Interactions on record — worth a quick check against your medications. Based on 3 of 5 ingredients. Check your meds →
Dietary supplement

Collagen + Protein Bone Broth Vanilla Ingredients & Drug Interactions

by Terra Origin

Collagen + Protein Bone Broth Vanilla label
See full label image
Powder Category: Botanical With Nutrients
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Collagen + Protein Bone Broth Vanilla against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Collagen + Protein Bone Broth Vanilla is a dietary supplement by Terra Origin with 5 active ingredients. Its ingredients are commonly taken for replacing fluids and electrolytes, preventing dehydration during exercise or illness, treating low blood sodium (under medical care).Based on those ingredients, 306 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Stevia leaf extract, Sodium, Potassium. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Collagen + Protein Bone Broth Vanilla by Terra Origin

Ask about any prescription or over-the-counter medication and we check it for interactions with Collagen + Protein Bone Broth Vanilla by Terra Origin — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Collagen + Protein Bone Broth Vanilla by Terra Origin

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 4 of its 4 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

This powder contains 4 active ingredients: sodium, potassium, medium chain triglycerides, and stevia leaf extract. Sodium and potassium are electrolytes that help regulate fluid balance and nerve function in your body.

Medium chain triglycerides are a type of fat, and stevia is a plant-derived sweetener. The product also includes inactive ingredients such as collagen hydrolysate, broth protein powders, maltodextrin, corn starch, natural flavors, and silicon dioxide.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: joint support, skin health and protein nutrition.
  • We looked for evidence on: Diabetes, Hypertension, Obesity, Joint flexibility, Cartilage health, Hair and nail health.
  • The closest evidence on file: Stevia is rated "Insufficient Reliable Evidence To Rate" for Diabetes (Natural Medicines).
  • Also on file: Stevia is rated "Insufficient Reliable Evidence To Rate" for Hypertension, Obesity.

The evidence for this product's active ingredients is limited. Sodium's effectiveness is rated from insufficient evidence (for heart failure and bipolar disorder) to possibly or likely effective for specific medical uses like cystic fibrosis and preventing kidney damage from amphotericin B, but those aren't typical reasons someone would use a bone broth powder.

Potassium, stevia, and medium chain triglycerides have no effectiveness ratings on file for us, meaning the evidence isn't established in our data.

The evidence, ingredient by ingredient Sodium Potassium Stevia

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 3 of the 3 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 3 of 3.
  • General safety write-ups exist for 3 of 3.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Sodium is well tolerated at normal dietary amounts, but too much is linked to high blood pressure and heart strain—avoid sodium supplements or very high intake without medical advice. Potassium from a normal diet is fine, but supplements can cause dangerously high blood levels in some people, especially those with kidney disease.

Stevia in typical food amounts appears well tolerated; most minor side effects like headache, dizziness, nausea, and numbness resolve after the first week. Regarding pregnancy and breastfeeding: sodium is likely safe during pregnancy but possibly unsafe during lactation, and potassium is likely safe during both.

We hold no pregnancy or breastfeeding data for stevia or medium chain triglycerides—talk with your doctor or pharmacist for personalized advice.

Side effects, ingredient by ingredient Sodium Potassium Stevia

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 3 of the 3 matched ingredients can interact with medications — Stevia, Potassium, Sodium.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications; lithium.
  • For scale: 306 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Double-check these with your pharmacist before starting: blood pressure medications (antihypertensives), because sodium can reduce their effectiveness; lithium, because both sodium and stevia can alter its levels; corticosteroids, because sodium increases the risk of dangerously high sodium levels; potassium-sparing diuretics and ACE inhibitors or ARBs, because potassium from this product raises the risk of dangerously high potassium levels; and didanosine, tolvaptan, sodium phosphates, or other sodium-containing drugs.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

This product is a bone broth powder, not a supplement designed to treat or prevent disease. If you take blood pressure medications, heart drugs, or lithium, you need to check your exact prescriptions before using it—the sodium and potassium content could interfere.

Anyone with kidney disease should talk to their doctor first. For most other people without those medications, the sodium and potassium amounts in a typical serving of bone broth powder are unlikely to cause problems, but run your medications through the checker below to be sure.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 3 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jul 27, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Collagen + Protein Bone Broth Vanilla, straight from the product label.

