Interactions on record — worth a quick check against your medications. Based on 3 of 8 ingredients. Check your meds →
Dietary supplement

Cardol Ingredients & Drug Interactions

by Pharmax

Cardol label
See full label image
Liquid Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 30, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Cardol against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Cardol is a dietary supplement by Pharmax with 8 active ingredients. Its ingredients are commonly taken for preventing neural tube birth defects, treating or preventing folate deficiency, supporting pregnancy health.Based on those ingredients, 258 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Coenzyme Q10, Folic Acid, Vitamin B12. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Cardol by Pharmax

Ask about any prescription or over-the-counter medication and we check it for interactions with Cardol by Pharmax — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Cardol by Pharmax

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 12, 2026

What’s inside

Partial disclosure
Ingredient Transparency · database check
Partial

Most active ingredients list an amount, but at least one is hidden in a blend or missing.

Why this rating?
  • The label discloses an exact amount for 6 of its 7 active ingredients.
  • “Total Omega-3 Fatty Acids” is listed as a grouped ingredient — the label gives one combined amount (570 mg) without saying how much of each component you get.

Cardol contains 7 active ingredients. The omega-3 fatty acids — eicosapentaenoic acid and docosahexaenoic acid — are the primary components, plus a total omega-3 fatty acids blend and other omega-3 fatty acids; these are long-chain omega-3s often used to support heart health.

You'll also find folic acid (a B vitamin), vitamin B12 (another B vitamin), coenzyme Q10 (an antioxidant your cells produce), and plant sterol esters (compounds that may help with cholesterol). The product is delivered as a liquid and contains inactive ingredients including purified water, sugars, mixed tocopherols (vitamin E), and flavoring to make it palatable.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: Essential fatty acid supplement.
  • We looked for evidence on: Cardiovascular disease (CVD), Atherosclerosis, Angina, Congestive heart failure (CHF), Angioplasty, Anthracycline cardiotoxicity — and 3 related terms.
  • The strongest evidence on file: Coenzyme Q10 is rated "Possibly Effective" for Congestive heart failure (CHF) (Natural Medicines).
  • Also on file: Vitamin B12 is rated "Insufficient Reliable Evidence To Rate" for Atherosclerosis, Cardiovascular disease (CVD), Angioplasty.
  • Also on file: Coenzyme Q10 is rated "Insufficient Reliable Evidence To Rate" for Angina, Cardiovascular disease (CVD), Anthracycline cardiotoxicity.

For folic acid, the evidence is solid for preventing folate deficiency and for reducing toxicity from methotrexate treatment; it's also likely effective for preventing neural tube birth defects (the reason it's recommended in pregnancy). Evidence is weaker but possibly effective for depression, gum overgrowth from phenytoin, and cognitive problems.

Vitamin B12 is effective for B12 deficiency and certain rare genetic conditions, and likely effective for cyanide poisoning; it's possibly effective for canker sores and nerve pain after shingles. Coenzyme Q10 is possibly effective for fibromyalgia, migraines, heart failure, and nerve damage from diabetes.

The effectiveness of the omega-3 fatty acids and plant sterol esters in this product is not established in the data we hold.

The evidence, ingredient by ingredient Folic Acid Vitamin B12 Coenzyme Q10

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 3 of the 3 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 3 of 3.
  • General safety write-ups exist for 3 of 3.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Folic acid is generally well tolerated at recommended doses in most adults. At doses of 5 mg daily, some people experience abdominal cramps, diarrhea, or rash; at higher doses (15 mg daily), confusion, sleep problems, nausea, and taste changes are possible.

Very large doses can rarely cause seizures or worsen nerve damage if you have low vitamin B12. Folic acid is recommended during pregnancy at standard prenatal doses to prevent birth defects and is safe while breastfeeding; however, folic acid taken late in pregnancy has been linked in population studies to a slightly increased risk of childhood asthma and lower respiratory infections, though early pregnancy use has not shown this risk.

Vitamin B12 is generally very safe with no established upper limit and is needed in both pregnancy and breastfeeding at normal doses. Allergic reactions (rash, itching) are rare but possible.

