Ashwagandha 450 mg Ingredients & Drug Interactions
by Vitabase
What is this page for?
First and foremost: checking Ashwagandha 450 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Ashwagandha 450 mg is a dietary supplement by Vitabase with 1 active ingredient. Its ingredients are commonly taken for stress and anxiety, sleep problems, fatigue and low energy.Based on those ingredients, 1,372 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Ashwagandha extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Ashwagandha 450 mg by Vitabase
Ask about any prescription or over-the-counter medication and we check it for interactions with Ashwagandha 450 mg by Vitabase — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Ashwagandha 450 mg by Vitabase
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product contains one active ingredient: ashwagandha extract at 450 mg per serving. Ashwagandha is a traditional herb used in Ayurvedic medicine to support relaxation and stress management.
The inactive ingredients are rice flour, cellulose, and magnesium stearate.
Does it work?
Moderate evidence
Ashwagandha is possibly effective for insomnia, anxiety, stress, and generalized anxiety disorder (GAD) according to the evidence we've reviewed. For bipolar disorder, the evidence is too sparse to rate.
The research backing these uses is still emerging, so results can vary from person to person.
How safe is it?
Well-documented data
Short-term use of ashwagandha in healthy adults is generally well tolerated, but long-term safety data are limited and product quality can vary. The most common side effects from oral use are mild—diarrhea, nausea, vomiting, and gastrointestinal upset—and they don't happen often at typical doses.
Rare serious effects include liver damage (hepatitis or failure), and isolated case reports mention drowsiness, headache, and in one person taking multiple drugs, signs of blood vessel problems in the brain. Ashwagandha is likely unsafe in pregnancy because it's traditionally thought to raise miscarriage risk; safety data during breastfeeding are insufficient, so it's best avoided.
If you're pregnant, planning pregnancy, or breastfeeding, talk with your pharmacist or doctor before using this product.
Meds to double-check
Moderate interaction found
Before you start, double-check any CNS depressants (sedatives, painkillers that cause drowsiness), benzodiazepines, blood pressure drugs, diabetes medications, thyroid hormone, immunosuppressants, and drugs that stress the liver. Also check if you take any medications processed by the liver enzyme CYP1A2.
The bottom line
Scorecard at a glanceFully disclosed formula with some supporting evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.
Ashwagandha may help with sleep, anxiety, and everyday stress if you don't take other sedating drugs or blood pressure medication. If you're on any prescription drugs—especially sedatives, anti-anxiety pills, blood pressure meds, diabetes drugs, thyroid pills, or immunosuppressants—check your exact medications with the tool on this page before starting.
Not for pregnancy or breastfeeding.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Mar 23, 2012.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Ashwagandha 450 mg, straight from the product label.
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Ashwagandha 450 mg by Vitabase, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Ashwagandha extract | 450 mg | -- |
Other ingredients: Rice Flour, Cellulose, Magnesium Stearate
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Precautions
Warning: This product should not be taken if you are pregnant, breast-feeding or taking any prescription medications without prior medical consultation.
Please keep out of reach of children.
Do Not Eat Freshness Packet. Keep in Bottle.
Suggested/Recommended/Usage/Directions
SUGGESTED USE: As a dietary supplement take 1 Vcap(R) 2 to 3 times daily.
Storage
Store in a cool, dry place.
General Statements
Please Recycle.
MADE IN THE U.S.A.
Vitabase uses only high quality ingredients.
Seals/Symbols
Vb
FDA Statement of Identity
DIETARY SUPPLEMENT
Formulation
Contains no sugar, salt, yeast, wheat, gluten, corn, soy, milk, egg, shellfish or preservatives.
Vegetarian/Vegan Product.
Brand IP Statement(s)
Vcaps(R) is a registered trademark of Capsugel.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Ashwagandha 450 mg by Vitabase label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Ashwagandha 450 mg by Vitabase
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size1 Vegetarian Capsule(s) Dosage formOther (e.g. Tea Bag) Amounts shown are per serving.
