Interactions on record — worth a quick check against your medications. Based on 3 of 4 ingredients. Check your meds →
Dietary supplement

B12 Strips 2000 mcg Winter Berry Flavor Ingredients & Drug Interactions

by Transformations Weight Loss

B12 Strips 2000 mcg Winter Berry Flavor label
See full label image
Other (e.g. Tea Bag) Category: Vitamin
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking B12 Strips 2000 mcg Winter Berry Flavor against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

B12 Strips 2000 mcg Winter Berry Flavor is a dietary supplement by Transformations Weight Loss with 4 active ingredients. Its ingredients are commonly taken for hair growth and thinning hair, brittle nails, skin health.Based on those ingredients, 230 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Vitamin B6, Methylcobalamin. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against B12 Strips 2000 mcg Winter Berry Flavor by Transformations Weight Loss

Ask about any prescription or over-the-counter medication and we check it for interactions with B12 Strips 2000 mcg Winter Berry Flavor by Transformations Weight Loss — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of B12 Strips 2000 mcg Winter Berry Flavor by Transformations Weight Loss

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 12, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 4 of its 4 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

This product has 4 active ingredients. Methylcobalamin is the B12 form — your body needs it to make red blood cells, keep your nervous system healthy, and process amino acids.

Biotin (also called vitamin B7) supports hair, skin, and nail health and helps your body use the energy in food. Vitamin B6 helps your immune system work and assists with brain development.

Folate is essential for DNA synthesis and cell division. The product comes as a dissolvable strip with inactive ingredients including hydroxypropyl methylcellulose (the strip base), glycerin, stevia, modified starch, natural flavors, gum arabic, sodium carboxymethylcellulose, monoglyceride stearate, and menthol.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded its ingredients' overall clinical evidence instead.

Strong

Strong clinical evidence supports its ingredients for:

Why this rating?
  • The label markets general wellness (“Natural energy and B12 support”), not a specific health condition, so there is no single claim to grade against clinical-evidence data.
  • Since the label doesn't commit to one use, we graded the ingredients' overall clinical evidence instead.
  • On file: Imerslund-Grasbeck disease — rated "Effective" (Vitamin B12) (Natural Medicines).
  • On file: Pyridoxine-dependent epilepsy — rated "Effective" (Vitamin B6) (Natural Medicines).
  • On file: Vitamin B12 deficiency — rated "Effective" (Vitamin B12) (Natural Medicines).
  • On file: Sideroblastic anemia — rated "Effective" (Vitamin B6) (Natural Medicines).
  • On file: Vitamin B6 deficiency — rated "Effective" (Vitamin B6) (Natural Medicines).

Methylcobalamin is effective for treating B12 deficiency and Imerslund-Grasbeck disease (a rare absorption disorder), and likely effective for cyanide poisoning. It's possibly effective for canker sores and postherpetic neuralgia (nerve pain after shingles).

Biotin is likely effective for biotin deficiency. For other uses listed — multiple sclerosis and seborrheic dermatitis — the evidence suggests it's possibly ineffective.

For alopecia areata (patchy hair loss), we don't have enough reliable evidence to rate it. The evidence for vitamin B6 and folate effectiveness isn't established in the data we hold for this product.

The evidence, ingredient by ingredient Biotin Vitamin B12 Vitamin B6

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 3 of the 3 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 3 of 3.
  • General safety write-ups exist for 3 of 3.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Methylcobalamin and biotin are generally well tolerated. B12 has no established upper limit because your body removes excess in urine.

Biotin is similarly safe at high doses for the same reason — one rare case of mild diarrhea was reported at very high doses, and one isolated case of chest inflammation occurred in a patient taking multiple supplements. Vitamin B6 is safe at normal food and supplement amounts, but high doses over time can damage nerves — the risk is highest with doses over 1000 mg daily or cumulative totals of 1000 grams or more, though neuropathy can happen at lower doses too.

All three ingredients are considered likely safe in pregnancy and lactation at recommended amounts, though check with your doctor about high-dose B6 use in pregnancy. We don't have pregnancy or breastfeeding safety data on file for folate.

Side effects, ingredient by ingredient Biotin Vitamin B12 Vitamin B6

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 3 matched ingredients can interact with medications — Vitamin B12, Vitamin B6.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: Parkinson's medications.
  • For scale: 230 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take phenobarbital or phenytoin (seizure drugs), check with your pharmacist before starting — vitamin B6 can reduce how much of these drugs your body absorbs at high doses. The same goes for blood pressure medications and the heart drug amiodarone.

If you're on metformin for diabetes, this product's B12 actually helps offset a known side effect of that drug. Check your exact medications with the search tool on this page.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with strong clinical evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.

This strip is a solid option if you're deficient in B12, biotin, or B6, or if you're on metformin and need B12 support. If you take seizure medications, antihypertensive drugs, amiodarone, or levodopa (without carbidopa), check your specific drugs on this page first.

Talk with your pharmacist about whether the B6 dose here is right for you, especially if you're taking other medications.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 3 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Feb 21, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about B12 Strips 2000 mcg Winter Berry Flavor, straight from the product label.

Brand Transformations Weight Loss
Net contents 30 Fast Dissolving Strip(s)
Market status On market
Date entered into DSLD Feb 21, 2023
DSLD ID 284020
Product type Vitamin
Supplement form Other (e.g. Tea Bag)
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for B12 Strips 2000 mcg Winter Berry Flavor by Transformations Weight Loss, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Strip(s)
Maximum serving Sizes:
2 Strip(s)
Servings per container
30
IngredientAmount% DV
Biotin2500 mcg833%
Methylcobalamin2000 mcg33333%
Vitamin B65 mg250%
Folate800 mcg200%

Other ingredients: Hydroxypropyl Methylcellulose, Glycerin, Stevia, Modified Starch, Natural Flavors, Gum Arabic, Sodium Carboxymethylcellulose, Monoglyceride Stearate, Menthol

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested Use: For best results, allow strip to fully dissolve on tongue, swish fluid throughout entire mouth for 30 seconds making sure to pass fluid under tongue. As a dietary supplement take one to two strips daily as needed.

Precautions

Warning: Do not exceed this amount on a regular basis.

Keep out of reach of children.

Storage

Store at 55 to 78 degrees F in a dry place. Keep out of direct sunlight.

Formulation

This product contains no: animal byproduct; egg; fish & shellfish; gluten from wheat, rye, oats, or barley; milk (including lactose); peanuts; tree nuts; and soy.

Advanced delivery system Natural energy

This product was manufactured in a GMP approved facility.

General Statements

Please recycle

Strip B12 advanced delivery Oral B12 100% Sublingual B12 100% Q: Why should I take B12 strips instead of a pill or liquid? A: When you take a supplement in a digestible form, any B12 present is absorbed by tiny proteins in the stomach and intestines that bind B12. As a result, only a small percentage of any form of B12 makes it into your bloodstream. B12 utilization Cyanocobalamin B12 100% Methylcobalamin B12 100% Q: Why should I choose Methylcobalamin over Cyanocobalamin B12? A: Methylcobalamin is the most efficient form of B12. Before Cyanocobalamin can be properly utilized by the body, it has to be striped down in a time consuming, multi-step process. Methylcobalamin is already the most highly reduced form, allowing a high level of benefit.

B12 deficiency may cause: Fatigue Depression Poor memory Neurological symptoms High homocysteine levels Poor circulation

FDA Statement of Identity

Dietary Supplement

FDA Disclaimer Statement

These statements have not been evaluated by the FDA. This product is not intended to prevent, treat or cure any disease.

Formula

B12 strips promote jitter free energy plus better sleep!! B12 not only helps create energy for your body, but it also plays a role in your body's production of melatonin, your natural sleep hormone. Get a sustained boost of energy in the day and restful sleep at night from just one strip.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

B12 Strips 2000 mcg Winter Berry Flavor by Transformations Weight Loss label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

B12 Strips 2000 mcg Winter Berry Flavor label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in B12 Strips 2000 mcg Winter Berry Flavor by Transformations Weight Loss

These are the 4 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Strip(s) Dosage formOther (e.g. Tea Bag) Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Biotin

No known
interactions
2500 mcg per serving

Biotin (vitamin B7) is a water-soluble vitamin your body needs to turn food into energy and to support healthy hair, skin, and nails. Most people get...

Biotin monograph & interactions

Methylcobalamin

Interacts with
20 drugs
2000 mcg per serving Form: Vitamin B12

Vitamin B12 (cobalamin) is an essential nutrient your body needs to make red blood cells, keep nerves healthy, and support DNA. Supplements are very h...

Methylcobalamin monograph & interactions

Vitamin B6

Interacts with
210 drugs
5 mg per serving Form: Pyridoxal 5-Phosphate

Vitamin B6 (pyridoxine) is an essential water-soluble vitamin that your body needs for metabolism, brain function, and making red blood cells. It is b...

Vitamin B6 monograph & interactions

Folate

800 mcg per serving Form: 5-Methyltetrahydrofolate

Other (inactive) ingredients: Hydroxypropyl Methylcellulose, Glycerin, Stevia, Modified Starch, Natural Flavors, Gum Arabic, Sodium Carboxymethylcellulose, Monoglyceride Stearate, Menthol. These complete the product’s ingredient list but are not active constituents.

Interaction report

B12 Strips 2000 mcg Winter Berry Flavor by Transformations Weight Loss Drug Interactions

Want to check YOUR meds against B12 Strips 2000 mcg Winter Berry Flavor?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
230Drugs
205 Moderate 25 Minor

Ingredients driving the most interactions

Vitamin B6 210
Methylcobalamin 20

Individual Drug Interactions

The ingredients in B12 Strips 2000 mcg Winter Berry Flavor interact with 230 drugs. Click any drug to see the details.

2 of the 4 ingredients in B12 Strips 2000 mcg Winter Berry Flavor interact with drugs. Each result below shows which ingredient is responsible. Vitamin B6 Methylcobalamin

Each ingredient & the kinds of drugs it affects

For each ingredient in B12 Strips 2000 mcg Winter Berry Flavor with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Vitamin B65 drug types · 210 drugs

Amiodarone (Cordarone)

Theoretically, vitamin B6 might increase the photosensitivity caused by amiodarone.
Despite initial case reports suggesting that pyridoxine may have a protective effect against amiodarone-induced photosensitivity, preliminary clinical research suggests that pyridoxine may actually exacerbate this adverse effect.

Likelihood Possible Evidence B
Antihypertensive Drugs

Theoretically, vitamin B6 may have additive effects when used with antihypertensive drugs.
Research in hypertensive rats shows that vitamin B6 can decrease systolic blood pressure. Similarly, clinical research in patients with hypertension shows that taking high doses of vitamin B6 may reduce systolic and diastolic blood pressure, possibly by reducing plasma levels of epinephrine and norepinephrine.

Likelihood Possible Evidence B
Phenobarbital (Luminal)

High doses of vitamin B6 may reduce the levels and clinical effects of phenobarbital.
Preliminary clinical evidence suggests that vitamin B6 200 mg daily can reduce plasma levels of phenobarbital, possibly by increasing metabolism. It is not known whether lower doses have any effect. Advise people taking phenobarbital to avoid high doses of vitamin B6.

Likelihood Possible Evidence D
Phenytoin (Dilantin)

High doses of vitamin B6 may reduce the levels and clinical effects of phenytoin.
Preliminary clinical evidence suggests that vitamin B6 200 mg daily can reduce plasma levels of phenytoin, possibly by increasing metabolism. It is not known whether lower doses have any effect. Advise people taking phenytoin to avoid high doses of vitamin B6.

Likelihood Possible Evidence D
Levodopa

Vitamin B6 may increase the metabolism of levodopa when taken alone, but not when taken in conjunction with carbidopa.
Vitamin B6 (pyridoxine) enhances the metabolism of levodopa, reducing its clinical effects. However, this interaction does not occur when carbidopa is used concurrently with levodopa (Sinemet). Therefore, it is not likely to be a problem in most people.

Likelihood Unlikely Evidence D
Vitamin B6 full monograph & interactions

Methylcobalamin1 drug type · 20 drugs

Metformin (Glucophage)

Metformin, a common medication used to manage type 2 diabetes, has been associated with lower vitamin B12 levels in some individuals. Prolonged use of metformin can interfere with the absorption of B12 in the digestive system, potentially leading to a deficiency in this essential vitamin.

Likelihood Possible Evidence A
Methylcobalamin full monograph & interactions
The maker

Brand information

Manufacturer and brand details for B12 Strips 2000 mcg Winter Berry Flavor, from the product label.

Transformations Weight Loss

See all Transformations Weight Loss products
Name
Transformations Intl.
Street Address
917 Rhinhart Rd. Suite 2001
City
Lake Mary
State
FL
ZipCode
32746
Phone Number
1-877-827-8669
Web Address
transformationsweightloss.com
Pharmacist Counseling Corner

B12 Strips 2000 mcg Winter Berry Flavor by Transformations Weight Loss: Common Questions

Does B12 Strips 2000 mcg Winter Berry Flavor by Transformations Weight Loss interact with any medications?
Yes. Based on its ingredients, B12 Strips 2000 mcg Winter Berry Flavor has a known interaction with 230 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
B12 Strips 2000 mcg Winter Berry Flavor contains 4 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is this safe to take while I'm pregnant or breastfeeding?
The B12 and biotin in this product are considered likely safe at recommended amounts during pregnancy and breastfeeding — in fact, B12 is needed during both. Vitamin B6 is also likely safe at normal recommended amounts, though one rating flags it as possibly unsafe in pregnancy, so talk with your doctor before starting any supplement while pregnant. We don't have pregnancy or breastfeeding data on file for folate in this product.
What's the difference between methylcobalamin and other forms of B12?
Methylcobalamin is one active form of B12 that your body can use directly without converting it. It's effective for treating B12 deficiency and works in your nerves and blood cells. The product facts we have focus on this form.
Can biotin help with hair loss?
For alopecia areata (patchy hair loss), we don't have enough reliable evidence to say whether biotin helps. Biotin is definitely effective for biotin deficiency itself, but for other uses like general hair health, the evidence isn't established in our data.
Will high-dose B6 hurt my nerves?
High doses of vitamin B6 over time can cause sensory neuropathy — nerve damage that usually happens with doses above 1000 mg daily or very high cumulative totals. But neuropathy has been reported at lower doses too. This strip's B6 dose isn't specified in the facts we hold, so ask your pharmacist whether it's considered high-dose.
Is this product a good idea if I take metformin?
Actually, yes — metformin can lower your B12 levels by interfering with absorption in your stomach over time. That's a minor interaction, and adding B12 is often recommended for people on metformin. Talk with your doctor about whether this product is right for your situation.
What's in this strip besides the active vitamins?
The inactive ingredients are hydroxypropyl methylcellulose (the dissolving strip base), glycerin, stevia, modified starch, natural flavors, gum arabic, sodium carboxymethylcellulose, monoglyceride stearate, and menthol. These are fillers and binders that give the strip its texture and taste.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if B12 Strips 2000 mcg Winter Berry Flavor is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

B12 Strips 2000 mcg Winter Berry Flavor label
Go deeper

The Full Monographs Behind B12 Strips 2000 mcg Winter Berry Flavor’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Biotin

Biotin (vitamin B7) is a water-soluble vitamin your body needs to turn food into energy and to support healthy hair, skin, and nails. Most people get plenty from a normal diet, and true defi...

Read the full Biotin monograph → Herb & supplement monograph

Vitamin B12

Interacts with 20 drugs

Vitamin B12 (cobalamin) is an essential nutrient your body needs to make red blood cells, keep nerves healthy, and support DNA. Supplements are very helpful for people who are deficient — su...

Read the full Vitamin B12 monograph → Herb & supplement monograph

Vitamin B6

Interacts with 210 drugs

Vitamin B6 (pyridoxine) is an essential water-soluble vitamin that your body needs for metabolism, brain function, and making red blood cells. It is best known for helping with pregnancy-rel...

Read the full Vitamin B6 monograph →
Sources

Sources & How We Checked

B12 Strips 2000 mcg Winter Berry Flavor's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 66 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Biotin 4 references
  1. Debourdeau PM, Djezzar S, Estival JL, et al. Life-threatening eosinophilic pleuropericardial effusion related to vitamins B5 and H. Ann Pharmacother 2001;35:424-6. DOI
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  3. Mock DM, Quirk JG, Mock NI. Marginal biotin deficiency during normal pregnancy. Am J Clin Nutr 2002;75:295-9. PubMed
  4. Sedel F, Papeix C, Bellanger A, Touitou V, Lebrun-Frenay C, Galanaud D, et al. High doses of biotin in chronic progressive multiple sclerosis: a pilot study.Mult Scler Relat Disord. 2015;4(2):159-69. doi: 10.1016/j.msard.2015.01.005. PubMed

See these in context on the Biotin monograph →

Vitamin B12 30 references
  1. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  2. Hartman TJ, Woodson K, Stolzenberg-Solomon R, et al. Association of the B-vitamins pyridoxal 5'-phosphate (B6), B12, and folate with lung cancer risk in older men. Am J Epidemiol 2001;153:688-94.. DOI
  3. Jansen T, Romiti R, Kreuter A, Altmeyer P. Rosacea fulminans triggered by high-dose vitamins B6 and B12. J Eur Acad Dermatol Venereol 2001;15:484-5..
  4. Lange H, Suryapranata H, De Luca G, et al. Folate therapy and in-stent restenosis after coronary stenting. N Engl J Med 2004;350:2673-81. PubMed
  5. Collin, S. M., Metcalfe, C., Refsum, H., Lewis, S. J., Zuccolo, L., Smith, G. D., Chen, L., Harris, R., Davis, M., Marsden, G., Johnston, C., Lane, J. A., Ebbing, M., Bonaa, K. H., Nygard, O., Ueland, P. M., Grau, M. V., Baron, J. A., Donovan, J. L., Nea
  6. Geissbuhler, P., Mermillod, B., and Rapin, C. H. Elevated serum vitamin B12 levels associated with CRP as a predictive factor of mortality in palliative care cancer patients: a prospective study over five years. J.Pain Symptom.Manage. 2000;20(2):93-103. PubMed
  7. Salles, N., Herrmann, F., Sakbani, K., Rapin, C. H., and Sieber, C. High vitamin B12 level: a strong predictor of mortality in elderly inpatients. J Am Geriatr.Soc 2005;53(5):917-918.
  8. Looker, H. C., Fagot-Campagna, A., Gunter, E. W., Pfeiffer, C. M., Sievers, M. L., Bennett, P. H., Nelson, R. G., Hanson, R. L., and Knowler, W. C. Homocysteine and vitamin B(12) concentrations and mortality rates in type 2 diabetes. Diabetes Metab Res R
  9. Uhl, W., Nolting, A., Golor, G., Rost, K. L., and Kovar, A. Safety of hydroxocobalamin in healthy volunteers in a randomized, placebo-controlled study. Clin Toxicol (Phila) 2006;44 Suppl 1:17-28. PubMed
  10. Borron, S. W., Baud, F. J., Barriot, P., Imbert, M., and Bismuth, C. Prospective study of hydroxocobalamin for acute cyanide poisoning in smoke inhalation. Ann Emerg.Med 2007;49(6):794-801, 801. PubMed
  11. Borron, S. W., Baud, F. J., Megarbane, B., and Bismuth, C. Hydroxocobalamin for severe acute cyanide poisoning by ingestion or inhalation. Am J Emerg.Med 2007;25(5):551-558. PubMed
  12. Lewis, J. G. Gout, Steatorrhoea, and Megaloblastic Anaemia. Ann Rheum.Dis 1962;21(3):284-286. PubMed
