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Dietary supplement

Alpha-GPC Ingredients & Drug Interactions

by Pure Encapsulations

Alpha-GPC label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Minor
Clinical methodology reviewed by · Updated Sep 30, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Alpha-GPC against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Minor

Alpha-GPC is a dietary supplement by Pure Encapsulations with 1 active ingredient. Its ingredients are commonly taken for memory and learning support, age-related cognitive decline, alzheimer's disease and dementia (under study).Based on those ingredients, 16 medications have a known interaction with it, the most serious rated minor. The ingredients most likely to interact are Alpha-GPC. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Alpha-GPC by Pure Encapsulations

Ask about any prescription or over-the-counter medication and we check it for interactions with Alpha-GPC by Pure Encapsulations — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Alpha-GPC by Pure Encapsulations

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 16, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: alpha-GPC, a naturally occurring compound involved in brain cell function. The capsule also contains a few inactive ingredients—glycerin, water, and the vegetarian capsule shell itself—which help deliver the dose.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: supports cognitive health.
  • We looked for evidence on: Cognitive function, Alzheimer disease, Vascular dementia, memory, age-related cognitive decline, learning.
  • The strongest evidence on file: Alpha-gpc is rated "Possibly Effective" for Alzheimer disease (Natural Medicines).
  • Also on file: Alpha-gpc is rated "Insufficient Reliable Evidence To Rate" for Cognitive function, Vascular dementia.

The evidence for alpha-GPC is mixed and limited. It's rated possibly effective for Alzheimer disease based on available studies.

For brain tumors, cognitive function, vascular dementia, and stroke, the evidence is insufficient to say whether it works. If you're considering it for any of these conditions, talk it over with your doctor about whether the current data supports a trial.

The evidence, ingredient by ingredient Alpha-gpc

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Alpha-GPC is generally well tolerated in studies, though long-term safety hasn't been fully established. Oral use has rarely been linked to dizziness, headache, insomnia, nausea, heartburn, diarrhea, and vomiting.

More concerning: alpha-GPC taken for at least 2 months has been rarely associated with an elevated stroke risk compared with non-users or shorter-term users. Because safety data is incomplete, you should take this supplement only if your doctor directs you to do so.

Side effects, ingredient by ingredient Alpha-gpc

Meds to double-check

Minor interactions only
Known Interaction Concern · database check
Minor only

Only Minor-severity interactions are documented for these ingredients.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Alpha-gpc.
  • The most serious interaction on file is rated Minor.
  • For scale: 16 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you use the scopolamine motion sickness patch (Transderm Scop), alpha-GPC might reduce its effectiveness—mention both to your doctor or pharmacist so you can plan accordingly. Although we have limited interaction data, run your complete medication list through the search tool on this page before starting.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Only minor medication interactions are documented, and safety information is well characterized.

Alpha-GPC may be worth considering for Alzheimer disease support, but the evidence for other uses is too thin to recommend it. The long-term safety picture is unclear, and extended use carries a rare but documented stroke concern.

Talk with your doctor or pharmacist about whether this makes sense for you and how to monitor for side effects.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Mar 25, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Alpha-GPC, straight from the product label.

Brand Pure Encapsulations
Barcode (UPC) 766298015941
Net contents 60 Caplique Capsule(s)
Market status On market
Date entered into DSLD Mar 25, 2021
DSLD ID 245975
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Alpha-GPC by Pure Encapsulations, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Caplique Capsule(s)
Maximum serving Sizes:
2 Caplique Capsule(s)
Servings per container
30
UPC/BARCODE
766298015941
IngredientAmount% DV
Alpha-GPC400 mg--

Other ingredients: Glycerin, Vegetarian Caplique (symbols) Capsule, Water

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Storage

Store in a cool, dry place.

Suggested/Recommended/Usage/Directions

Recommendations: As a dietary supplement, take 2 caplique capsules, 3 times daily, with or between meals.

Precautions

Warning: If you are pregnant or lactating, have any health condition or are taking any medication, consult your health professional before use.

Keep out of the reach of children.

Use only if safety seal is intact.

Contains soy

General Statements

Scan to learn about our hypoallergenic supplements Contents may not fill package in order to accommodate required labeling. Please rely on stated quantity.

Neurotransmitter and phospholipid precursor: Supports cognitive health

Formulation

Gluten-free & Non-GMO

Each Caplique Capsule is preserved with a nitrogen bubble, with may give the appearance of the capsule not being full. Contents may appear cloudy or thick and may settle or separate.

FDA Statement of Identity

Dietary Supplement

Brand IP Statement(s)

Caplique Capsule is a registered trademark used by Pure Encapsulations under license.

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Alpha-GPC by Pure Encapsulations label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Alpha-GPC label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Alpha-GPC by Pure Encapsulations

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size2 Caplique Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Alpha-GPC

Interacts with
16 drugs
400 mg per serving

Alpha-GPC is a choline-containing compound used mainly for memory, brain health, and as a choline source. There is some evidence it may help cognition...

Alpha-GPC monograph & interactions

Other (inactive) ingredients: Glycerin, Vegetarian Caplique (symbols) Capsule, Water. These complete the product’s ingredient list but are not active constituents.

Interaction report

Alpha-GPC by Pure Encapsulations Drug Interactions

Want to check YOUR meds against Alpha-GPC?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
16Drugs
16 Minor

Ingredients driving the most interactions

Alpha-GPC 16

Individual Drug Interactions

The ingredients in Alpha-GPC interact with 16 drugs. Click any drug to see the details.

1 of the 1 ingredient in Alpha-GPC interact with drugs. Each result below shows which ingredient is responsible. Alpha-GPC

Each ingredient & the kinds of drugs it affects

For each ingredient in Alpha-GPC with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Alpha-GPC1 drug type · 16 drugs

Scopolamine (Transderm Scop)

Theoretically, alpha-GPC might decrease the effects of scopolamine.
A small clinical study shows that alpha-GPC can partially counteract the attention and memory impairment effects caused by scopolamine given intramuscularly. Whether alpha-GPC can decrease the beneficial anti-motion sickness effects of the scopolamine patch (Transderm Scop) is unclear.

Likelihood Possible Evidence B
Alpha-GPC full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Alpha-GPC, from the product label.

Pure Encapsulations

See all Pure Encapsulations products
Name
Pure Encapsulations
Street Address
490 Boston Post Road
City
Sudbury
State
MA
Phone Number
1-800-753-2277
Web Address
www.PureEncapsulations.com
Pharmacist Counseling Corner

Alpha-GPC by Pure Encapsulations: Common Questions

Does Alpha-GPC by Pure Encapsulations interact with any medications?
Yes. Based on its ingredients, Alpha-GPC has a known interaction with 16 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Alpha-GPC contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this help my memory or cognitive function?
The evidence isn't strong enough yet to say. Alpha-GPC is possibly effective for Alzheimer disease, but for general cognitive function or memory in other conditions, the data is insufficient. Talk with your doctor about whether it's worth trying in your situation.
What side effects should I watch for?
Most people tolerate alpha-GPC well, but rarely it can cause dizziness, headache, insomnia, nausea, heartburn, diarrhea, or vomiting. More importantly, if you take it for 2 months or longer, there's a rare association with increased stroke risk. If you experience chest pain, severe headache, sudden weakness, or slurred speech, seek immediate medical attention.
Is alpha-GPC safe to take long-term?
Long-term safety hasn't been fully established, and extended use (at least 2 months) carries a rare but documented higher stroke risk. Because of this gap in safety data, you should only take it under your doctor's direction and with regular check-ins about your health.
Can I take this while pregnant or breastfeeding?
There isn't enough safety information to know either way. Talk with your doctor or pharmacist before taking alpha-GPC if you're pregnant, planning to become pregnant, or breastfeeding—they can help you weigh the unknowns against your individual needs.
Does this product contain any fillers or artificial ingredients?
No. The capsule contains only glycerin, water, and the vegetarian capsule shell—just the inactive ingredients needed to deliver the alpha-GPC itself.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Alpha-GPC is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Alpha-GPC label
Go deeper

The Full Monographs Behind Alpha-GPC’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Alpha-gpc

Interacts with 16 drugs

Alpha-GPC is a choline-containing compound used mainly for memory, brain health, and as a choline source. There is some evidence it may help cognition in people with dementia, but evidence i...

Read the full Alpha-gpc monograph →
Sources

Sources & How We Checked

Alpha-GPC's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 4 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Alpha-gpc 4 references
  1. Di Perri R, Coppola G, Ambrosio LA, et al. A multicentre trial to the evaluate the efficacy and tolerability of alpha-glycerylphosphorylcholine versus cytosine diphosphocholine in patients with vascular dementia. J Int Med Res 1991;19:330-41.
  2. Barbagallo Sangiorgi G, Barbagallo M, Giordano M, et al. Alpha-glycerophosphocholine in the mental recovery of cerebral ischemic attacks: An Italian multicenter clinical trial. Ann N Y Acad Sci 1994;717:253-69. PubMed
  3. Canal N, Franceschi M, Alberoni M, et al. Effect of L-alpha-glyceryl-phosphorylcholine on amnesia caused by scopolamine. Int J Clin Pharmacol Ther Toxicol 1991;29:103-7.
  4. Lee G, Choi S, Chang J, et al. Association of L-a glycerylphosphorylcholine with subsequent stroke risk after 10 Years. JAMA Netw Open 2021;4(11):e2136008.

See these in context on the Alpha-gpc monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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