Interactions on record — worth a quick check against your medications. Based on 1 of 2 ingredients. Check your meds →
Dietary supplement

Apidren 400 mg Ingredients & Drug Interactions

by NutriPharm

Apidren 400 mg label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Apidren 400 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Apidren 400 mg is a dietary supplement by NutriPharm with 2 active ingredients. Its ingredients are commonly taken for antioxidant support, anti-inflammatory support, immune support.Based on those ingredients, 125 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Garcinia mangostana [fruit rind] extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Apidren 400 mg by NutriPharm

Ask about any prescription or over-the-counter medication and we check it for interactions with Apidren 400 mg by NutriPharm — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Apidren 400 mg by NutriPharm

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 2 active ingredients.
  • “CardiaSlim Proprietary Blend (Herb/Botanical)” is a proprietary blend — the label gives one combined amount (400 mg) without saying how much of each component you get.

Apidren has two active ingredients: CardiaSlim Proprietary Blend (a combination of herbs and botanicals) and Sphaeranthus indicus flower extract. The product also contains mangosteen fruit rind extract.

The inactive ingredients are microcrystalline cellulose, magnesium stearate, and silicon dioxide — these are fillers and binders that help hold the capsule together.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Mangosteen's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: cardiovascular health and weight management.
  • We looked for evidence on: Obesity, hypertension, dyslipidemia, metabolic syndrome.
  • The closest evidence on file: Mangosteen is rated "Insufficient Reliable Evidence To Rate" for Obesity (Natural Medicines).

Mangosteen extract in this product has been studied for a few conditions. It's rated possibly effective for periodontitis (gum infection).

For male-pattern hair loss, Alzheimer disease, and eczema, the evidence we hold is insufficient to say whether it works. We don't have effectiveness ratings for the CardiaSlim blend or Sphaeranthus indicus in our data.

The evidence, ingredient by ingredient Mangosteen

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Mangosteen extract is generally well tolerated, though long-term safety of supplements hasn't been thoroughly studied. In trials at doses up to 560 mg daily, a small number of participants reported tiredness, headache, dizziness, mild stomach issues (nausea, constipation, bloating), and respiratory symptoms like cough or nasal congestion — though it's unclear if mangosteen caused them.

During pregnancy, the safety data advises against using mangosteen supplements. The same goes for breastfeeding — there isn't enough information to know whether it's safe, so talk with your doctor or pharmacist for personalized advice.

Side effects, ingredient by ingredient Mangosteen

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Mangosteen.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 125 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take Apidren, double-check if you're on blood thinners or antiplatelet drugs (warfarin, aspirin, clopidogrel, and others) — mangosteen may increase bleeding risk. If you take donepezil for Alzheimer disease, mention this product to your pharmacist as well.

One ingredient (Sphaeranthus indicus) we couldn't check for interactions, so a complete medication review is important.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

Apidren may be worth considering if you're interested in mangosteen for gum health, but if you take blood thinners, antiplatelet drugs, or donepezil, check with your pharmacist first. The interactions are real enough to warrant a quick medication review before you start.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Mar 23, 2018.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Apidren 400 mg, straight from the product label.

Brand NutriPharm
Barcode (UPC) 702669931502
Net contents 60 Capsule(s)
Market status On market
Date entered into DSLD Mar 23, 2018
DSLD ID 175030
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Apidren 400 mg by NutriPharm, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
60
UPC/BARCODE
702669931502
IngredientAmount% DV
CardiaSlim Proprietary Blend (Herb/Botanical)400 mg--
Sphaeranthus indicus [flower heads] extract0 NP--
Garcinia mangostana [fruit rind] extract0 NP--

Other ingredients: Microcrystalline Cellulose, Magnesium Stearate, Silicon Dioxide

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

CardiaSlim is a patent-pending ingredient for cardiovasular health and weight management, derived from two natural plant extracts, Sphaeranthus indicus and Garcinia mangostana.

Apidren 400 mg per serving with CardiaSlim

Suggested/Recommended/Usage/Directions

Recommended Use: As a dietary supplement, take 1 capsule two times a day, 30 minutes before breakfast and dinner.

Recommended Use: As a dietary supplement, take 1 capsule, 30 minutes before breakfast and dinner.

Precautions

Keep out of reach of children.

Warning: Not intended for use by persons under 18 years of age.

Do not take this product if you are pregnant or nursing.

Keep this and all drugs out of children's reach.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Brand IP Statement(s)

2016 Nutripharm, LLC

CardiaSlim is a registered trademark of InterHealth N.I. and Laila Nutraceuticals.

General

05-16 Rev. 1008

General Statements

Made in USA

WC7P-CCGR-1NR

Based on 3 clinical trials with a 2000 calorie diet and moderate exercise.

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Apidren 400 mg by NutriPharm label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Apidren 400 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Apidren 400 mg by NutriPharm

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

CardiaSlim Proprietary Blend (Herb/Botanical)

400 mg per serving

Other (inactive) ingredients: Microcrystalline Cellulose, Magnesium Stearate, Silicon Dioxide. These complete the product’s ingredient list but are not active constituents.

