Bitter Melon Ingredients & Drug Interactions
What is this page for?
First and foremost: checking Bitter Melon against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Bitter Melon is a dietary supplement by Herbalist & Alchemist with 1 active ingredient. Its ingredients are commonly taken for blood sugar support, diabetes, digestive complaints.Based on those ingredients, 282 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are dried Bitter Melon fruit extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Bitter Melon by Herbalist & Alchemist
Ask about any prescription or over-the-counter medication and we check it for interactions with Bitter Melon by Herbalist & Alchemist — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Bitter Melon by Herbalist & Alchemist
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product contains one active ingredient: dried bitter melon fruit extract. Bitter melon is a tropical vine fruit with a long history in traditional medicine, and this liquid form delivers the extract suspended in distilled water and ethyl alcohol (the alcohol helps preserve and extract the plant compounds).
Does it work?
Not established
The evidence we hold doesn't establish that bitter melon works for any condition. Studies rate it "insufficient reliable evidence" for amenorrhea, athletic performance, liver disease, constipation, diabetes, and indigestion — meaning the research isn't there yet to say whether it actually does what people hope it will.
How safe is it?
Well-documented data
Bitter melon is generally well tolerated when eaten as food, but supplement doses may lower your blood sugar and cause stomach upset. The most common side effects in studies are gastrointestinal — heartburn, nausea, vomiting, diarrhea, constipation, flatulence, and belly discomfort occurred in roughly 3–16% of people who took it.
Rare serious side effects include very low blood sugar (hypoglycemic coma) and seizures in children. The safety data advises against bitter melon in pregnancy because seeds and high doses may cause harm to the uterus or the pregnancy itself.
There isn't enough reliable safety information to know whether it's safe while breastfeeding, so it's best avoided then. One case report also documented kidney function decline linked to high-dose bitter melon extract, which reversed when the supplement was stopped.
Meds to double-check
Moderate interaction found
Before you take this bitter melon extract, double-check with your pharmacist if you're on pazopanib (Votrient) for cancer, any antidiabetes drugs, or medications that are P-glycoprotein substrates — a large group that includes many anticancer, antibiotic, and heart medications. Altogether, these interactions span 275 individual medications, so use the checker below with your complete medication list.
The bottom line
Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.
Bitter melon may appeal to you if you're interested in traditional herbal remedies, but the evidence for what it actually does isn't solid. If you take diabetes drugs, pazopanib, or any medication processed through your intestines' P-glycoprotein pump, you should check with your pharmacist before starting — the interactions could be meaningful.
Pregnant or breastfeeding? Skip it and talk to your doctor.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Oct 23, 2019.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Bitter Melon, straight from the product label.
| Brand | Herbalist & Alchemist |
|---|---|
| Barcode (UPC) | 667056138592 |
| Net contents | 2 fl. Oz.; 60 mL |
| Market status | On market |
| Date entered into DSLD | Oct 23, 2019 |
| DSLD ID | 208095 |
| Product type | Botanical |
| Supplement form | Liquid |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Kosher, Organic |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Bitter Melon by Herbalist & Alchemist, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| dried Bitter Melon fruit extract | 2 mL | -- |
Other ingredients: distilled Water, Ethyl Alcohol
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula
Mormordica charantia
OK
General Statements
Supports healthy blood sugar levels already in the normal range
Botanical preparation ratio 1:4
FDA Statement of Identity
Herbal Supplement
Suggested/Recommended/Usage/Directions
Suggested use: 30-40 drops (1.5 - 2 mL) in juice or water. Take 3 times per day. Shake well before using.
Precautions
Contraindications: Monitor blood sugar levels carefully when using in combination with blood sugar lowering medications.
Keep out of children's reach
FDA Disclaimer Statement
This statement has not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.
Seals/Symbols
OK
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Bitter Melon by Herbalist & Alchemist label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Bitter Melon by Herbalist & Alchemist
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size1.5 mL Dosage formLiquid Servings per container30 Amounts shown are per serving.