Ashwagandha extract
Interacts with1,372 drugs
Ashwagandha is an Ayurvedic herb most often taken to help with stress, anxiety, and sleep, and some small studies suggest it may help, though the evid...
Ashwagandha extract monograph & interactionsOther (inactive) ingredients: Rice Flour, Cellulose, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.
Ashwagandha 450 mg by Vitabase Drug Interactions
HelloPharmacist Interaction Report
Ashwagandha 450 mg by Vitabase does interact with a number of medications.
The biggest concern is that ashwagandha may boost how your body processes certain drugs through a liver enzyme called CYP1A2, which can lower their effectiveness. This is a Minor interaction, but it's worth checking if you take any medications that depend on that enzyme.
Read the full breakdown — every affected drug type, severity by severity
More pressing are the Moderate interactions. Ashwagandha has sedative effects, so it can add to the drowsiness from CNS depressants (sedatives, painkillers that cause drowsiness), benzodiazepines (anti-anxiety drugs like Valium or Xanax), and other sedating medications.
It may also lower your blood pressure on top of blood pressure drugs (antihypertensives), raising the risk of dizziness or fainting. If you take diabetes medications, ashwagandha might lower your blood sugar further, and with thyroid hormone pills, it may amplify both the benefits and side effects.
Because ashwagandha may boost immune activity, it could work against immunosuppressants (drugs that calm your immune system after transplant or for autoimmune conditions). Finally, combining ashwagandha with drugs that stress the liver raises concern for liver damage.
Altogether, these interactions span 1,351 individual medications. Please use the search tool on this page to check your exact drugs before starting this product.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Ashwagandha 450 mg?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Ashwagandha 450 mg interact with 1,372 drugs. Click any drug to see the details.
1 of the 1 ingredient in Ashwagandha 450 mg interact with drugs. Each result below shows which ingredient is responsible. Ashwagandha extract
AlogliptinNesina
How Alogliptin interacts with Ashwagandha 450 mg — through 1 ingredient. Tap an ingredient for the detail:
Ashwagandha ExtractHepatotoxic Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates +1 Moderate
Interaction Summary
Theoretically, taking ashwagandha with hepatotoxic drugs might increase the risk of liver damage.
Read the full Ashwagandha Extract + Alogliptin interactionAlogliptin, MetforminKazano
How Alogliptin, Metformin interacts with Ashwagandha 450 mg — through 1 ingredient. Tap an ingredient for the detail:
Ashwagandha ExtractAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, taking ashwagandha with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Ashwagandha Extract + Alogliptin, Metformin interactionAlogliptin, PioglitazoneOseni
How Alogliptin, Pioglitazone interacts with Ashwagandha 450 mg — through 1 ingredient. Tap an ingredient for the detail:
Ashwagandha ExtractAntidiabetes Drugs, Hepatotoxic Drugs +1 Moderate
Interaction Summary
Theoretically, taking ashwagandha with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Ashwagandha Extract + Alogliptin, Pioglitazone interactionAlprazolamNiravam, Xanax
How Alprazolam interacts with Ashwagandha 450 mg — through 1 ingredient. Tap an ingredient for the detail:
Ashwagandha ExtractBenzodiazepines, Cytochrome P450 3a4 (cyp3a4) Substrates +1 Moderate
Interaction Summary
Theoretically, taking ashwagandha might increase the sedative effects of benzodiazepines.
Read the full Ashwagandha Extract + Alprazolam interactionAluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium HydroxideAscriptin Codeine #2
How Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide interacts with Ashwagandha 450 mg — through 1 ingredient. Tap an ingredient for the detail:
Ashwagandha ExtractCns Depressants Moderate
Interaction Summary
Theoretically, taking ashwagandha might increase the sedative effects of CNS depressants.
