Interactions on record — worth a quick check against your medications. Based on 1 of 2 ingredients. Check your meds →
Dietary supplement

BeFlexible Ingredients & Drug Interactions

by TheraBotanics

BeFlexible label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking BeFlexible against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

BeFlexible is a dietary supplement by TheraBotanics with 2 active ingredients. Its ingredients are commonly taken for osteoarthritis joint pain, rheumatoid arthritis, inflammation.Based on those ingredients, 952 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Bio-Boswellia Indian Frankincense gum extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against BeFlexible by TheraBotanics

Ask about any prescription or over-the-counter medication and we check it for interactions with BeFlexible by TheraBotanics — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of BeFlexible by TheraBotanics

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 23, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 2 of its 2 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

BeFlexible contains 2 active ingredients: Phyto-Boron and Bio-Boswellia Indian Frankincense gum extract. The boswellia extract comes from the gum resin of the Boswellia serrata tree, traditionally used for joint support and inflammation.

The product also contains inactive ingredients like microcrystalline cellulose (a filler), gelatin (the capsule), and colorants.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded Boswellia Serrata's overall clinical evidence instead.

Moderate

Some clinical evidence supports Boswellia Serrata for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredient's overall clinical evidence instead.
  • On file: Osteoarthritis — rated "Possibly Effective" (Natural Medicines).

The boswellia extract in this product is possibly effective for osteoarthritis. For other conditions listed — hay fever, Alzheimer disease, asthma, and cluster headache — the evidence we hold is insufficient to rate whether it works.

If you're considering this product for one of those other uses, talk with your doctor or pharmacist about what the current research shows.

The evidence, ingredient by ingredient Boswellia Serrata

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Boswellia serrata extract taken by mouth is generally well tolerated, though quality and strength vary widely between products. The most common side effects are abdominal pain, diarrhea, headache, heartburn, itching, and nausea.

Headache appears in a small number of users — roughly 11% in one study of a specific extract. Dizziness and vertigo have also been reported but at lower rates.

Very rarely, large amounts of boswellia gum resin can form a bezoar (a hard mass in the stomach). The safety data advises against use during pregnancy.

Safety while breastfeeding is unknown, so it's best avoided. If you're pregnant, breastfeeding, or planning either, talk with your doctor or pharmacist before taking this product.

Side effects, ingredient by ingredient Boswellia Serrata

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Boswellia Serrata.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: immunosuppressants / transplant drugs.
  • For scale: 953 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking BeFlexible, check with your doctor or pharmacist if you take any drugs processed by CYP2D6, CYP2C19, CYP1A2, CYP2C9, or CYP3A4 liver enzymes (Moderate severity) — the boswellia extract can raise their levels. Also check if you take immunosuppressant medications (Moderate severity) — the extract might interfere with how they work.

Use the medication checker on this page to look up your exact drugs.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.

BeFlexible may be worth considering if you have osteoarthritis and want to try boswellia, but you'll need to clear it with your own doctor or pharmacist first because the extract affects how your liver processes many medications. If you take any prescription drugs — especially those processed by your liver — run them through our interaction checker before starting.

Be aware that side effects like stomach upset and headache can occur, and avoid this product if you're pregnant or breastfeeding.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Nov 22, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about BeFlexible, straight from the product label.

Brand TheraBotanics
Barcode (UPC) 874617001992
Net contents 30 Capsule(s)
Market status On market
Date entered into DSLD Nov 22, 2022
DSLD ID 277049
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for BeFlexible by TheraBotanics, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
30
UPC/BARCODE
874617001992
IngredientAmount% DV
Phyto-Boron216 mg--
Bio-Boswellia Indian Frankincense gum extract100 mg--

Other ingredients: Microcrystaline Cellulose, Gelatin, Titanium Dioxide, FD&C Red #3, FD&C Blue #1

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Directions Take 1 capsule daily with a meal.

1 capsule per day

Precautions

Caution If you are pregnant, nursing, taking any medications or have a preexisting medical condition, consult your doctor before use.

Discontinue use and consult your doctor if any adverse reactions occur.

Do not use if safety seal is broken or missing.

Keep out of the reach of children.

Storage

Store in a cool, dry place.

General Statements

For reorder or customer service, call 800.503.1194

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to treat, diagnose, cure or prevent any disease.

Formulation

Total joint therapy Patented breakthrough ingredients Works in just 7 days Joint comfort Range of motion Healthy cartilage Joint nourishment

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

BeFlexible by TheraBotanics label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

BeFlexible label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in BeFlexible by TheraBotanics

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Phyto-Boron

216 mg per serving Form: Calcium Fructoborate

Bio-Boswellia Indian Frankincense gum extract

Interacts with
952 drugs
100 mg per serving

Boswellia serrata is a tree resin used in traditional medicine, mainly for joint pain and inflammation. Some studies suggest it may help with osteoart...

Bio-Boswellia Indian Frankincense gum extract monograph & interactions

Other (inactive) ingredients: Microcrystaline Cellulose, Gelatin, Titanium Dioxide, FD&C Red #3, FD&C Blue #1. These complete the product’s ingredient list but are not active constituents.

Interaction report

BeFlexible by TheraBotanics Drug Interactions

Want to check YOUR meds against BeFlexible?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
952Drugs
952 Moderate

Ingredients driving the most interactions

Bio-Boswellia Indian Frankincense gum extract 952

Individual Drug Interactions

The ingredients in BeFlexible interact with 952 drugs. Click any drug to see the details.

1 of the 2 ingredients in BeFlexible interact with drugs. Each result below shows which ingredient is responsible. Bio-Boswellia Indian Frankincense gum extract

Each ingredient & the kinds of drugs it affects

For each ingredient in BeFlexible with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Bio-Boswellia Indian Frankincense gum extract6 drug types · 952 drugs

Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, Boswellia serrata might increase the levels of CYP1A2 substrates.
In vitro research shows that Boswellia serrata gum resin inhibits CYP1A2 enzymes.

Likelihood Possible Evidence D
Cytochrome P450 2C19 (Cyp2C19) Substrates

Theoretically, Boswellia serrata might increase the levels of CYP2C19 substrates.
In vitro research shows that Boswellia serrata gum resin inhibits CYP2C19 enzymes.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, Boswellia serrata might increase the levels of CYP2C9 substrates.
In vitro research shows that Boswellia serrata gum resin inhibits CYP2C9 enzymes.

Likelihood Possible Evidence D
Cytochrome P450 2D6 (Cyp2D6) Substrates

Theoretically, Boswellia serrata might increase the levels of CYP2D6 substrates.
In vitro research shows that Boswellia serrata gum resin inhibits CYP2D6 enzymes.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, Boswellia serrata might increase or decrease the levels and clinical effects of CYP3A4 substrates.
In vitro research shows that Boswellia serrata gum resin inhibits CYP3A4 enzymes. Other in vitro research shows that Boswellia serrata extract inhibits CYP3A4 enzymes at most concentrations, although it may modestly induce enzyme activity at low concentrations.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, Boswellia serrata might alter the effects of immunosuppressive drugs.
Some in vitro research suggests that Boswellia serrata extracts might inhibit mediators of autoimmune disorders such as leukotrienes and reduce production of antibodies and cell-mediated immunity. However, other in vitro research suggests that, when coupled with calcium ions, boswellic acids containing the keto group have immunostimulant properties within specific cell signaling pathways.

Likelihood Possible Evidence D
Bio-Boswellia Indian Frankincense gum extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for BeFlexible, from the product label.

TheraBotanics

See all TheraBotanics products
Name
TheraBotanics Supplements, LLC
Street Address
2777 USA Parkway
City
McCarran
State
NV
ZipCode
89434
Phone Number
800.503.1194
Web Address
TheraBotanics.com
Pharmacist Counseling Corner

BeFlexible by TheraBotanics: Common Questions

Does BeFlexible by TheraBotanics interact with any medications?
Yes. Based on its ingredients, BeFlexible has a known interaction with 952 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
BeFlexible contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is Bio-Boswellia Indian Frankincense gum extract, and what does it do?
It's an extract from the gum resin of the Boswellia serrata tree. The product is possibly effective for osteoarthritis. For other conditions like hay fever, Alzheimer disease, asthma, and cluster headache, we don't have enough reliable evidence to say whether it works.
Can I take BeFlexible while pregnant or breastfeeding?
The safety data advises against use during pregnancy. Safety while breastfeeding is unknown, so it's best avoided then too. Talk with your doctor or pharmacist if you're pregnant, breastfeeding, or planning either.
What side effects does the boswellia extract cause?
The most common ones are abdominal pain, diarrhea, headache, heartburn, itching, and nausea. Headache shows up in roughly 11% of users in one study. Dizziness and vertigo are less common. Very rarely, large amounts can form a bezoar (a hard mass in the stomach).
Why do I need to check my medications before taking this?
The boswellia extract inhibits several liver enzymes that break down drugs, so it can raise the levels of many common medications in your blood and cause side effects. Over 950 individual medications are affected by these enzymes, so it's important to check yours first.
What is Phyto-Boron, and does it interact with drugs?
Phyto-Boron is one of the two active ingredients in this product, but we don't hold interaction data for it, so we can't tell you whether it interacts with medications. Your pharmacist may be able to help fill that gap.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

BeFlexible label
Go deeper

The Full Monographs Behind BeFlexible’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Boswellia Serrata

Interacts with 952 drugs

Boswellia serrata is a tree resin used in traditional medicine, mainly for joint pain and inflammation. Some studies suggest it may help with osteoarthritis symptoms, but the overall evidenc...

Read the full Boswellia Serrata monograph →
Sources

Sources & How We Checked

BeFlexible's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 16 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Boswellia Serrata 16 references
  1. Gupta I, Gupta V, Parihar A, et al. Effects of Boswellia serrata gum resin in patients with bronchial asthma: results of a double-blind, placebo-controlled, 6-week clinical study. Eur J Med Res 1998;3:511-4.
  2. Electronic Code of Federal Regulations. Title 21. Part 182 -- Substances Generally Recognized As Safe. Available at: https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?CFRPart=182
  3. Kimmatkar N, Thawani V, Hingorani L, et al. Efficacy and tolerability of Boswellia serrata extract in treatment of osteoarthritis of knee--a randomized double blind placebo controlled trial. Phytomedicine 2003;10:3-7. PubMed
  4. Liu JJ, Nilsson A, Oredsson S, et al. Boswellic acids trigger apoptosis via a pathway dependent on caspase-8 activation but independent on Fas/Fas ligand interaction in colon cancer HT-29 cells. Carcinogenesis 2002;23:2087-93. PubMed
  5. Wildfeuer A, Neu IS, Safayhi H, et al. Effects of boswellic acids extracted from a herbal medicine on the biosynthesis of leukotrienes and the course of experimental autoimmune encephalomyelitis. Arzneimittelforschung 1998;48:668-74.
  6. Gupta I, Parihar A, Malhotra P, et al. Effects of gum resin of Boswellia serrata in patients with chronic colitis. Planta Med 2001;67:391-5. PubMed
  7. Sengupta K, Alluri KV, Satish AR, et al. A double blind, randomized, placebo controlled study of the efficacy and safety of 5-Loxin. Arthritis Res Ther 2008;10:R85.
  8. Sengupta K, Krishnaraju AV, Vishal AA, et al. Comparative efficacy and tolerability of 5-Loxin and Aflapin against osteoarthritis of the knee: a double blind, randomized, placebo controlled clinical study. Int J Med Sci 2010;7:366-77.
  9. Ernst E. Frankincense: systematic review. BMJ 2008;337:a2813. PubMed
  10. Kirste S, Treier M, Wehrle SJ, et al. Boswellia serratea extract acts on cerebral edema in patients irradiated for brain tumors: a prospective, randomized, placebo-controlled, double-blind pilot trial. Cancer 2011;117:3788-95.
  11. Frank A, Unger M. Analysis of frankincense from various Boswellia species with inhibitory activity on human drug metabolising cytochrome P450 enzymes using liquid chromatography mass spectrometry after automated on-line extraction. J Chromatogr A 2006;111 PubMed
  12. Altmann A, Poeckel D, Fischer L, et al. Coupling of boswellic acid-incuded Ca2+ mobilisation and MAPK activation to lipid metabolism and peroxide formation in human leucocytes. Br J Pharmacol 2004;141:223-32.
  13. El Fortia, M., Badi, H., Elalem, Kh, Kadiki, O., and Topov, Y. Olibanum bezoar: complication of a traditional popular medicine. East Mediterr.Health J 2006;12(6):927-929.
  14. Meshkat S, Mahmoodi Baram S, Rajaei S, et al. Boswellia serrata extract shows cognitive benefits in a double-blind, randomized, placebo-controlled pilot clinical trial in individuals who suffered traumatic brain injury. Brain Inj 2022;36(4):553-559. PubMed
  15. Haron MH, Dale O, Martin K, et al. Evaluation of the Herb-Drug Interaction Potential of Commonly Used Botanicals on the US Market with Regard to PXR- and AhR-Mediated Influences on CYP3A4 and CYP1A2. J Diet Suppl 2022. PubMed
  16. Valente IVB, Garcia D, Abbott A, et al. The anti-proliferative effects of a frankincense extract in a window of opportunity phase ia clinical trial for patients with breast cancer. Breast Cancer Res Treat 2024;204(3):521-530. PubMed

See these in context on the Boswellia Serrata monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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