Chromium Picolinate Ingredients & Drug Interactions
by SuperiorLabs
What is this page for?
First and foremost: checking Chromium Picolinate against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Chromium Picolinate is a dietary supplement by SuperiorLabs with 1 active ingredient. Its ingredients are commonly taken for blood sugar support in type 2 diabetes, weight loss and appetite control, insulin sensitivity.Based on those ingredients, 178 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Chromium. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Chromium Picolinate by SuperiorLabs
Ask about any prescription or over-the-counter medication and we check it for interactions with Chromium Picolinate by SuperiorLabs — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
Ask the Pharmacist
A licensed pharmacist will answer your question by email — free, usually within 24 hours.
Got it — thank you!
A licensed pharmacist will answer within 24 hours. Keep an eye on your email (worth checking spam, just in case).
HelloPharmacist Scorecard of Chromium Picolinate by SuperiorLabs
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product contains one active ingredient: chromium picolinate, a form of the mineral chromium. Chromium picolinate works by helping your body use insulin more effectively and may help support healthy blood sugar levels.
The capsule also contains inactive ingredients — rice concentrate and cellulose — which are common fillers and binders.
Does it work?
Strong evidence
The evidence for chromium picolinate depends on what you're using it for. It's rated likely effective for treating chromium deficiency, which is rare but can happen.
For type 2 diabetes, the evidence is less clear — it's rated possibly effective, meaning some research suggests a benefit but more study is needed. For prediabetes, schizophrenia, and high blood pressure, the current evidence suggests it's probably not effective.
How safe is it?
Well-documented data
Chromium picolinate is generally well tolerated at typical supplement doses. The most common side effects from oral use are gastrointestinal irritation, headaches, insomnia, irritability, and mood changes.
Skin reactions like rashes and itching have also been reported, especially in people with contact allergies to chromium. Rare serious effects — kidney or liver damage, muscle breakdown (rhabdomyolysis), and low platelet counts — have been reported, mostly with higher doses taken long-term.
The safety data on higher supplement doses is limited, so stick with typical doses unless your doctor recommends otherwise. If you're pregnant or breastfeeding, small amounts from a balanced diet or prenatal vitamin are considered acceptable, but extra supplement doses should be avoided unless your doctor advises it.
Meds to double-check
Moderate interaction found
Before you take this product, check it against insulin and antidiabetes medications (blood sugar drugs) — chromium may lower blood sugar and increase the risk of hypoglycemia. Also check levothyroxine (thyroid hormone); chromium can reduce its absorption.
NSAIDs and aspirin may increase chromium levels in your blood.
The bottom line
Scorecard at a glanceFully disclosed formula with clinical evidence supporting its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
If you have type 2 diabetes or low blood sugar issues, chromium picolinate might be worth talking about with your pharmacist — but only after you've checked it against your exact medications. If you take thyroid hormone replacement or insulin, definitely double-check this product first.
For most other uses, the evidence doesn't support it.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Sep 25, 2025.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Chromium Picolinate, straight from the product label.
| Brand | SuperiorLabs |
|---|---|
| Barcode (UPC) | 850569006087 |
| Net contents | 120 Vegetable Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Sep 25, 2025 |
| DSLD ID | 338174 |
| Product type | Mineral |
| Supplement form | Capsule |
| Dietary claims / uses | Nutrient, All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years) |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Chromium Picolinate by SuperiorLabs, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Chromium | 62 mcg | 177% |
| Chromium Picolinate | 500 mcg | -- |
Other ingredients: Rice Concentrate, Cellulose
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula
Chromium Picolinate is an essential trace element that maintains healthy blood sugar levels. It is also used to support energy levels and athletic performance. Superior Labs Chromium Picolinate capsules contain 62 mcg pure chromium from at least 500 mcg chromium picolinate.
Pure chromium
Formulation
Our capsules contain absolutely no magnesium stearate, dioxides, preservatives, or other potentially harmful artificial ingredients of any kind.
