Interactions on record — worth a quick check against your medications. Based on 4 of 5 ingredients. Check your meds →
Dietary supplement

Apple Cider Vinegar Gummies Apple Ingredients & Drug Interactions

by Vital Proteins

Apple Cider Vinegar Gummies Apple label
See full label image
Gummy Or Jelly Category: Botanical With Nutrients
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Apple Cider Vinegar Gummies Apple against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Apple Cider Vinegar Gummies Apple is a dietary supplement by Vital Proteins with 5 active ingredients. Its ingredients are commonly taken for treating or preventing b12 deficiency, pernicious anemia, low energy and fatigue.Based on those ingredients, 339 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Sodium, Apple Cider Vinegar, Folic Acid. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Apple Cider Vinegar Gummies Apple by Vital Proteins

Ask about any prescription or over-the-counter medication and we check it for interactions with Apple Cider Vinegar Gummies Apple by Vital Proteins — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Apple Cider Vinegar Gummies Apple by Vital Proteins

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 4 of its 4 active ingredients.
  • “Folate” is listed as a grouped ingredient — the label gives one combined amount (400 mcg DFE) without saying how much of each component you get.

This product has 4 active ingredients. Vitamin B12 supports red blood cell formation and nervous system health; folic acid is a B vitamin that helps with cell division and is especially important in pregnancy for preventing birth defects; sodium is an essential mineral that regulates fluid balance and nerve function, though the amount in any supplement should be modest; and apple cider vinegar, derived from fermented apples, is included for its potential effects on digestion and blood sugar.

The gummies also contain several inactive ingredients—glucose syrup, sugar, gelatin, citric acid, fruit and vegetable concentrates, pectin, and oils—which serve as sweeteners, binders, and flavoring.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: Supports gut and immune health.
  • We looked for evidence on: Anemia, Diarrhea, Dyspepsia, Folate deficiency, Inflammatory bowel disease (IBD), Digestive health — and 2 related terms.
  • The strongest evidence on file: Folic Acid is rated "Effective" for Folate deficiency (Natural Medicines).
  • Also on file: Folic Acid is rated "Possibly Ineffective" for Anemia, Diarrhea.
  • Also on file: Apple Cider Vinegar is rated "Insufficient Reliable Evidence To Rate" for Dyspepsia.

Vitamin B12 in this product is effective for treating B12 deficiency and Imerslund-Grasbeck disease, and likely effective for cyanide poisoning; it's possibly effective for canker sores and nerve pain after shingles (postherpetic neuralgia). Folic acid is effective for folate deficiency and likely effective for preventing neural tube birth defects and treating methotrexate toxicity; it's possibly effective for depression, gum swelling related to seizure medications, and cognitive impairment.

Sodium's effectiveness is mostly limited to rare conditions like cystic fibrosis (likely effective) and amphotericin B kidney damage (possibly effective); for more common uses like heart failure or bipolar disorder, the evidence is insufficient. Apple cider vinegar shows insufficient evidence to rate for any condition in our data—acne, athletic performance, cognitive function, dental plaque, depression, and eczema all lack established efficacy.

The evidence, ingredient by ingredient Vitamin B12 Sodium Folic Acid Apple Cider Vinegar

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 4 of the 4 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 4 of 4.
  • General safety write-ups exist for 4 of 4.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Vitamin B12 is generally well-tolerated with no upper limit because excess is excreted in the urine. It's safe at normal recommended amounts in pregnancy and breastfeeding, where it's actually needed.

Allergic reactions are rare but possible, especially in people with cobalt allergy. Sodium is essential in small amounts, but the safety data advises caution: too much is linked to high blood pressure, heart strain, and increased gastric cancer risk; normal dietary amounts are fine, but avoid sodium supplements or very high intake without medical guidance.

Folic acid is generally safe at recommended doses and is safe during pregnancy and breastfeeding at standard prenatal levels. At high doses (15 mg daily and above), it can cause sleep disturbances, vivid dreaming, irritability, and confusion; it may also worsen nerve damage in people deficient in B12.

Apple cider vinegar is well-tolerated in food amounts, but larger medicinal doses long-term can cause hypokalemia, elevated renin, and osteoporosis—one case involved chronic high intake over 6 years.

