Interactions on record — worth a quick check against your medications. Based on 6 of 11 ingredients. Check your meds →
Dietary supplement

Amino Build Green Apple Ingredients & Drug Interactions

by MuscleTech Performance Series

Powder Category: Other Combinations
Most serious interaction: Moderate
The interaction bottom line Most serious interaction: Moderate

Amino Build Green Apple is a dietary supplement by MuscleTech Performance Series with 11 active ingredients. Its ingredients are commonly taken for replacing fluids and electrolytes, preventing dehydration during exercise or illness, treating low blood sodium (under medical care).Based on those ingredients, 275 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Sodium, L-Citrulline Malate, Taurine. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

HelloPharmacist Scorecard of Amino Build Green Apple by MuscleTech Performance Series

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 10 of its 10 active ingredients.
  • “2:1:1 BCAA Matrix” is a proprietary blend — the label doesn't break down how much of each component you get.
  • “Cell-Volumizing Muscle Complex” is a proprietary blend — the label doesn't break down how much of each component you get.
  • “Strength-Enhancing Compound” is listed as a grouped ingredient — the label doesn't break down how much of each component you get.

Amino Build Green Apple contains 10 active ingredients. The foundation is L-glutamine, a branched-chain amino acid that supports muscle recovery and immune function.

You'll also get sodium and potassium—essential electrolytes—along with other amino acids like L-alanine and taurine, which support muscle energy and heart health. The product includes a 2:1:1 BCAA (branched-chain amino acid) matrix, a cell-volumizing complex, L-citrulline malate for blood flow, and a strength-enhancing compound.

Several other amino acids—L-leucine, L-isoleucine, and L-valine—round out the profile. Inactive ingredients include malic acid, acesulfame potassium, salt, sucralose, FD&C Yellow No.

5, and FD&C Blue No. 1.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: increase strength and muscle endurance.
  • We looked for evidence on: Athletic performance, Exercise-induced muscle damage, Exercise-induced muscle soreness, Muscle strength, Physical performance, Sarcopenia — and 3 related terms.
  • The strongest evidence on file: L-citrulline is rated "Possibly Effective" for Athletic performance (Natural Medicines).
  • Also on file: Glutamine is rated "Possibly Ineffective" for Athletic performance.
  • Also on file: L-citrulline is rated "Possibly Ineffective" for Sarcopenia.

The evidence for these ingredients is mixed. L-glutamine is rated effective for sickle cell disease and possibly effective for HIV/AIDS-related muscle wasting, recovery after surgery, and critical illness from trauma.

L-citrulline malate is possibly effective for athletic performance. Taurine is possibly effective for hepatitis and congestive heart failure but possibly ineffective for weight loss.

For L-alanine, there's insufficient evidence to rate it for any of the conditions studied—cognitive function, diabetes, dehydration-related diarrhea, and fatigue. That means the science doesn't establish whether it works for those purposes.

Sodium and potassium don't have effectiveness ratings on file for athletic or muscle-building uses; we hold data mainly for medical uses like cystic fibrosis and heart conditions.

The evidence, ingredient by ingredient Sodium Potassium Glutamine Alpha-alanine Taurine L-citrulline

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 5 of the 6 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 6 of 6.
  • General safety write-ups exist for 6 of 6.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

L-glutamine is generally well tolerated in healthy adults, though people with kidney or liver disease should use it only under medical supervision. Gastrointestinal side effects—belching, bloating, constipation, diarrhea, flatulence, nausea, and vomiting—are common.

Rare cases of dizziness, headache, and mood changes (mania) have been reported at high doses. Sodium should be used cautiously; excessive intake is linked to high blood pressure and heart and kidney strain.

Taurine is generally well tolerated short-term, but long-term safety is less certain; constipation, diarrhea, and heartburn are the most common side effects. L-citrulline malate is usually well tolerated but may cause gastrointestinal discomfort and heartburn.

Potassium from this product is generally well tolerated, but dangerously high potassium levels—though rare—can cause heart rhythm problems, confusion, and low blood pressure. For pregnancy: L-glutamine, sodium, L-alanine, taurine, and potassium are rated likely safe.

L-citrulline malate should be avoided during pregnancy (not enough safety data), and we hold no pregnancy/lactation data for L-citrulline malate while breastfeeding—talk with your doctor or pharmacist.