Metal Safe Heavy Metal Tested
Optimal absorption Pure and potent Upholds metabolism function Supports energy levels Supports already healthy blood sugar levels This product is formulated, developed and manufactured in a FDA registered and GMP certified facility, 3rd party inspected by a leading compliance authority for superior quality assurance.
Does not contain: magnesium stearate, dioxides, preservatives, or artificial ingredients of any kind.
Suggested/Recommended/Usage/Directions
Suggested use: As a dietary supplement, adults take 1 capsule per day or as directed by your health care practitioner. Best when taken with a meal.
Precautions
Caution: Do not exceed recommended dosage. Do not use if safety seal is damaged or missing.
Please consult a physician before consuming this product if you are pregnant or nursing, taking medication or have a medical condition.
Not intended for use by individuals under the age of 18. Keep out of reach of children.
Storage
Store in a cool, dry place.
Seals/Symbols
Metal Safe Heavy Metal Tested GMP Certified Facility Manufactured in the USA with globally sourced ingredients
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
FDA Statement of Identity
Dietary Supplement
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Chromium Picolinate by SuperiorLabs label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Chromium Picolinate by SuperiorLabs
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size1 Capsule(s) Dosage formCapsule Servings per container120 Amounts shown are per serving.
Chromium
Interacts with178 drugs
Chromium is an essential trace mineral involved in how the body handles sugar and fat. Some studies suggest it may modestly help blood sugar control i...
Chromium monograph & interactionsOther (inactive) ingredients: Rice Concentrate, Cellulose. These complete the product’s ingredient list but are not active constituents.
Chromium Picolinate by SuperiorLabs Drug Interactions
HelloPharmacist Interaction Report
Chromium Picolinate by SuperiorLabs can interact with several medication types, and the most serious concern is with insulin and other antidiabetes drugs.
Chromium may increase insulin sensitivity and lower blood sugar, which means it could theoretically add to the blood-sugar-lowering effect of these medications and raise the risk of low blood sugar (hypoglycemia). If you take insulin or diabetes medications, this is worth checking before you start.
Read the full breakdown — every affected drug type, severity by severity
Chromium also interacts with levothyroxine (thyroid hormone replacement, sold as Synthroid and others). Research shows that taking chromium picolinate can reduce how much levothyroxine your body absorbs — in one study, levels dropped by 17%.
This could make your thyroid medication less effective. NSAIDs and aspirin are listed as Minor interactions; they may increase how much chromium your body absorbs, which could raise chromium levels in your blood.
Additionally, you'll want to run your exact medications through the interaction checker on this page, because these interactions span 177 individual medications.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Chromium Picolinate?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Chromium Picolinate interact with 178 drugs. Click any drug to see the details.
1 of the 1 ingredient in Chromium Picolinate interact with drugs. Each result below shows which ingredient is responsible. Chromium
GlucoseIV Glucose
How Glucose interacts with Chromium Picolinate — through 1 ingredient. Tap an ingredient for the detail:
Chromium PicolinateAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, chromium may have additive effects with antidiabetic agents and increase the risk of hypoglycemia.
Read the full Chromium Picolinate + Glucose interactionGlyburideAlbert Glyburide, Diabeta, Glycron, Glynase, Glynase PresTab, Micronase +1 more
How Glyburide interacts with Chromium Picolinate — through 1 ingredient. Tap an ingredient for the detail:
Chromium PicolinateAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, chromium may have additive effects with antidiabetic agents and increase the risk of hypoglycemia.
Read the full Chromium Picolinate + Glyburide interactionGlyburide, MetforminGlucovance
How Glyburide, Metformin interacts with Chromium Picolinate — through 1 ingredient. Tap an ingredient for the detail:
Chromium PicolinateAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, chromium may have additive effects with antidiabetic agents and increase the risk of hypoglycemia.
Read the full Chromium Picolinate + Glyburide, Metformin interactionInhaled InsulinExubera
How Inhaled Insulin interacts with Chromium Picolinate — through 1 ingredient. Tap an ingredient for the detail:
Chromium PicolinateAntidiabetes Drugs, Insulin Moderate
Interaction Summary
Theoretically, chromium may have additive effects with antidiabetic agents and increase the risk of hypoglycemia.