Interaction report

Apidren 400 mg by NutriPharm Drug Interactions

Want to check YOUR meds against Apidren 400 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
125Drugs
122 Moderate 3 Minor

Ingredients driving the most interactions

Garcinia mangostana [fruit rind] extract 125

Individual Drug Interactions

The ingredients in Apidren 400 mg interact with 125 drugs. Click any drug to see the details.

1 of the 2 ingredients in Apidren 400 mg interact with drugs. Each result below shows which ingredient is responsible. Garcinia mangostana [fruit rind] extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Apidren 400 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Garcinia mangostana [fruit rind] extract2 drug types · 125 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, concomitant use of mangosteen with anticoagulant or antiplatelet drugs may increase the risk of bleeding.
In vitro and animal research shows that gamma-mangostin, a constituent of mangosteen, is a potent and competitive antagonist of the serotonin 2A (5-HT2A) receptor. Antagonism of the 5-HT2A receptor is believed to reduce platelet aggregation.

Likelihood Possible Evidence D
Donepezil (Aricept)

Theoretically, concomitant use of mangosteen with donepezil might increase the effects of donepezil.
Animal research shows that concomitant use of an aqueous extract of mangosteen pericarp with donepezil increases brain concentrations of donepezil at 4 hours by 64% without associated effects on systemic exposure.

Likelihood Possible Evidence D
Garcinia mangostana [fruit rind] extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Apidren 400 mg, from the product label.

NutriPharm

See all NutriPharm products
Name
NutriPharm
City
Provo
State
UT
ZipCode
84604
Phone Number
1-856-917-0541
Pharmacist Counseling Corner

Apidren 400 mg by NutriPharm: Common Questions

Does Apidren 400 mg by NutriPharm interact with any medications?
Yes. Based on its ingredients, Apidren 400 mg has a known interaction with 125 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Apidren 400 mg contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is mangosteen extract supposed to do?
In our data, mangosteen is rated possibly effective for periodontitis — a gum infection. For other uses like hair loss, Alzheimer disease, and eczema, the evidence isn't established enough to say whether it works.
Can I take this while pregnant or breastfeeding?
The safety data advises against using mangosteen supplements during pregnancy. If you're breastfeeding, there isn't enough information to know either way — talk with your doctor or pharmacist before using Apidren.
What side effects might I get from mangosteen?
In trials, some people reported tiredness, headache, dizziness, mild stomach discomfort (nausea, constipation, bloating), and respiratory symptoms like cough — though it's not certain mangosteen caused them. Most people tolerate it well at typical doses.
Does this product have any fillers?
Yes — it contains microcrystalline cellulose, magnesium stearate, and silicon dioxide as inactive ingredients to help form the capsule.
What is CardiaSlim Proprietary Blend?
It's a combination of herbs and botanicals, but the full breakdown of individual components isn't listed separately on the label — it's a proprietary blend, so we don't have detailed effectiveness or interaction data for each part.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Apidren 400 mg is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Apidren 400 mg label
Go deeper

The Full Monographs Behind Apidren 400 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Mangosteen

Interacts with 125 drugs

Mangosteen is a tropical fruit whose rind is rich in plant compounds called xanthones that act as antioxidants. While it is popular in juices and supplements for inflammation, immune support...

Read the full Mangosteen monograph →
Sources

Sources & How We Checked

Apidren 400 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 6 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Mangosteen 6 references
  1. Chairungsrilerd N, Furukawa K, Ohta T, et al. Histaminergic and serotonergic receptor blocking substances from the medicinal plant Garcinia mangostana. Planta Med 1996;62:471-2.
  2. Wong LP, Klemmer PJ. Severe lactic acidosis associated with juice of the mangosteen fruit Garcinia mangostana. Am J Kidney Dis 2008;51:829-33. PubMed
  3. Furukawa, K., Chairungsrilerd, N., Ohta, T., Nozoe, S., and Ohizumi, Y. [Novel types of receptor antagonists from the medicinal plant Garcinia mangostana]. Nippon Yakurigaku Zasshi 1997;110 Suppl 1:153P-158P. PubMed
  4. Chairungsrilerd, N., Furukawa, K., Tadano, T., Kisara, K., and Ohizumi, Y. Effect of gamma-mangostin through the inhibition of 5-hydroxy-tryptamine2A receptors in 5-fluoro-alpha-methyltryptamine-induced head-twitch responses of mice. Br J Pharmacol. 1998
  5. Suthammarak W, Numpraphrut P, Charoensakdi R, et al. Antioxidant-enhancing property of the polar fraction of mangosteen pericarp extract and evaluation of its safety in humans. Oxid Med Cell Longev 2016;2016:1293036. PubMed
  6. Bae M, Han SY, Kim ES, et al. Effect of Water Extract of Mangosteen Pericarp on Donepezil Pharmacokinetics in Mice. Molecules 2021;26(17):5246. PubMed

See these in context on the Mangosteen monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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