Side effects, ingredient by ingredient Sodium Potassium Glutamine Alpha-alanine Taurine L-citrulline

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 5 of the 6 matched ingredients can interact with medications — Potassium, Glutamine, Taurine, L-citrulline, Sodium.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: seizure medications; lithium.
  • For scale: 275 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, double-check if you're on seizure medications (anticonvulsants), blood pressure or heart medications (antihypertensives, ACE inhibitors, ARBs), lithium, potassium-sparing diuretics, corticosteroids, didanosine, or any sodium-containing medications. All of these have documented interactions with ingredients in this formula—mainly Moderate severity.

Your pharmacist can tell you whether it's safe for your specific regimen.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This is a branched-chain amino acid supplement aimed at muscle building and recovery. It's a good fit if you're working out and want amino acid support, but it's not for everyone.

If you take blood pressure medications, seizure medications, lithium, potassium-sparing diuretics, or heart medications, check your specific drugs with your pharmacist before using this product.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 6 of 10 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Feb 25, 2015.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Amino Build Green Apple, straight from the product label.

Brand MuscleTech Performance Series
Barcode (UPC) 631656703931
Net contents 0.59 lbs; 267 Gram(s)
Market status On market
Date entered into DSLD Feb 25, 2015
DSLD ID 42658
Product type Other Combinations
Supplement form Powder
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Amino Build Green Apple by MuscleTech Performance Series, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
9 Gram(s)
Maximum serving Sizes:
18 Gram(s)
Servings per container
30
UPC/BARCODE
631656703931
IngredientAmount% DV
Calories70 {Calories}, 30 {Calories}--
Total Carbohydrates2 Gram(s), 1 Gram(s)1%, 1%
L-Glutamine1000 mg, 500 mg--
Sugar0 Gram(s), 0 Gram(s)--
Sodium60 mg, 30 mg1%, 1%
L-Leucine4000 mg, 2000 mg--
L-Alanine1000 mg, 500 mg--
L-Isoleucine2000 mg, 1000 mg--
Taurine1000 mg, 500 mg--
L-Valine2000 mg, 1000 mg--
Betaine2500 mg, 1250 mg--
Potassium36 mg, 18 mg1%, 1%
2:1:1 BCAA Matrix0 NP, 0 NP--
Cell-Volumizing Muscle Complex0 NP, 0 NP--
L-Citrulline Malate1000 mg, 500 mg--
Strength-Enhancing Compound0 NP, 0 NP--

Other ingredients: Natural and Artificial flavors, Malic Acid, Acesulfame-Potassium, Salt, Sucralose, FD&C Yellow No. 5, FD&C Blue No. 1

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Brand IP Statement(s)

If you’re serious about performance and results, you need the ALL-NEW MuscleTech(R) Performance Series!

(C) 2012.

Formulation

NO Proprietary Blends ~ NO Underdosed Key Ingredients ~ NO Banned Substances (WADA) ~ NO Fillers ~ NO Hype ~ NO Exceptions

0g Sugar

General Statements

Just the Most Powerful Formulas Available

This amino fuel tastes great, mixes easily, and can be used to aid strength and muscle endurance.

~ Increase Strength by over 40%

Together, these will help you get stronger and go longer.,2

~ Enhances Endurance with First Dose

REFERENCES 1. Ispoglou et al. 2011. International Journal of Sports Physiology and Performance. 6(1), 38-50. 2. Hoffman et al. 2009. Journal of the International Society of Sports Nutrition. 6:7. 3. Balshaw et al. 2012. Amino Acids.

~ Added Cell-Volumizing Compounds

Together, these compounds work to enhance cell volumization during training.

~ Best-in-Class Taste

AMINO BUILD(TM) was flavored by experts in one of the world’s top flavoring houses in order to taste better than any other amino acid powder on the market.

~ Get More for Your Money Unlike the competition, Performance Series products contain superior key ingredients in clinically dosed amounts that are fully disclosed so you know exactly what you are paying for.

NEW

INCREASES STRENGTH BY OVER 40% ENHANCES ENDURANCE WITH FIRST DOSE VOLUMIZES MUSCLES DURING TRAINING

NATURAL AND ARTIFICIAL FLAVORS

Made in the U.S.A. from domestic and international ingredients.

For lot no. and expiry date: see bottle.

8457US 1212

{QRC Code}

Formula

World’s First Strength-Enhancing BCAA+ Formula ALL-NEW AMINO BUILD(TM) is a superior BCAA+ amino acid formula designed with a 2:1:1 BCAA matrix powered by a 4-gram dose of Leucine shown to increase strength by over 40%. Other cutting-edge compounds were added to enhance the overall workout experience including a clinical dose of Betaine.