Read the full Ashwagandha Extract + Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide interactionAmbrisentanLetairis, Volibris
How Ambrisentan interacts with Ashwagandha 450 mg — through 1 ingredient. Tap an ingredient for the detail:
Ashwagandha ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Antihypertensive Drugs +1 Moderate
Interaction Summary
Theoretically, ashwagandha might decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Ashwagandha Extract + Ambrisentan interactionAmilorideAmilamont, Midamor
How Amiloride interacts with Ashwagandha 450 mg — through 1 ingredient. Tap an ingredient for the detail:
Ashwagandha ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking ashwagandha with antihypertensive drugs might increase the risk of hypotension.
Read the full Ashwagandha Extract + Amiloride interactionAmiloride, HydrochlorothiazideAmil-Co, Amilzide, Moduret 25, Moduretic
How Amiloride, Hydrochlorothiazide interacts with Ashwagandha 450 mg — through 1 ingredient. Tap an ingredient for the detail:
Ashwagandha ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking ashwagandha with antihypertensive drugs might increase the risk of hypotension.
Read the full Ashwagandha Extract + Amiloride, Hydrochlorothiazide interactionAminoglutethimideCytadren
How Aminoglutethimide interacts with Ashwagandha 450 mg — through 1 ingredient. Tap an ingredient for the detail:
Ashwagandha ExtractCns Depressants Moderate
Interaction Summary
Theoretically, taking ashwagandha might increase the sedative effects of CNS depressants.
Read the full Ashwagandha Extract + Aminoglutethimide interactionAminophylline, Amobarbital, EphedrineAmesec
How Aminophylline, Amobarbital, Ephedrine interacts with Ashwagandha 450 mg — through 1 ingredient. Tap an ingredient for the detail:
Ashwagandha ExtractCns Depressants Moderate
Interaction Summary
Theoretically, taking ashwagandha might increase the sedative effects of CNS depressants.
Read the full Ashwagandha Extract + Aminophylline, Amobarbital, Ephedrine interactionAminosalicylic AcidPaser
How Aminosalicylic Acid interacts with Ashwagandha 450 mg — through 1 ingredient. Tap an ingredient for the detail:
Ashwagandha ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, taking ashwagandha with hepatotoxic drugs might increase the risk of liver damage.
Read the full Ashwagandha Extract + Aminosalicylic Acid interactionAmiodaroneCordarone, Pacerone
How Amiodarone interacts with Ashwagandha 450 mg — through 1 ingredient. Tap an ingredient for the detail:
Ashwagandha ExtractHepatotoxic Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, taking ashwagandha with hepatotoxic drugs might increase the risk of liver damage.
Read the full Ashwagandha Extract + Amiodarone interactionAmitriptylineElavil
How Amitriptyline interacts with Ashwagandha 450 mg — through 1 ingredient. Tap an ingredient for the detail:
Ashwagandha ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates +2 Moderate
Interaction Summary
Theoretically, ashwagandha might decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Ashwagandha Extract + Amitriptyline interactionAmitriptyline, ChlordiazepoxideLimbitrol DS
How Amitriptyline, Chlordiazepoxide interacts with Ashwagandha 450 mg — through 1 ingredient. Tap an ingredient for the detail:
Ashwagandha ExtractSerotonergic Drugs, Cytochrome P450 1a2 (cyp1a2) Substrates +3 Moderate
Interaction Summary
Some animal studies have reported that ashwagandha can enhance serotonergic transmission by altering certain serotonin (5-HT) receptors.
Read the full Ashwagandha Extract + Amitriptyline, Chlordiazepoxide interactionAmitriptyline, PerphenazineEtrafon, Etrafon-A, Etrafon-Forte, Triavil
How Amitriptyline, Perphenazine interacts with Ashwagandha 450 mg — through 1 ingredient. Tap an ingredient for the detail:
Ashwagandha ExtractCns Depressants, Serotonergic Drugs +2 Moderate
Interaction Summary
Theoretically, taking ashwagandha might increase the sedative effects of CNS depressants.
Read the full Ashwagandha Extract + Amitriptyline, Perphenazine interactionAmlodipineNorliqva
How Amlodipine interacts with Ashwagandha 450 mg — through 1 ingredient. Tap an ingredient for the detail:
Ashwagandha ExtractAntihypertensive Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, taking ashwagandha with antihypertensive drugs might increase the risk of hypotension.
Read the full Ashwagandha Extract + Amlodipine interactionAmlodipine BenzoateKaterzia
How Amlodipine Benzoate interacts with Ashwagandha 450 mg — through 1 ingredient. Tap an ingredient for the detail:
Ashwagandha ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Antihypertensive Drugs Moderate
Interaction Summary
Theoretically, ashwagandha might decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Ashwagandha Extract + Amlodipine Benzoate interactionAmlodipine BesilateIstin
How Amlodipine Besilate interacts with Ashwagandha 450 mg — through 1 ingredient. Tap an ingredient for the detail:
Ashwagandha ExtractAntihypertensive Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, taking ashwagandha with antihypertensive drugs might increase the risk of hypotension.
Read the full Ashwagandha Extract + Amlodipine Besilate interactionAmlodipine BesylateNorvasc
How Amlodipine Besylate interacts with Ashwagandha 450 mg — through 1 ingredient. Tap an ingredient for the detail:
Ashwagandha ExtractAntihypertensive Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, taking ashwagandha with antihypertensive drugs might increase the risk of hypotension.
Read the full Ashwagandha Extract + Amlodipine Besylate interactionAmlodipine Besylate, BenazeprilLotrel
How Amlodipine Besylate, Benazepril interacts with Ashwagandha 450 mg — through 1 ingredient. Tap an ingredient for the detail:
Ashwagandha ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Antihypertensive Drugs Moderate
Interaction Summary
Theoretically, ashwagandha might decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Ashwagandha Extract + Amlodipine Besylate, Benazepril interactionAmlodipine, CelecoxibConsensi
How Amlodipine, Celecoxib interacts with Ashwagandha 450 mg — through 1 ingredient. Tap an ingredient for the detail:
Ashwagandha ExtractAntihypertensive Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, taking ashwagandha with antihypertensive drugs might increase the risk of hypotension.
Read the full Ashwagandha Extract + Amlodipine, Celecoxib interactionAmmonium ChlorideAmmonium Chloride
How Ammonium Chloride interacts with Ashwagandha 450 mg — through 1 ingredient. Tap an ingredient for the detail:
Ashwagandha ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking ashwagandha with antihypertensive drugs might increase the risk of hypotension.
Read the full Ashwagandha Extract + Ammonium Chloride interactionAmobarbitalAmytal
How Amobarbital interacts with Ashwagandha 450 mg — through 1 ingredient. Tap an ingredient for the detail:
Ashwagandha ExtractCns Depressants Moderate
Interaction Summary
Theoretically, taking ashwagandha might increase the sedative effects of CNS depressants.
Read the full Ashwagandha Extract + Amobarbital interactionAmobarbital, Ephedrine SulfateEphedrine & Amytal
How Amobarbital, Ephedrine Sulfate interacts with Ashwagandha 450 mg — through 1 ingredient. Tap an ingredient for the detail:
Ashwagandha ExtractCns Depressants Moderate
Interaction Summary
Theoretically, taking ashwagandha might increase the sedative effects of CNS depressants.
Read the full Ashwagandha Extract + Amobarbital, Ephedrine Sulfate interactionAmobarbital, SecobarbitalTuinal
How Amobarbital, Secobarbital interacts with Ashwagandha 450 mg — through 1 ingredient. Tap an ingredient for the detail:
Ashwagandha ExtractCns Depressants Moderate
Interaction Summary
Theoretically, taking ashwagandha might increase the sedative effects of CNS depressants.
Read the full Ashwagandha Extract + Amobarbital, Secobarbital interactionAmoxicillinAmix, Amoram, Amoxident, Amoxil Capsules, Amoxil Injection, Galenamox +3 more
How Amoxicillin interacts with Ashwagandha 450 mg — through 1 ingredient. Tap an ingredient for the detail:
Ashwagandha ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, taking ashwagandha with hepatotoxic drugs might increase the risk of liver damage.