Side effects, ingredient by ingredient Vitamin B12 Sodium Folic Acid Apple Cider Vinegar

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 4 of the 4 matched ingredients can interact with medications — Apple Cider Vinegar, Vitamin B12, Folic Acid, Sodium.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications; heart-rhythm medications; lithium.
  • For scale: 339 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, double-check with your pharmacist if you take seizure medications (phenobarbital, primidone, or phenytoin), blood pressure drugs, lithium, digoxin or other heart medications, diuretics, insulin, other diabetes medications, cancer drugs (capecitabine, methotrexate, 5-fluorouracil), metformin, corticosteroids, or pyrimethamine. No interactions are documented for the other inactive ingredients in the product.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with clinical evidence supporting its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This product combines B vitamins and apple cider vinegar in gummy form and is most relevant if you need B12 or folic acid supplementation or are interested in apple cider vinegar's potential blood-sugar effects. However, the sodium content and ingredient interactions mean you should check with your pharmacist before starting, especially if you take diabetes medications, seizure drugs, heart or blood pressure medications, diuretics, or lithium.

Pregnant or breastfeeding individuals should speak with their doctor first, and anyone with a suspected anemia shouldn't self-treat with this product.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 4 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Apr 23, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Apple Cider Vinegar Gummies Apple, straight from the product label.

Brand Vital Proteins
Barcode (UPC) 850026494891
Net contents 6 Gummy(ies)
Market status On market
Date entered into DSLD Apr 23, 2024
DSLD ID 309493
Product type Botanical With Nutrients
Supplement form Gummy Or Jelly
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Apple Cider Vinegar Gummies Apple by Vital Proteins, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Gummy(ies)
Maximum serving Sizes:
2 Gummy(ies)
Servings per container
3
UPC/BARCODE
850026494891
IngredientAmount% DV
Protein1 Gram(s)--
Vitamin B122.4 mcg100%
Calories30 Calorie(s)--
Total Carbohydrate7 Gram(s)3%
Total Sugars4 Gram(s)--
added Sugars4 Gram(s)8%
Sodium5 mg1%
Folic Acid240 mcg--
Folate400 mcg DFE100%
Apple Cider Vinegar500 mg--

Other ingredients: Glucose Syrup, Sugar, Water, Gelatin, Citric Acid, Orange Juice Concentrate, Natural flavor, Pectin, Sweet Potato, Apple, Radish, Cherry, Pepper, Carrot, Vegetable Oil, Carnauba leaf wax, Pomegranate Fruit Peel Extract

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Supports gut & immune health

For illustrative purposes only, does not contain whole fruit.

Made without dairy Made without gluten

Formula

ACV with The 'Mother' Naturally flavored with other natural flavors

FDA Statement of Identity

Dietary Supplement

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Suggested/Recommended/Usage/Directions

Suggested Use: Enjoy 2 gummies per serving. Do not exceed 4 gummies per day.

Brand IP Statement(s)

Copyright 2021 Vital Proteins LLC. All Rights Reserved.

Precautions

This product is manufactured in a facility that processes dairy, egg, fish, peanut, tree nut, wheat, and soy.

Keep out of reach of children

If you are pregnant, nursing or have a medical condition, consult your physician before use.

Storage

Storage Information: Store in a cool, dry place away from direct sunlight.

General Statements

Container filled by count, not by volume.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Apple Cider Vinegar Gummies Apple by Vital Proteins label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Apple Cider Vinegar Gummies Apple label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Apple Cider Vinegar Gummies Apple by Vital Proteins

These are the 5 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Gummy(ies) Dosage formGummy Or Jelly Servings per container3 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Protein

1 Gram(s) per serving

Vitamin B12

Interacts with
20 drugs
2.4 mcg per serving Form: Cyanocobalamin

Vitamin B12 (cobalamin) is an essential nutrient your body needs to make red blood cells, keep nerves healthy, and support DNA. Supplements are very h...

Vitamin B12 monograph & interactions

Sodium

Interacts with
205 drugs
5 mg per serving

Sodium is an essential mineral and electrolyte your body needs to balance fluids, support nerves, and help muscles work. Most people in modern diets g...

Sodium monograph & interactions

Folate

400 mcg DFE per serving

Apple Cider Vinegar

Interacts with
162 drugs
500 mg per serving Form: Acetic Acid

Apple cider vinegar is a fermented apple product that many people use hoping to help with blood sugar, weight, or digestion. The evidence for most of...

Apple Cider Vinegar monograph & interactions

Other (inactive) ingredients: Glucose Syrup, Sugar, Water, Gelatin, Citric Acid, Orange Juice Concentrate, Natural flavor, Pectin, Sweet Potato, Apple, Radish, Cherry, Pepper, Carrot, Vegetable Oil, Carnauba leaf wax, Pomegranate Fruit Peel Extract. These complete the product’s ingredient list but are not active constituents.

Interaction report

Apple Cider Vinegar Gummies Apple by Vital Proteins Drug Interactions

Want to check YOUR meds against Apple Cider Vinegar Gummies Apple?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
339Drugs
266 Moderate 73 Minor

Ingredients driving the most interactions

Sodium 205
Apple Cider Vinegar 162
Folic Acid 40
Vitamin B12 20

Individual Drug Interactions

The ingredients in Apple Cider Vinegar Gummies Apple interact with 339 drugs. Click any drug to see the details.

4 of the 5 ingredients in Apple Cider Vinegar Gummies Apple interact with drugs. Each result below shows which ingredient is responsible. Sodium Apple Cider Vinegar Folic Acid Vitamin B12

Each ingredient & the kinds of drugs it affects

For each ingredient in Apple Cider Vinegar Gummies Apple with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Sodium7 drug types · 205 drugs

Antihypertensive Drugs

Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.
High intake of dietary sodium can increase systolic and diastolic blood pressure. Also, high intake of sodium may necessitate increased use of antihypertensive medications to achieve blood pressure control in some patients, such as those with chronic kidney disease.

Likelihood Probable Evidence A
Corticosteroids

Concomitant use of mineralocorticoids and some glucocorticoids with sodium supplements might increase the risk of hypernatremia.
Mineralocorticoids and some glucocorticoids (corticosteroids) cause sodium retention. This effect is dose-related and depends on mineralocorticoid potency. It is most common with hydrocortisone, cortisone, and fludrocortisone, followed by prednisone and prednisolone.

Likelihood Possible Evidence D
Didanosine (Videx)

Concomitant use of didanosine with additional sodium from dietary or supplemental sources may increase the risk of hypernatremia.
Didanosine formulations contain a significant amount of sodium.

Likelihood Probable Evidence C
Lithium

Altering dietary intake of sodium might alter the levels and clinical effects of lithium.
High sodium intake can reduce plasma concentrations of lithium by increasing lithium excretion. Reducing sodium intake can significantly increase plasma concentrations of lithium and cause lithium toxicity in patients being treated with lithium carbonate. Stabilizing sodium intake is shown to reduce the percentage of patients with lithium level fluctuations above 0.8 mEq/L. Patients taking lithium should avoid significant alterations in their dietary intake of sodium.

Likelihood Probable Evidence B
Sodium Phosphates

Theoretically, concomitant use of sodium phosphate with sodium supplements might increase the risk of hypernatremia.
Use of high doses (> 45 mL in 24 hours) of sodium phosphate, such as those used for bowel cleansing before surgery, can lead to serious electrolyte disturbances, including hypernatremia. The risk of hypernatremia is highest in the elderly and people with other risk factors for electrolyte disturbances.

Likelihood Possible Evidence D
Sodium-Containing Drugs

Concomitant use of sodium-containing drugs with additional sodium from dietary or supplemental sources may increase the risk of hypernatremia and long-term sodium-related complications.
The Chronic Disease Risk Reduction (CDRR) intake level of 2.3 grams of sodium daily indicates the intake at which it is believed that chronic disease risk increases for the apparently healthy population. Some medications contain high quantities of sodium. When used in conjunction with sodium supplements or high-sodium diets, the CDRR may be exceeded. Additionally, concomitant use may increase the risk for hypernatremia; this risk is highest in the elderly and people with other risk factors for electrolyte disturbances.