AMINO BUILD(TM) also supplies vital electrolytes and Taurine, a powerful cell-volumizing agent, for a truly advanced BCAA-amino formula.

100% Free-Form 2:1:1 BCAA Matrix The branched chain amino acids in AMINO BUILD(TM) are 100% freeform. Free-form amino acids are singular molecules, which means they are quickly digested and absorbed by your bloodstream. The formula supplies a massive 8 grams of BCAAs in a 2:1:1 ratio, which helps fuel your skeletal muscles, preserves muscle glycogen stores, and helps to reduce the amount of protein breakdown.

AMINO BUILD(TM) is precisely formulated with a 4-gram dose of L-leucine shown in a clinical study to help subjects increase their 5-rep max strength by over 40% in just 12 weeks.1 A clinically studied 2.5-gram dose of Betaine has also been added to the formula that helped subjects significantly enhance their muscular endurance.

Enhances Endurance with First Dose A 1-gram dose of Taurine consumed 2 hours prior to cardio training, the same amount in AMINO BUILD, is clinically shown to improve performance in endurance athletes.,3

Added Cell-Volumizing Compounds In addition to its key ingredients, the formula delivers 4 grams of a Cell-Volumization Muscle Complex comprised of Taurine, L-glutamine, L-citrulline malate, and L-alani

WORLD’S FIRST STRENGTH-ENHANCING BCAA+ FORMULA

8G BCAAs 2:1:1 4g Leucine 2.5g Betaine

Seals/Symbols

AMERICAN MASTERS OF TASTE GOLD MEDAL SUPERIOR TASTE

FORMULATED WITH CLINICALLY DOSED KEY INGREDIENTS

FDA Statement of Identity

DIETARY SUPPLEMENT

Precautions

PROCESSED IN A FACILITY THAT ALSO PROCESSES MILK, EGG, WHEAT, SOY, FISH AND SHELLFISH INGREDIENTS.

WARNING: Not intended for use by persons under 18.

Do not use if you are pregnant or nursing.

Discontinue use and consult a medical doctor if you experience unusual symptoms.

Consult a medical doctor before use if you have been treated for, or diagnosed with or have a family history of any medical condition or if you are using any prescription or over-the-counter drug(s), including blood thinners.

Consult a medical doctor before starting any diet or exercise program. Do not exceed recommended serving. Improper use of this product will not improve results and is not advised. Use only as directed. Do not use if packaging has been tampered with.

KEEP OUT OF REACH OF CHILDREN.

Storage

Store in a cool, dry place (60(0)F to 80(0)F).

Suggested/Recommended/Usage/Directions

DIRECTIONS: Mix 1 scoop with 8 oz. of water. For full effects, mix 2 scoops with 16 oz. of water. Read the entire label before use and follow directions provided. For Improved Energy and Endurance Consume 2 hours before workout/activity For Strength and Recovery Consume during activity and post-workout If you want to add to your overall daily BCAA intake without the additional calories from drinking multiple protein shakes, you can also add 1-2 scoops to a jug of water and drink it over time.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

See for yourself

Amino Build Green Apple by MuscleTech Performance Series label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

What’s inside

The Ingredients in Amino Build Green Apple by MuscleTech Performance Series

These are the 11 active ingredients this product is made of. Select any to open its full monograph.

Serving size9 Gram(s) Dosage formPowder Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Sugar

0 Gram(s) per serving

Sodium

Interacts with
205 drugs
60 mg per serving

Sodium is an essential mineral and electrolyte your body needs to balance fluids, support nerves, and help muscles work. Most people in modern diets g...

Sodium monograph & interactions

Potassium

Interacts with
62 drugs
36 mg per serving Form: Dipotassium Phosphate

Potassium is an essential mineral your body needs for nerve signals, muscle function, and a steady heartbeat, and most people get enough from a balanc...

Potassium monograph & interactions

2:1:1 BCAA Matrix

0 NP per serving
  • › L-Leucine
  • › L-Isoleucine
  • › L-Valine

Cell-Volumizing Muscle Complex

0 NP per serving

Strength-Enhancing Compound

0 NP per serving
  • › Betaine

Other (inactive) ingredients: Natural and Artificial flavors, Malic Acid, Acesulfame-Potassium, Salt, Sucralose, FD&C Yellow No. 5, FD&C Blue No. 1. These complete the product’s ingredient list but are not active constituents.

Interaction report

Amino Build Green Apple by MuscleTech Performance Series Drug Interactions

Want to check YOUR meds against Amino Build Green Apple?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

Go to the checker
275Drugs
275 Moderate

Ingredients driving the most interactions

Sodium 205
Taurine 173

Each ingredient & the kinds of drugs it affects

For each ingredient in Amino Build Green Apple with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Sodium7 drug types · 205 drugs

Antihypertensive Drugs

Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.
High intake of dietary sodium can increase systolic and diastolic blood pressure. Also, high intake of sodium may necessitate increased use of antihypertensive medications to achieve blood pressure control in some patients, such as those with chronic kidney disease.

Likelihood Probable Evidence A
Corticosteroids

Concomitant use of mineralocorticoids and some glucocorticoids with sodium supplements might increase the risk of hypernatremia.
Mineralocorticoids and some glucocorticoids (corticosteroids) cause sodium retention. This effect is dose-related and depends on mineralocorticoid potency. It is most common with hydrocortisone, cortisone, and fludrocortisone, followed by prednisone and prednisolone.

Likelihood Possible Evidence D
Didanosine (Videx)

Concomitant use of didanosine with additional sodium from dietary or supplemental sources may increase the risk of hypernatremia.
Didanosine formulations contain a significant amount of sodium.

Likelihood Probable Evidence C
Lithium

Altering dietary intake of sodium might alter the levels and clinical effects of lithium.
High sodium intake can reduce plasma concentrations of lithium by increasing lithium excretion. Reducing sodium intake can significantly increase plasma concentrations of lithium and cause lithium toxicity in patients being treated with lithium carbonate. Stabilizing sodium intake is shown to reduce the percentage of patients with lithium level fluctuations above 0.8 mEq/L. Patients taking lithium should avoid significant alterations in their dietary intake of sodium.

Likelihood Probable Evidence B
Sodium Phosphates

Theoretically, concomitant use of sodium phosphate with sodium supplements might increase the risk of hypernatremia.
Use of high doses (> 45 mL in 24 hours) of sodium phosphate, such as those used for bowel cleansing before surgery, can lead to serious electrolyte disturbances, including hypernatremia. The risk of hypernatremia is highest in the elderly and people with other risk factors for electrolyte disturbances.

Likelihood Possible Evidence D
Sodium-Containing Drugs

Concomitant use of sodium-containing drugs with additional sodium from dietary or supplemental sources may increase the risk of hypernatremia and long-term sodium-related complications.
The Chronic Disease Risk Reduction (CDRR) intake level of 2.3 grams of sodium daily indicates the intake at which it is believed that chronic disease risk increases for the apparently healthy population. Some medications contain high quantities of sodium. When used in conjunction with sodium supplements or high-sodium diets, the CDRR may be exceeded. Additionally, concomitant use may increase the risk for hypernatremia; this risk is highest in the elderly and people with other risk factors for electrolyte disturbances.

Likelihood Possible Evidence D
Tolvaptan (Samsca)

Theoretically, concomitant use of tolvaptan with sodium might increase the risk of hypernatremia.
Tolvaptan is a vasopressin receptor 2 antagonist that is used to increase sodium levels in patients with hyponatremia. Patients taking tolvaptan should use caution with the use of sodium salts such as sodium chloride.

Likelihood Probable Evidence C

L-Citrulline Malate2 drug types · 178 drugs

Antihypertensive Drugs

Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
L-citrulline is converted to L-arginine, which can increase nitric oxide and cause vasodilation. However, a meta-analysis of 5 small clinical studies suggests that taking L-citrulline 3-6 grams daily for 1-8 weeks does not lower blood pressure when compared with control.

Likelihood Possible Evidence B
Phosphodiesterase-5 Inhibitors

Theoretically, concurrent use of phosphodiesterase-5 (PDE-5) inhibitors and L-citrulline might result in additive vasodilation.
L-citrulline is converted to L-arginine, which can increase nitric oxide and cause vasodilation. Theoretically, taking L-arginine with PDE-5 inhibitors might have additive vasodilatory and hypotensive effects. However, in studies evaluating the combined use of L-arginine and sildenafil for erectile dysfunction, hypotension was not reported.