Coenzyme Q10 is generally well tolerated; gastrointestinal upset (nausea, diarrhea, heartburn) occurs in less than 1% of users, and headache or dizziness have been reported. Safety in pregnancy has not been well studied, and you should check with your doctor before use while pregnant or breastfeeding.

Side effects, ingredient by ingredient Folic Acid Vitamin B12 Coenzyme Q10

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 3 of the 3 matched ingredients can interact with medications — Vitamin B12, Coenzyme Q10, Folic Acid.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 258 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Cardol, check your medications against these drug types: seizure medications (phenobarbital, phenytoin, primidone) — folic acid may reduce their effectiveness and increase seizure risk; blood thinners like warfarin — coenzyme Q10 may reduce anticoagulant effects; cancer medications including alkylating agents, capecitabine, and 5-fluorouracil — folic acid or coenzyme Q10 may interfere; methotrexate — folic acid may reduce efficacy; and blood pressure medications — coenzyme Q10 may add to their effect. Metformin users should note that vitamin B12 in this product may partially offset metformin-related B12 depletion, but monitoring is still important.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glancePartially disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Cardol combines omega-3 fatty acids with heart-health support ingredients like CoQ10 and plant sterols, plus B vitamins. If you take any seizure medication, blood thinner, cancer drug, or methotrexate, you must check with your pharmacist first — folic acid and coenzyme Q10 can significantly affect how these work.

For anyone else, talk to your pharmacist or doctor about whether this product fits your health goals.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 3 of 7 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jan 25, 2016.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Cardol, straight from the product label.

Brand Pharmax
Barcode (UPC) 88319621010
Net contents 10.1 fl. Oz.; 300 mL
Market status On market
Date entered into DSLD Jan 25, 2016
DSLD ID 55422
Product type Other Combinations
Supplement form Liquid
Dietary claims / uses Nutrient, All Other
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Cardol by Pharmax, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 tsp
Maximum serving Sizes:
1 tsp
Servings per container
60
UPC/BARCODE
88319621010
IngredientAmount% DV
Calories20 {Calories}--
Total Carbohydrates2 Gram(s)1%
Sugar2 Gram(s)--
Calories from Fat15 {Calories}--
Eicosapentaenoic Acid300 mg--
Docosahexaenoic Acid210 mg--
Saturated Fat0.5 Gram(s)1%
Folic Acid1000 mcg250%
Vitamin B121000 mcg16667%
Cholesterol15 mg5%
Total Fat1.5 Gram(s)2%
Total Omega-3 Fatty Acids570 mg--
Coenzyme Q1020 mg--
Other Omega-3 Fatty Acids0 NP--
Plant Sterol Esters650 mg--

Other ingredients: purified Water, Sucrose, Fructose, Mixed Tocopherols, Sucrose Stearate, Cellulose, Croscarmellose Sodium, Apricot flavor, Potassium Sorbate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

NEO-3 process utilizes lipase enzymes to naturally enrich EPA and DHA concentrations, while virtually eliminating contaminants, and helps to deliver a clean taste.

Suggested/Recommended/Usage/Directions

Recommended adult intake: One teaspoon (5 ml) taken twice daily with meals, or as professionally directed. Can be taken in water or juice or directly into the mouth.

Precautions

Vacuum-sealed for your protection and for product freshness. Do not use if outer seal is missing or broken.

Keep out of reach of children.

Storage

Refrigerate after opening.

General

V1.0 Code FA41-300

FDA Statement of Identity

Essential Fatty Acid Supplement

Seals/Symbols

Quality Tested Natural Triglyceride Form

General Statements

Pack size:

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Cardol by Pharmax label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Cardol label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Cardol by Pharmax

These are the 8 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 tsp Dosage formLiquid Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Sugar

2 Gram(s) per serving

Eicosapentaenoic Acid

300 mg per serving

Docosahexaenoic Acid

210 mg per serving

Folic Acid

Interacts with
40 drugs
1000 mcg per serving

Folic acid is the man-made form of vitamin B9 and is one of the most well-studied supplements, especially for preventing serious birth defects when ta...