Dried Bitter Melon fruit extract
Interacts with282 drugs
Bitter melon is a tropical fruit eaten as food and used in traditional medicine, most often for blood sugar control. While some small studies hint it...
Dried Bitter Melon fruit extract monograph & interactionsOther (inactive) ingredients: Distilled Water, Ethyl Alcohol. These complete the product’s ingredient list but are not active constituents.
Bitter Melon by Herbalist & Alchemist Drug Interactions
HelloPharmacist Interaction Report
Bitter Melon by Herbalist & Alchemist is a single-ingredient liquid extract that does interact with medications.
The most serious concern is with a cancer drug called pazopanib (Votrient) — a Moderate-severity interaction where bitter melon may raise pazopanib levels in your blood and increase the risk of side effects. One case reported a patient on pazopanib for 8 years who developed acute pancreatitis 4 days after drinking 100–150 mL of bitter melon juice daily.
Read the full breakdown — every affected drug type, severity by severity
Bitter melon also carries a Moderate interaction with antidiabetes drugs (medications that lower blood sugar). It can lower your blood glucose itself, so taking it together with these drugs might push your levels too low (low blood sugar, or hypoglycemia).
You'll want to monitor your blood sugar closely if you're on diabetes medication.
Additionally, bitter melon may affect P-glycoprotein substrates — a Moderate interaction involving a group of medications that rely on an intestinal pump to be absorbed. Bitter melon may block that pump and raise levels of these drugs in your body.
Altogether, these interactions span 275 individual medications.
Before you start, use the medication checker on this page to run through your exact prescriptions, especially if you take cancer drugs, diabetes medications, or any drugs processed by P-glycoprotein.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Bitter Melon?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Bitter Melon interact with 282 drugs. Click any drug to see the details.
1 of the 1 ingredient in Bitter Melon interact with drugs. Each result below shows which ingredient is responsible. dried Bitter Melon fruit extract
Insulin GlargineBasaglar, Lusduna, Semglee
How Insulin Glargine interacts with Bitter Melon — through 1 ingredient. Tap an ingredient for the detail:
Dried Bitter Melon Fruit ExtractAntidiabetes Drugs Moderate
Interaction Summary
Taking bitter melon with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Dried Bitter Melon Fruit Extract + Insulin Glargine interactionInsulin Glargine (rdna)Lantus
How Insulin Glargine (rdna) interacts with Bitter Melon — through 1 ingredient. Tap an ingredient for the detail:
Dried Bitter Melon Fruit ExtractAntidiabetes Drugs Moderate
Interaction Summary
Taking bitter melon with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Dried Bitter Melon Fruit Extract + Insulin Glargine (rdna) interactionInsulin Glargine RecombinantToujeo Solostar
How Insulin Glargine Recombinant interacts with Bitter Melon — through 1 ingredient. Tap an ingredient for the detail:
Dried Bitter Melon Fruit ExtractAntidiabetes Drugs Moderate
Interaction Summary
Taking bitter melon with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Dried Bitter Melon Fruit Extract + Insulin Glargine Recombinant interactionInsulin Glargine, LixisenatideSoliqua 100/33
How Insulin Glargine, Lixisenatide interacts with Bitter Melon — through 1 ingredient. Tap an ingredient for the detail:
Dried Bitter Melon Fruit ExtractAntidiabetes Drugs Moderate
Interaction Summary
Taking bitter melon with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Dried Bitter Melon Fruit Extract + Insulin Glargine, Lixisenatide interactionInsulin Glulisine (rdna)Apidra
How Insulin Glulisine (rdna) interacts with Bitter Melon — through 1 ingredient. Tap an ingredient for the detail:
Dried Bitter Melon Fruit ExtractAntidiabetes Drugs Moderate
Interaction Summary