Likelihood Possible Evidence D

Taurine2 drug types · 173 drugs

Antihypertensive Drugs

Theoretically, taurine might increase the risk of hypotension when taken with antihypertensive drugs.
Some clinical evidence suggests that taurine can reduce both systolic and diastolic blood pressure.

Likelihood Probable Evidence D
Lithium

Theoretically, taurine might reduce excretion and increase plasma levels of lithium.
Taurine is thought to have diuretic properties, which might reduce the excretion of lithium.

Likelihood Probable Evidence D

Potassium3 drug types · 62 drugs

Ace Inhibitors (Aceis)

Using ACEIs with high doses of potassium increases the risk of hyperkalemia.
ACEIs block the actions of the renin-angiotensin-aldosterone system and reduce potassium excretion. Concomitant use of these drugs with potassium supplements increases the risk of hyperkalemia. However, concomitant use of these drugs with moderate dietary potassium intake (about 3775-5200 mg daily) does not increase serum potassium levels.

Likelihood Likely Evidence C
Angiotensin Receptor Blockers (Arbs)

Using ARBs with high doses of potassium increases the risk of hyperkalemia.
ARBs block the actions of the renin-angiotensin-aldosterone system and reduce potassium excretion. Concomitant use of these drugs with potassium supplements increases the risk of hyperkalemia. However, concomitant use of these drugs with moderate dietary potassium intake (about 3775-5200 mg daily) does not increase serum potassium levels.

Likelihood Likely Evidence C
Potassium-Sparing Diuretics

Concomitant use increases the risk of hyperkalemia.
Using potassium-sparing diuretics with potassium supplements increases the risk of hyperkalemia.

Likelihood Likely Evidence C

L-Glutamine1 drug type · 50 drugs

Anticonvulsants

Theoretically, glutamine might antagonize the effects of anticonvulsant medications.
Glutamine is metabolized to the excitatory neurotransmitter glutamate. Glutamate might have antagonistic effects with anticonvulsant drugs. However, this interaction has not yet been reported in humans.

Likelihood Possible Evidence D
The maker

Brand information

Manufacturer and brand details for Amino Build Green Apple, from the product label.

MuscleTech Performance Series

See all MuscleTech Performance Series products
Name
Iovate Health Sciences U.S.A. Inc.
Street Address
1105 North Market Street, Suite 1330
City
Wilmington
State
DE
ZipCode
19801
Pharmacist Counseling Corner

Amino Build Green Apple by MuscleTech Performance Series: Common Questions

Does Amino Build Green Apple by MuscleTech Performance Series interact with any medications?
Yes. Based on its ingredients, Amino Build Green Apple has a known interaction with 275 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Amino Build Green Apple contains 11 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is L-glutamine in this product, and what does it do?
L-glutamine is an amino acid that your muscles and immune system use for recovery and function. It's rated effective for sickle cell disease and possibly effective for muscle wasting in HIV/AIDS, recovery after surgery, and critical illness. In healthy people doing regular exercise, the evidence is less clear.
Will this product give me a lot of sodium?
Yes, the product contains sodium as an ingredient. If you have high blood pressure, heart disease, or kidney disease, or if your doctor has told you to limit sodium, check the sodium content on the label and talk with your pharmacist before using it.
What are the most common side effects?
Gastrointestinal effects are most common—belching, bloating, constipation, diarrhea, flatulence, nausea, and vomiting. These typically happen when taking high doses. Heartburn and stomach discomfort have also been reported with L-citrulline malate.
Is this safe to use while pregnant?
Most of the amino acids in this product are rated likely safe in pregnancy, but L-citrulline malate carries a rating that advises against use during pregnancy. Because you're carrying a child, it's best to talk with your doctor or pharmacist before taking any supplement.
Can I use this while breastfeeding?
L-glutamine, sodium, L-alanine, taurine, and potassium are likely safe during breastfeeding, but there isn't enough safety data on L-citrulline malate while breastfeeding—avoid it unless your doctor says otherwise. A conversation with your pharmacist about your situation is your best bet.
What's the 2:1:1 BCAA Matrix?
BCAA stands for branched-chain amino acids—L-leucine, L-isoleucine, and L-valine. The 2:1:1 ratio means there's twice as much leucine as the other two. BCAAs are amino acids your muscles use for energy and repair during and after exercise.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Amino Build Green Apple is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Amino Build Green Apple label
Go deeper

The Full Monographs Behind Amino Build Green Apple’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Sodium

Interacts with 205 drugs

Sodium is an essential mineral and electrolyte your body needs to balance fluids, support nerves, and help muscles work. Most people in modern diets get more than enough—often too much—from...