Read the full Chromium Picolinate + Inhaled Insulin interactionInsulinNovoRapid Insulin
How Insulin interacts with Chromium Picolinate — through 1 ingredient. Tap an ingredient for the detail:
Chromium PicolinateAntidiabetes Drugs, Insulin Moderate
Interaction Summary
Theoretically, chromium may have additive effects with antidiabetic agents and increase the risk of hypoglycemia.
Read the full Chromium Picolinate + Insulin interactionInsulin (bovine)Hypurin Bovine Neutral
How Insulin (bovine) interacts with Chromium Picolinate — through 1 ingredient. Tap an ingredient for the detail:
Chromium PicolinateAntidiabetes Drugs, Insulin Moderate
Interaction Summary
Theoretically, chromium may have additive effects with antidiabetic agents and increase the risk of hypoglycemia.
Read the full Chromium Picolinate + Insulin (bovine) interactionInsulin (human)Afrezza, Novolin 70/30, Novolin L, Novolin N, Novolin R
How Insulin (human) interacts with Chromium Picolinate — through 1 ingredient. Tap an ingredient for the detail:
Chromium PicolinateAntidiabetes Drugs, Insulin Moderate
Interaction Summary
Theoretically, chromium may have additive effects with antidiabetic agents and increase the risk of hypoglycemia.
Read the full Chromium Picolinate + Insulin (human) interactionInsulin (pork)Hypurin Porcine Neutral, Lente Iletin II, NPH Iletin, NPH Iletin II, Pork Actrapid, Regular Iletin +1 more
How Insulin (pork) interacts with Chromium Picolinate — through 1 ingredient. Tap an ingredient for the detail:
Chromium PicolinateAntidiabetes Drugs, Insulin Moderate
Interaction Summary
Theoretically, chromium may have additive effects with antidiabetic agents and increase the risk of hypoglycemia.
Read the full Chromium Picolinate + Insulin (pork) interactionInsulin (rdna)Actrapid, Humalog, Humalog Mix 75/25, Humulin 50/50, Humulin 70/30, Humulin L +8 more
How Insulin (rdna) interacts with Chromium Picolinate — through 1 ingredient. Tap an ingredient for the detail:
Chromium PicolinateAntidiabetes Drugs, Insulin Moderate
Interaction Summary
Theoretically, chromium may have additive effects with antidiabetic agents and increase the risk of hypoglycemia.
Read the full Chromium Picolinate + Insulin (rdna) interactionInsulin AspartFiasp
How Insulin Aspart interacts with Chromium Picolinate — through 1 ingredient. Tap an ingredient for the detail:
Chromium PicolinateAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, chromium may have additive effects with antidiabetic agents and increase the risk of hypoglycemia.
Read the full Chromium Picolinate + Insulin Aspart interactionInsulin Aspart, Insulin DegludecRyzodeg 70/30
How Insulin Aspart, Insulin Degludec interacts with Chromium Picolinate — through 1 ingredient. Tap an ingredient for the detail:
Chromium PicolinateAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, chromium may have additive effects with antidiabetic agents and increase the risk of hypoglycemia.
Read the full Chromium Picolinate + Insulin Aspart, Insulin Degludec interactionInsulin DegludecTresiba
How Insulin Degludec interacts with Chromium Picolinate — through 1 ingredient. Tap an ingredient for the detail:
Chromium PicolinateAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, chromium may have additive effects with antidiabetic agents and increase the risk of hypoglycemia.
Read the full Chromium Picolinate + Insulin Degludec interactionInsulin Degludec, LiraglutideXultophy 100/3.6
How Insulin Degludec, Liraglutide interacts with Chromium Picolinate — through 1 ingredient. Tap an ingredient for the detail:
Chromium PicolinateAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, chromium may have additive effects with antidiabetic agents and increase the risk of hypoglycemia.