Folic Acid monograph & interactions

Vitamin B12

Interacts with
20 drugs
1000 mcg per serving Form: Cyanocobalamin

Vitamin B12 (cobalamin) is an essential nutrient your body needs to make red blood cells, keep nerves healthy, and support DNA. Supplements are very h...

Vitamin B12 monograph & interactions

Total Omega-3 Fatty Acids

570 mg per serving
  • › Other Omega-3 Fatty Acids

Coenzyme Q10

Interacts with
198 drugs
20 mg per serving

CoQ10 is a vitamin-like substance your body makes naturally that helps cells produce energy and acts as an antioxidant. It is generally well tolerated...

Coenzyme Q10 monograph & interactions

Plant Sterol Esters

650 mg per serving Form: Vegetable Oil

Other (inactive) ingredients: Purified Water, Sucrose, Fructose, Mixed Tocopherols, Sucrose Stearate, Cellulose, Croscarmellose Sodium, Apricot flavor, Potassium Sorbate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Cardol by Pharmax Drug Interactions

Want to check YOUR meds against Cardol?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
258Drugs
66 Moderate 192 Minor

Ingredients driving the most interactions

Coenzyme Q10 198
Folic Acid 40
Vitamin B12 20

Individual Drug Interactions

The ingredients in Cardol interact with 258 drugs. Click any drug to see the details.

3 of the 8 ingredients in Cardol interact with drugs. Each result below shows which ingredient is responsible. Coenzyme Q10 Folic Acid Vitamin B12

Each ingredient & the kinds of drugs it affects

For each ingredient in Cardol with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Coenzyme Q103 drug types · 198 drugs

Alkylating Agents

Coenzyme Q10 has antioxidant effects. Theoretically, this may reduce the activity of chemotherapy drugs that generate free radicals.
Theoretically, antioxidants such as coenzyme Q10 might protect tumor cells from chemotherapeutic agents that work by inducing oxidative stress, such as alkylating agents (e.g., cyclophosphamide) and radiation therapy. The clinical importance of this interaction is unknown.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Coenzyme Q10 is chemically similar to menaquinone and might have vitamin K-like procoagulant effects, which could decrease the effects of warfarin.
Concomitant use of coenzyme Q10 and warfarin might reduce the anticoagulant effects of warfarin. Four cases of decreased warfarin efficacy thought to be due to coenzyme Q10 have been reported. However, there is some preliminary clinical research that suggests coenzyme Q10 might not significantly decrease the effects of warfarin in patients who have a stable INR.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, coenzyme Q10 might have additive effects with antihypertensive drugs.
Some clinical research shows that coenzyme Q10 can significantly lower blood pressure, although other studies have shown conflicting results.

Likelihood Possible Evidence B
Coenzyme Q10 full monograph & interactions

Folic Acid7 drug types · 40 drugs

5-Fluorouracil

Theoretically, high doses of folic acid might increase the toxicity of 5-fluorouracil.
Increases in gastrointestinal side effects of 5-fluorouracil, such as stomatitis and diarrhea, have been described in two clinical studies when leucovorin, a form of folic acid, was administered with 5-fluorouracil.

Likelihood Possible Evidence D
Capecitabine (Xeloda)

Use of high-dose folic acid might contribute to capecitabine toxicity.
Clinical research suggests that higher serum folate levels are associated with an increased risk for moderate or severe toxicity during capecitabine-based treatment for colorectal cancer. Additionally, in one case report, taking folic acid 15 mg daily might have contributed to increased toxicity, including severe diarrhea, vomiting, edema, hand-foot syndrome, and eventually death, in a patient prescribed capecitabine.

Likelihood Possible Evidence D
Methotrexate (Trexall, Others)

Folic acid might reduce the efficacy of methotrexate as a cancer treatment when given concurrently.
Methotrexate exerts its cytotoxic effects by preventing conversion of folic acid to the active form needed by cells. There is some evidence that folic acid supplements reduce the efficacy of methotrexate in the treatment of acute lymphoblastic leukemia, and theoretically they could reduce its efficacy in the treatment of other cancers. Advise cancer patients to consult their oncologist before using folic acid supplements. In patients treated with long-term, low-dose methotrexate for rheumatoid arthritis (RA) or psoriasis, folic acid supplements can reduce the incidence of side effects, without reducing efficacy.

Likelihood Probable Evidence B
Phenobarbital (Luminal)

Folic acid might have antagonistic effects on phenobarbital and increase the risk for seizures.
Folic acid can have direct convulsant activity in some people, reversing the effects of phenobarbital and worsening seizure control. Monitor closely for increased seizure activity.

Likelihood Probable Evidence B
Phenytoin (Dilantin)

Folic acid might reduce serum levels of phenytoin in some patients.
Folic acid may be a cofactor in phenytoin metabolism. Folic acid, in doses of 1 mg daily or more, can reduce serum levels of phenytoin in some patients. Increases in seizure frequency have been reported. If folic acid supplements are added to established phenytoin therapy, monitor serum phenytoin levels closely. If phenytoin and folic acid are started at the same time and continued together, adverse changes in phenytoin pharmacokinetics are avoided. Note that phenytoin also reduces serum folate levels.

Likelihood Probable Evidence B
Primidone (Mysoline)

Folic acid might have antagonistic effects on primidone and increase the risk for seizures.
Folic acid can have direct convulsant activity in some people, reversing the effects of primidone and worsening seizure control. Monitor closely for increased seizure activity. Note that primidone also reduces serum folate levels.

Likelihood Probable Evidence B
Pyrimethamine (Daraprim)

Folic acid might antagonize the effects of pyrimethamine.
Folic acid can antagonize the antiparasitic effects of pyrimethamine against toxoplasmosis and Pneumocystis carinii pneumonia. Folic acid doesn't antagonize the effects of pyrimethamine in the treatment of malaria, because malarial parasites cannot use exogenous folic acid. Use folinic acid as an alternative to folic acid when indicated.

Likelihood Probable Evidence D
Folic Acid full monograph & interactions

Vitamin B121 drug type · 20 drugs

Metformin (Glucophage)

Metformin, a common medication used to manage type 2 diabetes, has been associated with lower vitamin B12 levels in some individuals. Prolonged use of metformin can interfere with the absorption of B12 in the digestive system, potentially leading to a deficiency in this essential vitamin.

Likelihood Possible Evidence A
Vitamin B12 full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Cardol, from the product label.

Pharmax

See all Pharmax products
Name
Seroyal USA
City
Pittsburgh
State
PA
ZipCode
15275
Phone Number
1-888-737-6925
Web Address
seroyal.com
Pharmacist Counseling Corner

Cardol by Pharmax: Common Questions

Does Cardol by Pharmax interact with any medications?
Yes. Based on its ingredients, Cardol has a known interaction with 258 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Cardol contains 8 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take Cardol if I'm pregnant?
The folic acid and vitamin B12 in Cardol are recommended during pregnancy and considered safe at normal recommended doses — in fact, folic acid is recommended to help prevent birth defects. However, coenzyme Q10 safety in pregnancy hasn't been well studied. Talk with your doctor or midwife before starting any supplement during pregnancy to make sure it's right for you.
Is Cardol safe while breastfeeding?
Folic acid and vitamin B12 are safe at normal recommended doses while breastfeeding and are actually important nutrients during this time. Coenzyme Q10 safety while breastfeeding hasn't been well studied, so check with your doctor before use.
What are omega-3 fatty acids, and why are they in this product?
Omega-3 fatty acids (eicosapentaenoic acid and docosahexaenoic acid) are long-chain omega-3s that your body cannot make on its own — you get them from food or supplements. They're included in Cardol because they're commonly used to support heart health, though the specific effects for your situation depend on your individual health.
What is coenzyme Q10 and what does it do?
Coenzyme Q10 is an antioxidant that your cells naturally produce. It's possibly effective for migraine headaches, fibromyalgia, heart failure, and nerve damage from diabetes. The evidence is weaker for these uses than for the B vitamins in this product, but it's generally well tolerated.
Can folic acid in Cardol affect my seizure medications?
Yes — folic acid can interfere with phenobarbital, phenytoin, and primidone by reversing their effects and increasing seizure risk. If you take any seizure medication, you must check with your pharmacist before starting Cardol.
Are there common side effects from Cardol?
Folic acid at normal supplement doses is usually well tolerated, though some people experience stomach upset or rash. Coenzyme Q10 may cause gastrointestinal side effects like nausea or diarrhea in less than 1% of users. If you notice any unwanted effects, stop and talk to your pharmacist.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Cardol label
Go deeper