Read the full Sodium monograph →
Herb & supplement monograph

Potassium

Interacts with 62 drugs

Potassium is an essential mineral your body needs for nerve signals, muscle function, and a steady heartbeat, and most people get enough from a balanced diet rich in fruits and vegetables. P...

Read the full Potassium monograph →
Herb & supplement monograph

Glutamine

Interacts with 50 drugs

Glutamine is the most abundant amino acid in the body and is usually made in your muscles. A prescription form is FDA-approved to help reduce sickle cell disease complications, but for most...

Read the full Glutamine monograph →
Herb & supplement monograph

Alpha-alanine

Alpha-alanine (usually called alanine) is a non-essential amino acid your body can make on its own and that you also get from protein foods. Most people do not need a supplement, and strong...

Read the full Alpha-alanine monograph →
Herb & supplement monograph

Taurine

Interacts with 173 drugs

Taurine is an amino acid your body makes naturally and that you also get from animal foods. It is widely used in energy drinks and sports supplements, and short-term use appears generally sa...

Read the full Taurine monograph →
Herb & supplement monograph

L-citrulline

Interacts with 178 drugs

L-citrulline is an amino acid that the body turns into L-arginine to help make nitric oxide, which relaxes blood vessels and may improve blood flow. It is popular for exercise performance an...

Read the full L-citrulline monograph →
Sources

Sources & How We Checked

Amino Build Green Apple's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 92 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Glutamine 11 references
  1. Miller AL. Therapeutic considerations of L-glutamine: a review of the literature. Altern Med Rev 1999;4:239-48..
  2. Bozzetti F, Biganzoli L, Gavazzi C, et al. Glutamine supplementation in cancer patients receiving chemotherapy: a double-blind randomized study. Nutrition 1997;13:748-51.. PubMed
  3. Mebane AH. L-Glutamine and mania. Am J Psychiatry 984;141:1302-3.
  4. Meldrum BS. Glutamate as a neurotransmitter in the brain: review of physiology and pathology. J Nutr 2000;130:1007S-15S.. PubMed
  5. Garlick PJ. Assessment of the safety of glutamine and other amino acids. J Nutr 2001;131:2556S-61S.. PubMed
  6. Chapman AG. Glutamate and epilepsy. J Nutr 2000;130:1043S-5S.. PubMed
  7. Ziegler TR. Glutamine supplementation in cancer patients receiving bone marrow transplantation and high dose chemotherapy. J Nutr 2001;131:2578S-84S.. PubMed
  8. Laviano A, Molfino A, Lacaria MT, Canelli A, De Leo S, Preziosa I, Rossi Fanelli F. Glutamine supplementation favors weight loss in nondieting obese female patients. A pilot study. Eur J Clin Nutr. 2014 Nov;68(11):1264-6. PubMed
  9. Endari (l-glutamine) [package insert]. Torrance, CA: Emmaus Medical,Inc; 2017.
  10. Niihara Y, Miller ST, Kanter J, et al. A Phase 3 Trial of l-Glutamine in Sickle Cell Disease. N Engl J Med 2018;379(3):226-35. doi: 10.1056/NEJMoa1715971.
  11. Ogden HB, Child RB, Fallowfield JL, et al. Gastrointestinal Tolerance of Low, Medium and High Dose Acute Oral l-Glutamine Supplementation in Healthy Adults: A Pilot Study. Nutrients. 2020;12(10):2953. PubMed

See these in context on the Glutamine monograph →

Sodium 38 references
  1. Garabedian-Ruffalo SM, Ruffalo RL. Drug and nutrient interactions. Am Fam Physician 1986;33:165-74.
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Alpha-alanine 2 references
  1. Amino acids — MedlinePlus (NIH) Source
  2. Dietary Supplements: What You Need to Know — NIH Office of Dietary Supplements Source

