Major interaction on record — check this product against your medications before combining. Based on 5 of 10 ingredients. Check your meds →
Dietary supplement

Amplified 100% Whey Protein Chocolate Ingredients & Drug Interactions

by GNC Pro Performance AMP

Amplified 100% Whey Protein Chocolate label
See full label image
Powder Category: Other Combinations
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Amplified 100% Whey Protein Chocolate against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Amplified 100% Whey Protein Chocolate is a dietary supplement by GNC Pro Performance AMP with 10 active ingredients. Its ingredients are commonly taken for constipation, diarrhea, high cholesterol.Based on those ingredients, 2,052 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Dietary Fiber, Sodium, Calcium. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Amplified 100% Whey Protein Chocolate by GNC Pro Performance AMP

Ask about any prescription or over-the-counter medication and we check it for interactions with Amplified 100% Whey Protein Chocolate by GNC Pro Performance AMP — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Amplified 100% Whey Protein Chocolate by GNC Pro Performance AMP

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Partial disclosure
Ingredient Transparency · database check
Partial

Most active ingredients list an amount, but at least one is hidden in a blend or missing.

Why this rating?
  • The label discloses an exact amount for 5 of its 9 active ingredients.
  • “Amino Acceleration System” is listed as a grouped ingredient — the label gives one combined amount (100 mg) without saying how much of each component you get.
  • “Micronized Amino Acids” is listed as a grouped ingredient — the label gives one combined amount (8 g) without saying how much of each component you get.
  • “BioCore Edge(TM) Blend” is a proprietary blend — the label doesn't break down how much of each component you get.

This powder contains 8 active ingredients. The main ones are whey protein and a blend of amino acids—including glutamine, leucine, and a micronized amino acid complex—designed to support muscle recovery and repair.

It also includes sodium, potassium, and calcium for electrolyte balance, plus protease and peptidase (enzymes that help break down protein), and proprietary blends labeled Amino Acceleration System and BioCore Edge. We couldn't check two of the ingredient components—Tri-MG and Peptidase—against our interaction database.

The inactive ingredients are fillers and binders like guar gum, lecithin, and polydextrose, plus sweeteners and flavorings.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: muscle recovery and athletic performance support.
  • We looked for evidence on: Athletic performance, Exercise-induced muscle damage, Postoperative recovery, Muscle strength, Sports nutrition, Protein synthesis.
  • The strongest evidence on file: Glutamine is rated "Possibly Effective" for Postoperative recovery (Natural Medicines).
  • Also on file: Glutamine is rated "Possibly Ineffective" for Athletic performance.
  • Also on file: Calcium is rated "Insufficient Reliable Evidence To Rate" for Exercise-induced muscle damage.

The whey protein itself isn't rated in our data for a specific health claim, but the glutamine in the blend is rated effective for sickle cell disease and possibly effective for HIV/AIDS-related wasting, postoperative recovery, and trauma recovery. The calcium is effective for kidney failure and hypocalcemia and likely effective for osteoporosis.

Sodium and potassium don't have effectiveness ratings in our files for supplemental use—they're present as electrolytes. We hold no effectiveness data for the other amino acids or the enzyme blends in this product.

The evidence, ingredient by ingredient Black Psyllium Sodium Potassium Calcium Glutamine

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 6 of the 6 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 6 of 6.
  • General safety write-ups exist for 6 of 6.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Sodium in normal food amounts is fine, but this product adds to your total intake; too much is linked to high blood pressure and heart disease. Potassium from food is safe, but supplements can cause dangerously high blood levels, especially if you have kidney disease.

Calcium at recommended doses is generally well tolerated, though very high intakes have been linked to kidney stones and possibly prostate cancer risk in some research. Glutamine is generally well tolerated in healthy adults but should be used only under medical supervision if you have kidney or liver disease.

Common side effects across these ingredients include gastrointestinal upset—belching, bloating, constipation, diarrhea, nausea. Protease may rarely trigger allergic reactions.

Pregnancy safety data on glutamine and protease are not established, so talk with your doctor before using this product if you're pregnant or breastfeeding.

Side effects, ingredient by ingredient Black Psyllium Sodium Potassium Calcium Glutamine

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 5 of the 6 matched ingredients can interact with medications — Black Psyllium, Calcium, Potassium, Glutamine, Sodium.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: seizure medications; heart-rhythm medications; lithium.
  • For scale: 2,053 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before using this product, check if you take dolutegravir or elvitegravir (HIV drugs)—calcium can significantly lower their levels. Also double-check if you're on blood pressure medications, lithium, potassium-sparing diuretics, ACE inhibitors, ARBs, levothyroxine, heart medications like diltiazem, ceftriaxone injections, or anticonvulsants.

These are the drug types most likely to interact with ingredients in this powder.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glancePartially disclosed formula with some supporting evidence for its stated purpose. Major medication interactions have been identified, and safety information is well characterized.

This is a whey protein powder with added amino acids and electrolytes, useful for muscle recovery if you exercise. If you take any prescription medications—especially for blood pressure, HIV, thyroid disease, heart rhythm, kidney disease, mood disorders, or seizures—check your exact drugs with the tool on this page before you start.

People with kidney disease should talk to their doctor first. Run it past your pharmacist if you're pregnant, breastfeeding, or unsure.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 6 of 9 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jan 25, 2012.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Amplified 100% Whey Protein Chocolate, straight from the product label.

