nusko G, Schneider B, Schneider I, et al. Anthranoid laxative use is not a risk factor for colorectal neoplasia: results of a prospective case control study. Gut 2000;46:651-5. PubMed
  5. Luyckx VA, Ballantine R, Claeys M, et al. Herbal remedy-associated acute renal failure secondary to Cape aloes. Am J Kidney Dis 2002;39:E13. PubMed
  6. Rajasekaran S, Sivagnanam K, Ravi K, Subramanian S. Hypoglycemic effect of Aloe vera gel on streptozotocin-induced diabetes in experimental rats. J Med Food 2004;7:61-6.
  7. Williams MS, Burk M, Loprinzi CL, et al. Phase III double-blind evaluation of an aloe vera gel as a prophylactic agent for radiation-induced skin toxicity. Int J Radiat Oncol Biol Phys 1996;36:345-9. PubMed
  8. Vogler BK, Ernst E. Aloe vera: a systematic review of its clinical effectiveness. Br J Gen Pract 1999;49:823-8.
  9. Bottenberg MM, Wall GC, Harvey RL, Habib S. Oral aloe vera-induced hepatitis. Ann Pharmacother 2007;41:1740-3. PubMed
  10. Rabe C, Musch A, Schirmacher P, et al. Acute hepatitis induced by an Aloe vera preparation: a case report. World J Gastroenterol 2005;11:303-4. PubMed
  11. Kanat O, Ozet A, Ataergin S. Aloe vera-induced acute toxic hepatitis in a healthy young man. Eur J Int Med 2006;17:589. PubMed
  12. Mueller SO, Stopper H. Characterization of the genotoxicity of anthraquinones in mammalian cells. Biochim Biophys Acta 1999;1428:406-14. PubMed
  13. Schorkhuber M, Richter M, Dutter A, et al. Effect of anthraquinone laxatives on the proliferation and urokinase secretion of normal, premalignant and malignant colonic epithelial cells. Eur J Cancer 1998;34:1091-8. PubMed
  14. Yang HN, Kim DJ, Kim YM, et al. Aloe-induced toxic hepatitis. J Korean Med Sci 2010;25:492-5. PubMed
  15. Choonhakarn C, Busaracome P, Sripanidkulchai B, et al. A prospective, randomized clinical trial comparing topical aloe vera with 0.1% triamcinolone acetonide in mild to moderate plaque psoriasis. J.Eur.Acad.Dermatol.Venereol. 2010;24:168-72. PubMed
  16. Ishii Y, Tanizawa H, Takino Y. Studies of aloe. IV. Mechanism of cathartic effect. (3). Biol Pharm Bull. 1994;17:495-7. PubMed
  17. Ishii Y, Tanizawa H, Takino Y. Studies of aloe. V. Mechanism of cathartic effect. (4). Biol Pharm Bull. 1994;17:651-3. PubMed
  18. Nelemans FA. Clinical and toxicological aspects of anthraquinone laxatives. Pharmacology. 1976;14 Suppl 1:73-7. PubMed
  19. Paulsen E, Korsholm L, Brandrup F. A double-blind, placebo-controlled study of a commercial Aloe vera gel in the treatment of slight to moderate psoriasis vulgaris. J Eur Acad Dermatol Venereol. 2005;19:326-31.
  20. Huseini HF, Kianbakht S, Hajiaghaee R, et al. Anti-hyperglycemic and anti-hypercholesterolemic effects of Aloe vera leaf gel in hyperlipidemic type 2 diabetic patients: a randomized double-blind placebo-controlled clinical trial. Planta Med. 2012;78:311-6
  21. Ferreira, M., Teixeira, M., Silva, E., and Selores, M. Allergic contact dermatitis to Aloe vera. Contact Dermatitis 2007;57(4):278-279.
  22. Choonhakarn, C., Busaracome, P., Sripanidkulchai, B., and Sarakarn, P. The efficacy of aloe vera gel in the treatment of oral lichen planus: a randomized controlled trial. Br J Dermatol 2008;158(3):573-577. PubMed
  23. Baretta, Z., Ghiotto, C., Marino, D., and Jirillo, A. Aloe-induced hypokalemia in a patient with breast cancer during chemotherapy. Ann.Oncol. 2009;20(8):1445-1446. PubMed
  24. Hunter, D. and Frumkin, A. Adverse reactions to vitamin E and aloe vera preparations after dermabrasion and chemical peel. Cutis 1991;47(3):193-196.
  25. Alvarez-Perea, A., Garcia, A. P., Hernandez, A. L., de, Barrio M., and Baeza, M. L. Urticaria due to aloe vera: a new sensitizer? Ann.Allergy Asthma Immunol. 2010;105(5):404-405. PubMed