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Taurine 21 references
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  11. Calabro, R. S., Italiano, D., Gervasi, G., and Bramanti, P. Single tonic-clonic seizure after energy drink abuse. Epilepsy Behav 2012;23(3):384-385. PubMed
  12. Fujita, T., Ando, K., Noda, H., Ito, Y., and Sato, Y. Effects of increased adrenomedullary activity and taurine in young patients with borderline hypertension. Circulation 1987;75(3):525-532. PubMed
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  14. Fukuyama, Y. and Ochiai, Y. Therapeutic trial by taurine for intractable childhood epilepsies. Brain Dev. 1982;4(1):63-69. PubMed
  15. Franconi, F., Bennardini, F., Mattana, A., Miceli, M., Ciuti, M., Mian, M., Gironi, A., Anichini, R., and Seghieri, G. Plasma and platelet taurine are reduced in subjects with insulin-dependent diabetes mellitus: effects of taurine supplementation. Am.J. DOI
  16. Stohs SJ, Miller M. A case study involving allergic reactions to sulfur-containing compounds including, sulfite, taurine, acesulfame potassium and sulfonamides. Food Chem Toxicol. 2014 Jan;63:240-3. PubMed
  17. Sun Q, Wang B, Li Y, Sun F, et al. Taurine supplementation lowers blood pressure and improves vascular function in prehypertension: randomized, double-blind, placebo-controlled study. Hypertension 2016 Mar;67(3):541-9. PubMed
  18. Jang ES, Hwang SH, Kim JW, Jeong SH. Effectiveness of 4-week oral taurine treatment for muscle cramps in patients with liver cirrhosis: a single-arm pilot study. Yonsei Med J 2021;62(1):21-8. PubMed
  19. Guan L, Miao P. The effects of taurine supplementation on obesity, blood pressure and lipid profile: A meta-analysis of randomized controlled trials. Eur J Pharmacol 2020;885:173533. PubMed
  20. Higgins JP, Liras GN, Liras IN, et al. Energy Drink Effects on Hemodynamics and Endothelial Function in Young Adults. Cardiology. 2021;146(2):258-262. PubMed
  21. Pallangyo P, Bhalia SV, Komba M, et al. Acute Myocardial Infarction Following the Consumption of Energy Drink in a 28-Year-Old Male: A Case Report. J Investig Med High Impact Case Rep. 2023 Jan-Dec;11:23247096231168811. PubMed

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Potassium 12 references
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  2. Gennaro A. Remington: The Science and Practice of Pharmacy. 19th ed. Lippincott: Williams & Wilkins, 1996.
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  4. Phillips, C. O., Kashani, A., Ko, D. K., Francis, G., and Krumholz, H. M. Adverse effects of combination angiotensin II receptor blockers plus angiotensin-converting enzyme inhibitors for left ventricular dysfunction: a quantitative review of data from ra DOI
  5. Altieri, P. I., Herrero, C., Suero, R., and Ortiz, A. Bleeding duodenal ulcer in a patient taking slow-releasing potassium tablets. Bol.Asoc.Med P.R. 1977;69(8):276.
  6. Raf, L. E. Enteric-coated potassium chloride tablets and ulcer of the small intestine. Acta Chir Scand Suppl 1967;(374):1-87.
  7. Potassium chloride oral solution [package insert]. Allentown, PA: Lehigh Valley Technologies, Inc.; 2014.
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  10. Malta D, Arcand J, Ravindran A, Floras V, Allard JP, Newton GE. Adequate intake of potassium does not cause hyperkalemia in hypertensive individuals taking medications that antagonize the renin angiotensin aldosterone system. Am J Clin Nutr 2016 Oct;104(4 PubMed
  11. Keskin M, Kaya A, Tatlisu MA, et al. The effect of serum potassium level on in-hospital and long-term mortality in ST elevation myocardial infarction. Int J cardiol. 2016 Oct 15;221:505-10.
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L-citrulline 8 references
  1. Cheng JW, Balwin SN. L-arginine in the management of cardiovascular diseases. Ann Pharmacother 2001;35:755-64. PubMed
  2. Schwedhelm E, Maas R, Freese R, et al. Pharmacokinetic and pharmacodynamic properties of oral L-citrulline and L-arginine: impact on nitric oxide metabolism. Br J Clin Pharmacol 2008;65:51-9. PubMed
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  6. Pérez-Guisado J, Jakeman PM. Citrulline malate enhances athletic anaerobic performance and relieves muscle soreness. J Strength Cond Res 2010;24:1215-22. PubMed
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  8. Xu Z, Liu C, Liu S, Zhou Z. Comparison of efficacy and safety of daily oral L-arginine and PDE5Is alone or combination in treating erectile dysfunction: A systematic review and meta-analysis of randomised controlled trials. Andrologia. 2021:e14007. PubMed

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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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