Interactions on record — worth a quick check against your medications. Based on 1 of 4 ingredients. Check your meds →
Dietary supplement

BioActive B12 Ingredients & Drug Interactions

by Pure TheraPro Rx

BioActive B12 label
See full label image
Liquid Category: Vitamin
Most serious interaction: Minor
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking BioActive B12 against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Minor

BioActive B12 is a dietary supplement by Pure TheraPro Rx with 4 active ingredients. Its ingredients are commonly taken for treating or preventing b12 deficiency, pernicious anemia, low energy and fatigue.Based on those ingredients, 20 medications have a known interaction with it, the most serious rated minor. The ingredients most likely to interact are Vitamin B12. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against BioActive B12 by Pure TheraPro Rx

Ask about any prescription or over-the-counter medication and we check it for interactions with BioActive B12 by Pure TheraPro Rx — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of BioActive B12 by Pure TheraPro Rx

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 12, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 4 of its 4 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

BioActive B12 is a liquid supplement with four active B12 ingredients: Vitamin B12, MecobalActive Methylcobalamin, Adenosylcobalamin, and Hydroxocobalamin. These are different forms of the same essential vitamin, which your body needs for nerve function, red blood cell formation, and DNA synthesis.

The product also contains inactive ingredients — water, vegetable glycerin, potassium sorbate, and citric acid — that help preserve and deliver the B12.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: Energy and methylation support.
  • We looked for evidence on: Fatigue, Vitamin B12 deficiency, Cognitive function, Peripheral neuropathy, Hyperhomocysteinemia, Energy metabolism — and 1 related terms.
  • The strongest evidence on file: Vitamin B12 is rated "Effective" for Vitamin B12 deficiency (Natural Medicines).
  • Also on file: Vitamin B12 is rated "Possibly Effective" for Hyperhomocysteinemia.
  • Also on file: Vitamin B12 is rated "Insufficient Reliable Evidence To Rate" for Chemotherapy-induced peripheral neuropathy, Cognitive function, Fatigue, Peripheral neuropathy.

Vitamin B12 in this product is Effective for treating B12 deficiency and Imerslund-Grasbeck disease, a rare genetic condition that prevents B12 absorption. It's also Likely Effective for cyanide poisoning (a serious medical emergency).

For canker sores and postherpetic neuralgia (a type of nerve pain after shingles), the evidence is Possibly Effective — meaning there's some support, but it's not conclusive.

The evidence, ingredient by ingredient Vitamin B12

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

B12 is generally very well tolerated and has no upper limit because your body excretes excess amounts in your urine. Allergic reactions are rare but can happen — watch for rash, itching, or hives, especially if you have a cobalt allergy.

This product is considered safe in pregnancy and breastfeeding at recommended amounts, though you should follow your provider's guidance on dosing.

Side effects, ingredient by ingredient Vitamin B12

Meds to double-check

Minor interactions only
Known Interaction Concern · database check
Minor only

Only Minor-severity interactions are documented for these ingredients.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Vitamin B12.
  • The most serious interaction on file is rated Minor.
  • For scale: 20 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take metformin (Glucophage) for diabetes, let your pharmacist know you're starting B12 — your levels are worth keeping an eye on. Check all your other medications with the search tool on this page to be sure.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with clinical evidence supporting its stated purpose. Only minor medication interactions are documented, and safety information is well characterized.

This liquid B12 is good for correcting a deficiency or supporting your B12 needs if you're at risk — especially if you take metformin. It's very safe overall, but if you have a cobalt allergy or take any medications, run them through the checker below first.

Talk with your pharmacist about the right dose for your situation.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 4 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Sep 25, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about BioActive B12, straight from the product label.

Brand Pure TheraPro Rx
Barcode (UPC) X002GHXNEL
Net contents 1 fl. Oz.; 30 mL
Market status On market
Date entered into DSLD Sep 25, 2023
DSLD ID 272010
Product type Vitamin
Supplement form Liquid
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for BioActive B12 by Pure TheraPro Rx, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
4 Drop(s)
Maximum serving Sizes:
4 Drop(s)
Servings per container
180
UPC/BARCODE
X002GHXNEL
IngredientAmount% DV
Vitamin B124000 mcg166667%
MecobalActive Methylcobalamin2000 mcg83333%
Adenosylcobalamin1200 mcg50000%
Hydroxocobalamin800 mcg33333%

Other ingredients: triple distilled Water, USP Kosher certified Vegetable Glycerin, Potassium Sorbate, Citric Acid

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

180 Day Supply

Please retain box for reference

Please recycle

Formulation

Full Spectrum Maximum Absorption for Energy & Methylation

Vegan + Vegetarian

Non-GMO Soy + Gluten Free

Concentrated Formula

Formulated to exclude: Alcohol, fillers, wheat, gluten, corn, yeast, soy, animal or dairy products, fish, shellfish, peanuts, tree nuts, egg, ingredients derived from genetically modified organisms (GMOs), artificial preservatives, colors and sweeteners.

Formulated, tested & packaged in the USA

FDA Statement of Identity

Professional Dietary Supplement

Formula

3-in-1 Support Methylcobalamin Biologically Active Form Patented. Exceptional purity, no harmful solvents are used in production of this product. Adenosylcobalamin Mitochondrial Form Considered an active coenzyme form of B12-utilized directly in B12-dependeint enzyme reactions in the body. Hydroxocobalamin Protector Form Readily converts to methylcobalamin and has a unique role of supporting detoxification processes. BioActive B12 is a high quality vegan vitamin B12 complex utilizing three bioavailable forms. These forms require no conversion in the liver in order to be available for use by your cells. As a sublingual supplement, BioActive B12 provides maximum absorption with a mild taste that is easy on the palate.

Drops Methyl Adenosyl Hydroxo 1 500 300 200 2 1000 600 400 3 1500 900 600 4 2000 1200 800 # of Drops = Units in mcg

Brand IP Statement(s)

MecobalActive The active form of B. Patented. MECOBALACTIVE is a trademark of HEALTHTECH BIO ACTIVES, S.L.U. Copyright 2021 Pure Therapro RX

Seals/Symbols

GMP Certified Good Manufacturing Practice

Suggested/Recommended/Usage/Directions

Directions: Shake gently before use. Take up to four (4) drops daily or as directed by a healthcare practitioner. Best taken sublingually or directly onto your tongue. Drops may also be placed into juice or water.

Precautions

Warning: Individuals taking medication, children and pregnant or lactating women should consult their healthcare practitioner prior to use.

Warning: Individuals taking medication, children and pregnant or lactating women should consult their healthcare practitioner prior to use.

When taking high levels of vitamin B12, track blood levels. Do not use if tamper seal is damaged.

Keep out of reach of children.

Storage

Storage: Keep tightly closed. Refrigerate for optimal freshness. May be kept in a cool, dry place away from direct sunlight.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

BioActive B12 by Pure TheraPro Rx label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

BioActive B12 label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in BioActive B12 by Pure TheraPro Rx

These are the 4 active ingredients this product is made of. Select any to open its full monograph.

Serving size4 Drop(s) Dosage formLiquid Servings per container180 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Vitamin B12

Interacts with
20 drugs
4000 mcg per serving

Vitamin B12 (cobalamin) is an essential nutrient your body needs to make red blood cells, keep nerves healthy, and support DNA. Supplements are very h...

Vitamin B12 monograph & interactions

MecobalActive Methylcobalamin

Interacts with
20 drugs
2000 mcg per serving

Vitamin B12 (cobalamin) is an essential nutrient your body needs to make red blood cells, keep nerves healthy, and support DNA. Supplements are very h...

MecobalActive Methylcobalamin monograph & interactions

Adenosylcobalamin

Interacts with
20 drugs
1200 mcg per serving

Vitamin B12 (cobalamin) is an essential nutrient your body needs to make red blood cells, keep nerves healthy, and support DNA. Supplements are very h...

Adenosylcobalamin monograph & interactions

Hydroxocobalamin

Interacts with
20 drugs
800 mcg per serving

Vitamin B12 (cobalamin) is an essential nutrient your body needs to make red blood cells, keep nerves healthy, and support DNA. Supplements are very h...

Hydroxocobalamin monograph & interactions

Other (inactive) ingredients: Triple distilled Water, USP Kosher certified Vegetable Glycerin, Potassium Sorbate, Citric Acid. These complete the product’s ingredient list but are not active constituents.

Interaction report

BioActive B12 by Pure TheraPro Rx Drug Interactions

Want to check YOUR meds against BioActive B12?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
20Drugs
20 Minor

Ingredients driving the most interactions

Vitamin B12 20

Individual Drug Interactions

The ingredients in BioActive B12 interact with 20 drugs. Click any drug to see the details.

1 of the 4 ingredients in BioActive B12 interact with drugs. Each result below shows which ingredient is responsible. Vitamin B12

Each ingredient & the kinds of drugs it affects

For each ingredient in BioActive B12 with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Vitamin B121 drug type · 20 drugs

Metformin (Glucophage)

Metformin, a common medication used to manage type 2 diabetes, has been associated with lower vitamin B12 levels in some individuals. Prolonged use of metformin can interfere with the absorption of B12 in the digestive system, potentially leading to a deficiency in this essential vitamin.

Likelihood Possible Evidence A
Vitamin B12 full monograph & interactions
The maker

Brand information

Manufacturer and brand details for BioActive B12, from the product label.

Pure TheraPro Rx

See all Pure TheraPro Rx products
Name
Pure TheraPro RX
Street Address
9888 W. Belleview Ave. #2006
City
Denver
State
Colorado
ZipCode
80123
Phone Number
888-655-4648
Web Address
Purethera.com
Pharmacist Counseling Corner

BioActive B12 by Pure TheraPro Rx: Common Questions

Does BioActive B12 by Pure TheraPro Rx interact with any medications?
Yes. Based on its ingredients, BioActive B12 has a known interaction with 20 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
BioActive B12 contains 4 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What's the difference between all these B12 forms in the product?
They're all vitamin B12, just in different chemical forms — methylcobalamin, adenosylcobalamin, hydroxocobalamin, and standard B12. Your body uses them all the same way. The idea behind using several forms is to cover different roles B12 plays in your cells, though they all do the same essential job.
Is this safe if I'm pregnant or breastfeeding?
Yes — B12 is actually important during pregnancy and breastfeeding and is considered safe at recommended amounts. Just follow your doctor's or midwife's advice on how much you need.
Can B12 cause side effects?
When taken by mouth, B12 is generally well tolerated. Allergic reactions like rash or itching are rare but can happen — especially if you're allergic to cobalt. If you've had skin reactions to B12 before, let your pharmacist know.
I take metformin — is this product okay for me?
It's generally okay, but metformin can lower your B12 levels over time, so B12 supplementation makes sense for you. Talk with your pharmacist or doctor about the right dose and whether they should check your B12 levels periodically.
What is B12 used for?
B12 helps your nerves work properly, keeps your red blood cells healthy, and supports DNA synthesis. This product is effective for treating B12 deficiency and a rare genetic condition called Imerslund-Grasbeck disease, and it may help with nerve pain after shingles or canker sores.
Does this product have fillers?
It has inactive ingredients — water, vegetable glycerin, potassium sorbate, and citric acid — which help preserve and deliver the B12. These are standard excipients, not fillers added for bulk.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if BioActive B12 is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

BioActive B12 label
Go deeper

The Full Monographs Behind BioActive B12’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Vitamin B12

Interacts with 20 drugs

Vitamin B12 (cobalamin) is an essential nutrient your body needs to make red blood cells, keep nerves healthy, and support DNA. Supplements are very helpful for people who are deficient — su...