  26. Hogan, D. J. Widespread dermatitis after topical treatment of chronic leg ulcers and stasis dermatitis. CMAJ. 2-15-1988;138(4):336-338.
  27. Savchak VI. Acute bullous allergic dermatitis due to local application of aloe leaves. Vestnik Dermatologii i Venerologii 1977;12:44-45.
  28. Nakamura, T. and Kotajima, S. Contact dermatitis from aloe arborescens. Contact Dermatitis 1984;11(1):51. PubMed
  29. Shoji, A. Contact dermatitis to Aloe arborescens. Contact Dermatitis 1982;8(3):164-167. PubMed
  30. Morrow, D. M., Rapaport, M. J., and Strick, R. A. Hypersensitivity to aloe. Arch Dermatol. 1980;116(9):1064-1065. DOI
  31. Cosmetic Ingredient Review Expert Panel. Final report on the safety assessment of AloeAndongensis Extract, Aloe Andongensis Leaf Juice,aloe Arborescens Leaf Extract, Aloe Arborescens Leaf Juice, Aloe Arborescens Leaf Protoplasts, Aloe Barbadensis Flower E
  32. Bhalang K, Thunyakitpisal P, Rungsirisatean N. Acemannan, a polysaccharide extracted from Aloe vera, is effective in the treatment of oral aphthous ulceration. J Altern Complement Med 2013;19(5):429-34.
  33. Hajheydari Z, Saeedi M, Morteza-Semnani K, Soltani A. Effect of Aloe vera topical gel combined with tretinoin in treatment of mild and moderate acne vulgaris: a randomized, double-blind, prospective trial. J Dermatolog Treat 2014;25(2):123-9.
  34. Jiménez-Encarnación E, Ríos G, Muñoz-Mirabal A, Vilá LM. Euforia-induced acute hepatitis in a patient with scleroderma. BMJ Case Rep 2012;2012. PubMed
  35. Lee J, Lee MS, Nam KW. Acute toxic hepatitis caused by an aloe vera preparation in a young patient: a case report with a literature review. Korean J Gastroenterol 2014;64(1):54-8. PubMed
  36. Guo X, Mei N. Aloe Vera - A Review of Toxicity and Adverse Clinical Effects. J Environ Sci Health C Environ Carcinog Ecotoxicol Rev 2016;34(2):77-96.
  37. Hoogenboom TCH, Patel N, Cook NA, Williams R, Taylor-Robinson SD, Lim AKP. The effect of Aloe vera juice on liver enzymes and hepatic structure in a healthy population. Integr Med (Encinitas) 2020;19(3):30-4.
  38. Mushtaq S, Mushtaq Z, Sarfraz J, et al. Comparison of effect of aloe vera gel with aspirin and celecoxib on platelet aggregation. Professional Med J. 2020; 27(5):973-978. DOI
  39. Haron MH, Dale O, Martin K, et al. Evaluation of the Herb-Drug Interaction Potential of Commonly Used Botanicals on the US Market with Regard to PXR- and AhR-Mediated Influences on CYP3A4 and CYP1A2. J Diet Suppl 2022. PubMed
  40. Sabbaghzadegan S, Soltani MH, Kamalinejad M, Bahrami M, Kabir A, Dadmehr M. The effect of a standardized capsule of Aloe vera gel on the quality of life in patients with systolic heart failure: A randomized double-blind placebo-controlled clinical trial.
  41. Lewis ED, Crowley DC, Guthrie N, Evans M. Healthy adults supplemented with a nutraceutical formulation containing Aloe vera gel, rosemary and Poria cocos enhances the effect of influenza vaccination in a randomized, triple-blind, placebo-controlled trial. PubMed

See these in context on the Aloe monograph →

Yucca 3 references
  1. <p><span>Kanerva, L., Estlander, T., Petman, L., Makinen-Kiljunen, S. Occupational allergic contact urticaria to yucca (Yucca aloifolia), weeping fig (Ficus benjamina), and spathe flower (Spathiphyllum wallisii). Allergy. 2001;56(10): 1008-11.</span></p>
  2. Poljacki, M., Paravina, M., Jovanovic, M., Subotic, M., and Duran, V. [Contact allergic dermatitis caused by plants]. Med Pregl. 1993;46(9-10):371-375.
  3. Mahillon, V., Saussez, S., and Michel, O. High incidence of sensitization to ornamental plants in allergic rhinitis. Allergy 2006;61(9):1138-1140. PubMed

See these in context on the Yucca monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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