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Dietary supplement

Boneset 1000 mg Ingredients & Drug Interactions

by Nature's Answer

Boneset 1000 mg label
See full label image
Liquid Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Boneset 1000 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Boneset 1000 mg is a dietary supplement by Nature's Answer with 1 active ingredient. Its ingredients are commonly taken for colds and flu, fever, body aches.Based on those ingredients, 87 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Boneset. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Boneset 1000 mg by Nature's Answer

Ask about any prescription or over-the-counter medication and we check it for interactions with Boneset 1000 mg by Nature's Answer — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Boneset 1000 mg by Nature's Answer

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 16, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

Boneset 1000 mg is a liquid extract with one active ingredient: boneset (also known as thoroughwort), an herb traditionally used for cold symptoms. The product comes in a liquid form made with purified water, certified organic alcohol (12–15%), and vegetable glycerin as inactive ingredients that help preserve and deliver the herb.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Boneset product and its label doesn't state a use — see Boneset's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The evidence for boneset in treating the common cold is insufficient to rate. We don't have reliable data showing whether it actually works for this purpose, so we can't tell you whether taking it will help.

The evidence, ingredient by ingredient Boneset

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Boneset is generally well tolerated in short-term use, but caution is warranted. Some people report nausea, diarrhea, and vomiting.

More concerning is that boneset contains potentially liver-toxic alkaloids—compounds that may damage your liver, especially at higher doses. The exact toxic potential of boneset's alkaloids hasn't been fully studied, so long-term or high-dose use isn't recommended.

During pregnancy, boneset is rated possibly unsafe due to potential toxicity and lack of safety data, so you should avoid it. Similarly, avoid boneset while breastfeeding because alkaloids may pass to your infant and safety hasn't been established.

Side effects, ingredient by ingredient Boneset

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Boneset.
  • The most serious interaction on file is rated Moderate.
  • For scale: 88 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Boneset 1000 mg, double-check with your doctor or pharmacist if you take CYP3A4 inducers—drugs that speed up liver metabolism. Examples include carbamazepine (Tegretol) for seizures and nerve pain.

Boneset's liver-toxic alkaloids could be converted to harmful forms more quickly when these drugs are present.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Boneset may appeal to you if you're looking for a traditional cold remedy, but the liver-toxicity concern and lack of proven effectiveness mean it's not a clear choice. If you take seizure medications or other drugs that induce CYP3A4, check with your doctor or pharmacist before adding this product—the interaction risk is real.

Pregnant or breastfeeding women should skip it. Talk it over with your own healthcare provider about whether boneset is right for you.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Apr 22, 2016.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Boneset 1000 mg, straight from the product label.

Brand Nature's Answer
Barcode (UPC) 083000001635
Net contents 1 fl. Oz.; 30 mL
Market status On market
Date entered into DSLD Apr 22, 2016
DSLD ID 58954
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years), Kosher
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Boneset 1000 mg by Nature's Answer, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 mL
Maximum serving Sizes:
1 mL
Servings per container
30
UPC/BARCODE
083000001635
IngredientAmount% DV
Boneset1000 mg--

Other ingredients: purified Water, 12-15% certified organic Alcohol, Vegetable Glycerin

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Brand IP Statement(s)

Authentic Botanical Fingerprint

Discover Nature's Answer

Our organic alcohol extracts are produced using our cold Bio-Chelated proprietary extraction process, yielding a Holistically Balanced Authentic Botanical Fingerprint extract in the same ratios as in the plant

2008 Nature's Answer

Formula

Eupatorium perfoliatum

Low-Alcohol

K Parve

General Statements

Super Concentrated 1000 mg

Our facility is NSF GMP certified, organic and kosher certified

FDA Statement of Identity

Herbal Supplement

Suggested/Recommended/Usage/Directions

Suggested Use: As a dietary supplement take 1 mL (28 drops) three (3) times a day in a small amount of water. Shake well.

Precautions

Keep out of reach of children

Warning: Do not use if pregnant or nursing

Do not use if safety seal is damaged or missing

General

9214 Rev. 6/13

Seals/Symbols

K Parve

Bio-Chelated Cold Extraction Process

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Boneset 1000 mg by Nature's Answer label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Boneset 1000 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Boneset 1000 mg by Nature's Answer

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 mL Dosage formLiquid Servings per container30 Amounts shown are per serving.

Boneset

Interacts with
87 drugs
1000 mg per serving

Boneset is a traditional North American herb long used in teas for fevers, colds, and flu, but modern human studies are very limited. It contains comp...

