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Dietary supplement

Alpha GPC 300 mg Ingredients & Drug Interactions

by Zazzee Naturals

Alpha GPC 300 mg label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Minor
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Alpha GPC 300 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Minor

Alpha GPC 300 mg is a dietary supplement by Zazzee Naturals with 1 active ingredient. Its ingredients are commonly taken for memory and learning support, age-related cognitive decline, alzheimer's disease and dementia (under study).Based on those ingredients, 16 medications have a known interaction with it, the most serious rated minor. The ingredients most likely to interact are L Alpha Glycerylphosphorylcholine. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Alpha GPC 300 mg by Zazzee Naturals

Ask about any prescription or over-the-counter medication and we check it for interactions with Alpha GPC 300 mg by Zazzee Naturals — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Alpha GPC 300 mg by Zazzee Naturals

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

Zazzee Naturals Alpha GPC contains one active ingredient: alpha-GPC (L Alpha Glycerylphosphorylcholine), a naturally occurring compound in the brain that plays a role in cell membrane function and neurotransmitter production. The capsule also contains inactive ingredients—cellulose, rice powder, and silica—which are fillers and binders.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: support optimal cognitive function.
  • We looked for evidence on: Cognitive function, Alzheimer disease, Vascular dementia, Memory, Age-related cognitive decline, Learning.
  • The strongest evidence on file: Alpha-gpc is rated "Possibly Effective" for Alzheimer disease (Natural Medicines).
  • Also on file: Alpha-gpc is rated "Insufficient Reliable Evidence To Rate" for Cognitive function, Vascular dementia.

The evidence supporting alpha-GPC is mixed. For Alzheimer disease, it's rated possibly effective — meaning there's some clinical support, but it's not definitive.

For cognitive function, stroke recovery, brain tumors, and vascular dementia, the evidence isn't established enough in our data to rate it. If you're considering this for brain health or memory, talk with your doctor about whether the current evidence makes sense for your situation.

The evidence, ingredient by ingredient Alpha-gpc

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Alpha-GPC is generally well tolerated in studies, though long-term safety hasn't been fully established. Rarely, people have reported dizziness, headache, insomnia, nausea, heartburn, diarrhea, vomiting, and excitation.

There's one important caution: oral alpha-GPC use for 2 months or longer has been rarely associated with an elevated stroke risk compared to non-users or those using it for shorter periods. Pregnancy and lactation safety information isn't on file for this ingredient, so talk with your doctor or pharmacist if you're pregnant or nursing.

Side effects, ingredient by ingredient Alpha-gpc

Meds to double-check

Minor interactions only
Known Interaction Concern · database check
Minor only

Only Minor-severity interactions are documented for these ingredients.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Alpha-gpc.
  • The most serious interaction on file is rated Minor.
  • For scale: 16 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you use a scopolamine patch (Transderm Scop) for motion sickness, check with your pharmacist before adding this product — alpha-GPC may reduce its effects. Because we hold data on only one documented interaction, run your complete medication list through the checker on this page before you start.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Only minor medication interactions are documented, and safety information is well characterized.

Alpha-GPC may be worth considering if you're exploring options for Alzheimer disease, but the evidence for other cognitive claims is unclear. Because of the rare stroke risk with longer-term use and the incomplete long-term safety data, this isn't something to start on your own — check with your doctor first, especially if you're older or have cardiovascular risk factors.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Oct 24, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Alpha GPC 300 mg, straight from the product label.

Brand Zazzee Naturals
Barcode (UPC) X001RROU8J
Net contents 75 Veggie Cap(s)
Market status On market
Date entered into DSLD Oct 24, 2022
DSLD ID 276068
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Alpha GPC 300 mg by Zazzee Naturals, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Veggie Capsule(s)
Maximum serving Sizes:
2 Veggie Capsule(s)
Servings per container
38
UPC/BARCODE
X001RROU8J
IngredientAmount% DV
L Alpha Glycerylphosphorylcholine600 mg--

Other ingredients: Cellulose, Cellulose powder, Rice, Powder, Silica

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested Usage: As a dietary supplement, take 2 capsules twice daily with food, or as directed by your healthcare practitioner.

Formula

Zazzee Naturals Alpha GPC is a high-quality, all-natural choline compound that is particularly important to support optimal cognitive function. Alpha GPC is a highly bioavailable form of choline that crosses the blood brain barrier. Studies have shown that Alpha GPC supports healthy brain function, memory, mental sharpness and overall mental acuity.

Alpha GPC (Choline Alfoscerate) 300 mg per capsule

Precautions

Warnings: For adults only.

Consult physician if pregnant or nursing, taking medication, or have a medical condition.

Keep out of reach of children.

Do not eat freshness packet. Keep in bottle.

Allergen Information: Not manufactured with yeast, soy, wheat, corn, gluten, milk, egg, fish, shellfish or tree nut ingredients. Produced in a GMP facility that processes other ingredients containing these allergens.

Storage

Store in a cool, dry place after opening.

General Statements

Please recycle.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Formulation

Supports healthy mental acuity Supports enhanced memory function Supports increased mental sharpness

Allergen Information: Not manufactured with yeast, soy, wheat, corn, gluten, milk, egg, fish, shellfish or tree nut ingredients.

Natural color variation may occur in this product.

Made with Non GMO ingredients

FDA Statement of Identity

Dietary Supplement

Seals/Symbols

GMP Good Manufacturing Practice Consistent Quality Made in USA

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Alpha GPC 300 mg by Zazzee Naturals label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Alpha GPC 300 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Alpha GPC 300 mg by Zazzee Naturals

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size2 Veggie Capsule(s) Dosage formCapsule Servings per container38 Amounts shown are per serving.

L Alpha Glycerylphosphorylcholine

Interacts with
16 drugs
600 mg per serving

Alpha-GPC is a choline-containing compound used mainly for memory, brain health, and as a choline source. There is some evidence it may help cognition...

L Alpha Glycerylphosphorylcholine monograph & interactions

Other (inactive) ingredients: Cellulose, Cellulose powder, Rice, Powder, Silica. These complete the product’s ingredient list but are not active constituents.

Interaction report

Alpha GPC 300 mg by Zazzee Naturals Drug Interactions

Want to check YOUR meds against Alpha GPC 300 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
16Drugs
16 Minor

Ingredients driving the most interactions

L Alpha Glycerylphosphorylcholine 16

Individual Drug Interactions

The ingredients in Alpha GPC 300 mg interact with 16 drugs. Click any drug to see the details.

1 of the 1 ingredient in Alpha GPC 300 mg interact with drugs. Each result below shows which ingredient is responsible. L Alpha Glycerylphosphorylcholine

Each ingredient & the kinds of drugs it affects

For each ingredient in Alpha GPC 300 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

L Alpha Glycerylphosphorylcholine1 drug type · 16 drugs

Scopolamine (Transderm Scop)

Theoretically, alpha-GPC might decrease the effects of scopolamine.
A small clinical study shows that alpha-GPC can partially counteract the attention and memory impairment effects caused by scopolamine given intramuscularly. Whether alpha-GPC can decrease the beneficial anti-motion sickness effects of the scopolamine patch (Transderm Scop) is unclear.

Likelihood Possible Evidence B
L Alpha Glycerylphosphorylcholine full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Alpha GPC 300 mg, from the product label.

Zazzee Naturals

See all Zazzee Naturals products
Name
Zazzee Naturals
Street Address
400 Rella Boulevard Suite 123 Dept. 182
City
Montebello
State
NY
ZipCode
10901
Pharmacist Counseling Corner

Alpha GPC 300 mg by Zazzee Naturals: Common Questions

Does Alpha GPC 300 mg by Zazzee Naturals interact with any medications?
Yes. Based on its ingredients, Alpha GPC 300 mg has a known interaction with 16 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Alpha GPC 300 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is alpha-GPC and what does it do?
Alpha-GPC is a compound naturally found in the brain that helps build and maintain cell membranes and supports the production of acetylcholine, a neurotransmitter involved in memory and learning. That's why it's studied for brain health and cognitive function.
Does it actually work for memory or Alzheimer disease?
For Alzheimer disease, alpha-GPC is rated possibly effective, meaning there's some clinical support — but it's not a proven cure. For general memory and cognitive function, the evidence we hold isn't strong enough to rate. Your doctor can discuss whether it might help your specific situation.
Are there any side effects I should know about?
Alpha-GPC is generally well tolerated, but rarely people report dizziness, headache, insomnia, nausea, or upset stomach. One important note: longer-term use (2 months or more) has been rarely linked to a higher stroke risk compared to non-users or short-term users — so this isn't casual, long-term supplementing without medical oversight.
Is it safe to use if I'm pregnant or breastfeeding?
We don't have enough safety information for alpha-GPC during pregnancy or breastfeeding. Talk with your doctor or pharmacist before using it if you're pregnant, planning to become pregnant, or nursing.
Can I take this with my other medications?
The main documented concern is the scopolamine patch (Transderm Scop) — alpha-GPC might reduce its motion sickness effects. Run all your medications through the checker on this page to be sure, or ask your pharmacist.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Alpha GPC 300 mg is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Alpha GPC 300 mg label
Go deeper

The Full Monographs Behind Alpha GPC 300 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Alpha-gpc

Interacts with 16 drugs

Alpha-GPC is a choline-containing compound used mainly for memory, brain health, and as a choline source. There is some evidence it may help cognition in people with dementia, but evidence i...

Read the full Alpha-gpc monograph →
Sources

Sources & How We Checked

Alpha GPC 300 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 4 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Alpha-gpc 4 references
  1. Di Perri R, Coppola G, Ambrosio LA, et al. A multicentre trial to the evaluate the efficacy and tolerability of alpha-glycerylphosphorylcholine versus cytosine diphosphocholine in patients with vascular dementia. J Int Med Res 1991;19:330-41.
  2. Barbagallo Sangiorgi G, Barbagallo M, Giordano M, et al. Alpha-glycerophosphocholine in the mental recovery of cerebral ischemic attacks: An Italian multicenter clinical trial. Ann N Y Acad Sci 1994;717:253-69. PubMed
  3. Canal N, Franceschi M, Alberoni M, et al. Effect of L-alpha-glyceryl-phosphorylcholine on amnesia caused by scopolamine. Int J Clin Pharmacol Ther Toxicol 1991;29:103-7.
  4. Lee G, Choi S, Chang J, et al. Association of L-a glycerylphosphorylcholine with subsequent stroke risk after 10 Years. JAMA Netw Open 2021;4(11):e2136008.

See these in context on the Alpha-gpc monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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