  13. Tal, S., Shavit, Y., Stern, F., and Malnick, S. Association between vitamin B12 levels and mortality in hospitalized older adults. J Am Geriatr.Soc 2010;58(3):523-526. PubMed
  14. Baztan, J. J., Gavidia, J. J., Gomez-Pavon, J., Esteve, A., and Ruiperez, I. High vitamin B12 levels and in-hospital mortality. J Am Geriatr.Soc 2010;58(11):2237-2238. PubMed
  15. Omboni, E., Checchini, M., and Longoni, F. [Hypopotassemia and megaloblastic anemia. Presentation of a case]. Minerva Med 8-31-1987;78(16):1255-1257.
  16. Aalfs As, Scholvinck LH, Horvath B. Acneiform eruption in a 5-year old due to vitamin B12 supplementation. Eur J Dermatol 2013;23(5):726-7. PubMed
  17. Balta I, Ozuguz P. Vitamin B12-induced acneiform eruption. Cutan Ocul Toxicol 2014;33(2):94-5. PubMed
  18. Carman KB, Belgemen T, Yis U. Involuntary movements misdiagnosed as seizure during vitamin B12 treatment. Pediatr Emerg Care 2013;29(11):1223-4. PubMed
  19. Djuric V, Bogic M, Popadic AP, et al. Anaphylactic reaction to hydroxycobalamin with tolerance to cyanocobalamin. Ann Allergy Asthma Immunol 2012;108(3):207-8. PubMed
  20. Kartel O, Gulec M, Demirel F, et al. Vitamin B12 allergy and successful desensitization with cyanocobalamin: A case report. Allergol Immunopath (Madr) 2012;40(5):324-5.
  21. Patiroglu T, Unal E, Yildirim S. Infantile tremor syndrome associated with cobalamin therapy: A case report. Clin Neurol Neurosurg 2013;115(9):1903-5. PubMed
  22. Schulte S, Barkema LW, Kardaun SH. Long-lasting atypical acneiform eruption with prominent comedones induced by hydroxocobalamin (vitamin B12). J Dtsch Dermatol Ges 2014;12(6):502-3.
  23. Zanus C, Alberini E, Costa P, et al. Involuntary movements after correction of vitamin B12 deficiency: A video-case report. Epileptic Disord 2012;14(2):174-80. PubMed
  24. Fanidi A, Carreras-Torres R, Larose TL, et al. Is high vitamin B12 status a cause of lung cancer? Int J Cancer. 2019 Sep 15;145(6):1499-1503. PubMed
  25. Fujita Y, Mizukami T, Maya Y, et al. Vitamin B12 allergy manifesting as lymphomatoid contact dermatitis. Eur J Dermatol. 2020;30(3):304-305. PubMed
  26. Dépret F, Hoffmann C, Daoud L, et al. Association between hydroxocobalamin administration and acute kidney injury after smoke inhalation: a multicenter retrospective study. Crit Care. 2019;23(1):421. PubMed
  27. Khairan P, Sobue T, Eshak ES, et al. Association of dietary intakes of vitamin B12, vitamin B6, folate, and methionine with the risk of esophageal cancer: the Japan Public Health Center-based (JPHC) prospective study. BMC Cancer 2021;21(1):982. PubMed
  28. Evans J, Pandya A, Ding Y, Qunibi WY. Hydroxocobalamin-Induced Oxalate Nephropathy in a Patient With Smoke Inhalation. Kidney Int Rep 2021;6(8):2228-2231. PubMed
  29. Lacombe V, Chabrun F, Lacout C, et al. Persistent elevation of plasma vitamin B12 is strongly associated with solid cancer. Sci Rep 2021;11(1):13361. PubMed
  30. Pegalajar-García MD, Cebolla-Verdugo M, Prados-Carmona Á, Llamas-Segura C, Navarro-Triviño FJ. Systemic allergic dermatitis to cobalt present in cyanocobalamin supplementation. Contact Dermatitis 2023;89(3):203-205. PubMed

See these in context on the Vitamin B12 monograph →

Vitamin B6 32 references
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See these in context on the Vitamin B6 monograph →

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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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