Read the full Ashwagandha Extract + Amoxicillin interactionAmoxicillin VeterinaryBiomox
How Amoxicillin Veterinary interacts with Ashwagandha 450 mg — through 1 ingredient. Tap an ingredient for the detail:
Ashwagandha ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, taking ashwagandha with hepatotoxic drugs might increase the risk of liver damage.
Read the full Ashwagandha Extract + Amoxicillin Veterinary interactionAmoxicillin, Clavulanate PotassiumAugmentin, Augmentin '125/31 SF', Augmentin '250/62 SF', Augmentin XR, Augmentin-Duo 400/57, Clavulin
How Amoxicillin, Clavulanate Potassium interacts with Ashwagandha 450 mg — through 1 ingredient. Tap an ingredient for the detail:
Ashwagandha ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, taking ashwagandha with hepatotoxic drugs might increase the risk of liver damage.
Read the full Ashwagandha Extract + Amoxicillin, Clavulanate Potassium interactionAmoxicillin, Omeprazole Magnesium, RifabutinTalicia
How Amoxicillin, Omeprazole Magnesium, Rifabutin interacts with Ashwagandha 450 mg — through 1 ingredient. Tap an ingredient for the detail:
Ashwagandha ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Hepatotoxic Drugs Moderate
Interaction Summary
Theoretically, ashwagandha might decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Ashwagandha Extract + Amoxicillin, Omeprazole Magnesium, Rifabutin interactionAmphotericin, TetracyclineMysteclin-F
How Amphotericin, Tetracycline interacts with Ashwagandha 450 mg — through 1 ingredient. Tap an ingredient for the detail:
Ashwagandha ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, taking ashwagandha with hepatotoxic drugs might increase the risk of liver damage.
Read the full Ashwagandha Extract + Amphotericin, Tetracycline interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Ashwagandha 450 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
Ashwagandha extract
Antidiabetes Drugs
Theoretically, taking ashwagandha with antidiabetes drugs might increase the risk of hypoglycemia.
There is preliminary clinical evidence suggesting that ashwagandha might lower blood glucose levels. Theoretically, ashwagandha might have additive effects when used with antidiabetes drugs and increase the risk of hypoglycemia.
Antihypertensive Drugs
Theoretically, taking ashwagandha with antihypertensive drugs might increase the risk of hypotension.
Animal research suggests that ashwagandha might lower systolic and diastolic blood pressure. Theoretically, ashwagandha might have additive effects when used with antihypertensive drugs and increase the risk of hypotension.
Benzodiazepines
Theoretically, taking ashwagandha might increase the sedative effects of benzodiazepines.
There is preliminary evidence that ashwagandha might have an additive effect with diazepam (Valium) and clonazepam (Klonopin). This may also occur with other benzodiazepines.
Cns Depressants
Theoretically, taking ashwagandha might increase the sedative effects of CNS depressants.
Ashwagandha seems to have sedative effects. Theoretically, this may potentiate the effects of barbiturates, other sedatives, and anxiolytics.
Hepatotoxic Drugs
Theoretically, taking ashwagandha with hepatotoxic drugs might increase the risk of liver damage.
Ashwagandha has been linked to cases of acute hepatitis, liver failure, hepatic encephalopathy, autoimmune hepatitis, the need for liver transplantation, and death due to liver failure.
Immunosuppressants
Theoretically, taking ashwagandha might decrease the effects of immunosuppressants.
Ashwagandha has demonstrated immunostimulant effects in humans. Animal research has shown that ashwagandha can attenuate the immunosuppression caused by cyclophosphamide.
Thyroid Hormone
Ashwagandha might increase the effects and adverse effects of thyroid hormone.
Concomitant use of ashwagandha with thyroid hormones may cause additive therapeutic and adverse effects. Preliminary clinical research and animal studies suggest that ashwagandha boosts thyroid hormone synthesis and secretion. In one clinical study, ashwagandha increased triiodothyronine (T3) and thyroxine (T4) levels by 41.5% and 19.6%, respectively, and reduced serum TSH levels by 17.4% from baseline in adults with subclinical hypothyroidism.