Read the full Chromium Picolinate + Insulin Degludec, Liraglutide interactionInsulin GlargineBasaglar, Lusduna, Semglee
How Insulin Glargine interacts with Chromium Picolinate — through 1 ingredient. Tap an ingredient for the detail:
Chromium PicolinateAntidiabetes Drugs, Insulin Moderate
Interaction Summary
Theoretically, chromium may have additive effects with antidiabetic agents and increase the risk of hypoglycemia.
Read the full Chromium Picolinate + Insulin Glargine interactionInsulin Glargine (rdna)Lantus
How Insulin Glargine (rdna) interacts with Chromium Picolinate — through 1 ingredient. Tap an ingredient for the detail:
Chromium PicolinateAntidiabetes Drugs, Insulin Moderate
Interaction Summary
Theoretically, chromium may have additive effects with antidiabetic agents and increase the risk of hypoglycemia.
Read the full Chromium Picolinate + Insulin Glargine (rdna) interactionInsulin Glargine RecombinantToujeo Solostar
How Insulin Glargine Recombinant interacts with Chromium Picolinate — through 1 ingredient. Tap an ingredient for the detail:
Chromium PicolinateAntidiabetes Drugs, Insulin Moderate
Interaction Summary
Theoretically, chromium may have additive effects with antidiabetic agents and increase the risk of hypoglycemia.
Read the full Chromium Picolinate + Insulin Glargine Recombinant interactionInsulin Glargine, LixisenatideSoliqua 100/33
How Insulin Glargine, Lixisenatide interacts with Chromium Picolinate — through 1 ingredient. Tap an ingredient for the detail:
Chromium PicolinateAntidiabetes Drugs, Insulin Moderate
Interaction Summary
Theoretically, chromium may have additive effects with antidiabetic agents and increase the risk of hypoglycemia.
Read the full Chromium Picolinate + Insulin Glargine, Lixisenatide interactionInsulin Glulisine (rdna)Apidra
How Insulin Glulisine (rdna) interacts with Chromium Picolinate — through 1 ingredient. Tap an ingredient for the detail:
Chromium PicolinateAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, chromium may have additive effects with antidiabetic agents and increase the risk of hypoglycemia.
Read the full Chromium Picolinate + Insulin Glulisine (rdna) interactionInsulin Human, Sodium ChlorideMyxredlin
How Insulin Human, Sodium Chloride interacts with Chromium Picolinate — through 1 ingredient. Tap an ingredient for the detail:
Chromium PicolinateAntidiabetes Drugs, Insulin Moderate
Interaction Summary
Theoretically, chromium may have additive effects with antidiabetic agents and increase the risk of hypoglycemia.
Read the full Chromium Picolinate + Insulin Human, Sodium Chloride interactionInsulin LisproAdmelog, Admelog Solostar
How Insulin Lispro interacts with Chromium Picolinate — through 1 ingredient. Tap an ingredient for the detail:
Chromium PicolinateAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, chromium may have additive effects with antidiabetic agents and increase the risk of hypoglycemia.
Read the full Chromium Picolinate + Insulin Lispro interactionInsulin Lispro RecombinantHumalog Kwikpen
How Insulin Lispro Recombinant interacts with Chromium Picolinate — through 1 ingredient. Tap an ingredient for the detail:
Chromium PicolinateAntidiabetes Drugs, Insulin Moderate
Interaction Summary
Theoretically, chromium may have additive effects with antidiabetic agents and increase the risk of hypoglycemia.
Read the full Chromium Picolinate + Insulin Lispro Recombinant interactionInsulin Lispro-aabcLyumjev
How Insulin Lispro-aabc interacts with Chromium Picolinate — through 1 ingredient. Tap an ingredient for the detail:
Chromium PicolinateAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, chromium may have additive effects with antidiabetic agents and increase the risk of hypoglycemia.
Read the full Chromium Picolinate + Insulin Lispro-aabc interactionInsulin DetermirLevemir
How Insulin Determir interacts with Chromium Picolinate — through 1 ingredient. Tap an ingredient for the detail:
Chromium PicolinateAntidiabetes Drugs, Insulin Moderate
Interaction Summary
Theoretically, chromium may have additive effects with antidiabetic agents and increase the risk of hypoglycemia.