Taking bitter melon with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Dried Bitter Melon Fruit Extract + Insulin Glulisine (rdna) interactionInsulin Human, Sodium ChlorideMyxredlin
How Insulin Human, Sodium Chloride interacts with Bitter Melon — through 1 ingredient. Tap an ingredient for the detail:
Dried Bitter Melon Fruit ExtractAntidiabetes Drugs Moderate
Interaction Summary
Taking bitter melon with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Dried Bitter Melon Fruit Extract + Insulin Human, Sodium Chloride interactionInsulin LisproAdmelog, Admelog Solostar
How Insulin Lispro interacts with Bitter Melon — through 1 ingredient. Tap an ingredient for the detail:
Dried Bitter Melon Fruit ExtractAntidiabetes Drugs Moderate
Interaction Summary
Taking bitter melon with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Dried Bitter Melon Fruit Extract + Insulin Lispro interactionInsulin Lispro RecombinantHumalog Kwikpen
How Insulin Lispro Recombinant interacts with Bitter Melon — through 1 ingredient. Tap an ingredient for the detail:
Dried Bitter Melon Fruit ExtractAntidiabetes Drugs Moderate
Interaction Summary
Taking bitter melon with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Dried Bitter Melon Fruit Extract + Insulin Lispro Recombinant interactionInsulin Lispro-aabcLyumjev
How Insulin Lispro-aabc interacts with Bitter Melon — through 1 ingredient. Tap an ingredient for the detail:
Dried Bitter Melon Fruit ExtractAntidiabetes Drugs Moderate
Interaction Summary
Taking bitter melon with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Dried Bitter Melon Fruit Extract + Insulin Lispro-aabc interactionInsulin DetermirLevemir
How Insulin Determir interacts with Bitter Melon — through 1 ingredient. Tap an ingredient for the detail:
Dried Bitter Melon Fruit ExtractAntidiabetes Drugs Moderate
Interaction Summary
Taking bitter melon with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Dried Bitter Melon Fruit Extract + Insulin Determir interactionItraconazoleSporanox, Sporanox Injection, Tolsura
How Itraconazole interacts with Bitter Melon — through 1 ingredient. Tap an ingredient for the detail:
Dried Bitter Melon Fruit ExtractP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Dried Bitter Melon Fruit Extract + Itraconazole interactionIvermectinMectizan, Sklice, Soolantra, Stromectol
How Ivermectin interacts with Bitter Melon — through 1 ingredient. Tap an ingredient for the detail:
Dried Bitter Melon Fruit ExtractP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Dried Bitter Melon Fruit Extract + Ivermectin interactionLedipasvir, SofosbuvirHarvoni
How Ledipasvir, Sofosbuvir interacts with Bitter Melon — through 1 ingredient. Tap an ingredient for the detail:
Dried Bitter Melon Fruit ExtractP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Dried Bitter Melon Fruit Extract + Ledipasvir, Sofosbuvir interactionLevonorgestrel, Ethinyl EstradiolLogynon ED, Microgynon 30, Nordette, Ovranette, Quartette, Trinordiol +1 more
How Levonorgestrel, Ethinyl Estradiol interacts with Bitter Melon — through 1 ingredient. Tap an ingredient for the detail:
Dried Bitter Melon Fruit ExtractP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Dried Bitter Melon Fruit Extract + Levonorgestrel, Ethinyl Estradiol interactionLinagliptinTradjenta
How Linagliptin interacts with Bitter Melon — through 1 ingredient. Tap an ingredient for the detail:
Dried Bitter Melon Fruit ExtractP-glycoprotein Substrates, Antidiabetes Drugs Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Dried Bitter Melon Fruit Extract + Linagliptin interactionLinagliptin, Metformin HydrochlorideJentadueto XR
How Linagliptin, Metformin Hydrochloride interacts with Bitter Melon — through 1 ingredient. Tap an ingredient for the detail:
Dried Bitter Melon Fruit ExtractAntidiabetes Drugs, P-glycoprotein Substrates Moderate
Interaction Summary