Read the full Vitamin B12 monograph →
Sources

Sources & How We Checked

BioActive B12's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 30 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Vitamin B12 30 references
  1. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  2. Hartman TJ, Woodson K, Stolzenberg-Solomon R, et al. Association of the B-vitamins pyridoxal 5'-phosphate (B6), B12, and folate with lung cancer risk in older men. Am J Epidemiol 2001;153:688-94.. DOI
  3. Jansen T, Romiti R, Kreuter A, Altmeyer P. Rosacea fulminans triggered by high-dose vitamins B6 and B12. J Eur Acad Dermatol Venereol 2001;15:484-5..
  4. Lange H, Suryapranata H, De Luca G, et al. Folate therapy and in-stent restenosis after coronary stenting. N Engl J Med 2004;350:2673-81. PubMed
  5. Collin, S. M., Metcalfe, C., Refsum, H., Lewis, S. J., Zuccolo, L., Smith, G. D., Chen, L., Harris, R., Davis, M., Marsden, G., Johnston, C., Lane, J. A., Ebbing, M., Bonaa, K. H., Nygard, O., Ueland, P. M., Grau, M. V., Baron, J. A., Donovan, J. L., Nea
  6. Geissbuhler, P., Mermillod, B., and Rapin, C. H. Elevated serum vitamin B12 levels associated with CRP as a predictive factor of mortality in palliative care cancer patients: a prospective study over five years. J.Pain Symptom.Manage. 2000;20(2):93-103. PubMed
  7. Salles, N., Herrmann, F., Sakbani, K., Rapin, C. H., and Sieber, C. High vitamin B12 level: a strong predictor of mortality in elderly inpatients. J Am Geriatr.Soc 2005;53(5):917-918.
  8. Looker, H. C., Fagot-Campagna, A., Gunter, E. W., Pfeiffer, C. M., Sievers, M. L., Bennett, P. H., Nelson, R. G., Hanson, R. L., and Knowler, W. C. Homocysteine and vitamin B(12) concentrations and mortality rates in type 2 diabetes. Diabetes Metab Res R
  9. Uhl, W., Nolting, A., Golor, G., Rost, K. L., and Kovar, A. Safety of hydroxocobalamin in healthy volunteers in a randomized, placebo-controlled study. Clin Toxicol (Phila) 2006;44 Suppl 1:17-28. PubMed
  10. Borron, S. W., Baud, F. J., Barriot, P., Imbert, M., and Bismuth, C. Prospective study of hydroxocobalamin for acute cyanide poisoning in smoke inhalation. Ann Emerg.Med 2007;49(6):794-801, 801. PubMed
  11. Borron, S. W., Baud, F. J., Megarbane, B., and Bismuth, C. Hydroxocobalamin for severe acute cyanide poisoning by ingestion or inhalation. Am J Emerg.Med 2007;25(5):551-558. PubMed
  12. Lewis, J. G. Gout, Steatorrhoea, and Megaloblastic Anaemia. Ann Rheum.Dis 1962;21(3):284-286. PubMed
  13. Tal, S., Shavit, Y., Stern, F., and Malnick, S. Association between vitamin B12 levels and mortality in hospitalized older adults. J Am Geriatr.Soc 2010;58(3):523-526. PubMed
  14. Baztan, J. J., Gavidia, J. J., Gomez-Pavon, J., Esteve, A., and Ruiperez, I. High vitamin B12 levels and in-hospital mortality. J Am Geriatr.Soc 2010;58(11):2237-2238. PubMed
  15. Omboni, E., Checchini, M., and Longoni, F. [Hypopotassemia and megaloblastic anemia. Presentation of a case]. Minerva Med 8-31-1987;78(16):1255-1257.
  16. Aalfs As, Scholvinck LH, Horvath B. Acneiform eruption in a 5-year old due to vitamin B12 supplementation. Eur J Dermatol 2013;23(5):726-7. PubMed
  17. Balta I, Ozuguz P. Vitamin B12-induced acneiform eruption. Cutan Ocul Toxicol 2014;33(2):94-5. PubMed
  18. Carman KB, Belgemen T, Yis U. Involuntary movements misdiagnosed as seizure during vitamin B12 treatment. Pediatr Emerg Care 2013;29(11):1223-4. PubMed
  19. Djuric V, Bogic M, Popadic AP, et al. Anaphylactic reaction to hydroxycobalamin with tolerance to cyanocobalamin. Ann Allergy Asthma Immunol 2012;108(3):207-8. PubMed
  20. Kartel O, Gulec M, Demirel F, et al. Vitamin B12 allergy and successful desensitization with cyanocobalamin: A case report. Allergol Immunopath (Madr) 2012;40(5):324-5.
  21. Patiroglu T, Unal E, Yildirim S. Infantile tremor syndrome associated with cobalamin therapy: A case report. Clin Neurol Neurosurg 2013;115(9):1903-5. PubMed
  22. Schulte S, Barkema LW, Kardaun SH. Long-lasting atypical acneiform eruption with prominent comedones induced by hydroxocobalamin (vitamin B12). J Dtsch Dermatol Ges 2014;12(6):502-3.
  23. Zanus C, Alberini E, Costa P, et al. Involuntary movements after correction of vitamin B12 deficiency: A video-case report. Epileptic Disord 2012;14(2):174-80. PubMed
  24. Fanidi A, Carreras-Torres R, Larose TL, et al. Is high vitamin B12 status a cause of lung cancer? Int J Cancer. 2019 Sep 15;145(6):1499-1503. PubMed
  25. Fujita Y, Mizukami T, Maya Y, et al. Vitamin B12 allergy manifesting as lymphomatoid contact dermatitis. Eur J Dermatol. 2020;30(3):304-305. PubMed
  26. Dépret F, Hoffmann C, Daoud L, et al. Association between hydroxocobalamin administration and acute kidney injury after smoke inhalation: a multicenter retrospective study. Crit Care. 2019;23(1):421. PubMed
  27. Khairan P, Sobue T, Eshak ES, et al. Association of dietary intakes of vitamin B12, vitamin B6, folate, and methionine with the risk of esophageal cancer: the Japan Public Health Center-based (JPHC) prospective study. BMC Cancer 2021;21(1):982. PubMed
  28. Evans J, Pandya A, Ding Y, Qunibi WY. Hydroxocobalamin-Induced Oxalate Nephropathy in a Patient With Smoke Inhalation. Kidney Int Rep 2021;6(8):2228-2231. PubMed
  29. Lacombe V, Chabrun F, Lacout C, et al. Persistent elevation of plasma vitamin B12 is strongly associated with solid cancer. Sci Rep 2021;11(1):13361. PubMed
  30. Pegalajar-García MD, Cebolla-Verdugo M, Prados-Carmona Á, Llamas-Segura C, Navarro-Triviño FJ. Systemic allergic dermatitis to cobalt present in cyanocobalamin supplementation. Contact Dermatitis 2023;89(3):203-205. PubMed

See these in context on the Vitamin B12 monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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