Cytochrome P450 1A2 (Cyp1A2) Substrates
Theoretically, ashwagandha might decrease the levels and clinical effects of CYP1A2 substrates.
In vitro research shows that ashwagandha extract induces CYP1A2 enzymes.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Theoretically, ashwagandha might decrease the levels and clinical effects of CYP3A4 substrates.
In vitro research shows that ashwagandha extract induces CYP3A4 enzymes.
Serotonergic Drugs
Some animal studies have reported that ashwagandha can enhance serotonergic transmission by altering certain serotonin (5-HT) receptors. However, there is no evidence to suggest that ashwagandha increases the risk of serotonin-related effects, and there have been no published case reports of serotonin syndrome when combined with other serotonergic drugs. Nevertheless, due to the lack of extensive studies on the matter and the fact that ashwagandha appears to affect serotonergic pathways, it would be prudent to exercise caution when combining it with drugs that affect serotonin. [References: - Effects of Withania somnifera (Ashwaga ndha) on Stress and the Stress-Related Neuropsychiatric Disorders Anxiety, Depression, and Insomnia. Curr Neuropharmacol. 2021 Sep 14; 19: 1468–1495. - A Prospective, Randomized Double-Blind, Placebo-Controlled Study of Safety and Efficacy of a High-Concentration Full-Spectrum Extract of Ashwagandha Root in Reducing Stress and Anxiety in Adults. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3573577/]
Brand information
Manufacturer and brand details for Ashwagandha 450 mg, from the product label.
Vitabase
See all Vitabase products- Name
- Vitabase.com
- City
- Monroe
- State
- GA
- ZipCode
- 30656
- Phone Number
- 888.559.3802
Ashwagandha 450 mg by Vitabase: Common Questions
Does Ashwagandha 450 mg by Vitabase interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Is ashwagandha safe to take if I'm pregnant?
Can I take ashwagandha while breastfeeding?
What are the common side effects?
Does ashwagandha really help with anxiety?
Will ashwagandha interact with my sleep medication?
What's in this product besides ashwagandha?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Ashwagandha 450 mg is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Ashwagandha 450 mg’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Ashwagandha 450 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 32 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Ashwagandha 32 references
- McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
- Upton R, ed. Ashwagandha Root (Withania somnifera): Analytical, quality control, and therapuetic monograph. Santa Cruz, CA: American Herbal Pharmacopoeia 2000:1-25.
- Davis L, Kuttan G. Effect of Withania somnifera on cyclophosphamide-induced urotoxicity. Cancer Lett 2000;148:9-17. PubMed
- Davis L, Kuttan G. Suppressive effect of cyclophosphamide-induced toxicity by Withania somnifera extract in mice. J Ethnopharmacol 1998;62:209-14. PubMed
- Mishra LC, Singh BB, Dagenais S. Scientific basis for the therapeutic use of Withania somnifera (ashwagandha): a review. Altern Med Rev 2000;5:334-46. DOI
- Andallu B, Radhika B. Hypoglycemic, diuretic and hypocholesterolemic effect of winter cherry (Withania somnifera, Dunal) root. Indian J Exp Biol 2000;38:607-9.
- Kulkarni RR, Patki PS, Jog VP, et al. Treatment of osteoarthritis with a herbomineral formulation: a double-blind, placebo-controlled, cross-over study. J Ethnopharmacol 1991;33:91-5. PubMed
- Ahumada F, Aspee F, Wikman G, Hancke J. Withania somnifera exract. Its effects on arterial blood pressure in anaesthetized dogs. Phytother Res 1991;5:111-14.
- Panda S, Kar A. Withania somnifera and Bauhinia purpurea in the regulation of circulating thyroid hormone concentrations in female mice. J Ethnopharmacol 1999;67:233-39. PubMed
- Panda S, Kar A. Changes in thyroid hormone concentrations after administration of ashwagandha root extract to adult male mice. J Pharm Pharmacol 1998;50:1065-68. PubMed
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