Taking bitter melon with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Dried Bitter Melon Fruit Extract + Linagliptin, Metformin Hydrochloride interactionLiraglutideVictoza
How Liraglutide interacts with Bitter Melon — through 1 ingredient. Tap an ingredient for the detail:
Dried Bitter Melon Fruit ExtractAntidiabetes Drugs Moderate
Interaction Summary
Taking bitter melon with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Dried Bitter Melon Fruit Extract + Liraglutide interactionLiraglutide RecombinantSaxenda
How Liraglutide Recombinant interacts with Bitter Melon — through 1 ingredient. Tap an ingredient for the detail:
Dried Bitter Melon Fruit ExtractAntidiabetes Drugs Moderate
Interaction Summary
Taking bitter melon with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Dried Bitter Melon Fruit Extract + Liraglutide Recombinant interactionLixisenatideAdlyxin
How Lixisenatide interacts with Bitter Melon — through 1 ingredient. Tap an ingredient for the detail:
Dried Bitter Melon Fruit ExtractAntidiabetes Drugs Moderate
Interaction Summary
Taking bitter melon with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Dried Bitter Melon Fruit Extract + Lixisenatide interactionLoncastuximab Tesirine-lpylZynlontab
How Loncastuximab Tesirine-lpyl interacts with Bitter Melon — through 1 ingredient. Tap an ingredient for the detail:
Dried Bitter Melon Fruit ExtractP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Dried Bitter Melon Fruit Extract + Loncastuximab Tesirine-lpyl interactionLoperamideImodium, Loperamide
How Loperamide interacts with Bitter Melon — through 1 ingredient. Tap an ingredient for the detail:
Dried Bitter Melon Fruit ExtractP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Dried Bitter Melon Fruit Extract + Loperamide interactionLoperamide, SimethiconeImodium Advanced
How Loperamide, Simethicone interacts with Bitter Melon — through 1 ingredient. Tap an ingredient for the detail:
Dried Bitter Melon Fruit ExtractP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Dried Bitter Melon Fruit Extract + Loperamide, Simethicone interactionLusutrombopagMulpleta
How Lusutrombopag interacts with Bitter Melon — through 1 ingredient. Tap an ingredient for the detail:
Dried Bitter Melon Fruit ExtractP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Dried Bitter Melon Fruit Extract + Lusutrombopag interactionMedroxyprogesterone Acetate, Oestrogens, ConjugatedPremique
How Medroxyprogesterone Acetate, Oestrogens, Conjugated interacts with Bitter Melon — through 1 ingredient. Tap an ingredient for the detail:
Dried Bitter Melon Fruit ExtractP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Dried Bitter Melon Fruit Extract + Medroxyprogesterone Acetate, Oestrogens, Conjugated interactionMetforminGlucophage, Metformin
How Metformin interacts with Bitter Melon — through 1 ingredient. Tap an ingredient for the detail:
Dried Bitter Melon Fruit ExtractAntidiabetes Drugs Moderate
Interaction Summary
Taking bitter melon with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Dried Bitter Melon Fruit Extract + Metformin interactionMetformin HydrochlorideRiomet ER
How Metformin Hydrochloride interacts with Bitter Melon — through 1 ingredient. Tap an ingredient for the detail:
Dried Bitter Melon Fruit ExtractAntidiabetes Drugs Moderate
Interaction Summary
Taking bitter melon with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Dried Bitter Melon Fruit Extract + Metformin Hydrochloride interactionMetformin XrGlucophage XR
How Metformin Xr interacts with Bitter Melon — through 1 ingredient. Tap an ingredient for the detail:
Dried Bitter Melon Fruit ExtractAntidiabetes Drugs Moderate
Interaction Summary
Taking bitter melon with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Dried Bitter Melon Fruit Extract + Metformin Xr interactionMetformin, LinagliptinJentadueto
How Metformin, Linagliptin interacts with Bitter Melon — through 1 ingredient. Tap an ingredient for the detail:
Dried Bitter Melon Fruit ExtractAntidiabetes Drugs, P-glycoprotein Substrates Moderate
Interaction Summary