Brand Terra Origin
Barcode (UPC) 857668007106
Net contents 16.43 Oz(s); 466 Gram(s)
Market status On market
Date entered into DSLD Jul 27, 2021
DSLD ID 247881
Product type Botanical With Nutrients
Supplement form Powder
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Collagen + Protein Bone Broth Vanilla by Terra Origin, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
24.73 Gram(s)
Maximum serving Sizes:
24.73 Gram(s)
Servings per container
20
UPC/BARCODE
857668007106
IngredientAmount% DV
Calories90 Calorie(s)--
Total Carbohydrates1 Gram(s)1%
Protein18 Gram(s)--
Sodium210 mg9%
Potassium230 mg5%
Total Fat1.5 Gram(s)2%
Medium Chain Triglycerides1.5 Gram(s)--
Stevia leaf extract225 mg--
Saturated Fat1.5 Gram(s)8%

Other ingredients: Collagen Hydrolysate, Turkey Broth Protein powder, Chicken Broth powder, Maltodextrin, Corn Starch, Natural Flavors, Silicon Dioxide

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Contains types I and III collagen from real whole food sources. Collagen + Protein Bone Broth also contains important nutrient cofactors found in real bone broth, giving you delicious flavor along with vital ingredients to improve your health.

Benefits Made with collagen for joint support 17 grams protein per serving from chicken, beef and turkey 2 grams carbs

17 g protein/serving 13.3 collage/serving

18 grams of protein per serving Supports daily recommended protein of .8-2.2 grams per kilogram of body weight depending on lifestyle Medium Chain Triglycerides 1.5 g Increases endurance and performance, improves muscle strength and function and aids in weight loss Bovine Collagen Hydrolysate Protects and repairs joint cartilage, bone matter, tendons and ligaments, builds muscle, burns fat and strengthens the lining of the digestive tract reducing permeability Turkey and Chicken Broth Protein Powder Helps to heal leaky gut syndrome, boosts the immune system, fights food allergies and sensitivities, repairs joints and tendons and lessens cellulite

Formulation

Dairy free, gluten free, preservative free, soy free

Supports joint comfort, flexibility and cartilage health Supports healthy hair, skin and nails Source of medium chain triglycerides, a powerhouse of sustained energy fuel during exercise

Non GMO

Supports joint comfort Supports healthy hair, skin & nails

Dairy free Gluten free Preservative free Soy free Non GMO

100% Grass fed Made in USA GMP Bone broth deserves its place among the healing superfoods flooding the market, but making it yourself is unbelievably time consuming! When you want ultimate joint and cartilage support, collagen levels restored in your hair, skin and nails and improved digestion, bone broth is the ideal supplement. We have created a powder that harnesses all of the qualities of freshly made bone broth without taking all your time.

If you suffer from IBS, leaky gut syndrome or have food allergies and sensitivities, taking this supplement daily can dramatically improve and completely heal certain digestive ailments. It can restore the gut lining decreasing permeability, support the growth of healthy bacteria in the digestive tract and provides numerous trace minerals and amino acids along with high doses of collagen and gelatin in an easy to digest form that soothes the GI tract. Bone broth protein is a great way to get your daily protein shake while also supplying your body with skeletal support. The collagen not only works to repair tendons and ligaments, it lubricates joints, supports bone matter helps build lean muscle mass and reduces cellulite. As part of a regular exercise routing, this supplement can increase weight loss, boost your energy and stamina during workouts and increase overall muscle strength. The daily protein will help muscles recover faster after use and rebuild bigger and stronger when strength training. You will see benefits externally and experience them internally making this bone broth supplement an all around support for a healthy lifestyle.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

General Statements

At Terra Origin, we seek to improve the mind and body's well-being with all-natural and effective, scientifically studied ingredients. Terra Origin believes in the power of this combination to improve ones overall health and restore balance to life, with nutrients both of the earth and created within it. Our supplements promote a better inside and outside, giving you the power to live life as the best version of yourself.

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Collagen + Protein Bone Broth Vanilla by Terra Origin label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Collagen + Protein Bone Broth Vanilla label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Collagen + Protein Bone Broth Vanilla by Terra Origin

These are the 5 active ingredients this product is made of. Select any to open its full monograph.