Read the full Chromium Picolinate + Insulin Determir interactionLevothyroxineEltroxin, Estre, Euthyrox, Levo-T, Levolet, Levothroid +5 more
How Levothyroxine interacts with Chromium Picolinate — through 1 ingredient. Tap an ingredient for the detail:
Chromium PicolinateLevothyroxine (synthroid, Others) Moderate
Interaction Summary
Chromium might bind levothyroxine in the intestinal tract and decrease levothyroxine absorption.
Read the full Chromium Picolinate + Levothyroxine interactionLevothyroxine SodiumErmez, Thyquidity, Tirosint-Sol
How Levothyroxine Sodium interacts with Chromium Picolinate — through 1 ingredient. Tap an ingredient for the detail:
Chromium PicolinateLevothyroxine (synthroid, Others) Moderate
Interaction Summary
Chromium might bind levothyroxine in the intestinal tract and decrease levothyroxine absorption.
Read the full Chromium Picolinate + Levothyroxine Sodium interactionLevothyroxine, LiothyronineArmour Thyroid
How Levothyroxine, Liothyronine interacts with Chromium Picolinate — through 1 ingredient. Tap an ingredient for the detail:
Chromium PicolinateLevothyroxine (synthroid, Others) Moderate
Interaction Summary
Chromium might bind levothyroxine in the intestinal tract and decrease levothyroxine absorption.
Read the full Chromium Picolinate + Levothyroxine, Liothyronine interactionLinagliptinTradjenta
How Linagliptin interacts with Chromium Picolinate — through 1 ingredient. Tap an ingredient for the detail:
Chromium PicolinateAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, chromium may have additive effects with antidiabetic agents and increase the risk of hypoglycemia.
Read the full Chromium Picolinate + Linagliptin interactionLinagliptin, Metformin HydrochlorideJentadueto XR
How Linagliptin, Metformin Hydrochloride interacts with Chromium Picolinate — through 1 ingredient. Tap an ingredient for the detail:
Chromium PicolinateAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, chromium may have additive effects with antidiabetic agents and increase the risk of hypoglycemia.
Read the full Chromium Picolinate + Linagliptin, Metformin Hydrochloride interactionLiraglutideVictoza
How Liraglutide interacts with Chromium Picolinate — through 1 ingredient. Tap an ingredient for the detail:
Chromium PicolinateAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, chromium may have additive effects with antidiabetic agents and increase the risk of hypoglycemia.
Read the full Chromium Picolinate + Liraglutide interactionLiraglutide RecombinantSaxenda
How Liraglutide Recombinant interacts with Chromium Picolinate — through 1 ingredient. Tap an ingredient for the detail:
Chromium PicolinateAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, chromium may have additive effects with antidiabetic agents and increase the risk of hypoglycemia.
Read the full Chromium Picolinate + Liraglutide Recombinant interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Chromium Picolinate with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
Chromium
Antidiabetes Drugs
Theoretically, chromium may have additive effects with antidiabetic agents and increase the risk of hypoglycemia.
Some research shows that taking chromium might lower blood glucose levels, especially in patients with poorly controlled type 2 diabetes.
Insulin
Theoretically, concomitant use of chromium and insulin might increase the risk of hypoglycemia.
In clinical research, chromium has been shown to increase insulin sensitivity,
Levothyroxine (Synthroid, Others)
Chromium might bind levothyroxine in the intestinal tract and decrease levothyroxine absorption.
Clinical research in healthy volunteers shows that taking chromium picolinate 1000 mcg with levothyroxine 1 mg decreases serum levels of levothyroxine by 17% when compared to taking levothyroxine alone. Advise patients to take levothyroxine at least 30 minutes before or 3-4 hours after taking chromium.
Aspirin
Theoretically, aspirin might increase chromium absorption.
Animal research suggests that aspirin may increase chromium absorption and chromium levels in the blood.
Nonsteroidal Anti-Inflammatory Drugs (Nsaids)
NSAIDs might increase chromium levels in the body.
Drugs that are prostaglandin inhibitors, such as NSAIDs, seem to increase chromium absorption and retention.
Brand information
Manufacturer and brand details for Chromium Picolinate, from the product label.
SuperiorLabs
See all SuperiorLabs products- Name
- Superior Labs, LLC.
- City
- Park City
- State
- UT
- ZipCode
- 84098
- Phone Number
- (888) 708-5227
- Web Address
- www.superiorlabs.com
Chromium Picolinate by SuperiorLabs: Common Questions
Does Chromium Picolinate by SuperiorLabs interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Does chromium picolinate actually help with blood sugar?
What are the most common side effects?
Can I take chromium picolinate if I'm pregnant?
Will this interfere with my thyroid medication?
Is this supplement safe to take long-term?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Chromium Picolinate is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Chromium Picolinate’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Chromium Picolinate's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 53 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Chromium 53 references
- Cerulli J, Grabe DW, Gauthier I, et al. Chromium picolinate toxicity. Ann Pharmacother 1998;32:428-31. PubMed
- Urberg M, Zemel MB. Evidence for synergism between chromium and nicotinic acid in the control of glucose tolerance in elderly humans. Metabolism 1987;36:896-9. PubMed
- Mohamedshah FY, Moser-Veillon PB, Yamini S, et al. Distribution of a stable isotope of chromium (53Cr) in serum, urine, and breast milk in lactating women. Am J Clin Nutr 1998;67:1250-5. PubMed
- Wasser WG, Feldman NS, D'Agati VD. Chronic renal failure after ingestion of over-the-counter chromium picolinate. [letter]. Ann Intern Med 1997;126:410. PubMed
- Mertz W. Interaction of chromium with insulin: a progress report. Nutr Rev 1998;56:174-7. PubMed
- Anderson RA. Chromium, glucose intolerance and diabetes. J Am Coll Nutr 1998;17:548-55. PubMed
- McLeod MN, Gaynes BN, Golden RN. Chromium potentiation of antidepressant pharmacotherapy for dysthymic disorder in 5 patients. J Clin Psych 1999;60:237-40. PubMed
- Fowler JF Jr. Systemic contact dermatitis caused by oral chromium picolinate. Cutis 2000;65:116. DOI
- Trent LK, Thieding-Cancel D. Effects of chromium picolinate on body composition. J Sports Med Phys Fitness 1995;35:273-80.
- Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002.
- Rabinovitz H, Friedensohn A, Leibovitz A, et al. Effect of chromium supplementation on blood glucose and lipid levels in type 2 diabetes mellitus elderly patients. Int J Vitam Nutr Res 2004;74:178-82. PubMed
- Lanca S, Alves A, Vieira AI, et al. Chromium-induced toxic hepatitis. Eur J Intern Med 2002;13:518-20. PubMed
- Kockler DR, McCarthy MW, Lawson CL. Seizure activity and unresponsiveness after hydroxycut ingestion. Pharmacotherapy 2001;21:647-51.. PubMed
- Davidson JR, Abraham K, Connor KM, McLeod MN. Effectiveness of chromium in atypical depression: a placebo-controlled trial. Biol Psychiatry 2003;53:261-4.. PubMed
- Food Standards Agency. Medicines and Healthcare products Regulatory Agency (MHRA). Expert Group on Vitamins and Minerals. Available at: http://cot.food.gov.uk/sites/default/files/vitmin2003.pdf.
- Mouser JF, Hak EB, Helms RA, et al. Chromium and zinc concentrations in pediatric patients receiving long-term parenteral nutrition. Am J Health Syst Pharm 1999;56:1950-6. PubMed
- Stevens T, Qadri A, Zein NN. Two patients with acute liver injury associated with use of the herbal weight-loss supplement hydroxycut. Ann Intern Med 2005;142:477-8. PubMed
- Wani S, Weskamp C, Marple J, Spry L. Acute tubular necrosis associated with chromium picolinate-containing dietary supplement. Ann Pharmacother 2006;40:563-6. PubMed
- Kleefstra N, Houweling ST, Jansman FG, et al. Chromium treatment has no effect in patients with poorly controlled, insulin-treated type 2 diabetes in an obese Western population: a randomized, double-blind, placebo-controlled trial. Diabetes Care 2006;29: PubMed
- Martin J, Wang ZQ, Zhang XH, et al. Chromium picolinate supplementation attenuates body weight gain and increases insulin sensitivity in subjects with type 2 diabetes. Diabetes Care 2006;29:1826-32. PubMed
- Singer GM, Geohas J. The effect of chromium picolinate and biotin supplementation on glycemic control in poorly controlled patients with type 2 diabetes mellitus: a placebo-controlled, double-blinded, randomized trial. Diabetes Technol Ther 2006;8:636-43. PubMed
- John-Kalarickal J, Pearlman G, Carlson HE. New medications which decrease levothyroxine absorption. Thyroid 2007;17:763-5. PubMed
- Yazaki Y, Faridi Z, Ma Y, et al. A pilot study of chromium picolinate for weight loss. J Altern Complement Med 2010;16:291-9. PubMed
- Davis ML, Seaborn CD, and Stoecker BJ. Effects of over-the-counter drugs on chromium retention and urinary excretion in rats. Nutrition Research 1995;15(2):201-210.
- Young P, Turiansky G, Bonner M, and et al. Acute generalized exanthematous pustulosis induced by chromium picolinate. J.Am Acad.Dermatol. 1999;41(5 Pt 2):820-823. PubMed
- Gibb, H. J., Lees, P. S., Pinsky, P. F., and Rooney, B. C. Lung cancer among workers in chromium chemical production. Am J Ind.Med 2000;38(2):115-126. DOI
- Gibb, H. J., Lees, P. S., Pinsky, P. F., and Rooney, B. C. Clinical findings of irritation among chromium chemical production workers. Am J Ind.Med 2000;38(2):127-131. PubMed
- Pittler, M. H. and Ernst, E. Dietary supplements for body-weight reduction: a systematic review. Am.J.Clin Nutr. 2004;79(4):529-536. PubMed
- Pei, D., Hsieh, C. H., Hung, Y. J., Li, J. C., Lee, C. H., and Kuo, S. W. The influence of chromium chloride-containing milk to glycemic control of patients with type 2 diabetes mellitus: a randomized, double-blind, placebo-controlled trial. Metabolism 2 PubMed
- Hisatomi, K., Ishii, H., Hashiguchi, K., Seki, M., Ide, M., Sugiyama, K., Ishimoto, H., Nakayama, S., Mukae, H., and Kohno, S. Interstitial pneumonia caused by inhalation of fumes of nickel and chrome. Respirology. 2006;11(6):814-817. PubMed
- Kleefstra, N., Houweling, S. T., Bakker, S. J., Verhoeven, S., Gans, R. O., Meyboom-de Jong, B., and Bilo, H. J. Chromium treatment has no effect in patients with type 2 diabetes in a Western population: a randomized, double-blind, placebo-controlled tri DOI
- Parsons, A., Ingram, J., Inglis, J., Aveyard, P., Johnstone, E., Brown, K., Franklin, M., and Bermudez, I. A proof of concept randomised placebo controlled factorial trial to examine the efficacy of St John's wort for smoking cessation and chromium to pr
- Bagdon RE and Hazen RE. Skin permeation and cutaneous hypersensitivity as a basis for making risk assessments of chromium as a soil contaminant. Environ.Health Perspect. 1991;92:111-119. PubMed
- Bharmal, S. V., Moyes, V., Ahmed, S., and Grossman, A. Hypoglycaemia: possible mediation by chromium salt medication. Hormones.(Athens.) 2010;9(2):181-183. PubMed
- Krol, E., Krejpcio, Z., Byks, H., Bogdanski, P., and Pupek-Musialik, D. Effects of chromium brewer's yeast supplementation on body mass, blood carbohydrates, and lipids and minerals in type 2 diabetic patients. Biol.Trace Elem.Res. 2011;143(2):726-737.
