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Dietary supplement

Alpha-GPC Ingredients & Drug Interactions

by Momentous

Alpha-GPC label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Minor
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Alpha-GPC against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Minor

Alpha-GPC is a dietary supplement by Momentous with 1 active ingredient. Its ingredients are commonly taken for memory and learning support, age-related cognitive decline, alzheimer's disease and dementia (under study).Based on those ingredients, 16 medications have a known interaction with it, the most serious rated minor. The ingredients most likely to interact are AlphaSize Alpha-Glyceryl Phosphoryl Choline. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Alpha-GPC by Momentous

Ask about any prescription or over-the-counter medication and we check it for interactions with Alpha-GPC by Momentous — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Alpha-GPC by Momentous

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

Momentous Alpha-GPC is a single-ingredient supplement containing AlphaSize Alpha-Glyceryl Phosphoryl Choline, commonly called alpha-GPC. This is a naturally occurring compound in the body that plays a role in cell membrane structure and signaling, particularly in the brain.

The capsule itself also contains several inactive ingredients — hypromellose, microcrystalline cellulose, calcium silicate, silica, and magnesium stearate — which are common binders and fillers used to form and stabilize the capsule.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: Supports cognitive function, memory, focus and clarity.
  • We looked for evidence on: Cognitive function, Alzheimer disease, Vascular dementia, Age-related cognitive decline, Memory.
  • The strongest evidence on file: Alpha-gpc is rated "Possibly Effective" for Alzheimer disease (Natural Medicines).
  • Also on file: Alpha-gpc is rated "Insufficient Reliable Evidence To Rate" for Cognitive function, Vascular dementia.

The evidence for alpha-GPC is mixed depending on what you're hoping it will do. For Alzheimer disease, it's rated as possibly effective, meaning there's some research support but it's not conclusive.

For cognitive function, stroke, vascular dementia, and brain tumors, we don't have enough reliable evidence yet to rate how well it works. If you're considering it for memory or brain health, talk to your pharmacist about whether the current evidence matches your particular situation.

The evidence, ingredient by ingredient Alpha-gpc

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Alpha-GPC is generally well tolerated in studies, but long-term safety hasn't been fully established, so there's a limit to what we know about using it indefinitely. Rare adverse effects reported orally include dizziness, headache, insomnia, excitation, nausea, vomiting, diarrhea, and heartburn.

There's also a rare but serious concern: people taking alpha-GPC orally for at least 2 months showed an elevated risk of stroke compared with non-users or those using it for less than 2 months. We don't have enough safety information for pregnancy and breastfeeding, so talk with your doctor or pharmacist before using it if you're pregnant, nursing, or planning to become pregnant.

Side effects, ingredient by ingredient Alpha-gpc

Meds to double-check

Minor interactions only
Known Interaction Concern · database check
Minor only

Only Minor-severity interactions are documented for these ingredients.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Alpha-gpc.
  • The most serious interaction on file is rated Minor.
  • For scale: 16 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take scopolamine (Transderm Scop) for motion sickness, alpha-GPC might reduce its effectiveness. Before starting this supplement, check any prescription medications you take with the search tool below — we want to make sure nothing else comes up that could be affected.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Only minor medication interactions are documented, and safety information is well characterized.

Alpha-GPC may be worth considering if you're interested in brain health and have looked into the limited evidence for Alzheimer disease, but know that long-term safety isn't fully proven and there's a rare stroke risk with extended use. If you're on any medications — especially if you wear a scopolamine patch — or if you're pregnant or breastfeeding, talk with your pharmacist first.

Check your exact medications with the tool on this page before you start.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Feb 23, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Alpha-GPC, straight from the product label.

Brand Momentous
Barcode (UPC) 850030796028
Net contents 60 Capsule(s)
Market status On market
Date entered into DSLD Feb 23, 2025
DSLD ID 321462
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Alpha-GPC by Momentous, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
60
UPC/BARCODE
850030796028
IngredientAmount% DV
AlphaSize Alpha-Glyceryl Phosphoryl Choline300 mg--

Other ingredients: Hypromellose, Microcrystalline Cellulose, Calcium Silicate, Silica, Magnesium Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

The continuous pursuit of progress in human health and performance.

Formula

Momentous Alpha-GPC promotes the release of the neurotransmitter acetylcholine and supports cognitive function. Alpha-GPC supports memory, focus and clarity while helping to protect against cognitive decline.

Suggested/Recommended/Usage/Directions

Directions: Take 1 capsule daily or as directed by your healthcare professional.

Formulation

Cognitive and muscle function.

Gluten free GMO free

FDA Statement of Identity

Dietary Supplement

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Alpha-GPC by Momentous label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Alpha-GPC label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Alpha-GPC by Momentous

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

AlphaSize Alpha-Glyceryl Phosphoryl Choline

Interacts with
16 drugs
300 mg per serving

Alpha-GPC is a choline-containing compound used mainly for memory, brain health, and as a choline source. There is some evidence it may help cognition...

AlphaSize Alpha-Glyceryl Phosphoryl Choline monograph & interactions

Other (inactive) ingredients: Hypromellose, Microcrystalline Cellulose, Calcium Silicate, Silica, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Alpha-GPC by Momentous Drug Interactions

Want to check YOUR meds against Alpha-GPC?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
16Drugs
16 Minor

Ingredients driving the most interactions

AlphaSize Alpha-Glyceryl Phosphoryl Choline 16

Individual Drug Interactions

The ingredients in Alpha-GPC interact with 16 drugs. Click any drug to see the details.

1 of the 1 ingredient in Alpha-GPC interact with drugs. Each result below shows which ingredient is responsible. AlphaSize Alpha-Glyceryl Phosphoryl Choline

Each ingredient & the kinds of drugs it affects

For each ingredient in Alpha-GPC with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

AlphaSize Alpha-Glyceryl Phosphoryl Choline1 drug type · 16 drugs

Scopolamine (Transderm Scop)

Theoretically, alpha-GPC might decrease the effects of scopolamine.
A small clinical study shows that alpha-GPC can partially counteract the attention and memory impairment effects caused by scopolamine given intramuscularly. Whether alpha-GPC can decrease the beneficial anti-motion sickness effects of the scopolamine patch (Transderm Scop) is unclear.

Likelihood Possible Evidence B
AlphaSize Alpha-Glyceryl Phosphoryl Choline full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Alpha-GPC, from the product label.

Momentous

See all Momentous products
Name
Momentous
Street Address
2700 Rasmussen Road
City
Park City
State
UT
ZipCode
84098
Web Address
www.livemomentous.com
Pharmacist Counseling Corner

Alpha-GPC by Momentous: Common Questions

Does Alpha-GPC by Momentous interact with any medications?
Yes. Based on its ingredients, Alpha-GPC has a known interaction with 16 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Alpha-GPC contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is alpha-GPC supposed to do?
Alpha-GPC is a compound that supports cell membranes and signaling in the brain. It's been studied most for Alzheimer disease, where it shows some promise, but the evidence for general memory or cognitive function isn't strong enough yet to say it works for those purposes.
Is it safe to take long-term?
Alpha-GPC is generally well tolerated in short-term studies, but we don't know much about safety over months or years of continuous use. One concern is that people taking it for 2 months or longer had a higher stroke risk than non-users — talk with your doctor before committing to long-term use.
What side effects should I watch for?
Most people tolerate it fine, but rarely people report dizziness, headache, insomnia, nausea, vomiting, diarrhea, and heartburn. Stroke is a rare but serious risk with long-term use. If you notice any new or unusual symptoms, stop taking it and call your doctor.
Can I take it if I'm pregnant or breastfeeding?
We don't have enough safety data for pregnancy and breastfeeding. Talk with your doctor or pharmacist about whether it's right for you before taking it in either situation.
Does it interact with my motion sickness patch?
Alpha-GPC might reduce how well a scopolamine patch (Transderm Scop) works by partially counteracting its effects in the brain. If you wear one, check with your pharmacist before starting this supplement.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Alpha-GPC is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Alpha-GPC label
Go deeper

The Full Monographs Behind Alpha-GPC’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Alpha-gpc

Interacts with 16 drugs

Alpha-GPC is a choline-containing compound used mainly for memory, brain health, and as a choline source. There is some evidence it may help cognition in people with dementia, but evidence i...

Read the full Alpha-gpc monograph →
Sources

Sources & How We Checked

Alpha-GPC's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 4 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Alpha-gpc 4 references
  1. Di Perri R, Coppola G, Ambrosio LA, et al. A multicentre trial to the evaluate the efficacy and tolerability of alpha-glycerylphosphorylcholine versus cytosine diphosphocholine in patients with vascular dementia. J Int Med Res 1991;19:330-41.
  2. Barbagallo Sangiorgi G, Barbagallo M, Giordano M, et al. Alpha-glycerophosphocholine in the mental recovery of cerebral ischemic attacks: An Italian multicenter clinical trial. Ann N Y Acad Sci 1994;717:253-69. PubMed
  3. Canal N, Franceschi M, Alberoni M, et al. Effect of L-alpha-glyceryl-phosphorylcholine on amnesia caused by scopolamine. Int J Clin Pharmacol Ther Toxicol 1991;29:103-7.
  4. Lee G, Choi S, Chang J, et al. Association of L-a glycerylphosphorylcholine with subsequent stroke risk after 10 Years. JAMA Netw Open 2021;4(11):e2136008.

See these in context on the Alpha-gpc monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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