Likelihood Possible Evidence D
Tolvaptan (Samsca)

Theoretically, concomitant use of tolvaptan with sodium might increase the risk of hypernatremia.
Tolvaptan is a vasopressin receptor 2 antagonist that is used to increase sodium levels in patients with hyponatremia. Patients taking tolvaptan should use caution with the use of sodium salts such as sodium chloride.

Likelihood Probable Evidence C
Sodium full monograph & interactions

Apple Cider Vinegar4 drug types · 162 drugs

Digoxin (Lanoxin)

Theoretically, concomitant use of apple cider vinegar with digoxin might increase the risk of cardiac toxicity.
A case of hypokalemia related to chronic use of apple cider vinegar has been reported. Theoretically, overuse of apple cider vinegar could decrease potassium levels, increasing the risk of toxicity with digoxin.

Likelihood Possible Evidence D
Diuretic Drugs

Theoretically, concomitant use of apple cider vinegar with diuretic drugs might increase the risk of hypokalemia.
A case of hypokalemia related to chronic use of apple cider vinegar has been reported. There is some concern that people taking apple cider vinegar along with potassium depleting diuretics might have an increased risk for hypokalemia.

Likelihood Possible Evidence D
Insulin

Theoretically, concomitant use of apple cider vinegar with insulin might increase the risk of hypokalemia.
A case of hypokalemia related to chronic use of apple cider vinegar has been reported. Theoretically, overuse of apple cider vinegar concomitantly with insulin might increase the risk of hypokalemia.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, taking apple cider vinegar with antidiabetes drugs might increase the risk of hypoglycemia.
Apple cider vinegar might reduce fasting and postprandial blood glucose levels and decrease gastric emptying in people with diabetes. However, not all research agrees. Theoretically, it might have additive effects on glucose levels when used with antidiabetes drugs.

Likelihood Possible Evidence B
Apple Cider Vinegar full monograph & interactions

Folic Acid7 drug types · 40 drugs

5-Fluorouracil

Theoretically, high doses of folic acid might increase the toxicity of 5-fluorouracil.
Increases in gastrointestinal side effects of 5-fluorouracil, such as stomatitis and diarrhea, have been described in two clinical studies when leucovorin, a form of folic acid, was administered with 5-fluorouracil.

Likelihood Possible Evidence D
Capecitabine (Xeloda)

Use of high-dose folic acid might contribute to capecitabine toxicity.
Clinical research suggests that higher serum folate levels are associated with an increased risk for moderate or severe toxicity during capecitabine-based treatment for colorectal cancer. Additionally, in one case report, taking folic acid 15 mg daily might have contributed to increased toxicity, including severe diarrhea, vomiting, edema, hand-foot syndrome, and eventually death, in a patient prescribed capecitabine.

Likelihood Possible Evidence D
Methotrexate (Trexall, Others)

Folic acid might reduce the efficacy of methotrexate as a cancer treatment when given concurrently.
Methotrexate exerts its cytotoxic effects by preventing conversion of folic acid to the active form needed by cells. There is some evidence that folic acid supplements reduce the efficacy of methotrexate in the treatment of acute lymphoblastic leukemia, and theoretically they could reduce its efficacy in the treatment of other cancers. Advise cancer patients to consult their oncologist before using folic acid supplements. In patients treated with long-term, low-dose methotrexate for rheumatoid arthritis (RA) or psoriasis, folic acid supplements can reduce the incidence of side effects, without reducing efficacy.

Likelihood Probable Evidence B
Phenobarbital (Luminal)

Folic acid might have antagonistic effects on phenobarbital and increase the risk for seizures.
Folic acid can have direct convulsant activity in some people, reversing the effects of phenobarbital and worsening seizure control. Monitor closely for increased seizure activity.

Likelihood Probable Evidence B
Phenytoin (Dilantin)

Folic acid might reduce serum levels of phenytoin in some patients.
Folic acid may be a cofactor in phenytoin metabolism. Folic acid, in doses of 1 mg daily or more, can reduce serum levels of phenytoin in some patients. Increases in seizure frequency have been reported. If folic acid supplements are added to established phenytoin therapy, monitor serum phenytoin levels closely. If phenytoin and folic acid are started at the same time and continued together, adverse changes in phenytoin pharmacokinetics are avoided. Note that phenytoin also reduces serum folate levels.