Taking bitter melon with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Dried Bitter Melon Fruit Extract + Metformin, Linagliptin interactionMetformin, RosiglitazoneAvandamet
How Metformin, Rosiglitazone interacts with Bitter Melon — through 1 ingredient. Tap an ingredient for the detail:
Dried Bitter Melon Fruit ExtractAntidiabetes Drugs Moderate
Interaction Summary
Taking bitter melon with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Dried Bitter Melon Fruit Extract + Metformin, Rosiglitazone interactionMetformin, SitagliptinJanumet, Janumet XR
How Metformin, Sitagliptin interacts with Bitter Melon — through 1 ingredient. Tap an ingredient for the detail:
Dried Bitter Melon Fruit ExtractAntidiabetes Drugs Moderate
Interaction Summary
Taking bitter melon with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Dried Bitter Melon Fruit Extract + Metformin, Sitagliptin interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Bitter Melon with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
dried Bitter Melon fruit extract
Antidiabetes Drugs
Taking bitter melon with antidiabetes drugs might increase the risk of hypoglycemia.
Bitter melon can lower blood glucose levels and might have additive effects when used with antidiabetes drugs. This might increase the risk of hypoglycemia in some patients. Monitor blood glucose levels closely.
P-Glycoprotein Substrates
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Bitter melon might inhibit the p-glycoprotein (P-gp) intestinal pump and increase intracellular levels of P-gp substrates. In vitro research in intestinal cells shows that 1-monopalmitin, a constituent of bitter melon, increases levels of daunomycin, a P-gp substrate. Additionally, drinking bitter melon juice has been associated with a case of acute pancreatitis in a patient who had been taking pazopanib, a P-gp substrate, for 8 years. Researchers theorize that inhibition of P-gp led to increased levels of pazopanib, resulting in pazopanib-induced pancreatitis.
Pazopanib (Votrient)
Theoretically, bitter melon might increase levels of pazopanib, potentially increasing the risk of adverse effects.
In one case, a 65-year-old patient taking pazopanib for 8 years for renal cell carcinoma experienced signs and symptoms consistent with acute pancreatitis 4 days after drinking bitter melon juice at a dose of 100-150 mL daily. The patient's symptoms, amylase levels, and lipase levels improved upon discontinuation of bitter melon and pazopanib. Pazopanib treatment was re-initiated with no further evidence of pancreatitis. Researchers theorize that inhibition of P-glycoprotein by bitter melon led to increased levels of pazopanib, a P-glycoprotein substrate, resulting in pazopanib-induced pancreatitis.
Brand information
Manufacturer and brand details for Bitter Melon, from the product label.
Herbalist & Alchemist
See all Herbalist & Alchemist products- Name
- Herbalist & Alchemist, Inc.
- City
- Washington
- State
- NJ
- ZipCode
- 07882
- Phone Number
- 800-611-8235
- Web Address
- www.herbalist-alchemist.com
Bitter Melon by Herbalist & Alchemist: Common Questions
Does Bitter Melon by Herbalist & Alchemist interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Can I take bitter melon if I'm pregnant or breastfeeding?
What are the most common side effects?
Does bitter melon actually work for diabetes?
What's in this liquid besides the bitter melon extract?
Should I monitor anything if I'm on diabetes medication and take this?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Bitter Melon is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Bitter Melon’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Bitter Melon's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 18 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Bitter Melon 18 references
- Leatherdale B, Panesar RK, Singh G, et al. Improvement in glucose tolerance due to Momordica charantia. Br Med J (Clin Res Ed) 1981;282:1823-4.