Boneset monograph & interactions

Other (inactive) ingredients: Purified Water, 12-15% certified organic Alcohol, Vegetable Glycerin. These complete the product’s ingredient list but are not active constituents.

Interaction report

Boneset 1000 mg by Nature's Answer Drug Interactions

Want to check YOUR meds against Boneset 1000 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
87Drugs
87 Moderate

Ingredients driving the most interactions

Boneset 87

Individual Drug Interactions

The ingredients in Boneset 1000 mg interact with 87 drugs. Click any drug to see the details.

1 of the 1 ingredient in Boneset 1000 mg interact with drugs. Each result below shows which ingredient is responsible. Boneset

Each ingredient & the kinds of drugs it affects

For each ingredient in Boneset 1000 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Boneset1 drug type · 87 drugs

Cytochrome P450 3A4 (Cyp3A4) Inducers

Boneset belongs to the genus Eupatorium, and many species of this genus contain hepatotoxic pyrrolizidine alkaloids (PAs). Hepatotoxic PAs are substrates of cytochrome P450 3A4 (CYP3A4). Theoretically, drugs that induce CYP3A4 might increase the conversion of PAs to toxic metabolites. Some drugs that induce CYP3A4 include carbamazepine (Tegretol), phenobarbital, phenytoin (Dilantin), rifampin, rifabutin (Mycobutin), and others.

Likelihood Possible Evidence D
Boneset full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Boneset 1000 mg, from the product label.

Nature's Answer

See all Nature's Answer products
Name
Nature's Answer
City
Hauppauge
State
NY
ZipCode
11788-3943
Phone Number
(800) 439-2324
Web Address
www.naturesanswer.com
Pharmacist Counseling Corner

Boneset 1000 mg by Nature's Answer: Common Questions

Does Boneset 1000 mg by Nature's Answer interact with any medications?
Yes. Based on its ingredients, Boneset 1000 mg has a known interaction with 87 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Boneset 1000 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take boneset if I'm pregnant or breastfeeding?
No. Boneset is rated possibly unsafe in pregnancy due to potential toxicity and lack of safety data, so you should avoid it. You should also skip it while breastfeeding because the herb's alkaloids may pass to your infant and safety hasn't been established. Talk with your doctor or pharmacist about safer alternatives.
Does boneset actually work for colds?
The evidence isn't there. We don't have reliable data showing boneset helps treat the common cold, so we can't say whether taking it will make a difference.
What side effects might I get from boneset?
Some people report nausea, diarrhea, and vomiting when taking boneset by mouth. A bigger concern is possible liver damage from the plant's alkaloids, especially at higher doses—though the exact risk hasn't been fully characterized.
Why is there a warning about liver toxicity?
Boneset contains compounds called pyrrolizidine alkaloids that can be toxic to your liver. These haven't been thoroughly studied in boneset itself, so we don't know the exact risk—but it's real enough that short-term use and caution are recommended.
Is boneset safe to use long-term?
No, not really. The safety data is limited and the potential liver toxicity means boneset should only be used short-term, if at all. Talk with your doctor or pharmacist about how long it's safe for you to take it.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Boneset 1000 mg is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Boneset 1000 mg label
Go deeper

The Full Monographs Behind Boneset 1000 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Boneset

Interacts with 87 drugs

Boneset is a traditional North American herb long used in teas for fevers, colds, and flu, but modern human studies are very limited. It contains compounds (pyrrolizidine alkaloids) that may...

Read the full Boneset monograph →
Sources

Sources & How We Checked

Boneset 1000 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 5 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Boneset 5 references
  1. Chojkier M. Hepatic sinusoidal-obstruction syndrome: toxicity of pyrrolizidine alkaloids. J Hepatol 2003;39:437-46. PubMed
  2. Roeder E. Medicinal plants in Europe containing pyrrolizidine alkaloids. Pharmazie 1995;50:83-98.
  3. Wang YP, Yan J, Fu PP, Chou MW. Human liver microsomal reduction of pyrrolizidine alkaloid N-oxides to form the corresponding carcinogenic parent alkaloid. Toxicol Lett 2005;155:411-20. PubMed
  4. Gassinger, C. A., Wunstel, G., and Netter, P. [A controlled clinical trial for testing the efficacy of the homeopathic drug eupatorium perfoliatum D2 inthe treatment of common cold (author's transl)]. Arzneimittelforschung. 1981;31(4):732-736.
  5. Colegate SM, Upton R, Gardner DR, Panter KE, Betz JM. Potentially toxic pyrrolizidine alkaloids in Eupatorium perfoliatum and three related species. Implications for herbal use as boneset. Phytochem Anal. 2018;29(6):613-626.

See these in context on the Boneset monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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