Likelihood Probable Evidence B
Primidone (Mysoline)

Folic acid might have antagonistic effects on primidone and increase the risk for seizures.
Folic acid can have direct convulsant activity in some people, reversing the effects of primidone and worsening seizure control. Monitor closely for increased seizure activity. Note that primidone also reduces serum folate levels.

Likelihood Probable Evidence B
Pyrimethamine (Daraprim)

Folic acid might antagonize the effects of pyrimethamine.
Folic acid can antagonize the antiparasitic effects of pyrimethamine against toxoplasmosis and Pneumocystis carinii pneumonia. Folic acid doesn't antagonize the effects of pyrimethamine in the treatment of malaria, because malarial parasites cannot use exogenous folic acid. Use folinic acid as an alternative to folic acid when indicated.

Likelihood Probable Evidence D
Folic Acid full monograph & interactions

Vitamin B121 drug type · 20 drugs

Metformin (Glucophage)

Metformin, a common medication used to manage type 2 diabetes, has been associated with lower vitamin B12 levels in some individuals. Prolonged use of metformin can interfere with the absorption of B12 in the digestive system, potentially leading to a deficiency in this essential vitamin.

Likelihood Possible Evidence A
Vitamin B12 full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Apple Cider Vinegar Gummies Apple, from the product label.

Vital Proteins

See all Vital Proteins products
Name
Vital Proteins LLC
Street Address
3400 Wolf Road Ste. 200
City
Franklin Park
State
IL
ZipCode
60131
Pharmacist Counseling Corner

Apple Cider Vinegar Gummies Apple by Vital Proteins: Common Questions

Does Apple Cider Vinegar Gummies Apple by Vital Proteins interact with any medications?
Yes. Based on its ingredients, Apple Cider Vinegar Gummies Apple has a known interaction with 339 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Apple Cider Vinegar Gummies Apple contains 5 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is this safe to take if I'm pregnant or breastfeeding?
Vitamin B12 and folic acid are both safe at normal recommended doses during pregnancy and breastfeeding—in fact, folic acid is recommended in pregnancy to prevent birth defects. However, the safety data for sodium and apple cider vinegar in pregnancy and breastfeeding is either mixed or limited. Talk with your doctor or midwife before starting any new supplement while pregnant or nursing.
Will these gummies actually help my blood sugar?
Apple cider vinegar might lower blood sugar slightly, but our data shows insufficient evidence to confirm it works for this purpose. If you're taking diabetes medication, the theoretical risk is that apple cider vinegar could lower your blood sugar too far—so this is something to discuss with your doctor first rather than try on your own.
I've heard apple cider vinegar helps with weight loss. Does it?
The evidence in our data is insufficient to rate apple cider vinegar for weight loss or any of its common wellness claims. That doesn't mean it doesn't work, just that we don't have strong research backing those uses yet.
What's the difference between the folic acid and folate in this product?
The product facts show 'folate' listed as a blend or group container—its components are the individual folic acid ingredient listed separately. So the active ingredient here is folic acid, the synthetic form of the B vitamin folate.
Can I take this long-term?
Vitamin B12 and folic acid are generally safe long-term at normal doses. Apple cider vinegar, however, carries a caution for long-term use at large doses—one case report involved someone taking a very high amount daily for 6 years and developing serious electrolyte problems and bone loss. Stick to the recommended dose and talk with your pharmacist if you're considering taking this for months or longer.
Will this interact with my metformin?
Yes, there's a Minor interaction: metformin can lower your B12 levels over time by interfering with how your gut absorbs it. This supplement adds B12, which could help offset that effect, but you should mention both the metformin and this product to your pharmacist so they can monitor your B12 status.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Apple Cider Vinegar Gummies Apple label
Go deeper

The Full Monographs Behind Apple Cider Vinegar Gummies Apple’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Vitamin B12

Interacts with 20 drugs

Vitamin B12 (cobalamin) is an essential nutrient your body needs to make red blood cells, keep nerves healthy, and support DNA. Supplements are very helpful for people who are deficient — su...

Read the full Vitamin B12 monograph → Herb & supplement monograph

Sodium

Interacts with 205 drugs

Sodium is an essential mineral and electrolyte your body needs to balance fluids, support nerves, and help muscles work. Most people in modern diets get more than enough—often too much—from...

Read the full Sodium monograph → Herb & supplement monograph

Folic Acid

Interacts with 40 drugs

Folic acid is the man-made form of vitamin B9 and is one of the most well-studied supplements, especially for preventing serious birth defects when taken before and during early pregnancy. I...

Read the full Folic Acid monograph → Herb & supplement monograph

Apple Cider Vinegar

Interacts with 162 drugs

Apple cider vinegar is a fermented apple product that many people use hoping to help with blood sugar, weight, or digestion. The evidence for most of these uses is limited and mixed, and the...

Read the full Apple Cider Vinegar monograph →
Sources

Sources & How We Checked

Apple Cider Vinegar Gummies Apple's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 135 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Vitamin B12 30 references
  1. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  2. Hartman TJ, Woodson K, Stolzenberg-Solomon R, et al. Association of the B-vitamins pyridoxal 5'-phosphate (B6), B12, and folate with lung cancer risk in older men. Am J Epidemiol 2001;153:688-94.. DOI
  3. Jansen T, Romiti R, Kreuter A, Altmeyer P. Rosacea fulminans triggered by high-dose vitamins B6 and B12. J Eur Acad Dermatol Venereol 2001;15:484-5..
  4. Lange H, Suryapranata H, De Luca G, et al. Folate therapy and in-stent restenosis after coronary stenting. N Engl J Med 2004;350:2673-81. PubMed
  5. Collin, S. M., Metcalfe, C., Refsum, H., Lewis, S. J., Zuccolo, L., Smith, G. D., Chen, L., Harris, R., Davis, M., Marsden, G., Johnston, C., Lane, J. A., Ebbing, M., Bonaa, K. H., Nygard, O., Ueland, P. M., Grau, M. V., Baron, J. A., Donovan, J. L., Nea
  6. Geissbuhler, P., Mermillod, B., and Rapin, C. H. Elevated serum vitamin B12 levels associated with CRP as a predictive factor of mortality in palliative care cancer patients: a prospective study over five years. J.Pain Symptom.Manage. 2000;20(2):93-103. PubMed
  7. Salles, N., Herrmann, F., Sakbani, K., Rapin, C. H., and Sieber, C. High vitamin B12 level: a strong predictor of mortality in elderly inpatients. J Am Geriatr.Soc 2005;53(5):917-918.
  8. Looker, H. C., Fagot-Campagna, A., Gunter, E. W., Pfeiffer, C. M., Sievers, M. L., Bennett, P. H., Nelson, R. G., Hanson, R. L., and Knowler, W. C. Homocysteine and vitamin B(12) concentrations and mortality rates in type 2 diabetes. Diabetes Metab Res R
  9. Uhl, W., Nolting, A., Golor, G., Rost, K. L., and Kovar, A. Safety of hydroxocobalamin in healthy volunteers in a randomized, placebo-controlled study. Clin Toxicol (Phila) 2006;44 Suppl 1:17-28. PubMed
  10. Borron, S. W., Baud, F. J., Barriot, P., Imbert, M., and Bismuth, C. Prospective study of hydroxocobalamin for acute cyanide poisoning in smoke inhalation. Ann Emerg.Med 2007;49(6):794-801, 801. PubMed
  11. Borron, S. W., Baud, F. J., Megarbane, B., and Bismuth, C. Hydroxocobalamin for severe acute cyanide poisoning by ingestion or inhalation. Am J Emerg.Med 2007;25(5):551-558. PubMed
  12. Lewis, J. G. Gout, Steatorrhoea, and Megaloblastic Anaemia. Ann Rheum.Dis 1962;21(3):284-286. PubMed
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Folic Acid 56 references
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Apple Cider Vinegar 11 references
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