Brand GNC Pro Performance AMP
Barcode (UPC) 048107091866
Net contents 32 oz.; 2 lb; 909 g
Market status On market
Date entered into DSLD Jan 25, 2012
DSLD ID 4815
Product type Other Combinations
Supplement form Powder
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Amplified 100% Whey Protein Chocolate by GNC Pro Performance AMP, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
36.5 Gram(s)
Maximum serving Sizes:
36.5 Gram(s)
Servings per container
24
UPC/BARCODE
048107091866
IngredientAmount% DV
Calories130 {Calories}--
Total Carbohydrates8 g3%
Sugar2 g--
Calories from Fat20 {Calories}--
Total Fat2 g3%
Dietary Fiber3 g12%
Protein20 g--
Saturated Fat1 g5%
Sodium210 mg9%
Potassium280 mg8%
Cholesterol55 mg18%
Calcium90 mg9%
Amino Acceleration System100 mg--
Micronized Amino Acids8 g--
Tri-MG1.25 g--
Leucine0 NP--
Glutamine0 NP--
Protease0 NP--
Peptidase0 NP--
BioCore Edge(TM) Blend0 NP--

Other ingredients: Protein Blend, Cocoa, Sunfiber(R) partially hydrolyzed Guar Gum, Natural and Artificial flavors, Polyethylene Glycol, Lecithin, Polydextrose, Salt, Potassium Chloride, Acesulfame Potassium, Sucralose

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

The Amplified 100% Whey Protein Evolution What makes this protein AMPlified? Using cutting-edge technology and top notch research and development principles, this protein was designed to be the new champion of the whey protein category. Micronized Protein with Hydrolysates and Amino Acids – This premium whey features micronized whey protein with hydrolysates, leucine and glutamine! Using MicroSorb(TM) Amino Technology, the micronized whey protein and amino acids in this formula have been pulverized into smaller particles that are easier to absorb. As a result, Amplified 100% Whey Protein is proven to deliver superior amino acid uptake compared to regular whey.~ That means more amino acids are available for your muscles to use as fuel! These key amino acids all support proteins involved in muscle building, recovery and other key processes crucial to your muscles.* Amino Acceleration System – to make this protein even more absorbable, a unique digestive enzyme blend was included as an Amino Acceleration System. These efficacious enzymes were scientifically designed to further accelerate the availability of amino acids for absorption. More Key Aminos – In addition to an impressive 4.5 grams of leucine for muscle protein synthesis and 3.5 grams of glutamine to support the recovery process, this formula is loaded with an array of aminos necessary for your muscles before, during and after workouts.* Tri-MG(TM) - Amplified 100% Whey Protein is enhanced with this unique clinically studied ingredient, also known as betaine or trimethylglycine, which has been shown to enhance athletic performance.* Who Can Benefit from Taking Amplified 100% Whey Protein? Everyone including athletes, fitness enthusiasts and extreme sports competitors who are exercising regularly and looking for a fast-absorbing quality protein to help meet protein needs can benefit from Amplified 100% Whey Protein. When Should I Take It? Consume GNC Pro Performance(R) AMP Amplified 100% Whey Protein with or between meals to add more quality protein to your diet.

The Proof is in the Amino Absorption – And More… Faster Absorption of Critical Amino Acids for Muscle Fuel: A clinical study has proven that the proprietary protein blend in Amplified 100% Whey Protein delivers more critical aminos into the blood stream – better and faster than regular whey!~ Compared to regular whey protein, two servings of Amplified 100% Whey Protein maximize amino acid absorption by delivering: • 107% More Total Amino Acids~ - These critical amino acids are crucial to feeding your muscles before, during and after exercise.* • 114% More Branched Chain Amino Acids Absorbed 142% Faster!~ - BCAA are involved in reducing the amount of protein breakdown from exercise and help to preserve muscle glycogen stores.* • 234% More Leucine Absorbed 370% Faster!~ - Leucine is a key branched chain amino acid that is essential to fueling your muscles.* Its key role is to help regulation of muscle protein synthesis during muscle building and recovery.* This key amino acid is important for all types of athletes. ABSORB MORE TOTAL AMINO ACIDS, BCAA AND LEUCINE WITH AMPLIFIED 100% WHEY PROTEIN COMPARED TO REGULAR WHEY PROTEIN! 50 100 150 200 250 234% MORE LEUCINE ABSORBED 114% MORE BCAA ABSORBED 107% MORE TOTAL AMINO ACIDS ABSORBED ~ In a randomized, double blind, controlled cross-over study of 16 healthy male volunteers, subjects experienced significantly higher maximum concentrations of Total Amino Acids, Branched Chain Amino Acids and Leucine one hour post-ingestion of two servings of the protein blend in GNC Pro Performance(R) AMP Amplified 100% Whey Protein relative to amino acid concentrations measured post-ingestion of whey protein concentrate. Significant differences for the Rate of Change of BCAA and leucine absorption were also observed relative to the control group.

TYPICAL AMINO ACID PROFILE PER SERVING Alanine 444 mg Arginine 955 mg Aspartate 2400 mg Cystine 516 mg Glutamine 3513 mg Glycine 345 mg Histidine 355 mg Isoleucine` 1200 mg Leucine`• 4502 mg Lysine 1721 mg Methionine 442 mg Phenylalanine 652 mg Proline 1123 mg Serine 944 mg Threonine 1311 mg Tryptophan 384 mg Tyrosine 578 mg Valine` 1115 mg `Indicates Branched Chain Amino Acids (BCAA). •Denotes naturally occurring and added free form amino acids.