Serving size24.73 Gram(s) Dosage formPowder Servings per container20 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Protein

18 Gram(s) per serving

Sodium

Interacts with
205 drugs
210 mg per serving

Sodium is an essential mineral and electrolyte your body needs to balance fluids, support nerves, and help muscles work. Most people in modern diets g...

Sodium monograph & interactions

Potassium

Interacts with
62 drugs
230 mg per serving

Potassium is an essential mineral your body needs for nerve signals, muscle function, and a steady heartbeat, and most people get enough from a balanc...

Potassium monograph & interactions

Medium Chain Triglycerides

1.5 Gram(s) per serving

Stevia leaf extract

Interacts with
259 drugs
225 mg per serving

Stevia is a plant-based, calorie-free sweetener that is widely used as a sugar alternative and is considered safe in normal food amounts by major regu...

Stevia leaf extract monograph & interactions

Other (inactive) ingredients: Collagen Hydrolysate, Turkey Broth Protein powder, Chicken Broth powder, Maltodextrin, Corn Starch, Natural Flavors, Silicon Dioxide. These complete the product’s ingredient list but are not active constituents.

Interaction report

Collagen + Protein Bone Broth Vanilla by Terra Origin Drug Interactions

Want to check YOUR meds against Collagen + Protein Bone Broth Vanilla?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
306Drugs
220 Moderate 86 Minor

Ingredients driving the most interactions

Stevia leaf extract 259
Sodium 205
Potassium 62

Individual Drug Interactions

The ingredients in Collagen + Protein Bone Broth Vanilla interact with 306 drugs. Click any drug to see the details.

3 of the 5 ingredients in Collagen + Protein Bone Broth Vanilla interact with drugs. Each result below shows which ingredient is responsible. Stevia leaf extract Sodium Potassium

Each ingredient & the kinds of drugs it affects

For each ingredient in Collagen + Protein Bone Broth Vanilla with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Stevia leaf extract3 drug types · 259 drugs

Lithium

Theoretically, stevia might decrease clearance and increase levels of lithium.
Animal research suggests that stevia extracts might have diuretic activity. Theoretically, increased reabsorption of lithium along with sodium might reduce excretion and increase levels of lithium.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, stevia might increase the risk for hypoglycemia when combined with antidiabetes drugs.
Preliminary clinical research in patients with type 2 diabetes suggests that taking a single dose of stevia extract 1000 mg reduces postprandial blood glucose levels when taken with a meal. However, other clinical research in patients with type 1 or type 2 diabetes suggests that taking stevioside 250 mg three times daily does not significantly affect blood glucose levels or glycated hemoglobin (HbA1C) after three months of treatment.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, combining stevia or stevia constituents with antihypertensive agents might increase the risk of hypotension.
Stevia extract and stevioside might lower blood pressure in patients with hypertension. However, other clinical research suggests that stevioside does not significantly lower blood pressure in patients with hypertension.

Likelihood Possible Evidence D
Stevia leaf extract full monograph & interactions

Sodium7 drug types · 205 drugs

Antihypertensive Drugs

Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.
High intake of dietary sodium can increase systolic and diastolic blood pressure. Also, high intake of sodium may necessitate increased use of antihypertensive medications to achieve blood pressure control in some patients, such as those with chronic kidney disease.

Likelihood Probable Evidence A
Corticosteroids

Concomitant use of mineralocorticoids and some glucocorticoids with sodium supplements might increase the risk of hypernatremia.
Mineralocorticoids and some glucocorticoids (corticosteroids) cause sodium retention. This effect is dose-related and depends on mineralocorticoid potency. It is most common with hydrocortisone, cortisone, and fludrocortisone, followed by prednisone and prednisolone.

Likelihood Possible Evidence D
Didanosine (Videx)

Concomitant use of didanosine with additional sodium from dietary or supplemental sources may increase the risk of hypernatremia.
Didanosine formulations contain a significant amount of sodium.

Likelihood Probable Evidence C
Lithium

Altering dietary intake of sodium might alter the levels and clinical effects of lithium.
High sodium intake can reduce plasma concentrations of lithium by increasing lithium excretion. Reducing sodium intake can significantly increase plasma concentrations of lithium and cause lithium toxicity in patients being treated with lithium carbonate. Stabilizing sodium intake is shown to reduce the percentage of patients with lithium level fluctuations above 0.8 mEq/L. Patients taking lithium should avoid significant alterations in their dietary intake of sodium.

Likelihood Probable Evidence B
Sodium Phosphates

Theoretically, concomitant use of sodium phosphate with sodium supplements might increase the risk of hypernatremia.
Use of high doses (> 45 mL in 24 hours) of sodium phosphate, such as those used for bowel cleansing before surgery, can lead to serious electrolyte disturbances, including hypernatremia. The risk of hypernatremia is highest in the elderly and people with other risk factors for electrolyte disturbances.

Likelihood Possible Evidence D
Sodium-Containing Drugs

Concomitant use of sodium-containing drugs with additional sodium from dietary or supplemental sources may increase the risk of hypernatremia and long-term sodium-related complications.
The Chronic Disease Risk Reduction (CDRR) intake level of 2.3 grams of sodium daily indicates the intake at which it is believed that chronic disease risk increases for the apparently healthy population. Some medications contain high quantities of sodium. When used in conjunction with sodium supplements or high-sodium diets, the CDRR may be exceeded. Additionally, concomitant use may increase the risk for hypernatremia; this risk is highest in the elderly and people with other risk factors for electrolyte disturbances.

Likelihood Possible Evidence D
Tolvaptan (Samsca)

Theoretically, concomitant use of tolvaptan with sodium might increase the risk of hypernatremia.
Tolvaptan is a vasopressin receptor 2 antagonist that is used to increase sodium levels in patients with hyponatremia. Patients taking tolvaptan should use caution with the use of sodium salts such as sodium chloride.

Likelihood Probable Evidence C
Sodium full monograph & interactions

Potassium3 drug types · 62 drugs

Ace Inhibitors (Aceis)

Using ACEIs with high doses of potassium increases the risk of hyperkalemia.
ACEIs block the actions of the renin-angiotensin-aldosterone system and reduce potassium excretion. Concomitant use of these drugs with potassium supplements increases the risk of hyperkalemia. However, concomitant use of these drugs with moderate dietary potassium intake (about 3775-5200 mg daily) does not increase serum potassium levels.

Likelihood Likely Evidence C
Angiotensin Receptor Blockers (Arbs)

Using ARBs with high doses of potassium increases the risk of hyperkalemia.
ARBs block the actions of the renin-angiotensin-aldosterone system and reduce potassium excretion. Concomitant use of these drugs with potassium supplements increases the risk of hyperkalemia. However, concomitant use of these drugs with moderate dietary potassium intake (about 3775-5200 mg daily) does not increase serum potassium levels.

Likelihood Likely Evidence C
Potassium-Sparing Diuretics

Concomitant use increases the risk of hyperkalemia.
Using potassium-sparing diuretics with potassium supplements increases the risk of hyperkalemia.

Likelihood Likely Evidence C
Potassium full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Collagen + Protein Bone Broth Vanilla, from the product label.

Terra Origin

See all Terra Origin products
Name
Terra Origin
Web Address
terraorigin.com
Pharmacist Counseling Corner

Collagen + Protein Bone Broth Vanilla by Terra Origin: Common Questions

Does Collagen + Protein Bone Broth Vanilla by Terra Origin interact with any medications?
Yes. Based on its ingredients, Collagen + Protein Bone Broth Vanilla has a known interaction with 306 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Collagen + Protein Bone Broth Vanilla contains 5 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I use this if I take blood pressure medication?
Not without checking first. Sodium in this product can reduce how well blood pressure drugs work, and some blood pressure medications (ACE inhibitors and ARBs) combined with potassium raise serious safety concerns. Run your specific medications through the checker on this page, then talk to your pharmacist.
Is this safe during pregnancy?
The sodium in this product is likely safe during pregnancy, but we don't hold pregnancy safety data for stevia or medium chain triglycerides. Talk with your doctor or pharmacist about whether this product is right for you during pregnancy.
What are the common side effects?
Stevia can cause headache, dizziness, nausea, or numbness, but these usually go away after the first week. At normal sodium and potassium levels from food, side effects are rare. High potassium levels can cause stomach upset, but that's not typical from a bone broth powder.
Can I use this if I have kidney disease?
You should talk to your doctor first. Potassium can build up dangerously in people with kidney disease, and you need medical guidance about sodium intake too.
Will this help me lose weight or manage blood sugar?
We don't have reliable evidence that the ingredients in this product work for weight loss or blood sugar control. It's marketed as a bone broth protein powder, not as a treatment for those conditions.
Does this contain any fillers?
Yes—the inactive ingredients include maltodextrin, corn starch, silicon dioxide, natural flavors, and the broth protein powders. If you're looking to avoid certain fillers, check the label for which ones you want to skip.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Collagen + Protein Bone Broth Vanilla label
Go deeper

The Full Monographs Behind Collagen + Protein Bone Broth Vanilla’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Sodium

Interacts with 205 drugs

Sodium is an essential mineral and electrolyte your body needs to balance fluids, support nerves, and help muscles work. Most people in modern diets get more than enough—often too much—from...

