Chitrak Root Powder Ingredients & Drug Interactions
by Herbal Hills
What is this page for?
First and foremost: checking Chitrak Root Powder against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Chitrak Root Powder is a dietary supplement by Herbal Hills with 1 active ingredient. Its ingredients are commonly taken for digestive complaints and poor appetite, skin conditions and wounds (applied to the skin), joint pain and swelling.Based on those ingredients, 1,097 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Chitrak root powder. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Chitrak Root Powder by Herbal Hills
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HelloPharmacist Scorecard of Chitrak Root Powder by Herbal Hills
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Low disclosure
This product contains one active ingredient: chitrak root powder, also known as Ceylon leadwort root. According to our data, it has been traditionally used and studied for various purposes, though the strength of evidence varies.
The product has no other inactive ingredients listed.
Does it work?
Couldn't assess
The only effectiveness rating we hold for chitrak root powder is for asthma, where the evidence is insufficient to rate it reliably. We don't have effectiveness data on file for any other uses.
How safe is it?
Some data gaps
Chitrak root powder contains a compound called plumbagin that can irritate your skin and digestive tract and may be toxic at higher doses—keep that in mind if you use it. The safety data advises against this supplement during pregnancy because it's been traditionally used to cause abortion.
For breastfeeding, there isn't enough safety information, so it's best to avoid it during that time as well.
Meds to double-check
Moderate interaction found
Before taking chitrak root powder, check with your doctor or pharmacist if you take antidepressants or other drugs metabolized by CYP2D6, CYP1A2, CYP2C9, or CYP3A4—all are Moderate-severity interactions. Also verify with your healthcare provider if you're on blood thinners or antiplatelet drugs, hormone therapy, immunosuppressants, or diabetes medications.
The bottom line
Scorecard at a glanceFormula with limited ingredient disclosure with no assessable stated purpose. Moderate medication interactions have been identified, and some safety-information gaps remain.
Chitrak root powder is a single-ingredient herbal supplement with significant potential to interact with your medications through liver enzyme inhibition—an effect seen in the lab but not yet confirmed in people. If you take any prescription drugs, especially those for depression, blood thinning, blood sugar control, or immune suppression, check with your doctor or pharmacist before starting it.
It's not for use in pregnancy or while breastfeeding.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Sep 24, 2019.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Chitrak Root Powder, straight from the product label.
| Brand | Herbal Hills |
|---|---|
| Barcode (UPC) | 8906008268546 |
| Net contents | 1 kg |
| Market status | On market |
| Date entered into DSLD | Sep 24, 2019 |
| DSLD ID | 203343 |
| Product type | Botanical |
| Supplement form | Powder |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Halal |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Chitrak Root Powder by Herbal Hills, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Chitrak root powder | 0 NP | -- |
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula
According to ancient texts, Chitrak is a powerful healing herb that is traditionally used to enkindle the digestive fire, support healthy metabolism and remove natural toxins from the intestines. Chitrak may support the proper functions of the liver and help in healthy digestion of fat and sugars. May support healthy digestion. May help natural removal of toxins from the body. May support healthy metabolism.
Halal India www.halalindia.com S No. 001548
Suggested/Recommended/Usage/Directions
Dosage: Take 3 gms powder, 1 to 2 times a day or as advised by the physician.
Precautions
Caution: Pregnant or lactating women are advised to consume herbal products under the advice of the physician.
Keep out of reach of children.
Do not use if pouch is broken.
FDA Disclaimer Statement
These statements have not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
Storage
Store in a cool dry place away from direct sunlight.
FDA Statement of Identity
Ayurvedic Product
General Statements
Mfg. Lic. No. : PD/AYU/002/10 (An ISO 22000:2005 Certified Company) Customer Care : 91 22 28686868 (10 a.m. to 6 p.m. on weekdays)
Seals/Symbols
ISO Certified Company 22000:2005 Halal India www.halalindia.com S No. 001548 GMP Good Manufacturing Practice
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Chitrak Root Powder by Herbal Hills label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Chitrak Root Powder by Herbal Hills
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size3 Not Present Dosage formPowder Amounts shown are per serving.
Chitrak root powder
Interacts with1,097 drugs
Ceylon Leadwort (Plumbago zeylanica) is a plant long used in Ayurvedic and other traditional medicine systems, mainly for digestion, skin problems, an...
Chitrak root powder monograph & interactionsChitrak Root Powder by Herbal Hills Drug Interactions
HelloPharmacist Interaction Report
Chitrak Root Powder by Herbal Hills contains a single active ingredient—chitrak root powder (Ceylon leadwort)—that interacts with a significant number of medications.
The main concern is that plumbagin, a compound in this herb, inhibits several liver enzymes that break down drugs. In theory, this could raise the levels of medications metabolized by these pathways, though human cases haven't been reported yet.
Read the full breakdown — every affected drug type, severity by severity
The herb affects drugs broken down by four major liver enzymes: CYP2D6 (which metabolizes antidepressants like amitriptyline and desipramine, as well as codeine), CYP1A2 (including clozapine and cyclobenzaprine), CYP2C9 (such as celecoxib and diclofenac), and CYP3A4 (including lovastatin and clarithromycin). All of these are rated Moderate severity.
Additionally, there are Moderate concerns with blood thinners and antiplatelet drugs—animal data suggests the herb may increase bleeding risk, though this hasn't been seen in humans—as well as hormone therapy (the herb may have anti-estrogenic activity), immunosuppressant drugs, and blood sugar medications (which could go either way).
Altogether, these interactions span 1,098 individual medications. Before you start chitrak root powder, use the search tool on this page to check your exact prescriptions with your doctor or pharmacist.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Chitrak Root Powder?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Chitrak Root Powder interact with 1,097 drugs. Click any drug to see the details.
1 of the 1 ingredient in Chitrak Root Powder interact with drugs. Each result below shows which ingredient is responsible. Chitrak root powder
6-mercaptopurinePurinethol
How 6-mercaptopurine interacts with Chitrak Root Powder — through 1 ingredient. Tap an ingredient for the detail:
Chitrak Root PowderImmunosuppressants Moderate
Interaction Summary
Plumbagin, a constituent of Ceylon leadwort, has demonstrated immunosuppressant activity in animal research.
Read the full Chitrak Root Powder + 6-mercaptopurine interactionAdo-trastuzumab EmtansineKadcyla
How Ado-trastuzumab Emtansine interacts with Chitrak Root Powder — through 1 ingredient. Tap an ingredient for the detail:
Chitrak Root PowderCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Plumbagin, a constituent of Ceylon leadwort, has been shown to inhibit cytochrome P450 3A4 (CYP3A4) in vitro.
Read the full Chitrak Root Powder + Ado-trastuzumab Emtansine interactionAbciximabReoPro
How Abciximab interacts with Chitrak Root Powder — through 1 ingredient. Tap an ingredient for the detail:
Chitrak Root PowderAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
There is some concern that Ceylon leadwort might potentiate the effects of anticoagulant and antiplatelet drugs and possibly increase the risk of bleeding.
Read the full Chitrak Root Powder + Abciximab interactionAbemaciclibVerzenio
How Abemaciclib interacts with Chitrak Root Powder — through 1 ingredient. Tap an ingredient for the detail:
Chitrak Root PowderCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Plumbagin, a constituent of Ceylon leadwort, has been shown to inhibit cytochrome P450 3A4 (CYP3A4) in vitro.
Read the full Chitrak Root Powder + Abemaciclib interactionAbiraterone
How Abiraterone interacts with Chitrak Root Powder — through 1 ingredient. Tap an ingredient for the detail:
Chitrak Root PowderCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Plumbagin, a constituent of Ceylon leadwort, has been shown to inhibit cytochrome P450 3A4 (CYP3A4) in vitro.
Read the full Chitrak Root Powder + Abiraterone interactionAbiraterone AcetateYonsa, Zytiga
How Abiraterone Acetate interacts with Chitrak Root Powder — through 1 ingredient. Tap an ingredient for the detail:
Chitrak Root PowderCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Plumbagin, a constituent of Ceylon leadwort, has been shown to inhibit cytochrome P450 3A4 (CYP3A4) in vitro.
Read the full Chitrak Root Powder + Abiraterone Acetate interactionAbrocitinibCibinqo
How Abrocitinib interacts with Chitrak Root Powder — through 1 ingredient. Tap an ingredient for the detail:
Chitrak Root PowderCytochrome P450 2c9 (cyp2c9) Substrates, Anticoagulant/antiplatelet Drugs +1 Moderate
Interaction Summary
Plumbagin, a constituent of Ceylon leadwort, has been shown to inhibit cytochrome P450 2C9 (CYP2C9) in vitro.
Read the full Chitrak Root Powder + Abrocitinib interactionAcalabrutinibCalquence
How Acalabrutinib interacts with Chitrak Root Powder — through 1 ingredient. Tap an ingredient for the detail:
Chitrak Root PowderCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Plumbagin, a constituent of Ceylon leadwort, has been shown to inhibit cytochrome P450 3A4 (CYP3A4) in vitro.
Read the full Chitrak Root Powder + Acalabrutinib interactionAcarboseGlucobay, Prandase, Precose
How Acarbose interacts with Chitrak Root Powder — through 1 ingredient. Tap an ingredient for the detail:
Chitrak Root PowderAntidiabetes Drugs Moderate
Interaction Summary
Ceylon leadwort root extract has been shown to both increase and decrease blood glucose levels in animal research.
Read the full Chitrak Root Powder + Acarbose interactionAcenocoumarolSintrom
How Acenocoumarol interacts with Chitrak Root Powder — through 1 ingredient. Tap an ingredient for the detail:
Chitrak Root PowderAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
There is some concern that Ceylon leadwort might potentiate the effects of anticoagulant and antiplatelet drugs and possibly increase the risk of bleeding.
Read the full Chitrak Root Powder + Acenocoumarol interactionAcetaminophenChildren's Tylenol, Children's Tylenol Meltaways, Tylenol, Tylenol Ex Strength
How Acetaminophen interacts with Chitrak Root Powder — through 1 ingredient. Tap an ingredient for the detail:
Chitrak Root PowderCytochrome P450 2e1 (cyp2e1) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Plumbagin, a constituent of Ceylon leadwort, has been shown to inhibit cytochrome P450 2E1 (CYP2E1) in vitro.
Read the full Chitrak Root Powder + Acetaminophen interactionAcetaminophen, AspirinGemnisyn
How Acetaminophen, Aspirin interacts with Chitrak Root Powder — through 1 ingredient. Tap an ingredient for the detail:
Chitrak Root PowderCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 2e1 (cyp2e1) Substrates +1 Moderate
Interaction Summary
Plumbagin, a constituent of Ceylon leadwort, has been shown to inhibit cytochrome P450 1A2 (CYP1A2) in vitro.
Read the full Chitrak Root Powder + Acetaminophen, Aspirin interactionAcetaminophen, Aspirin, CaffeineExcedrin, Excedrin Extra Strength, Excedrin Migraine
How Acetaminophen, Aspirin, Caffeine interacts with Chitrak Root Powder — through 1 ingredient. Tap an ingredient for the detail:
Chitrak Root PowderAnticoagulant/antiplatelet Drugs, Cytochrome P450 1a2 (cyp1a2) Substrates +2 Moderate
Interaction Summary
There is some concern that Ceylon leadwort might potentiate the effects of anticoagulant and antiplatelet drugs and possibly increase the risk of bleeding.
Read the full Chitrak Root Powder + Acetaminophen, Aspirin, Caffeine interactionAcetaminophen, Brompheniramine, PhenylpropanolamineDimetapp Cold and Flu
How Acetaminophen, Brompheniramine, Phenylpropanolamine interacts with Chitrak Root Powder — through 1 ingredient. Tap an ingredient for the detail:
Chitrak Root PowderCytochrome P450 2e1 (cyp2e1) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Plumbagin, a constituent of Ceylon leadwort, has been shown to inhibit cytochrome P450 2E1 (CYP2E1) in vitro.
Read the full Chitrak Root Powder + Acetaminophen, Brompheniramine, Phenylpropanolamine interactionAcetaminophen, ButalbitalAxocet, Bancap, Bucet, Butex Forte, Esgic CF, Orbivan CF +5 more
How Acetaminophen, Butalbital interacts with Chitrak Root Powder — through 1 ingredient. Tap an ingredient for the detail:
Chitrak Root PowderCytochrome P450 2e1 (cyp2e1) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Plumbagin, a constituent of Ceylon leadwort, has been shown to inhibit cytochrome P450 2E1 (CYP2E1) in vitro.
Read the full Chitrak Root Powder + Acetaminophen, Butalbital interactionAcetaminophen, Butalbital, CaffeineEsgic, Esgic Plus, Fiogesic, Fioricet, Repan, Tecnal +1 more
How Acetaminophen, Butalbital, Caffeine interacts with Chitrak Root Powder — through 1 ingredient. Tap an ingredient for the detail:
Chitrak Root PowderCytochrome P450 2e1 (cyp2e1) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates +1 Moderate
Interaction Summary
Plumbagin, a constituent of Ceylon leadwort, has been shown to inhibit cytochrome P450 2E1 (CYP2E1) in vitro.
Read the full Chitrak Root Powder + Acetaminophen, Butalbital, Caffeine interactionAcetaminophen, Butalbital, Caffeine, CodeineEsgic with Codeine, Fioricet w/ Codeine
How Acetaminophen, Butalbital, Caffeine, Codeine interacts with Chitrak Root Powder — through 1 ingredient. Tap an ingredient for the detail:
Chitrak Root PowderCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates +2 Moderate
Interaction Summary
Plumbagin, a constituent of Ceylon leadwort, has been shown to inhibit cytochrome P450 1A2 (CYP1A2) in vitro.
Read the full Chitrak Root Powder + Acetaminophen, Butalbital, Caffeine, Codeine interactionAcetaminophen, Butalbital, CodeineBancap w/ Codeine
How Acetaminophen, Butalbital, Codeine interacts with Chitrak Root Powder — through 1 ingredient. Tap an ingredient for the detail:
Chitrak Root PowderCytochrome P450 2e1 (cyp2e1) Substrates, Cytochrome P450 2d6 (cyp2d6) Substrates +1 Moderate
Interaction Summary
Plumbagin, a constituent of Ceylon leadwort, has been shown to inhibit cytochrome P450 2E1 (CYP2E1) in vitro.
Read the full Chitrak Root Powder + Acetaminophen, Butalbital, Codeine interactionAcetaminophen, Butalbital, Codeine PhosphatePhrenilin #3
How Acetaminophen, Butalbital, Codeine Phosphate interacts with Chitrak Root Powder — through 1 ingredient. Tap an ingredient for the detail:
Chitrak Root PowderCytochrome P450 2d6 (cyp2d6) Substrates, Cytochrome P450 2e1 (cyp2e1) Substrates +1 Moderate
Interaction Summary
Plumbagin, a constituent of Ceylon leadwort, has been shown to inhibit cytochrome P450 2D6 (CYP2D6) in vitro.
Read the full Chitrak Root Powder + Acetaminophen, Butalbital, Codeine Phosphate interactionAcetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, PhenylephrineHycomine Compound
How Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interacts with Chitrak Root Powder — through 1 ingredient. Tap an ingredient for the detail:
Chitrak Root PowderCytochrome P450 2e1 (cyp2e1) Substrates, Cytochrome P450 2d6 (cyp2d6) Substrates +2 Moderate
Interaction Summary
Plumbagin, a constituent of Ceylon leadwort, has been shown to inhibit cytochrome P450 2E1 (CYP2E1) in vitro.
Read the full Chitrak Root Powder + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interactionAcetaminophen, Caffeine, CodeineGesic C15, Gesic C30, Gesic C8, Lenoltec 1, Lenoltec 2, Lenoltec 3 +1 more
How Acetaminophen, Caffeine, Codeine interacts with Chitrak Root Powder — through 1 ingredient. Tap an ingredient for the detail:
Chitrak Root PowderCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 2d6 (cyp2d6) Substrates +2 Moderate
Interaction Summary
Plumbagin, a constituent of Ceylon leadwort, has been shown to inhibit cytochrome P450 3A4 (CYP3A4) in vitro.
Read the full Chitrak Root Powder + Acetaminophen, Caffeine, Codeine interactionAcetaminophen, Caffeine, Codeine, SalicylamideCodalan No.1, Codalan No.2, Codalan No.3
How Acetaminophen, Caffeine, Codeine, Salicylamide interacts with Chitrak Root Powder — through 1 ingredient. Tap an ingredient for the detail:
Chitrak Root PowderCytochrome P450 2e1 (cyp2e1) Substrates, Cytochrome P450 2d6 (cyp2d6) Substrates +2 Moderate
Interaction Summary
Plumbagin, a constituent of Ceylon leadwort, has been shown to inhibit cytochrome P450 2E1 (CYP2E1) in vitro.
Read the full Chitrak Root Powder + Acetaminophen, Caffeine, Codeine, Salicylamide interactionAcetaminophen, Caffeine, DihydrocodeineDHC Plus, Panlor DC, Panlor SS
How Acetaminophen, Caffeine, Dihydrocodeine interacts with Chitrak Root Powder — through 1 ingredient. Tap an ingredient for the detail:
Chitrak Root PowderCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates +2 Moderate
Interaction Summary
Plumbagin, a constituent of Ceylon leadwort, has been shown to inhibit cytochrome P450 3A4 (CYP3A4) in vitro.
Read the full Chitrak Root Powder + Acetaminophen, Caffeine, Dihydrocodeine interactionAcetaminophen, Caffeine, IsomethepteneMigralam
How Acetaminophen, Caffeine, Isometheptene interacts with Chitrak Root Powder — through 1 ingredient. Tap an ingredient for the detail:
Chitrak Root PowderCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 2e1 (cyp2e1) Substrates +1 Moderate
Interaction Summary
Plumbagin, a constituent of Ceylon leadwort, has been shown to inhibit cytochrome P450 1A2 (CYP1A2) in vitro.
Read the full Chitrak Root Powder + Acetaminophen, Caffeine, Isometheptene interactionAcetaminophen, Caffeine, PyrilamineMidol Max Strength Menstrual
How Acetaminophen, Caffeine, Pyrilamine interacts with Chitrak Root Powder — through 1 ingredient. Tap an ingredient for the detail:
Chitrak Root PowderCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 2e1 (cyp2e1) Substrates +1 Moderate
Interaction Summary
Plumbagin, a constituent of Ceylon leadwort, has been shown to inhibit cytochrome P450 3A4 (CYP3A4) in vitro.
Read the full Chitrak Root Powder + Acetaminophen, Caffeine, Pyrilamine interactionAcetaminophen, Chlorpheniramine Maleate, Dextromethorphan HbrVicks Formula 44M Cough, Cold & Flu Relief
How Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interacts with Chitrak Root Powder — through 1 ingredient. Tap an ingredient for the detail:
Chitrak Root PowderCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates +2 Moderate
Interaction Summary
Plumbagin, a constituent of Ceylon leadwort, has been shown to inhibit cytochrome P450 1A2 (CYP1A2) in vitro.
Read the full Chitrak Root Powder + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interactionAcetaminophen, Chlorpheniramine, Codeine, PhenylephrineColrex
How Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interacts with Chitrak Root Powder — through 1 ingredient. Tap an ingredient for the detail:
Chitrak Root PowderCytochrome P450 2d6 (cyp2d6) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates +2 Moderate
Interaction Summary
Plumbagin, a constituent of Ceylon leadwort, has been shown to inhibit cytochrome P450 2D6 (CYP2D6) in vitro.
Read the full Chitrak Root Powder + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionAcetaminophen, Chlorpheniramine, DextromethorphanCoricidin II Extra Strength Cold and Flu
How Acetaminophen, Chlorpheniramine, Dextromethorphan interacts with Chitrak Root Powder — through 1 ingredient. Tap an ingredient for the detail:
Chitrak Root PowderCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 2e1 (cyp2e1) Substrates +2 Moderate
Interaction Summary
Plumbagin, a constituent of Ceylon leadwort, has been shown to inhibit cytochrome P450 1A2 (CYP1A2) in vitro.
Read the full Chitrak Root Powder + Acetaminophen, Chlorpheniramine, Dextromethorphan interactionAcetaminophen, Chlorpheniramine, Dextromethorphan HydrobromideCoricidin HBP Maximum Strength Flu
How Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interacts with Chitrak Root Powder — through 1 ingredient. Tap an ingredient for the detail:
Chitrak Root PowderCytochrome P450 2d6 (cyp2d6) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates +2 Moderate
Interaction Summary
Plumbagin, a constituent of Ceylon leadwort, has been shown to inhibit cytochrome P450 2D6 (CYP2D6) in vitro.
Read the full Chitrak Root Powder + Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interactionAcetaminophen, Chlorpheniramine, Dextromethorphan, PhenylpropanolamineMulti Symptom Cold Relief
How Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interacts with Chitrak Root Powder — through 1 ingredient. Tap an ingredient for the detail:
Chitrak Root PowderCytochrome P450 2e1 (cyp2e1) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates +2 Moderate
Interaction Summary
Plumbagin, a constituent of Ceylon leadwort, has been shown to inhibit cytochrome P450 2E1 (CYP2E1) in vitro.
Read the full Chitrak Root Powder + Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Chitrak Root Powder with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
Chitrak root powder
Anticoagulant/Antiplatelet Drugs
There is some concern that Ceylon leadwort might potentiate the effects of anticoagulant and antiplatelet drugs and possibly increase the risk of bleeding. Ceylon leadwort root extract has been shown to decrease platelet adhesion and prolong bleeding in animals. However, this effect has not yet been demonstrated in humans. Until more is known, use cautiously in patients taking anticoagulant or antiplatelet drugs. Some of these drugs include aspirin, clopidogrel (Plavix), dalteparin (Fragmin), enoxaparin (Lovenox), heparin, ticlopidine (Ticlid), warfarin (Coumadin), and others.
Antidiabetes Drugs
Ceylon leadwort root extract has been shown to both increase and decrease blood glucose levels in animal research. This effect has not yet been demonstrated in humans. Theoretically, Ceylon leadwort might reduce or potentiate the effects of antidiabetes drugs. Monitor blood glucose levels closely. Medication dose adjustments may be necessary. Some antidiabetes drugs include glimepiride (Amaryl), glyburide (Diabeta, Glynase PresTab, Micronase), insulin, pioglitazone (Actos), rosiglitazone (Avandia), and others.
Cytochrome P450 1A2 (Cyp1A2) Substrates
Plumbagin, a constituent of Ceylon leadwort, has been shown to inhibit cytochrome P450 1A2 (CYP1A2) in vitro. So far, this interaction has not been reported in humans. Theoretically, Ceylon leadwort might increase the levels of drugs metabolized by CYP1A2. Some substrates of CYP1A2 include clozapine (Clozaril), cyclobenzaprine (Flexeril), fluvoxamine (Luvox), haloperidol (Haldol), imipramine (Tofranil), mexiletine (Mexitil), olanzapine (Zyprexa), pentazocine (Talwin), propranolol (Inderal), tacrine (Cognex), zileuton (Zyflo), zolmitriptan (Zomig), and others.
Cytochrome P450 2B6 (Cyp2B6) Substrates
Plumbagin, a constituent of Ceylon leadwort, has been shown to inhibit cytochrome P450 2B6 (CYP2B6) in vitro. So far, this interaction has not been reported in humans. Theoretically, Ceylon leadwort might increase the levels of drugs metabolized by CYP2B6. Drugs that are metabolized by CYP2B6 include ketamine (Ketalar), phenobarbital, orphenadrine (Norflex), secobarbital (Seconal), and dexamethasone (Decadron).
Cytochrome P450 2C9 (Cyp2C9) Substrates
Plumbagin, a constituent of Ceylon leadwort, has been shown to inhibit cytochrome P450 2C9 (CYP2C9) in vitro. So far, this interaction has not been reported in humans. Theoretically, Ceylon leadwort might increase the levels of drugs metabolized by CYP2C9. Drugs that are metabolized by CYP2C9 include celecoxib (Celebrex), diclofenac (Voltaren), fluvastatin (Lescol), glipizide (Glucotrol), ibuprofen (Advil, Motrin), irbesartan (Avapro), losartan (Cozaar), phenytoin (Dilantin), piroxicam (Feldene), tamoxifen (Nolvadex), tolbutamide (Tolinase), torsemide (Demadex), and S-warfarin (Coumadin).
Cytochrome P450 2D6 (Cyp2D6) Substrates
Plumbagin, a constituent of Ceylon leadwort, has been shown to inhibit cytochrome P450 2D6 (CYP2D6) in vitro. So far, this interaction has not been reported in humans. Theoretically, Ceylon leadwort might increase the levels of drugs metabolized by CYP2D6. Some drugs metabolized by CYP2D6 include amitriptyline (Elavil), codeine, desipramine (Norpramin), flecainide (Tambocor), fluoxetine (Prozac), ondansetron (Zofran), tramadol (Ultram), and others.
Cytochrome P450 2E1 (Cyp2E1) Substrates
Plumbagin, a constituent of Ceylon leadwort, has been shown to inhibit cytochrome P450 2E1 (CYP2E1) in vitro. So far, this interaction has not been reported in humans. Theoretically, Ceylon leadwort might increase the levels of drugs metabolized by CYP2E1. Some drugs metabolized by CYP2E1 include acetaminophen, chlorzoxazone (Parafon Forte), ethanol, theophylline, and anesthetics such as enflurane (Ethrane), halothane (Fluothane), isoflurane (Forane), methoxyflurane (Penthrane).
Cytochrome P450 3A4 (Cyp3A4) Substrates
Plumbagin, a constituent of Ceylon leadwort, has been shown to inhibit cytochrome P450 3A4 (CYP3A4) in vitro. So far, this interaction has not been reported in humans. Theoretically, Ceylon leadwort might increase the levels of drugs metabolized by CYP3A4. Some drugs metabolized by CYP3A4 include lovastatin (Mevacor), clarithromycin (Biaxin), indinavir (Crixivan), sildenafil (Viagra), triazolam (Halcion), and numerous others.
Estrogens
Laboratory research suggests that Ceylon leadwort root extract has anti-estrogenic activity. Theoretically, Ceylon leadwort may interfere with hormone therapy.
Immunosuppressants
Plumbagin, a constituent of Ceylon leadwort, has demonstrated immunosuppressant activity in animal research. Theoretically, Ceylon leadwort might interfere with immunosuppressive therapy. Immunosuppressant drugs include azathioprine (Imuran), basiliximab (Simulect), cyclosporine (Neoral, Sandimmune), daclizumab (Zenapax), muromonab-CD3 (OKT3, Orthoclone OKT3), mycophenolate (CellCept), tacrolimus (FK506, Prograf), sirolimus (Rapamune), prednisone (Deltasone, Orasone), corticosteroids (glucocorticoids), and others.
Brand information
Manufacturer and brand details for Chitrak Root Powder, from the product label.
Herbal Hills
See all Herbal Hills products- Name
- Isha Agro Developers Pvt. Ltd.
- Street Address
- 36A/55AB, Lonavala Co.op. Indl. Est. Ltd.
- City
- Village - Nangargaon, Lonavala, Pune
- State
- Maharashtra
- Phone Number
- 91 22 28686868
- Web Address
- www.herbalhills.in
Chitrak Root Powder by Herbal Hills: Common Questions
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Sources & How We Checked
Chitrak Root Powder's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
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The 10 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Ceylon Leadwort 10 references
- Mandavkar, YD, Jalalpure, SS. A comprehensive review on Plumbago zeylanica Linn. African J. Pharmacy and Pharmacology. 2011;5(25):2738-2747. DOI
- Kumar SS, Shanmugasundaram KR. Amrita Bindu-an antioxidant inducer therapy in asthma children. J. Ethnopharmacol. 2004;90:105-114. PubMed
- Sandeep G, Dheeraj A, Sharma NK, Jhade D, Bharti A. Effect of plumbagin free alcohol extract of Plumbago zeylanica Linn. root on reproductive system of female Wistar rats. Asian Pac J Trop Med. 2011 Dec;4(12):978-84. PubMed
- Vijayakumar R, Senthilvelan M, Ravindran R, Devi RS. Plumbago zeylanica action on blood coagulation profile with and without blood volume reduction. Vascul Pharmacol. 2006 Aug;45(2):86-90. PubMed
- Olagunju JA, Jobi AA, Oyedapo OO. An investigation into the biochemical basis of the observed hyperglycaemia in rats treated with ethanol root extract of plumbago zeylanica. Phytother Res. 1999 Jun;13(4):346-8.
- Chen A, Zhou X, Tang S, Liu M, Wang X. Evaluation of the inhibition potential of plumbagin against cytochrome P450 using LC-MS/MS and cocktail approach. Sci Rep. 2016 Jun 22;6:28482. PubMed
- Sunil C, Duraipandiyan V, Agastian P, Ignacimuthu S. Antidiabetic effect of plumbagin isolated from Plumbago zeylanica L. root and its effect on GLUT4 translocation in streptozotocin-induced diabetic rats. Food Chem Toxicol. 2012 Dec;50(12):4356-63. PubMed
- Checker R, Sharma D, Sandur SK, Khanam S, Poduval TB. Anti-inflammatory effects of plumbagin are mediated by inhibition of NF-kappaB activation in lymphocytes. Int Immunopharmacol. 2009 Jul;9(7-8):949-58. PubMed
- Jia Y, Jing J, Bai Y, Li Z, Liu L, Luo J, Liu M, Chen H. Amelioration of experimental autoimmune encephalomyelitis by plumbagin through down-regulation of JAK-STAT and NF-?B signaling pathways. PLoS One. 2011;6(10):e27006. PubMed
- Poosarla A, D N R, Athota RR, Sunkara VG. Modulation of T cell proliferation and cytokine response by Plumbagin, extracted from Plumbago zeylanica in collagen induced arthritis. BMC Complement Altern Med. 2011 Nov 16;11:114. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
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