What is Amplified 100% Whey Protein and Why is it better than Regular Whey? Think ordinary whey protein is good enough? Think again. Introducing the latest breakthrough in whey! Amplified 100% Whey Protein features technology-enhanced protein with hydrolysates clinically proven to deliver more amino acids into the blood stream – better and faster than regular whey!~ The result…more amino acids are available for muscle fuel! These critical amino acids support athletic strength, performance, endurance and recovery.* This is the cutting-edge protein product that delivers a whole new level of protein technology.

^When used in conjunction with a resistance training program.

ADVANCED MUSCLE PERFORMANCE

Natural + artificial flavors

Daily Power Strength Recovery

Micronized protein + amino acids

Brand IP Statement(s)

BioCore Edge(TM) is a trademark of National Enzyme Company.

Sunfiber(R) is a registered trademark of Taiyo International, Inc. Use of Sunfiber(R) is protected by US Trademark Registration No. 2,930,937.

Precautions

CONTAINS: Milk, Soybeans and Wheat.

KEEP OUT OF REACH OF CHILDREN.

NOTICE: Use this product as a food supplement only. Do not use for weight reduction. Significant product settling may occur.

FDA Statement of Identity

Dietary supplement

Suggested/Recommended/Usage/Directions

DIRECTIONS: Once per day as a dietary supplement, add one level scoop (36.5g) of Pro Performance(R) AMP Amplified 100% WheyProtein to 7-8 fl. oz. cold water and blend well. For maximum results, take twice daily.

FDA Disclaimer Statement

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Storage

Store in a cool, dry place.

Formula

• 20g of Protein Featuring Micronized Whey, Hydrolysates and 22.5g of Amino Acids • 107% Better Absorption of Total Amino Acids~ • 234% Better Absorption of Leucine~ • Formulated to Build Lean Muscle^

General

CODE 351212 ELG

Seals/Symbols

Clinically Researched

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Amplified 100% Whey Protein Chocolate by GNC Pro Performance AMP label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Amplified 100% Whey Protein Chocolate label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Amplified 100% Whey Protein Chocolate by GNC Pro Performance AMP

These are the 10 active ingredients this product is made of. Select any to open its full monograph.

Serving size36.5 Gram(s) Dosage formPowder Servings per container24 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Sugar

2 g per serving

Dietary Fiber

Interacts with
2,025 drugs
3 g per serving

Black psyllium is a soluble-fiber supplement made from the seeds of a Plantago plant, used mostly to ease constipation and support digestive health. I...

Dietary Fiber monograph & interactions

Protein

20 g per serving

Sodium

Interacts with
205 drugs
210 mg per serving

Sodium is an essential mineral and electrolyte your body needs to balance fluids, support nerves, and help muscles work. Most people in modern diets g...

Sodium monograph & interactions

Potassium

Interacts with
62 drugs
280 mg per serving

Potassium is an essential mineral your body needs for nerve signals, muscle function, and a steady heartbeat, and most people get enough from a balanc...

Potassium monograph & interactions

Calcium

Interacts with
168 drugs
90 mg per serving

Calcium is an essential mineral your body needs for strong bones, nerve signaling, and muscle function, and supplements can help fill gaps when diet f...

Calcium monograph & interactions

Amino Acceleration System

100 mg per serving
  • › BioCore Edge(TM) Blend

Micronized Amino Acids

8 g per serving

Tri-MG

1.25 g per serving

Other (inactive) ingredients: Protein Blend, Cocoa, Sunfiber(R) partially hydrolyzed Guar Gum, Natural and Artificial flavors, Polyethylene Glycol, Lecithin, Polydextrose, Salt, Potassium Chloride, Acesulfame Potassium, Sucralose. These complete the product’s ingredient list but are not active constituents.

Interaction report

Amplified 100% Whey Protein Chocolate by GNC Pro Performance AMP Drug Interactions

Want to check YOUR meds against Amplified 100% Whey Protein Chocolate?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
2,052Drugs
7 Major 371 Moderate 1,674 Minor

Ingredients driving the most interactions

Dietary Fiber 2,025
Sodium 205
Calcium 168
Potassium 62
Glutamine 50

Individual Drug Interactions

The ingredients in Amplified 100% Whey Protein Chocolate interact with 2,052 drugs. Click any drug to see the details.

5 of the 10 ingredients in Amplified 100% Whey Protein Chocolate interact with drugs. Each result below shows which ingredient is responsible. Dietary Fiber Sodium Calcium Potassium Glutamine

Each ingredient & the kinds of drugs it affects

For each ingredient in Amplified 100% Whey Protein Chocolate with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Dietary Fiber7 drug types · 2,025 drugs

Carbamazepine (Tegretol)

Theoretically, black psyllium might reduce the effects of carbamazepine and increase the risk for convulsions.
Theoretically, black psyllium might reduce carbamazepine absorption. A preliminary study using blond psyllium reported decreased carbamazepine bioavailability due to binding of the drug to psyllium, as well as reduction of available fluid in the gut for dissolution of the drug. This interaction may also occur with black psyllium.

Likelihood Probable Evidence D
Lithium

Theoretically, taking black psyllium at the same time as lithium might reduce lithium absorption.
The fiber in black psyllium might reduce lithium absorption and plasma levels. Some case reports describe a reduction in plasma lithium levels with concomitant administration of blond psyllium. This was reversed when psyllium was stopped. This interaction may also occur with black psyllium.