The Full Monographs Behind Cardol’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Folic Acid

Interacts with 40 drugs

Folic acid is the man-made form of vitamin B9 and is one of the most well-studied supplements, especially for preventing serious birth defects when taken before and during early pregnancy. I...

Read the full Folic Acid monograph → Herb & supplement monograph

Vitamin B12

Interacts with 20 drugs

Vitamin B12 (cobalamin) is an essential nutrient your body needs to make red blood cells, keep nerves healthy, and support DNA. Supplements are very helpful for people who are deficient — su...

Read the full Vitamin B12 monograph → Herb & supplement monograph

Coenzyme Q10

Interacts with 198 drugs

CoQ10 is a vitamin-like substance your body makes naturally that helps cells produce energy and acts as an antioxidant. It is generally well tolerated and is most studied for heart condition...

Read the full Coenzyme Q10 monograph →
Sources

Sources & How We Checked

Cardol's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 126 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Folic Acid 56 references
  1. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
  2. Duhra P. Treatment of gastrointestinal symptoms associated with methotrexate therapy for psoriasis. J Am Acad Dermatol 1993;28:466-9. PubMed
  3. Morgan SL, Baggott JE, Vaughn WH, et al. Supplementation with folic acid during methotrexate therapy for rheumatoid arthritis. A double-blind, placebo-controlled trial. Ann Intern Med 1994;121:833-41. PubMed
  4. Froscher W, Maier V, Laage M, et al. Folate deficiency, anticonvulsant drugs, and psychiatric morbidity. Clin Neuropharmacol 1995;18:165-82. PubMed
  5. Lewis DP, Van Dyke DC, Willhite LA, et al. Phenytoin-folic acid interaction. Ann Pharmacother 1995;29:726-35. PubMed
  6. Berg MJ, Stumbo PJ, Chenard CA, et al. Folic acid improves phenytoin pharmacokinetics. J Am Diet Assoc 1995;95:352-6. PubMed
  7. Berg MJ, Fincham RW, Ebert BE, et al. Phenytoin pharmacokinetics: Before and after folic acid administration. Epilepsia 1992;33:712-20. PubMed
  8. Shafer RB, Nuttall FQ. Calcium and folic acid absorption in patients taking anticonvulsant drugs. J Clin Endocrinol Metab 1975;41:1125-9. PubMed
  9. Leeb BF, Witzmann G, Ogris E, et al. Folic acid and cyanocobalamin levels in serum and erythrocytes during low-dose methotrexate therapy of rheumatoid arthritis and psoriatic arthritis patients. Clin Exp Rheumatol 1995;13:459-63.
  10. Morgan SL, Baggott JE, Lee JY, Alarcón GS. Folic acid supplementation prevents deficient blood folate levels and hyperhomocysteinemia during longterm, low dose methotrexate therapy for rheumatoid arthritis: implications for cardiovascular disease preventi
  11. Dijkmans BA. Folate supplementation and methotrexate. Br J Rheumatol 1995;34:1172-4. PubMed
  12. Segal S, Kaminski S. Drug-nutrient interactions. American Druggist 1996 Jul;42-8.
  13. Lambie DG, Johnson RH. Drugs and folate metabolism. Drugs 1985;30:145-55. PubMed
  14. Amer College of Rheumatology ad hoc committee on clinical guidelines. Guidelines for monitoring drug therapy in rheumatoid arthritis. Arthritis Rheum 1996;39:723-31. DOI
  15. Suitor CW, Bailey LB. Dietary folate equivalents: interpretation and application. J Am Diet Assoc 2000;100:88-94. PubMed
  16. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  17. Sandoval M, Charbonnet RM, Okuhama NN, et al. Cat's claw inhibits TNFalpha production and scavenges free radicals: role in cytoprotection. Free Radic Biol Med 2000;29:71-78.
  18. Antony AC. Megaloblastic Anemias. In: Hoffman R, Benz Jr EJ, Shattil SJ, et al. Hematology: Basic Principles and Practice. 3rd ed. New York, NY: Churchill Livingstone 2000: 451-79.
  19. Reynolds EH. Neurological aspects of folate and vitamin B12 metabolism. Clin Haematol 1976;5:661-96. DOI
  20. Reynolds EH. Folate metabolism and anticonvulsant therapy. Proc R Soc Med 1974;67:68.
  21. Ortiz Z, Shea B, Suarez Almazor M, et al. Folic acid and folinic acid for reducing side effects in patients receiving methotrexate for rheumatoid arthritis (Cochrane Review). Cochrane Database Syst Rev 2000;2:CD000951. PubMed
  22. Van Delden C, Hirschel B. Folinic acid supplements to pyrimethamine-sulfadiazine for Toxoplasma encephalitis are associated with better outcome (letter). J Infect Dis 1996;173:1294-5. PubMed
  23. Schroder H, Clausen N, Ostergard E, Pressler T. Folic acid supplements in vitamin tablets: a determinant of hematological drug tolerance in maintenance therapy of childhood acute lymphoblastic leukemia. Ped Hematol Oncol 1986;3:241-7. PubMed
  24. Lange H, Suryapranata H, De Luca G, et al. Folate therapy and in-stent restenosis after coronary stenting. N Engl J Med 2004;350:2673-81. PubMed
  25. Morris MC, Evans DA, Bienias JL, et al. Dietary folate and vitamin B12 intake and cognitive decline among community-dwelling older persons. Arch Neurol 2005;62:641-5. PubMed
  26. Bonaa KH, Njolstad I, Ueland PM, et al. NORVIT: Homocysteine lowering and cardiovascular events after acute myocardial infarction. N Enlg J Med 2006;354:1578-88. PubMed
  27. Lawson KA, Wright ME, Subar A, et al. Multivitamin use and risk of prostate cancer in the National Institutes of Health-AARP Diet and Health Study. J Natl Cancer Inst 2007;99:754-64. PubMed
  28. Figueiredo JC, Grau MV, Haile RW, et al. Folic acid and risk of prostate cancer: Results from a randomized clinical trial. J Natl Cancer Inst 2009;101:432-5. PubMed
  29. Clippe C, Freyer G, Milano G, Trillet-Lenoir V. Lethal toxicity of capecitabine due to abusive folic acid prescription. Clin Oncol (R Coll Radiol) 2003;15:299-300. PubMed
  30. Bedford Laboratories. Leucovorin calcium [package insert]. Bedford, OH. September 2008. Available at: http://www.bedfordlabs.com/BedfordLabsWeb/products/inserts/LCV-P02.pdf.
  31. Ebbing M, Bonaa KH, Nygard O, et al. Cancer incidence and mortality after treatment with folic acid and vitamin B12. JAMA 2009;302:2119-26.
  32. Haberg, S. E., London, S. J., Stigum, H., Nafstad, P., and Nystad, W. Folic acid supplements in pregnancy and early childhood respiratory health. Arch Dis.Child 2009;94(3):180-184. PubMed
  33. Whitrow, M. J., Moore, V. M., Rumbold, A. R., and Davies, M. J. Effect of supplemental folic acid in pregnancy on childhood asthma: a prospective birth cohort study. Am J Epidemiol. 12-15-2009;170(12):1486-1493. PubMed
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Coenzyme Q10 40 references
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