Read the full Sodium monograph → Herb & supplement monograph

Potassium

Interacts with 62 drugs

Potassium is an essential mineral your body needs for nerve signals, muscle function, and a steady heartbeat, and most people get enough from a balanced diet rich in fruits and vegetables. P...

Read the full Potassium monograph → Herb & supplement monograph

Stevia

Interacts with 259 drugs

Stevia is a plant-based, calorie-free sweetener that is widely used as a sugar alternative and is considered safe in normal food amounts by major regulators. Purified stevia extracts have a...

Read the full Stevia monograph →
Sources

Sources & How We Checked

Collagen + Protein Bone Broth Vanilla's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 60 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Sodium 38 references
  1. Garabedian-Ruffalo SM, Ruffalo RL. Drug and nutrient interactions. Am Fam Physician 1986;33:165-74.
  2. Food and Drug Administration Science Background: Safety of Sodium Phosphates Oral Solution. September 17, 2001. Available at: http://www.fda.gov/cder/drug/safety/sodiumphospate.htm
  3. Coton T, Mallaret C, Coilliot C, Carre D, Guisset M. Severe acute ulcerated gastritis induced by salt. Presse Med 2009;38(3):499-500. PubMed
  4. Frings-Meuthen P, Buehlmeier J, Baecker N, et al. High sodium chloride intake exacerbates immobilization-induced bone resorption and protein losses. J Appl Physiol 2011;111(2):537-542. PubMed
  5. Frings-Meuthen P, Baecker N, Heer M. Low-grade metabolic acidosis may be the cause of sodium chloride-induced exaggerated bone resorption. J Bone Miner Res 2008;23(4):517-524. PubMed
  6. Alam S, Johnson AG. A meta-analysis of randomised controlled trials (RCT) among healthy normotensive and essential hypertensive elderly patients to determine the effect of high salt (NaCl) diet of blood pressure. J Hum Hypertens 1999;13(6):367-74.
  7. Boudville N, Ward S, Benaroia M, House AA. Increased sodium intake correlates with greater use of antihypertensive agents by subjects with chronic kidney disease. Am J Hypertens 2005;18(10):1300-5. PubMed
  8. Bennett WM. Drug interactions and consequences of sodium restriction. Am J Clin Nutr 1997;65(2 Suppl):678S-681S. PubMed
  9. Okusa MD, Crystal LJ. Clinical manifestations and management of acute lithium intoxication. Am J Med 1994;97(4):383-9. PubMed
  10. Food and Nutrition Board, Institute of Medicine. Dietary reference intakes for water, potassium, sodium, chloride, and sulfate. Washington, DC: National Academy Press, 2005. Available at: http://www.nap.edu/openbook.php?record_id=10925. DOI
  11. D'Elia L, Rossi G, Ippolito R, Cappuccio FP, Strazzullo P. Habitual salt intake and risk of gastric cancer: a meta-analysis of prospective studies. Clin Nutr 2012;31(4):489-98. PubMed
  12. Goldsmith SR. Hyponatremia in heart failure: time for a trial. J Card Fail 2013;19(6):398-400. PubMed
  13. Willocks L, Brettle R, Keen J, Valentine C, Pinching AJ. Formulations of didanosine (ddI) and salt overload. Lancet 1992;339(8786):190.
  14. Chen L, Zhang Z, Chen W, Whelton PK, Appel LJ. Lower Sodium Intake and Risk of Headaches: Results From the Trial of Nonpharmacologic Interventions in the Elderly. Am J Public Health. 2016;106(7):1270-5. PubMed
  15. Cook NR, Appel LJ, Whelton PK. Lower levels of sodium intake and reduced cardiovascular risk. Circulation. 2014;129(9):981-9. PubMed
  16. Cook NR, Appel LJ, Whelton PK. Sodium Intake and All-Cause Mortality Over 20 Years in the Trials of Hypertension Prevention. J Am Coll Cardiol. 2016;68(15):1609-1617. PubMed
  17. Mente A, O'Donnell M, Rangarajan S, et al. Associations of urinary sodium excretion with cardiovascular events in individuals with and without hypertension: a pooled analysis of data from four studies. Lancet. 2016;388(10043):465-75. PubMed
  18. Moosavian SP, Haghighatdoost F, Surkan PJ, Azadbakht L. Salt and obesity: a systematic review and meta-analysis of observational studies. Int J Food Sci Nutr. 2017;68(3):265-277. PubMed
  19. O'Donnell M, Mente A, Rangarajan S, et al. Urinary sodium and potassium excretion, mortality, and cardiovascular events. N Engl J Med. 2014;371(7):612-23. DOI
  20. Poggio R, Gutierrez L, Matta MG, Elorriaga N, Irazola V, Rubinstein A. Daily sodium consumption and CVD mortality in the general population: systematic review and meta-analysis of prospective studies. Public Health Nutr. 2015;18(4):695-704. PubMed
  21. Stallings VA, Harrison M, Oria M; Committee to Review the Dietary Reference Intakes for Sodium and Potassium, Food and Nutrition Board, Health and Medicine Division, National Academies of Sciences, Engineering, and Medicine. Washington (DC): National Acad
  22. Mahtani KR, Heneghan C, Onakpoya I, et al. Reduced Salt Intake for Heart Failure: A Systematic Review. JAMA Intern Med. 2018 Dec 1;178(12):1693-1700. PubMed
  23. Yancy CW. Sodium Restriction in Heart Failure: Too Much Uncertainty-Do the Trials. JAMA Intern Med. 2018 Dec 1;178(12):1700-1701. PubMed
  24. He FJ, Campbell NRC, Ma Y, MacGregor GA, Cogswell ME, Cook NR. Errors in estimating usual sodium intake by the Kawasaki formula alter its relationship with mortality: implications for public health. Int J Epidemiol. 2018;47(6):1784-1795. PubMed
  25. Murthy K, Ondrey GJ, Malkani N, et al. THE EFFECTS OF HYPONATREMIA ON BONE DENSITY AND FRACTURES: A SYSTEMATIC REVIEW AND META-ANALYSIS. Endocr Pract. 2019;25(4):366-378. PubMed
  26. Messerli FH, Hofstetter L, Syrogiannouli L, et al. Sodium intake, life expectancy, and all-cause mortality. Eur Heart J 2021;42(21):2103-2112. PubMed
  27. Graudal NA, Hubeck-Graudal T, Jurgens G. Effects of low sodium diet versus high sodium diet on blood pressure, renin, aldosterone, catecholamines, cholesterol, and triglyceride. Cochrane Database Syst Rev 2020;12(12):CD004022. PubMed
  28. Giatti S, Santos RB, Aielo AN, et al. Association of sodium with obstructive sleep apnea. The ELSA-Brasil study. Ann Am Thorac Soc 2021;18(3):502-510. PubMed
  29. Nan X, Lu H, Wu J, et al. The interactive association between sodium intake, alcohol consumption and hypertension among elderly in northern China: a cross-sectional study. BMC Geriatr 2021;21(1):135. PubMed
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Potassium 12 references
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  5. Altieri, P. I., Herrero, C., Suero, R., and Ortiz, A. Bleeding duodenal ulcer in a patient taking slow-releasing potassium tablets. Bol.Asoc.Med P.R. 1977;69(8):276.
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  12. Stallings VA, Harrison M, Oria M; Committee to Review the Dietary Reference Intakes for Sodium and Potassium, Food and Nutrition Board, Health and Medicine Division, National Academies of Sciences, Engineering, and Medicine. Washington (DC): National Acad

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Stevia 10 references
  1. Chan P, Xu DY, Liu JC, et al. The effect of stevioside on blood pressure and plasma catecholamines in spontaneously hypertensive rats. Life Sci 1998;63:1679-84. PubMed
  2. Melis MS. A crude extract of Stevia rebaudiana increases the renal plasma flow of normal and hypertensive rats. Braz J Med Biol Res 1996;29:669-75.
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See these in context on the Stevia monograph →

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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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