Likelihood Probable Evidence D
Metformin (Glucophage)

Theoretically, black psyllium might increase the therapeutic and adverse effects of metformin.
Animal research shows that concurrent consumption of blond psyllium with metformin slows and increases the absorption of metformin. This interaction may also occur with black psyllium. To avoid changes in absorption, take psyllium 30-60 minutes after metformin.

Likelihood Possible Evidence D
Olanzapine (Zyprexa)

Theoretically, taking black psyllium at the same time as olanzapine might reduce olanzapine absorption.
The fiber in black psyllium might decrease the absorption of olanzapine. A single case report describes a reduction in the effectiveness of olanzapine when it was concomitantly administered with an unspecified type of psyllium 3 grams orally twice daily. This effect was reversed when psyllium was stopped.

Likelihood Possible Evidence D
Digoxin (Lanoxin)

Theoretically, taking black psyllium at the same time as digoxin might reduce digoxin absorption and decrease digoxin levels.
Psyllium might bind digoxin in the gut. However, some clinical evidence suggests that psyllium does not impact digoxin absorption.

Likelihood Unlikely Evidence B
Ethinyl Estradiol

Theoretically, taking black psyllium at the same time as ethinyl estradiol might alter levels of estradiol.
Concurrent use of blond psyllium with ethinyl estradiol results in a slight increase in the extent of ethinyl estradiol absorption and a slower rate of absorption. This is unlikely to be clinically significant.

Likelihood Unlikely Evidence D
Oral Drugs

Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Psyllium seems to have variable effects on drug absorption. To avoid changes in absorption, take psyllium 30-60 minutes after oral medications. Animal research shows that blond psyllium delays and increases the absorption of metformin and ethinyl estradiol. Case reports and animal research suggest that blond psyllium might reduce absorption of lithium, digoxin, olanzapine, and carbamazepine. Finally, some pharmacokinetic studies show that psyllium does not affect the absorption of levothyroxine or warfarin. Although many of these studies evaluated blond psyllium, the fiber content in black psyllium may have similar effects.

Likelihood Possible Evidence B
Dietary Fiber full monograph & interactions

Sodium7 drug types · 205 drugs

Antihypertensive Drugs

Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.
High intake of dietary sodium can increase systolic and diastolic blood pressure. Also, high intake of sodium may necessitate increased use of antihypertensive medications to achieve blood pressure control in some patients, such as those with chronic kidney disease.

Likelihood Probable Evidence A
Corticosteroids

Concomitant use of mineralocorticoids and some glucocorticoids with sodium supplements might increase the risk of hypernatremia.
Mineralocorticoids and some glucocorticoids (corticosteroids) cause sodium retention. This effect is dose-related and depends on mineralocorticoid potency. It is most common with hydrocortisone, cortisone, and fludrocortisone, followed by prednisone and prednisolone.

Likelihood Possible Evidence D
Didanosine (Videx)

Concomitant use of didanosine with additional sodium from dietary or supplemental sources may increase the risk of hypernatremia.
Didanosine formulations contain a significant amount of sodium.

Likelihood Probable Evidence C
Lithium

Altering dietary intake of sodium might alter the levels and clinical effects of lithium.
High sodium intake can reduce plasma concentrations of lithium by increasing lithium excretion. Reducing sodium intake can significantly increase plasma concentrations of lithium and cause lithium toxicity in patients being treated with lithium carbonate. Stabilizing sodium intake is shown to reduce the percentage of patients with lithium level fluctuations above 0.8 mEq/L. Patients taking lithium should avoid significant alterations in their dietary intake of sodium.

Likelihood Probable Evidence B
Sodium Phosphates

Theoretically, concomitant use of sodium phosphate with sodium supplements might increase the risk of hypernatremia.
Use of high doses (> 45 mL in 24 hours) of sodium phosphate, such as those used for bowel cleansing before surgery, can lead to serious electrolyte disturbances, including hypernatremia. The risk of hypernatremia is highest in the elderly and people with other risk factors for electrolyte disturbances.

Likelihood Possible Evidence D
Sodium-Containing Drugs

Concomitant use of sodium-containing drugs with additional sodium from dietary or supplemental sources may increase the risk of hypernatremia and long-term sodium-related complications.
The Chronic Disease Risk Reduction (CDRR) intake level of 2.3 grams of sodium daily indicates the intake at which it is believed that chronic disease risk increases for the apparently healthy population. Some medications contain high quantities of sodium. When used in conjunction with sodium supplements or high-sodium diets, the CDRR may be exceeded. Additionally, concomitant use may increase the risk for hypernatremia; this risk is highest in the elderly and people with other risk factors for electrolyte disturbances.

Likelihood Possible Evidence D
Tolvaptan (Samsca)

Theoretically, concomitant use of tolvaptan with sodium might increase the risk of hypernatremia.
Tolvaptan is a vasopressin receptor 2 antagonist that is used to increase sodium levels in patients with hyponatremia. Patients taking tolvaptan should use caution with the use of sodium salts such as sodium chloride.

Likelihood Probable Evidence C
Sodium full monograph & interactions

Calcium18 drug types · 168 drugs

Ceftriaxone (Rocephin)

Co-administration of intravenous calcium and ceftriaxone can result in precipitation of a ceftriaxone-calcium salt in the lungs and kidneys.
Avoid administering intravenous calcium in any form, such as parenteral nutrition or Lactated Ringers, within 48 hours of intravenous ceftriaxone. Case reports in neonates show that administering intravenous ceftriaxone and calcium can result in precipitation of a ceftriaxone-calcium salt in the lungs and kidneys. In several cases, neonates have died as a result of this interaction. So far there are no reports in adults; however, there is still concern that this interaction might occur in adults.

Likelihood Probable Evidence D
Dolutegravir (Tivicay)

Calcium seems to reduce levels of dolutegravir.
Advise patients to take dolutegravir either 2 hours before or 6 hours after taking calcium supplements. Pharmacokinetic research suggests that taking calcium carbonate 1200 mg concomitantly with dolutegravir 50 mg reduces plasma levels of dolutegravir by almost 40%. Calcium appears to decrease levels of dolutegravir through chelation.

Likelihood Probable Evidence B
Elvitegravir (Vitekta)

Calcium seems to reduce levels of elvitegravir.
Advise patients to take elvitegravir either 2 hours before or 2 hours after taking calcium supplements. Pharmacokinetic research suggests that taking calcium along with elvitegravir can reduce blood levels of elvitegravir through chelation.

Likelihood Probable Evidence B
Aluminum

Calcium citrate might increase aluminum absorption and toxicity. Other types of calcium do not increase aluminum absorption.
Calcium citrate can increase the absorption of aluminum when taken with aluminum hydroxide. The increase in aluminum levels may become toxic, particularly in individuals with kidney disease. However, the effect of calcium citrate on aluminum absorption is due to the citrate anion rather than calcium cation. Calcium acetate does not appear to increase aluminum absorption.

Likelihood Possible Evidence B
Bictegravir/Emtricitabine/Tenofovir Alafenamide (Biktarvy)

Calcium might decrease levels of bictegravir/emtricitabine/tenofovir alafenamide by reducing its absorption when taken in a fasting state.
Advise patients that bictegravir/emtricitabine/tenofovir alafenamide and calcium can be taken together if taken with food. However, if taken on an empty stomach, bictegravir/emtricitabine/tenofovir alafenamide should not be taken with, or 2 hours after, calcium containing products.

Likelihood Probable Evidence D
Bisphosphonates

Calcium reduces the absorption of bisphosphonates.
Advise patients to take bisphosphonates at least 30 minutes before calcium, but preferably at a different time of day. Calcium supplements decrease absorption of bisphosphonates.

Likelihood Probable Evidence C
Calcipotriene (Dovonex)

Taking calcipotriene with calcium might increase the risk for hypercalcemia.
Calcipotriene is a vitamin D analog used topically for psoriasis. It can be absorbed in sufficient amounts to cause systemic effects, including hypercalcemia. Theoretically, combining calcipotriene with calcium supplements might increase the risk of hypercalcemia.

Likelihood Possible Evidence B
Digoxin (Lanoxin)

Using intravenous calcium with digoxin might increase the risk of fatal cardiac arrhythmias.
Hypercalcemia increases the risk of fatal cardiac arrhythmias with digoxin. However, one retrospective analysis of clinical data suggests that intravenous calcium does not increase the risk of dysrhythmias or mortality in patients receiving digoxin.

Likelihood Possible Evidence B
Diltiazem (Cardizem, Others)

Theoretically, calcium may reduce the therapeutic effects of diltiazem.
Hypercalcemia can reduce the effectiveness of verapamil in atrial fibrillation. Theoretically, calcium might increase this risk of hypercalcemia and reduce the effectiveness of diltiazem.

Likelihood Probable Evidence D
Levothyroxine (Synthroid, Others)

Calcium seems to reduce the absorption and effectiveness of levothyroxine.
Advise patients to take levothyroxine and calcium supplements at least 4 hours apart. Calcium reduces levothyroxine absorption, probably by forming insoluble complexes. Calcium carbonate supplements reduce effectiveness of levothyroxine in patients with hypothyroidism.

Likelihood Probable Evidence B
Lithium

Theoretically, concomitant use of calcium and lithium may increase this risk of hypercalcemia.
Clinical research suggests that long-term use of lithium may cause hypercalcemia in 10% to 60% of patients. Theoretically, concomitant use of lithium and calcium supplements may further increase this risk.

Likelihood Possible Evidence B
Quinolone Antibiotics

Calcium seems to reduce the absorption of quinolone antibiotics.
Advise patients to take oral quinolones at least 2 hours before or 4-6 hours after calcium supplements or calcium-fortified foods. Taking calcium at the same time as oral quinolones can reduce quinolone absorption. Calcium binds to quinolones in the gut.

Likelihood Probable Evidence B
Raltegravir (Isentress)

Calcium may reduce levels of raltegravir.
Pharmacokinetic research shows that taking a single dose of calcium carbonate 3000 mg along with raltegravir 400 mg twice daily modestly decreases the mean area under the curve of raltegravir, but the decrease does not necessitate a dose adjustment of raltegravir. However, a case of elevated HIV-1 RNA levels and documented resistance to raltegravir has been reported for a patient taking calcium carbonate 1 gram three times daily plus vitamin D3 (cholecalciferol) 400 IU three times daily in combination with raltegravir 400 mg twice daily for 11 months. It is thought that calcium reduced raltegravir levels by chelation, leading to treatment failure.

Likelihood Possible Evidence B
Sotalol (Betapace)

Calcium seems to reduce the absorption of sotalol.
Advise patients to separate doses by at least 2 hours before or 4-6 hours after calcium. Calcium appears to reduce the absorption of sotalol, probably by forming insoluble complexes.

Likelihood Possible Evidence B
Tetracycline Antibiotics

Calcium seems to reduce the absorption of tetracycline antibiotics.
Advise patients to take oral tetracyclines at least 2 hours before, or 4-6 hours after calcium supplements. Taking calcium at the same time as oral tetracyclines can reduce tetracycline absorption. Calcium binds to tetracyclines in the gut.

Likelihood Probable Evidence C
Thiazide Diuretics

Taking calcium along with thiazides might increase the risk of hypercalcemia and renal failure.
Thiazides reduce calcium excretion by the kidneys. Using thiazides along with moderately large amounts of calcium carbonate increases the risk of milk-alkali syndrome (hypercalcemia, metabolic alkalosis, renal failure). Patients may need to have their serum calcium levels and/or parathyroid function monitored regularly.

Likelihood Probable Evidence C
Verapamil (Calan, Others)

Theoretically, calcium may reduce the therapeutic effects of verapamil.
Hypercalcemia can reduce the effectiveness of verapamil in atrial fibrillation. Theoretically, use of calcium supplements may increase this risk of hypercalcemia and reduce the effectiveness of verapamil.

Likelihood Probable Evidence D
Calcium Channel Blockers

Intravenous calcium may decrease the effects of calcium channel blockers; oral calcium is unlikely to have this effect.
Intravenous calcium is used to decrease the effects of calcium channel blockers in the management of overdose. Intravenous calcium gluconate has been used before intravenous verapamil (Isoptin) to prevent or reduce the hypotensive effects without affecting the antiarrhythmic effects. But there is no evidence that dietary or supplemental calcium when taken orally interacts with calcium channel blockers.

Likelihood Unlikely Evidence D
Calcium full monograph & interactions

Potassium3 drug types · 62 drugs

Ace Inhibitors (Aceis)

Using ACEIs with high doses of potassium increases the risk of hyperkalemia.
ACEIs block the actions of the renin-angiotensin-aldosterone system and reduce potassium excretion. Concomitant use of these drugs with potassium supplements increases the risk of hyperkalemia. However, concomitant use of these drugs with moderate dietary potassium intake (about 3775-5200 mg daily) does not increase serum potassium levels.

Likelihood Likely Evidence C
Angiotensin Receptor Blockers (Arbs)

Using ARBs with high doses of potassium increases the risk of hyperkalemia.
ARBs block the actions of the renin-angiotensin-aldosterone system and reduce potassium excretion. Concomitant use of these drugs with potassium supplements increases the risk of hyperkalemia. However, concomitant use of these drugs with moderate dietary potassium intake (about 3775-5200 mg daily) does not increase serum potassium levels.

Likelihood Likely Evidence C
Potassium-Sparing Diuretics

Concomitant use increases the risk of hyperkalemia.
Using potassium-sparing diuretics with potassium supplements increases the risk of hyperkalemia.

Likelihood Likely Evidence C
Potassium full monograph & interactions

Glutamine1 drug type · 50 drugs

Anticonvulsants

Theoretically, glutamine might antagonize the effects of anticonvulsant medications.
Glutamine is metabolized to the excitatory neurotransmitter glutamate. Glutamate might have antagonistic effects with anticonvulsant drugs. However, this interaction has not yet been reported in humans.

Likelihood Possible Evidence D
Glutamine full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Amplified 100% Whey Protein Chocolate, from the product label.

GNC Pro Performance AMP

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Phone Number
1-888-462-2548
Pharmacist Counseling Corner

Amplified 100% Whey Protein Chocolate by GNC Pro Performance AMP: Common Questions

Does Amplified 100% Whey Protein Chocolate by GNC Pro Performance AMP interact with any medications?
Yes. Based on its ingredients, Amplified 100% Whey Protein Chocolate has a known interaction with 2,052 medications, including 7 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Amplified 100% Whey Protein Chocolate contains 10 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this while pregnant?
Calcium and potassium are rated likely safe in pregnancy at normal amounts, but glutamine and protease don't have enough safety data established. Talk with your doctor or pharmacist about whether this product is right for you during pregnancy.
Can I take this while breastfeeding?
Potassium and glutamine are rated likely safe during breastfeeding, but protease has insufficient safety data. Check with your doctor or pharmacist before starting it.
Will this help me build muscle?
This powder is designed as a protein and amino acid supplement for muscle recovery after exercise, but we don't hold effectiveness ratings for whey protein itself in our data. It's commonly used by athletes for that purpose, but results depend on your training and diet.
What are the most common side effects?
Gastrointestinal upset is most common—bloating, belching, constipation, diarrhea, nausea, and flatulence. These tend to be mild and often decrease as your body adjusts.
Is there a lot of sodium in this product?
Yes, the product facts show sodium is an ingredient. If you're on blood pressure medication or have high blood pressure, this adds to your daily sodium intake, so talk with your doctor about whether it fits your diet.
What is Tri-MG and does it interact with medications?
We don't hold interaction data for Tri-MG, so we can't check it against medications. Ask your pharmacist if you have questions about this ingredient and any drugs you take.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Amplified 100% Whey Protein Chocolate label
Go deeper

The Full Monographs Behind Amplified 100% Whey Protein Chocolate’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Black Psyllium

Interacts with 2,025 drugs

Black psyllium is a soluble-fiber supplement made from the seeds of a Plantago plant, used mostly to ease constipation and support digestive health. It is best known and most studied for rel...

Read the full Black Psyllium monograph → Herb & supplement monograph

Sodium

Interacts with 205 drugs

Sodium is an essential mineral and electrolyte your body needs to balance fluids, support nerves, and help muscles work. Most people in modern diets get more than enough—often too much—from...

Read the full Sodium monograph → Herb & supplement monograph

Potassium

Interacts with 62 drugs

Potassium is an essential mineral your body needs for nerve signals, muscle function, and a steady heartbeat, and most people get enough from a balanced diet rich in fruits and vegetables. P...

Read the full Potassium monograph → Herb & supplement monograph

Calcium

Interacts with 168 drugs

Calcium is an essential mineral your body needs for strong bones, nerve signaling, and muscle function, and supplements can help fill gaps when diet falls short. Most people do best getting...

Read the full Calcium monograph → Herb & supplement monograph

Glutamine

Interacts with 50 drugs

Glutamine is the most abundant amino acid in the body and is usually made in your muscles. A prescription form is FDA-approved to help reduce sickle cell disease complications, but for most...

Read the full Glutamine monograph →
Sources

Sources & How We Checked

Amplified 100% Whey Protein Chocolate's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 144 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Black Psyllium 18 references
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  2. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  3. Covington TR, et al. Handbook of Nonprescription Drugs. 11th ed. Washington, DC: American Pharmaceutical Association, 1996.
  4. Etman M. Effect of a bulk forming laxative on the bioavailablility of carbamazepine in man. Drug Dev Ind Pharm 1995;21:1901-6.
  5. Perlman BB. Interaction between lithium salts and ispaghula husk. Lancet 1990;335:416.
  6. Vaswani SK, Hamilton RG, Valentine MD, Adkinson NF. Psyllium laxative-induced anaphylaxis, asthma, and rhinitis. Allergy 1996;51:266-8. PubMed
  7. Lantner RR, Espiritu BR, Zumerchik P, Tobin MC. Anaphylaxis following ingestion of a psyllium-containing cereal. JAMA 1990;264:2534-6. DOI
  8. Kaplan MJ. Anaphylactic reaction to "Heartwise." N Engl J Med 1990;323:1072-3. DOI
  9. Nordstrom M, Melander A, Robertsson E, Steen B. Influence of wheat bran and of a bulk-forming ispaghula cathartic on the bioavailability of digoxin in geriatric in-patients. Drug Nutr Interact 1987;5:67-9..
  10. Robinson DS, Benjamin DM, McCormack JJ. Interaction of warfarin and nonsystemic gastrointestinal drugs. Clin Pharmacol Ther 1971;12:491-5. PubMed
  11. Garcia JJ, Fernandez N, Diez MJ, et al. Influence of two dietary fibers in the oral bioavailability and other pharmacokinetic parameters of ethinyloestradiol. Contraception 2000;62:253-7. PubMed
  12. Fernandez N, Lopez C, Díez R, et al. Drug interactions with the dietary fiber Plantago ovata husk. Expert Opin Drug Metab Toxicol 2012;8(11):1377-86.
  13. Semen plantaginis in: WHO Monographs on Selected Medicinal Plants, volume 1. World Health Organization, Geneva, 1999. Available at http://apps.who.int/medicinedocs/en/d/Js2200e/. Accessed November 26, 1026.
  14. Code of Federal Regulations, Title 21 (21CFR 101.17). Food labeling warning, notice, and safe handling statements. Available at www.ecfr.gov/cgi-bin/text-idx?SID=20f647d3b74161501f46564b915b4048&mc=true&node=se21.2.101_117&rgn=div8. Accessed December 3, 2
  15. Code of Federal Regulations, Title 21 (21CFR 201.319). Specific labeling requirements - water-soluble gums, hydrophilic gums, and hydrophilic mucilloids. Available at www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=201.319. Accessed Dece
  16. Diez R, Garcia JJ, Diez MJ, Sierra M, Sahagun AM, Fernandez N. Influence of Plantago ovata husk (dietary fiber) on the bioavailability and other pharmacokinetic parameters of metformin in diabetic rabbits. BMC Complement Altern Med. 2017 Jun 7;17(1):298. PubMed
  17. Chiu AC, Sherman SI. Effects of pharmacological fiber supplements on levothyroxine absorption. Thyroid. 1998;8(8):667-71. PubMed
  18. Merrick C, Madden CA, Capurso NA. A Case of Blunted Orally Disintegrating Olanzapine Effect Due to Coadministered Psyllium. J Clin Psychiatry 2021;82(2):20cr13633. PubMed

See these in context on the Black Psyllium monograph →

Sodium 38 references
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  2. Food and Drug Administration Science Background: Safety of Sodium Phosphates Oral Solution. September 17, 2001. Available at: http://www.fda.gov/cder/drug/safety/sodiumphospate.htm
  3. Coton T, Mallaret C, Coilliot C, Carre D, Guisset M. Severe acute ulcerated gastritis induced by salt. Presse Med 2009;38(3):499-500. PubMed
  4. Frings-Meuthen P, Buehlmeier J, Baecker N, et al. High sodium chloride intake exacerbates immobilization-induced bone resorption and protein losses. J Appl Physiol 2011;111(2):537-542. PubMed
  5. Frings-Meuthen P, Baecker N, Heer M. Low-grade metabolic acidosis may be the cause of sodium chloride-induced exaggerated bone resorption. J Bone Miner Res 2008;23(4):517-524. PubMed
  6. Alam S, Johnson AG. A meta-analysis of randomised controlled trials (RCT) among healthy normotensive and essential hypertensive elderly patients to determine the effect of high salt (NaCl) diet of blood pressure. J Hum Hypertens 1999;13(6):367-74.
  7. Boudville N, Ward S, Benaroia M, House AA. Increased sodium intake correlates with greater use of antihypertensive agents by subjects with chronic kidney disease. Am J Hypertens 2005;18(10):1300-5. PubMed
  8. Bennett WM. Drug interactions and consequences of sodium restriction. Am J Clin Nutr 1997;65(2 Suppl):678S-681S. PubMed
  9. Okusa MD, Crystal LJ. Clinical manifestations and management of acute lithium intoxication. Am J Med 1994;97(4):383-9. PubMed
  10. Food and Nutrition Board, Institute of Medicine. Dietary reference intakes for water, potassium, sodium, chloride, and sulfate. Washington, DC: National Academy Press, 2005. Available at: http://www.nap.edu/openbook.php?record_id=10925. DOI
  11. D'Elia L, Rossi G, Ippolito R, Cappuccio FP, Strazzullo P. Habitual salt intake and risk of gastric cancer: a meta-analysis of prospective studies. Clin Nutr 2012;31(4):489-98. PubMed
  12. Goldsmith SR. Hyponatremia in heart failure: time for a trial. J Card Fail 2013;19(6):398-400. PubMed
  13. Willocks L, Brettle R, Keen J, Valentine C, Pinching AJ. Formulations of didanosine (ddI) and salt overload. Lancet 1992;339(8786):190.
  14. Chen L, Zhang Z, Chen W, Whelton PK, Appel LJ. Lower Sodium Intake and Risk of Headaches: Results From the Trial of Nonpharmacologic Interventions in the Elderly. Am J Public Health. 2016;106(7):1270-5. PubMed
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  16. Cook NR, Appel LJ, Whelton PK. Sodium Intake and All-Cause Mortality Over 20 Years in the Trials of Hypertension Prevention. J Am Coll Cardiol. 2016;68(15):1609-1617. PubMed
  17. Mente A, O'Donnell M, Rangarajan S, et al. Associations of urinary sodium excretion with cardiovascular events in individuals with and without hypertension: a pooled analysis of data from four studies. Lancet. 2016;388(10043):465-75. PubMed
  18. Moosavian SP, Haghighatdoost F, Surkan PJ, Azadbakht L. Salt and obesity: a systematic review and meta-analysis of observational studies. Int J Food Sci Nutr. 2017;68(3):265-277. PubMed
  19. O'Donnell M, Mente A, Rangarajan S, et al. Urinary sodium and potassium excretion, mortality, and cardiovascular events. N Engl J Med. 2014;371(7):612-23. DOI
  20. Poggio R, Gutierrez L, Matta MG, Elorriaga N, Irazola V, Rubinstein A. Daily sodium consumption and CVD mortality in the general population: systematic review and meta-analysis of prospective studies. Public Health Nutr. 2015;18(4):695-704. PubMed
  21. Stallings VA, Harrison M, Oria M; Committee to Review the Dietary Reference Intakes for Sodium and Potassium, Food and Nutrition Board, Health and Medicine Division, National Academies of Sciences, Engineering, and Medicine. Washington (DC): National Acad
  22. Mahtani KR, Heneghan C, Onakpoya I, et al. Reduced Salt Intake for Heart Failure: A Systematic Review. JAMA Intern Med. 2018 Dec 1;178(12):1693-1700. PubMed
  23. Yancy CW. Sodium Restriction in Heart Failure: Too Much Uncertainty-Do the Trials. JAMA Intern Med. 2018 Dec 1;178(12):1700-1701. PubMed
  24. He FJ, Campbell NRC, Ma Y, MacGregor GA, Cogswell ME, Cook NR. Errors in estimating usual sodium intake by the Kawasaki formula alter its relationship with mortality: implications for public health. Int J Epidemiol. 2018;47(6):1784-1795. PubMed
  25. Murthy K, Ondrey GJ, Malkani N, et al. THE EFFECTS OF HYPONATREMIA ON BONE DENSITY AND FRACTURES: A SYSTEMATIC REVIEW AND META-ANALYSIS. Endocr Pract. 2019;25(4):366-378. PubMed
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  27. Graudal NA, Hubeck-Graudal T, Jurgens G. Effects of low sodium diet versus high sodium diet on blood pressure, renin, aldosterone, catecholamines, cholesterol, and triglyceride. Cochrane Database Syst Rev 2020;12(12):CD004022. PubMed
  28. Giatti S, Santos RB, Aielo AN, et al. Association of sodium with obstructive sleep apnea. The ELSA-Brasil study. Ann Am Thorac Soc 2021;18(3):502-510. PubMed
  29. Nan X, Lu H, Wu J, et al. The interactive association between sodium intake, alcohol consumption and hypertension among elderly in northern China: a cross-sectional study. BMC Geriatr 2021;21(1):135. PubMed
  30. Kyozuka H, Fukusda T, Murata T, et al. Impact of preconception sodium intake on hypertensive disorders of pregnancy: The Japan Environment and Children's study. Pregnancy Hypertens 2021;23:66-72. PubMed
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  32. Ma Y, He FJ, Sun Q, et al. 24-Hour urinary sodium and potassium excretion and cardiovascular risk. N Engl J Med 2022;386(3):252-263. PubMed
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  38. Zhou TL, Schütten MTJ, Kroon AA, et al. Urinary Sodium Excretion and Salt Intake Are Not Associated With Blood Pressure Variability in a White General Population. J Am Heart Assoc 2023;12(1):e026578. PubMed

See these in context on the Sodium monograph →

Potassium 12 references
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See these in context on the Potassium monograph →

Calcium 62 references
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See these in context on the Calcium monograph →

Glutamine 11 references
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See these in context on the Glutamine monograph →

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See these in context on the Proteolytic Enzymes (proteases) monograph →

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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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