- Welihinda J, et al. Effect of Momordica charantia on the glucose tolerance in maturity onset diabetes. J Ethnopharmacol 1986;17:277-82. PubMed
- Srivastava Y, Venkatakrishna-Bhatt H, Verma Y, et al. Antidiabetic and adaptogenic properties of Momordica charantia extract: An experimental and clinical evaluation. Phytother Res 1993;7:285-9.
- Baldwa VS, Bhandari CM, Pangaria A, Goyal RK. Clinical trial in patients with diabetes mellitus of an insulin-like compound obtained from plant sources. Ups J Med Sci 1977;82:39-41. PubMed
- Aslam M, Stockley IH. Interaction between curry ingredient (karela) and drug (chlorpropamide). Lancet 1979:1:607. PubMed
- Ahmad N, Hassan MR, Halder H, Bennoor KS. Effect of Momordica charantia (Karolla) extracts on fasting and postprandial serum glucose levels in NIDDM patients (abstract). Bangladesh Med Res Counc Bull 1999;25:11-3.
- Basch E, Gabardi S, Ulbricht C. Bitter melon (Momordica charantia): a review of efficacy and safety. Am J Health Syst Pharm 2003;60:356-9. PubMed
- Yin RV, Lee NC, Hirpara H, Phung OJ. T. The effect of bitter melon (Mormordica charantia) in patients with diabetes mellitus: s systematic review and meta-analysis. Nutr Diabetes. 2014;4:e145.
- Rahman IU, Khan RU, Rahman KU, Bashir M. Lower hypoglycemic but higher antiatherogenic effects of bitter melon than glibenclamide in type 2 diabetic patients. Nutr J. 2015;14:13. PubMed
- Alam MA, Uddin R, Subhan N, Rahman MM, Jain P, Reza HM. Beneficial role of bitter melon supplementation in obesity and related complications in metabolic syndrome. J Lipids. 2015;2015:496169. PubMed
- Konishi T, Satsu H, Hatsugai Y, et al. Inhibitory effect of a bitter melon extract on the P-glycoprotein activity in intestinal Caco-2 cells. Br J Pharmacol. 2004;143(3):379-87. PubMed
- Peter EL, Kasali FM, Deyno S, et al. Momordica charantia L. lowers elevated glycaemia in type 2 diabetes mellitus patients: Systematic review and meta-analysis. J Ethnopharmacol. 2019;231:311-24. doi: 10.1016/j.jep.2018.10.033. PubMed
- Cortez-Navarrete M, Martínez-Abundis E, Pérez-Rubio KG, González-Ortiz M, Méndez-Del Villar M. Momordica charantia administration improves insulin secretion in type 2 diabetes mellitus. J Med Food. 2018;21(7):672-7. doi: 10.108
- Kim SK, Jung J, Jung JH, et al. Hypoglycemic efficacy and safety of Momordica charantia (bitter melon) in patients with type 2 diabetes mellitus. Complement Ther Med. 2020 Aug;52:102524. doi: 10.1016/j.ctim.2020.102524. PubMed
- Unsal O, Sütcüoglu O, Yazici O. Dangerous interaction of bitter melon (Momordica charantia) with pazopanib: a case of acute pancreatitis. J Oncol Pharm Pract 2022;28(2):486-8.
- Bae W, Kim S, Choi J, et al. Acute interstitial nephritis associated with ingesting a Momordica charantia extract: a case report. Medicine (Baltimore) 2021;100(27):e26606. PubMed
- Chattopadhyay K, Wang H, Kaur J, et al. Effectiveness and Safety of Ayurvedic Medicines in Type 2 Diabetes Mellitus Management: A Systematic Review and Meta-Analysis. Front Pharmacol. 2022;13:821810. Published 2022 Jun 8. PubMed
- Kim B, Lee HS, Kim HJ, et al. Momordica charantia (bitter melon) efficacy and safety on glucose metabolism in Korean prediabetes participants: a 12-week, randomized clinical study. Food Sci Biotechnol 2022;32(5):697-704. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC