Interactions on record — worth a quick check against your medications. Based on 4 of 5 ingredients. Check your meds →
Dietary supplement

T-UP Ingredients & Drug Interactions

by Nutrex Research Black Series

T-UP label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking T-UP against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

T-UP is a dietary supplement by Nutrex Research Black Series with 5 active ingredients. Its ingredients are commonly taken for morning sickness in pregnancy, premenstrual syndrome (pms), preventing or treating b6 deficiency.Based on those ingredients, 303 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Vitamin B6, Zinc, Folic Acid. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against T-UP by Nutrex Research Black Series

Ask about any prescription or over-the-counter medication and we check it for interactions with T-UP by Nutrex Research Black Series — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of T-UP by Nutrex Research Black Series

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 5 of its 5 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

T-UP contains five active ingredients. Vitamin B6 supports red blood cell formation and nerve function.

Vitamin B12 is essential for nerve and blood health, especially if you're deficient or have certain absorption issues. D-aspartic acid is an amino acid included in the formula.

Zinc supports immune function and wound healing. Folic acid (a B vitamin) plays a role in cell division and DNA synthesis.

The product also contains several inactive ingredients — gelatin capsule, magnesium stearate, silica, titanium dioxide, and food dyes (FD&C Red 3, Red 40, Blue 1, and Yellow 6) — which are fillers and binders.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: Natural testosterone booster for muscle and strength.
  • We looked for evidence on: Age-related testosterone deficiency, Athletic performance, Muscle mass, Physical strength.
  • The closest evidence on file: Zinc is rated "Insufficient Reliable Evidence To Rate" for Athletic performance (Natural Medicines).
  • Also on file: Folic Acid is rated "Insufficient Reliable Evidence To Rate" for Age-related testosterone deficiency.

The research backing for these ingredients varies. Vitamin B6 is effective for sideroblastic anemia and B6 deficiency, likely effective for high homocysteine levels, and possibly effective for pregnancy-related nausea.

Vitamin B12 is effective for B12 deficiency and Imerslund-Grasbeck disease, likely effective for cyanide poisoning, and possibly effective for canker sores and nerve pain after shingles. Zinc is effective for zinc deficiency, likely effective for Wilson disease, and possibly effective for acne, macular degeneration, and diabetes.

Folic acid is effective for folate deficiency, likely effective for preventing neural tube birth defects and managing methotrexate toxicity, and possibly effective for depression and cognitive issues. We don't have effectiveness data on file for D-aspartic acid in this product.

The evidence, ingredient by ingredient Vitamin B6 Vitamin B12 Zinc Folic Acid

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 4 of the 4 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 4 of 4.
  • General safety write-ups exist for 4 of 4.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Vitamin B6 is well tolerated at doses under 100 mg daily, but high doses over long periods can harm nerves (sensory neuropathy); be cautious about exceeding recommended amounts. Most common side effects are mild — abdominal pain, nausea, headache — but rare serious effects include nerve damage.

Vitamin B12 is generally very safe with no established upper limit and is well tolerated across all forms; injection-site reactions are the most common side effect, and allergic reactions are rare. Zinc is well tolerated at doses below 40 mg daily for adults but can cause nausea, diarrhea, and a metallic taste at higher doses; long-term high doses raise concerns about copper deficiency.

Folic acid is safe at recommended doses for most adults, during pregnancy at standard prenatal doses, and while breastfeeding. At higher doses (5–15 mg daily), it may cause abdominal cramps, diarrhea, rash, confusion, and sleep changes.

No pregnancy or breastfeeding data is on file for D-aspartic acid.

Side effects, ingredient by ingredient Vitamin B6 Vitamin B12 Zinc Folic Acid

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 4 of the 4 matched ingredients can interact with medications — Vitamin B12, Vitamin B6, Zinc, Folic Acid.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: Parkinson's medications.
  • For scale: 303 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with your pharmacist before using T-UP if you take seizure medications (phenobarbital, phenytoin, or primidone), blood pressure medications, antibiotics (especially quinolone or tetracycline types, cephalexin), HIV drugs (ritonavir, integrase inhibitors, or bictegravir-based combinations), cancer drugs (methotrexate, capecitabine, 5-fluorouracil, or cisplatin), metformin (diabetes), amiodarone (heart rhythm), levodopa (Parkinson's), penicillamine, or pyrimethamine (antiparasitic). These represent the main moderate and minor interactions documented for the ingredients we could check.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

If you take seizure medications, blood pressure drugs, antibiotics, HIV treatments, or chemotherapy, talk to your pharmacist before starting T-UP — the ingredients have documented interactions with those drug classes. Vitamin B6 users should avoid high doses long-term to protect nerve health.

For most other people taking no medications, these ingredients are generally well tolerated at the doses likely in this product.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 4 of 5 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Apr 25, 2018.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about T-UP, straight from the product label.

Brand Nutrex Research Black Series
Barcode (UPC) 853237000165
Net contents 120 Capsule(s)
Market status On market
Date entered into DSLD Apr 25, 2018
DSLD ID 176467
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for T-UP by Nutrex Research Black Series, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
4 Capsule(s)
Maximum serving Sizes:
4 Capsule(s)
Servings per container
30
UPC/BARCODE
853237000165
IngredientAmount% DV
Vitamin B62 mg100%
Vitamin B126 mcg100%
D-Aspartic Acid3000 mg--
Zinc15 mg100%
Folic Acid400 mcg100%

Other ingredients: Gelatin, Magnesium Stearate, Silica, Titanium Dioxide, FD&C Red 3, FD&C Red 40, FD&C Blue 1, FD&C Yellow 6

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Brand IP Statement(s)

T-Up Product Highlights D-Aspartic Acid is clinically proven to raise testosterone in healthy males Participants in a clinical study had a 42% testosterone increase in only 12 days Only one daily dose needed Supports muscle gains, strength and recovery Full 30 day supply

Formula

T-Up testosterone booster is raising the bar in natural testosterone elevation by bringing you scientifically researched D-Aspartic Acid.

General Statements

Unlike many products that claim to increase natural testosterone, our effects are real and supported by a clinical study.

1 Topo et al., 2009, Reprod. Biol. Endocrinol. 200. 7:120. Study lasted 12 days and showed an average increase of 42% in total testosterone levels. The effects of D-Aspartic Acid on free testosterone were not investigated. Although only free testosterone provides the muscle enhancement and other benefits associated with testosterone, many experts agree that an increase in total testosterone is accompanied by a similar increase in free testosterone. Swerdloff et al, 2000, J Clin Endocrinol Metabolism 85: 4500.

Natural testosterone booster Muscle Strength Recovery

Suggested/Recommended/Usage/Directions

One dose daily

Recommended Use: Take 4 capsules once per day between meals. Only one serving per day is needed. We suggest taking this product for 60 days. Use daily for best results.

FDA Statement of Identity

Dietary Supplement

Precautions

Warning: T-Up is not for use by persons under the age of 18.

Do not use if pregnant or nursing.

Keep out of reach of children.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

General

LBL-T-UP-120CT-V7-US

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

T-UP by Nutrex Research Black Series label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

T-UP label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in T-UP by Nutrex Research Black Series

These are the 5 active ingredients this product is made of. Select any to open its full monograph.

Serving size4 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Vitamin B6

Interacts with
210 drugs
2 mg per serving Form: Pyridoxine Hydrochloride

Vitamin B6 (pyridoxine) is an essential water-soluble vitamin that your body needs for metabolism, brain function, and making red blood cells. It is b...

Vitamin B6 monograph & interactions

Vitamin B12

Interacts with
20 drugs
6 mcg per serving Form: Cyanocobalamin

Vitamin B12 (cobalamin) is an essential nutrient your body needs to make red blood cells, keep nerves healthy, and support DNA. Supplements are very h...

Vitamin B12 monograph & interactions

D-Aspartic Acid

3000 mg per serving

Zinc

Interacts with
67 drugs
15 mg per serving Form: Zinc Picolinate

Zinc is an essential mineral that your body needs for immune function, wound healing, taste, and smell. Most people get enough from food, but suppleme...

Zinc monograph & interactions

Folic Acid

Interacts with
40 drugs
400 mcg per serving Form: Folic Acid

Folic acid is the man-made form of vitamin B9 and is one of the most well-studied supplements, especially for preventing serious birth defects when ta...

Folic Acid monograph & interactions

Other (inactive) ingredients: Gelatin, Magnesium Stearate, Silica, Titanium Dioxide, FD&C Red 3, FD&C Red 40, FD&C Blue 1, FD&C Yellow 6. These complete the product’s ingredient list but are not active constituents.

Interaction report

T-UP by Nutrex Research Black Series Drug Interactions

Want to check YOUR meds against T-UP?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
303Drugs
276 Moderate 27 Minor

Ingredients driving the most interactions

Vitamin B6 210
Zinc 67
Folic Acid 40
Vitamin B12 20

Individual Drug Interactions

The ingredients in T-UP interact with 303 drugs. Click any drug to see the details.

4 of the 5 ingredients in T-UP interact with drugs. Each result below shows which ingredient is responsible. Vitamin B6 Zinc Folic Acid Vitamin B12

Each ingredient & the kinds of drugs it affects

For each ingredient in T-UP with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Vitamin B65 drug types · 210 drugs

Amiodarone (Cordarone)

Theoretically, vitamin B6 might increase the photosensitivity caused by amiodarone.
Despite initial case reports suggesting that pyridoxine may have a protective effect against amiodarone-induced photosensitivity, preliminary clinical research suggests that pyridoxine may actually exacerbate this adverse effect.

Likelihood Possible Evidence B
Antihypertensive Drugs

Theoretically, vitamin B6 may have additive effects when used with antihypertensive drugs.
Research in hypertensive rats shows that vitamin B6 can decrease systolic blood pressure. Similarly, clinical research in patients with hypertension shows that taking high doses of vitamin B6 may reduce systolic and diastolic blood pressure, possibly by reducing plasma levels of epinephrine and norepinephrine.

Likelihood Possible Evidence B
Phenobarbital (Luminal)

High doses of vitamin B6 may reduce the levels and clinical effects of phenobarbital.
Preliminary clinical evidence suggests that vitamin B6 200 mg daily can reduce plasma levels of phenobarbital, possibly by increasing metabolism. It is not known whether lower doses have any effect. Advise people taking phenobarbital to avoid high doses of vitamin B6.

Likelihood Possible Evidence D
Phenytoin (Dilantin)

High doses of vitamin B6 may reduce the levels and clinical effects of phenytoin.
Preliminary clinical evidence suggests that vitamin B6 200 mg daily can reduce plasma levels of phenytoin, possibly by increasing metabolism. It is not known whether lower doses have any effect. Advise people taking phenytoin to avoid high doses of vitamin B6.

Likelihood Possible Evidence D
Levodopa

Vitamin B6 may increase the metabolism of levodopa when taken alone, but not when taken in conjunction with carbidopa.
Vitamin B6 (pyridoxine) enhances the metabolism of levodopa, reducing its clinical effects. However, this interaction does not occur when carbidopa is used concurrently with levodopa (Sinemet). Therefore, it is not likely to be a problem in most people.

Likelihood Unlikely Evidence D
Vitamin B6 full monograph & interactions

Zinc10 drug types · 67 drugs

Bictegravir/Emtricitabine/Tenofovir Alafenamide (Biktarvy)

Theoretically, zinc might decrease levels of bictegravir/emtricitabine/tenofovir alafenamide by reducing its absorption.
Advise patients that bictegravir/emtricitabine/tenofovir alafenamide should be taken at least 2 hours before or 6 hours after zinc containing products.

Likelihood Probable Evidence D
Cephalexin (Keflex)

Zinc might decrease cephalexin levels by chelating with cephalexin in the gut and preventing its absorption.
A pharmacokinetic study shows that zinc sulfate 250 mg taken concomitantly with cephalexin 500 mg decreases peak levels of cephalexin by 31% and reduces the exposure to cephalexin by 27%. Also, taking zinc sulfate 3 hours before cephalexin decreases peak levels of cephalexin by 11% and reduces the exposure to cephalexin by 18%. By decreasing cephalexin levels, zinc might increase the risk of treatment failure. This effect does not occur when zinc is taken 3 hours after the cephalexin dose. To avoid an interaction, advise patients take zinc sulfate 3 hours after taking cephalexin.

Likelihood Probable Evidence B
Cisplatin (Platinol-Aq)

Theoretically, zinc might interfere with the therapeutic effects of cisplatin.
Animal research suggests that zinc stimulates tumor cell production of the protein metallothionein, which binds and inactivates cisplatin. It is not known whether zinc supplements or high dietary zinc intake can cause clinically significant interference with cisplatin therapy. Cisplatin might also increase zinc excretion.

Likelihood Possible Evidence D
Integrase Inhibitors

Theoretically, taking zinc along with integrase inhibitors might decrease the levels and clinical effects of these drugs.
Zinc is a divalent cation. Pharmacokinetic studies have shown that other divalent cations such as calcium and iron can decrease blood levels of the integrase inhibitor dolutegravir through chelation.

Likelihood Possible Evidence D
Penicillamine (Cuprimine, Depen)

Zinc might reduce the levels and clinical effects of penicillamine.
By forming an insoluble complex with penicillamine, zinc interferes with penicillamine absorption and activity. Zinc supplements reduce the efficacy of low-dose penicillamine (0.5-1 gram/day), but do not seem to affect higher doses (1-2.75 gram/day), provided dosing times are separated. Advise patients to take zinc and penicillamine at least 2 hours apart.

Likelihood Probable Evidence B
Quinolone Antibiotics

Zinc can decrease the levels and clinical effects of quinolones antibiotics.
Quinolones form complexes with zinc in the gastrointestinal tract, reducing absorption of both the quinolone and zinc if taken at the same time. Advise patients to take these drugs at least 2 hours before, or 4-6 hours after, zinc supplements.

Likelihood Probable Evidence B
Ritonavir (Norvir)

Zinc modestly reduces levels of ritonavir.
Clinical research shows that zinc might reduce serum ritonavir levels by chelating with ritonavir in the gut and preventing its absorption. In patients with HIV, ritonavir is taken with atazanavir to prevent the metabolism and increase the effects of atazanavir. A pharmacokinetic study shows that, in patients being treated with atazanavir/ritonavir, co-administration of zinc sulfate (Solvazinc tablets) 125 mg as a single dose or as multiple daily doses for 2 weeks reduces plasma levels of ritonavir by about 16%. However, atazanavir levels still remains high enough to prevent HIV virus replication. Therefore, the decrease in ritonavir levels is not likely to be clinically significant.

Likelihood Probable Evidence B
Tetracycline Antibiotics

Zinc might reduce levels of tetracycline antibiotics.
Tetracyclines form complexes with zinc in the gastrointestinal tract, which can reduce absorption of both the tetracycline and zinc when taken at the same time. Taking zinc sulfate 200 mg with tetracycline reduces absorption of the antibiotic by 30% to 40%. Demeclocycline and minocycline cause a similar interaction. However, doxycycline does not seem to interact significantly with zinc. Advise patients to take tetracyclines at least 2 hours before, or 4-6 hours after, zinc supplements to avoid any interactions.

Likelihood Probable Evidence B
Amiloride (Midamor)

Amiloride can modestly reduce zinc excretion and increase zinc levels.
Clinical research shows that amiloride can reduce urinary zinc excretion, especially at doses of 10 mg per day or more. This zinc-sparing effect can help to counteract zinc losses caused by thiazide diuretics, but it is unlikely to cause zinc toxicity at usual amiloride doses. The other potassium-sparing diuretics, spironolactone (Aldactone) and triamterene (Dyrenium), do not seem to have a zinc-sparing effect.

Likelihood Probable Evidence B
Atazanavir (Reyataz)

Zinc modestly reduces levels of atazanavir, although this effect does not seem to be clinically significant.
Clinical research shows that zinc might decrease serum atazanavir levels by chelating with atazanavir in the gut and preventing its absorption. Although a single dose of zinc sulfate (Solvazinc tablets) 125 mg orally does not affect atazanavir concentrations in patients being treated with atazanavir/ritonavir, co-administration of zinc sulfate 125 mg daily for 2 weeks reduces plasma levels of atazanavir by about 22% in these patients. However, despite this decrease, atazanavir levels still remain at high enough concentrations for the prevention of HIV virus replication.

Likelihood Probable Evidence B
Zinc full monograph & interactions

Folic Acid7 drug types · 40 drugs

5-Fluorouracil

Theoretically, high doses of folic acid might increase the toxicity of 5-fluorouracil.
Increases in gastrointestinal side effects of 5-fluorouracil, such as stomatitis and diarrhea, have been described in two clinical studies when leucovorin, a form of folic acid, was administered with 5-fluorouracil.

Likelihood Possible Evidence D
Capecitabine (Xeloda)

Use of high-dose folic acid might contribute to capecitabine toxicity.
Clinical research suggests that higher serum folate levels are associated with an increased risk for moderate or severe toxicity during capecitabine-based treatment for colorectal cancer. Additionally, in one case report, taking folic acid 15 mg daily might have contributed to increased toxicity, including severe diarrhea, vomiting, edema, hand-foot syndrome, and eventually death, in a patient prescribed capecitabine.

Likelihood Possible Evidence D
Methotrexate (Trexall, Others)

Folic acid might reduce the efficacy of methotrexate as a cancer treatment when given concurrently.
Methotrexate exerts its cytotoxic effects by preventing conversion of folic acid to the active form needed by cells. There is some evidence that folic acid supplements reduce the efficacy of methotrexate in the treatment of acute lymphoblastic leukemia, and theoretically they could reduce its efficacy in the treatment of other cancers. Advise cancer patients to consult their oncologist before using folic acid supplements. In patients treated with long-term, low-dose methotrexate for rheumatoid arthritis (RA) or psoriasis, folic acid supplements can reduce the incidence of side effects, without reducing efficacy.

Likelihood Probable Evidence B
Phenobarbital (Luminal)

Folic acid might have antagonistic effects on phenobarbital and increase the risk for seizures.
Folic acid can have direct convulsant activity in some people, reversing the effects of phenobarbital and worsening seizure control. Monitor closely for increased seizure activity.

Likelihood Probable Evidence B
Phenytoin (Dilantin)

Folic acid might reduce serum levels of phenytoin in some patients.
Folic acid may be a cofactor in phenytoin metabolism. Folic acid, in doses of 1 mg daily or more, can reduce serum levels of phenytoin in some patients. Increases in seizure frequency have been reported. If folic acid supplements are added to established phenytoin therapy, monitor serum phenytoin levels closely. If phenytoin and folic acid are started at the same time and continued together, adverse changes in phenytoin pharmacokinetics are avoided. Note that phenytoin also reduces serum folate levels.

Likelihood Probable Evidence B
Primidone (Mysoline)

Folic acid might have antagonistic effects on primidone and increase the risk for seizures.
Folic acid can have direct convulsant activity in some people, reversing the effects of primidone and worsening seizure control. Monitor closely for increased seizure activity. Note that primidone also reduces serum folate levels.

Likelihood Probable Evidence B
Pyrimethamine (Daraprim)

Folic acid might antagonize the effects of pyrimethamine.
Folic acid can antagonize the antiparasitic effects of pyrimethamine against toxoplasmosis and Pneumocystis carinii pneumonia. Folic acid doesn't antagonize the effects of pyrimethamine in the treatment of malaria, because malarial parasites cannot use exogenous folic acid. Use folinic acid as an alternative to folic acid when indicated.

Likelihood Probable Evidence D
Folic Acid full monograph & interactions

Vitamin B121 drug type · 20 drugs

Metformin (Glucophage)

Metformin, a common medication used to manage type 2 diabetes, has been associated with lower vitamin B12 levels in some individuals. Prolonged use of metformin can interfere with the absorption of B12 in the digestive system, potentially leading to a deficiency in this essential vitamin.

Likelihood Possible Evidence A
Vitamin B12 full monograph & interactions
The maker

Brand information

Manufacturer and brand details for T-UP, from the product label.

Nutrex Research Black Series

See all Nutrex Research Black Series products
Name
Nutrex Research, Inc.
City
Oviedo
State
FL
ZipCode
32765
Phone Number
1-888-368-8739
Web Address
Nutrex.com
Pharmacist Counseling Corner

T-UP by Nutrex Research Black Series: Common Questions

Does T-UP by Nutrex Research Black Series interact with any medications?
Yes. Based on its ingredients, T-UP has a known interaction with 303 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
T-UP contains 5 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take T-UP if I'm pregnant?
Vitamin B6, B12, folic acid, and zinc all have safety data for pregnancy. Folic acid is actually recommended during pregnancy at standard prenatal doses to help prevent birth defects. Vitamin B12 is needed and safe in pregnancy, and zinc is safe at recommended amounts. No pregnancy data is on file for D-aspartic acid. Talk to your doctor or pharmacist before starting any new supplement in pregnancy to make sure it fits your personal situation.
What does each ingredient do?
Vitamin B6 supports red blood cell and nerve function. Vitamin B12 is essential for nerve and blood health. D-aspartic acid is an amino acid in the formula. Zinc supports immune and wound-healing function. Folic acid is a B vitamin needed for cell division and DNA work. The product combines these to support various body systems, though not all ingredients have established evidence for a single marketed purpose.
Can high doses of vitamin B6 in this product hurt my nerves?
Vitamin B6 is well tolerated in doses under 100 mg daily, but high doses over long periods can cause nerve damage (sensory neuropathy). The risk rises with very high daily doses or total lifetime doses. If you're taking this product as directed, you're likely within safe limits, but if you're stacking it with other B6 sources, check the total dose with your pharmacist.
Is vitamin B12 safe to take long-term?
Yes. Vitamin B12 is generally very safe and well tolerated with no established upper limit because excess is removed in your urine. It's safe at recommended doses during breastfeeding too. Serious side effects are rare.
Can I take this with my diabetes medication?
Vitamin B12 in this product may interact with metformin — metformin can lower B12 levels over time, and the supplement goes both directions. If you take metformin, mention T-UP to your pharmacist so they can monitor your B12 status. Check your full medication list against the interaction tool on this page as well.
What are the inactive ingredients?
The capsule contains gelatin, magnesium stearate, silica, titanium dioxide, and food dyes (FD&C Red 3, Red 40, Blue 1, and Yellow 6). These are standard fillers and binders used to hold the capsule together and add color.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

T-UP label
Go deeper

The Full Monographs Behind T-UP’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Vitamin B6

Interacts with 210 drugs

Vitamin B6 (pyridoxine) is an essential water-soluble vitamin that your body needs for metabolism, brain function, and making red blood cells. It is best known for helping with pregnancy-rel...

Read the full Vitamin B6 monograph → Herb & supplement monograph

Vitamin B12

Interacts with 20 drugs

Vitamin B12 (cobalamin) is an essential nutrient your body needs to make red blood cells, keep nerves healthy, and support DNA. Supplements are very helpful for people who are deficient — su...

Read the full Vitamin B12 monograph → Herb & supplement monograph

Zinc

Interacts with 67 drugs

Zinc is an essential mineral that your body needs for immune function, wound healing, taste, and smell. Most people get enough from food, but supplements can help correct or prevent a defici...

Read the full Zinc monograph → Herb & supplement monograph

Folic Acid

Interacts with 40 drugs

Folic acid is the man-made form of vitamin B9 and is one of the most well-studied supplements, especially for preventing serious birth defects when taken before and during early pregnancy. I...

Read the full Folic Acid monograph →
Sources

Sources & How We Checked

T-UP's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 206 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Vitamin B6 32 references
  1. Hansten PD, Horn JR. Drug Interactions Analysis and Management. Vancouver, WA: Applied Therapeutics Inc., 1997 and updates.
  2. Yates AA, Schlicker SA, Suitor CW. Dietary reference intakes: The new basis for recommendations for calcium and related nutrients, B vitamins, and choline. J Am Diet Assoc 1998;98:699-706. PubMed
  3. Geerling BJ, Dagnelie PC, Badart-Smook A, et al. Diet as a risk factor for the development of ulcerative colitis. Am J Gastroenterol 2000;95:1008-13. PubMed
  4. South M. Neonatal seizures after pyridoxine use -- reply. Lancet 1999;354:2083. PubMed
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See these in context on the Folic Acid monograph →

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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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