- Unisa, S., Jagannath, P., Dhir, V., Khandelwal, C., Sarangi, L., and Roy, T. K. Population-based study to estimate prevalence and determine risk factors of gallbladder diseases in the rural Gangetic basin of North India. HPB (Oxford) 2011;13(2):117-125. PubMed
- Noda, S., Asano, Y., and Sato, S. Lichen planus in a patient with long-term exposure to chrome. Eur.J.Dermatol. 2011;21(3):417-418. PubMed
- Xiang, J., Sun, Z., and Huan, J. N. Intensive chromic acid burns and acute chromium poisoning with acute renal failure. Chin Med.J.(Engl.) 7-5-2011;124(13):2071-2073.
- Chhabra, D., Oda, K., Jagannath, P., Utsunomiya, H., Takekoshi, S., and Nimura, Y. Chronic heavy metal exposure and gallbladder cancer risk in India, a comparative study with Japan. Asian Pac.J.Cancer Prev. 2012;13(1):187-190. PubMed
- Huszonek, J. Over-the-counter chromium picolinate. Am J Psychiatry 1993;150(10):1560-1561. PubMed
- Bunner S and McGinnis R. Chromium-induced hypoglycemia. Psychosomatics 1998;39(3):298-299. PubMed
- Martin, W. R. and Fuller, R. E. Suspected chromium picolinate-induced rhabdomyolysis. Pharmacotherapy 1998;18(4):860-862. DOI
- Proctor, D. M., Fredrick, M. M., Scott, P. K., Paustenbach, D. J., and Finley, B. L. The prevalence of chromium allergy in the United States and its implications for setting soil cleanup: a cost-effectiveness case study. Regul.Toxicol Pharmacol 1998;28(1 PubMed
- De Marchi S, Cecchin E, De Marchi SU. Systemic allergic dermatitis resulting from oral administration of chromium with a food supplement. Contact Dermatitis 2014;70(2):123-5. PubMed
- Hedberg YS, Gumulka M, Lind ML, Matura M, Lidén C. Severe occupational chromium allergy despite cement legislation. Contact Dermatitis. 2014;70(5):321-3. PubMed
- Thyssen JP, Jellesen MS, Møller P, Menné T, Johansen JD. Allergic chromium dermatitis from wearing 'chromium-free' footwear. Contact Dermatitis 2014;70(3):185-7. PubMed
- Liu Y, Cotillard A, Vatier C, et al. A Dietary Supplement Containing Cinnamon, Chromium and Carnosine Decreases Fasting Plasma Glucose and Increases Lean Mass in Overweight or Obese Pre-Diabetic Subjects: A Randomized, Placebo-Controlled Trial. PLoS One.
- Jamilian M, Asemi Z. Chromium Supplementation and the Effects on Metabolic Status in Women with Polycystic Ovary Syndrome: A Randomized, Double-Blind, Placebo-Controlled Trial. Ann Nutr Metab. 2015;67(1):42-8. PubMed
- Guimarães MM, Carvalho AC, Silva MS. Effect of chromium supplementation on the glucose homeostasis and anthropometry of type 2 diabetic patients: Double blind, randomized clinical trial: Chromium, glucose homeostasis and anthropometry. J Trace Elem Med Bi PubMed
- Paiva AN, Lima JG, Medeiros AC, et al. Beneficial effects of oral chromium picolinate supplementation on glycemic control in patients with type 2 diabetes: A randomized clinical study. J Trace Elem Med Biol. 2015;32:66-72. PubMed
- Yin RV, Phung OJ. Effect of chromium supplementation on glycated hemoglobin and fasting plasma glucose in patients with diabetes mellitus. Nutr J. 2015;14:14. PubMed
- Jamilian M, Zadeh Modarres S, Amiri Siavashani M, et al. The influences of chromium supplementation on glycemic control, markers of cardio-metabolic risk, and oxidative stress in infertile polycystic ovary syndrome women candidate for in vitro fertilizati
- Alinaghi F, Thyssen JP, Zachariae C, Johansen JD. No immediate effect of regulatory reduction of chromium in leather among adult patients with chromium allergy. Contact Dermatitis 2021;85(5):514-522. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC