Creatine Muscle Complex Ingredients & Drug Interactions
by Maxi Health
What is this page for?
First and foremost: checking Creatine Muscle Complex against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Creatine Muscle Complex is a dietary supplement by Maxi Health with 5 active ingredients. Its ingredients are commonly taken for exercise performance and endurance, heart health, energy support.Based on those ingredients, 514 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Magnesium, L-Taurine, Bioenergy Ribose. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Creatine Muscle Complex by Maxi Health
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HelloPharmacist Scorecard of Creatine Muscle Complex by Maxi Health
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
Creatine Muscle Complex contains four active ingredients. L-taurine is an amino acid that plays a role in heart and muscle function.
Creatine supports muscle strength and athletic performance by helping muscles produce energy. Magnesium is a mineral involved in muscle and nerve function.
Bioenergy Ribose is a sugar that cells use to make energy. The product contains no inactive ingredients.
Does it work?
Moderate evidence
Evidence for this product's ingredients is mixed. Taurine is possibly effective for hepatitis and congestive heart failure, but possibly ineffective for obesity.
Creatine is possibly effective for muscle strength, athletic performance, and sarcopenia (age-related muscle loss), but possibly ineffective for Huntington disease and low bone density. Magnesium is effective for constipation and indigestion, and for correcting low magnesium levels and preventing pre-eclampsia in pregnancy.
Ribose shows insufficient evidence to rate for athletic performance, restless legs syndrome, heart failure, muscle soreness, or recovery after heart surgery, and is possibly ineffective for McArdle disease.
How safe is it?
Well-documented data
Taurine and magnesium are generally well tolerated in typical doses. Taurine's most common side effects are constipation, diarrhea, and indigestion; rare hypersensitivity reactions have occurred in people sensitive to sulfites or sulfur-containing compounds.
Magnesium commonly causes diarrhea, nausea, and vomiting. Creatine is generally well tolerated but commonly causes dehydration, diarrhea, muscle cramps, and water retention; those with kidney problems should be careful.
Ribose is often well tolerated short-term but commonly causes diarrhea, nausea, headache, and low blood sugar; long-term safety is not well studied. Taurine in pregnancy and lactation is likely safe.
Creatine should be avoided in pregnancy and lactation due to insufficient safety data. Magnesium is likely safe in pregnancy but only under doctor guidance, and possibly safe in lactation with doctor approval.
Ribose should be avoided in both pregnancy and lactation due to insufficient safety data.
Meds to double-check
Major interaction found
Before taking this product, check with your doctor or pharmacist if you take levodopa/carbidopa (Parkinson's medication)—this is a major interaction. Also double-check if you take skeletal muscle relaxants, potassium-sparing diuretics, calcium channel blockers (blood pressure drugs), antacids or acid-reducers, sulfonylureas (diabetes drugs), quinolone antibiotics, bisphosphonates (osteoporosis drugs), antihypertensive drugs (blood pressure medication), lithium (mood stabilizer), antidiabetes drugs, or insulin.
The bottom line
Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Major medication interactions have been identified, and safety information is well characterized.
This product may appeal to people seeking muscle support during training or those with low magnesium or certain heart conditions, but it carries real medication interactions—especially if you take Sinemet, blood pressure drugs, diabetes medications, or antibiotics. Those with kidney problems, diabetes, or bipolar disorder should be extra cautious.
Talk with your doctor or pharmacist before starting, especially if you take any regular medications.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 4 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Feb 22, 2024.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Creatine Muscle Complex, straight from the product label.
| Brand | Maxi Health |
|---|---|
| Barcode (UPC) | 753406391028 |
| Net contents | 198 Gram(s); 6.98 Ounce(s) |
| Market status | On market |
| Date entered into DSLD | Feb 22, 2024 |
| DSLD ID | 304168 |
| Product type | Other Combinations |
| Supplement form | Powder |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Vegan, Vegetarian, Adult (18 - 50 Years), Kosher, Gluten Free, Dairy Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Creatine Muscle Complex by Maxi Health, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Calories | 18 Calorie(s) | -- |
| Total Carbohydrates | 1 Gram(s) | 2% |
| Added Sugars | 1 Gram(s) | 2% |
| Protein | 2.5 Gram(s) | 5% |
| L-Taurine | 500 mg | -- |
| Creatine | 2250 mg | -- |
| Magnesium | 400 mg | 95% |
| Creatine MagnaPower | 5000 mg | -- |
| Bioenergy Ribose | 1000 mg | -- |
Other ingredients: None
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions
Directions: Mix one (1) level scoop with water once or twice daily, or as directed.
Storage
Store tightly closed in a cool, dry place.
Precautions
Keep out of reach of children.
FDA Disclaimer Statement
This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Formulation
Vegetarian
Doctor formulated
Muscle support Body builder
This product contains no animal products, soy, wheat, gluten, sugar, salt, milk, yeast, artificial flavors, colorings or preservatives.
For better health and all
Formula
Certified-kosher
UK Vadd Hakashrus D'udvary (Kosher)
OU (Kosher)
BDZ Edah Charedis - Orthodox Council of Jerusalem (Kosher)
Seals/Symbols
UK Vadd Hakashrus D'udvary (Kosher)
BDZ Edah Charedis - Orthodox Council of Jerusalem (Kosher)
This product was manufactured in a GMP Certified facility Certified GMP facility
FDA Statement of Identity
Dietary Supplement
General Statements
Total wellness
Total wellness
Brand IP Statement(s)
Maxi Health True to total wellness
Creating MagnaPower is a registered trademark of Albion Laboratories, Inc.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Creatine Muscle Complex by Maxi Health label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Creatine Muscle Complex by Maxi Health
These are the 5 active ingredients this product is made of. Select any to open its full monograph.
Serving size6.6 Gram(s) Dosage formPowder Servings per container30 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Protein
L-Taurine
Interacts with173 drugs
Taurine is an amino acid your body makes naturally and that you also get from animal foods. It is widely used in energy drinks and sports supplements,...
L-Taurine monograph & interactionsMagnesium
Interacts with295 drugs
Magnesium is an essential mineral your body needs for muscles, nerves, blood pressure, and many other functions, and supplements are useful for preven...
Magnesium monograph & interactionsCreatine MagnaPower
Interacts with295 drugs
Magnesium is an essential mineral your body needs for muscles, nerves, blood pressure, and many other functions, and supplements are useful for preven...
Creatine MagnaPower monograph & interactions- › Creatine
Bioenergy Ribose
Interacts with86 drugs
Ribose (D-ribose) is a simple sugar your body makes naturally and uses to build energy molecules like ATP. Some people take it for fatigue, fibromyalg...
Bioenergy Ribose monograph & interactionsOther (inactive) ingredients: None. These complete the product’s ingredient list but are not active constituents.
Creatine Muscle Complex by Maxi Health Drug Interactions
HelloPharmacist Interaction Report
Creatine Muscle Complex by Maxi Health contains four ingredients, and through its taurine, magnesium, and ribose content, it interacts with a range of medications.
The most serious interaction is magnesium with levodopa/carbidopa (Sinemet), a Parkinson's medication: magnesium can reduce levodopa levels by 35% and carbidopa levels by 81%, which may reduce the medication's effectiveness.
Read the full breakdown — every affected drug type, severity by severity
Magnesium also has moderate interactions with skeletal muscle relaxants (which it can strengthen and prolong), potassium-sparing diuretics (which may raise magnesium levels too high), calcium channel blockers (blood pressure drugs where magnesium may add extra effect), antacids or acid-reducers (which may reduce magnesium's laxative action), sulfonylureas (diabetes drugs where magnesium may boost their effect and lower blood sugar more), quinolone antibiotics (where magnesium reduces their absorption), and bisphosphonates (osteoporosis drugs where magnesium reduces absorption). Taurine has moderate interactions with antihypertensive drugs (blood pressure medications that taurine may strengthen) and lithium (a bipolar mood stabilizer where taurine may raise levels).
Ribose carries moderate interactions with antidiabetes drugs and insulin, both of which may lower blood sugar further when combined with ribose.
Creatine, which makes up part of this product, shows no interactions documented in our data. Altogether, these interactions span 514 individual medications.
Check your exact medications with the search tool on this page before starting this product, and talk with your doctor or pharmacist about whether it's safe for you.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Creatine Muscle Complex?
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Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Creatine Muscle Complex interact with 514 drugs. Click any drug to see the details.
3 of the 5 ingredients in Creatine Muscle Complex interact with drugs. Each result below shows which ingredient is responsible. Magnesium L-Taurine Bioenergy Ribose
Benserazide, LevodopaMadopar, Prolopa
How Benserazide, Levodopa interacts with Creatine Muscle Complex — through 1 ingredient. Tap an ingredient for the detail:
Creatine MagnapowerLevodopa/carbidopa (sinemet) Major
Interaction Summary
Magnesium can reduce the bioavailability of levodopa/carbidopa.
Read the full Creatine Magnapower + Benserazide, Levodopa interactionCarbidopaLodosyn
How Carbidopa interacts with Creatine Muscle Complex — through 1 ingredient. Tap an ingredient for the detail:
Creatine MagnapowerLevodopa/carbidopa (sinemet) Major
Interaction Summary
Magnesium can reduce the bioavailability of levodopa/carbidopa.
Read the full Creatine Magnapower + Carbidopa interactionCarbidopa, LevodopaDhivy, Rytary, Sinemet, Sinemet CR
How Carbidopa, Levodopa interacts with Creatine Muscle Complex — through 1 ingredient. Tap an ingredient for the detail:
Creatine MagnapowerLevodopa/carbidopa (sinemet) Major
Interaction Summary
Magnesium can reduce the bioavailability of levodopa/carbidopa.
Read the full Creatine Magnapower + Carbidopa, Levodopa interactionCarbidopa, Levodopa, EntacaponeStalevo
How Carbidopa, Levodopa, Entacapone interacts with Creatine Muscle Complex — through 1 ingredient. Tap an ingredient for the detail:
Creatine MagnapowerLevodopa/carbidopa (sinemet) Major
Interaction Summary
Magnesium can reduce the bioavailability of levodopa/carbidopa.
Read the full Creatine Magnapower + Carbidopa, Levodopa, Entacapone interactionLevodopaInbrija, Larodopa
How Levodopa interacts with Creatine Muscle Complex — through 1 ingredient. Tap an ingredient for the detail:
Creatine MagnapowerLevodopa/carbidopa (sinemet) Major
Interaction Summary
Magnesium can reduce the bioavailability of levodopa/carbidopa.
Read the full Creatine Magnapower + Levodopa interactionLevodopa, CarbidopaDuodopa
How Levodopa, Carbidopa interacts with Creatine Muscle Complex — through 1 ingredient. Tap an ingredient for the detail:
Creatine MagnapowerLevodopa/carbidopa (sinemet) Major
Interaction Summary
Magnesium can reduce the bioavailability of levodopa/carbidopa.
Read the full Creatine Magnapower + Levodopa, Carbidopa interactionAcarboseGlucobay, Prandase, Precose
How Acarbose interacts with Creatine Muscle Complex — through 1 ingredient. Tap an ingredient for the detail:
Bioenergy RiboseAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, taking ribose in combination with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Bioenergy Ribose + Acarbose interactionAcebutololRhotral, Sectral
How Acebutolol interacts with Creatine Muscle Complex — through 1 ingredient. Tap an ingredient for the detail:
L-taurineAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taurine might increase the risk of hypotension when taken with antihypertensive drugs.
Read the full L-taurine + Acebutolol interactionAcetaminophen, ChlorzoxazoneAcetazone Forte, Extra Strength Tylenol Aches & Strains, Parafon Forte
How Acetaminophen, Chlorzoxazone interacts with Creatine Muscle Complex — through 1 ingredient. Tap an ingredient for the detail:
Creatine MagnapowerSkeletal Muscle Relaxants Moderate
Interaction Summary
Parenteral magnesium alters the pharmacokinetics of skeletal muscle relaxants, increasing their effects and accelerating the onset of effect.
Read the full Creatine Magnapower + Acetaminophen, Chlorzoxazone interactionAcetaminophen, Chlorzoxazone, CodeineAcetazone Forte C8, Parafon Forte C8
How Acetaminophen, Chlorzoxazone, Codeine interacts with Creatine Muscle Complex — through 1 ingredient. Tap an ingredient for the detail:
Creatine MagnapowerSkeletal Muscle Relaxants Moderate
Interaction Summary
Parenteral magnesium alters the pharmacokinetics of skeletal muscle relaxants, increasing their effects and accelerating the onset of effect.
Read the full Creatine Magnapower + Acetaminophen, Chlorzoxazone, Codeine interactionAcetaminophen, Codeine, MethocarbamolAcetaminophen, Codeine, Methocarbamol, Robaxacet 8
How Acetaminophen, Codeine, Methocarbamol interacts with Creatine Muscle Complex — through 1 ingredient. Tap an ingredient for the detail:
Creatine MagnapowerSkeletal Muscle Relaxants Moderate
Interaction Summary
Parenteral magnesium alters the pharmacokinetics of skeletal muscle relaxants, increasing their effects and accelerating the onset of effect.
Read the full Creatine Magnapower + Acetaminophen, Codeine, Methocarbamol interactionAcetaminophen, MethocarbamolRobaxacet
How Acetaminophen, Methocarbamol interacts with Creatine Muscle Complex — through 1 ingredient. Tap an ingredient for the detail:
Creatine MagnapowerSkeletal Muscle Relaxants Moderate
Interaction Summary
Parenteral magnesium alters the pharmacokinetics of skeletal muscle relaxants, increasing their effects and accelerating the onset of effect.
Read the full Creatine Magnapower + Acetaminophen, Methocarbamol interactionAcetaminophen, OrphenadrineOrfenagesic
How Acetaminophen, Orphenadrine interacts with Creatine Muscle Complex — through 1 ingredient. Tap an ingredient for the detail:
Creatine MagnapowerSkeletal Muscle Relaxants Moderate
Interaction Summary
Parenteral magnesium alters the pharmacokinetics of skeletal muscle relaxants, increasing their effects and accelerating the onset of effect.
Read the full Creatine Magnapower + Acetaminophen, Orphenadrine interactionAcetazolamideAk-Zol, Diamox
How Acetazolamide interacts with Creatine Muscle Complex — through 1 ingredient. Tap an ingredient for the detail:
L-taurineAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taurine might increase the risk of hypotension when taken with antihypertensive drugs.
Read the full L-taurine + Acetazolamide interactionAcetohexamideDymelor
How Acetohexamide interacts with Creatine Muscle Complex — through 2 ingredients. Tap an ingredient for the detail:
Creatine MagnapowerSulfonylureas Moderate
Interaction Summary
Magnesium increases the systemic absorption of sulfonylureas, increasing their effects and side effects.
Read the full Creatine Magnapower + Acetohexamide interactionBioenergy RiboseAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, taking ribose in combination with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Bioenergy Ribose + Acetohexamide interactionAlbiglutideTanzeum
How Albiglutide interacts with Creatine Muscle Complex — through 1 ingredient. Tap an ingredient for the detail:
Bioenergy RiboseAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, taking ribose in combination with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Bioenergy Ribose + Albiglutide interactionAlcuroniumAlcuronium
How Alcuronium interacts with Creatine Muscle Complex — through 1 ingredient. Tap an ingredient for the detail:
Creatine MagnapowerSkeletal Muscle Relaxants Moderate
Interaction Summary
Parenteral magnesium alters the pharmacokinetics of skeletal muscle relaxants, increasing their effects and accelerating the onset of effect.
Read the full Creatine Magnapower + Alcuronium interactionAlendronateBinosto, Fosamax
How Alendronate interacts with Creatine Muscle Complex — through 1 ingredient. Tap an ingredient for the detail:
Creatine MagnapowerBisphosphonates Moderate
Interaction Summary
Magnesium can decrease absorption of bisphosphonates.
Read the full Creatine Magnapower + Alendronate interactionAlendronate Sodium
How Alendronate Sodium interacts with Creatine Muscle Complex — through 1 ingredient. Tap an ingredient for the detail:
Creatine MagnapowerBisphosphonates Moderate
Interaction Summary
Magnesium can decrease absorption of bisphosphonates.
Read the full Creatine Magnapower + Alendronate Sodium interactionAlendronate Sodium, CholecalciferolFosamax Plus D
How Alendronate Sodium, Cholecalciferol interacts with Creatine Muscle Complex — through 1 ingredient. Tap an ingredient for the detail:
Creatine MagnapowerBisphosphonates Moderate
Interaction Summary
Magnesium can decrease absorption of bisphosphonates.
Read the full Creatine Magnapower + Alendronate Sodium, Cholecalciferol interactionAlginic Acid, Aluminum HydroxideRafton
How Alginic Acid, Aluminum Hydroxide interacts with Creatine Muscle Complex — through 1 ingredient. Tap an ingredient for the detail:
Creatine MagnapowerAntacids Moderate
Interaction Summary
Use of acid reducers may reduce the laxative effect of magnesium oxide.
Read the full Creatine Magnapower + Alginic Acid, Aluminum Hydroxide interactionAliskirenTekturna
How Aliskiren interacts with Creatine Muscle Complex — through 1 ingredient. Tap an ingredient for the detail:
L-taurineAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taurine might increase the risk of hypotension when taken with antihypertensive drugs.
Read the full L-taurine + Aliskiren interactionAlogliptinNesina
How Alogliptin interacts with Creatine Muscle Complex — through 1 ingredient. Tap an ingredient for the detail:
Bioenergy RiboseAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, taking ribose in combination with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Bioenergy Ribose + Alogliptin interactionAlogliptin, MetforminKazano
How Alogliptin, Metformin interacts with Creatine Muscle Complex — through 1 ingredient. Tap an ingredient for the detail:
Bioenergy RiboseAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, taking ribose in combination with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Bioenergy Ribose + Alogliptin, Metformin interactionAlogliptin, PioglitazoneOseni
How Alogliptin, Pioglitazone interacts with Creatine Muscle Complex — through 1 ingredient. Tap an ingredient for the detail:
Bioenergy RiboseAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, taking ribose in combination with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Bioenergy Ribose + Alogliptin, Pioglitazone interactionAluminum HydroxideAlu-Cap, Amphojel, Gaviscon
How Aluminum Hydroxide interacts with Creatine Muscle Complex — through 1 ingredient. Tap an ingredient for the detail:
Creatine MagnapowerAntacids Moderate
Interaction Summary
Use of acid reducers may reduce the laxative effect of magnesium oxide.
Read the full Creatine Magnapower + Aluminum Hydroxide interactionAluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium HydroxideAscriptin Codeine #2
How Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide interacts with Creatine Muscle Complex — through 1 ingredient. Tap an ingredient for the detail:
Creatine MagnapowerAntacids, Anticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Use of acid reducers may reduce the laxative effect of magnesium oxide.
Read the full Creatine Magnapower + Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide interactionAluminum Hydroxide, Aspirin, Magnesium HydroxideAscriptin
How Aluminum Hydroxide, Aspirin, Magnesium Hydroxide interacts with Creatine Muscle Complex — through 1 ingredient. Tap an ingredient for the detail:
Creatine MagnapowerAnticoagulant/antiplatelet Drugs, Antacids Moderate
Interaction Summary
Theoretically, magnesium may have antiplatelet effects, but the evidence is conflicting.
Read the full Creatine Magnapower + Aluminum Hydroxide, Aspirin, Magnesium Hydroxide interactionAluminum Hydroxide, Magnesium Hydroxide (otc Drug)Maalox, Mucogel
How Aluminum Hydroxide, Magnesium Hydroxide (otc Drug) interacts with Creatine Muscle Complex — through 1 ingredient. Tap an ingredient for the detail:
Creatine MagnapowerAntacids Moderate
Interaction Summary
Use of acid reducers may reduce the laxative effect of magnesium oxide.
Read the full Creatine Magnapower + Aluminum Hydroxide, Magnesium Hydroxide (otc Drug) interactionAluminum Hydroxide, Magnesium Hydroxide, Simethicone (otc Drug)Mylanta
How Aluminum Hydroxide, Magnesium Hydroxide, Simethicone (otc Drug) interacts with Creatine Muscle Complex — through 1 ingredient. Tap an ingredient for the detail:
Creatine MagnapowerAntacids Moderate
Interaction Summary
Use of acid reducers may reduce the laxative effect of magnesium oxide.
Read the full Creatine Magnapower + Aluminum Hydroxide, Magnesium Hydroxide, Simethicone (otc Drug) interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Creatine Muscle Complex with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
Magnesium
Levodopa/Carbidopa (Sinemet)
Magnesium can reduce the bioavailability of levodopa/carbidopa.
Clinical research in healthy volunteers shows that taking magnesium oxide 1000 mg with levodopa 100 mg/carbidopa 10 mg reduces the area under the curve (AUC) of levodopa by 35% and of carbidopa by 81%. In vitro and animal research shows that magnesium produces an alkaline environment in the digestive tract, which might lead to degradation and reduced bioavailability of levodopa/carbidopa.
Aminoglycoside Antibiotics
Concomitant use of aminoglycoside antibiotics and magnesium can increase the risk for neuromuscular weakness.
Both aminoglycosides and magnesium reduce presynaptic acetylcholine release, which can lead to neuromuscular blockade and possible paralysis. This is most likely to occur with high doses of magnesium given intravenously.
Antacids
Use of acid reducers may reduce the laxative effect of magnesium oxide.
A retrospective analysis shows that, in the presence of H2 receptor antagonists (H2RAs) or proton pump inhibitors (PPIs), a higher dose of magnesium oxide is needed for a laxative effect. This may also occur with antacids. Under acidic conditions, magnesium oxide is converted to magnesium chloride and then to magnesium bicarbonate, which has an osmotic laxative effect. By reducing acidity, antacids may reduce the conversion of magnesium oxide to the active bicarbonate salt.
Bictegravir/Emtricitabine/Tenofovir Alafenamide (Biktarvy)
Magnesium might decrease levels of bictegravir/emtricitabine/tenofovir alafenamide by reducing its absorption.
Advise patients that bictegravir/emtricitabine/tenofovir alafenamide should be taken at least 2 hours before or 6 hours after magnesium containing products.
Bisphosphonates
Magnesium can decrease absorption of bisphosphonates.
Cations, including magnesium, can decrease bisphosphonate absorption. Advise patients to separate doses of magnesium and these drugs by at least 2 hours.
Calcium Channel Blockers
Magnesium can have additive effects with calcium channel blockers, although evidence is conflicting.
Magnesium inhibits calcium entry into smooth muscle cells and may therefore have additive effects with calcium channel blockers. Severe hypotension and neuromuscular blockades may occur when nifedipine is used with intravenous magnesium, although some contradictory evidence suggests that concurrent use of magnesium with nifedipine does not increase the risk of neuromuscular weakness. High doses of magnesium could theoretically have additive effects with other calcium channel blockers.
Digoxin
Magnesium salts may reduce absorption of digoxin.
Clinical evidence suggests that treatment with oral magnesium hydroxide or magnesium trisilicate reduces absorption of digoxin from the intestines. This may reduce the blood levels of digoxin and decrease its therapeutic effects.
Potassium-Sparing Diuretics
Potassium-sparing diuretics decrease excretion of magnesium, possibly increasing magnesium levels.
Potassium-sparing diuretics also have magnesium-sparing properties, which can counteract the magnesium losses associated with loop and thiazide diuretics. Theoretically, increased magnesium levels could result from concomitant use of potassium-sparing diuretics and magnesium supplements.
Quinolone Antibiotics
Magnesium decreases absorption of quinolones.
Magnesium can form insoluble complexes with quinolones and decrease their absorption. Advise patients to take these drugs at least 2 hours before, or 4 to 6 hours after, magnesium supplements.
Skeletal Muscle Relaxants
Parenteral magnesium alters the pharmacokinetics of skeletal muscle relaxants, increasing their effects and accelerating the onset of effect.
Parenteral magnesium shortens the time to onset of skeletal muscle relaxants by about 1 minute and prolongs the duration of action by about 2 minutes. Magnesium potentiates the effects of skeletal muscle relaxants by decreasing calcium-mediated release of acetylcholine from presynaptic nerve terminals, reducing postsynaptic sensitivity to acetylcholine, and having a direct effect on the membrane potential of myocytes. Magnesium also has vasodilatory actions and increases cardiac output, allowing a greater amount of muscle relaxant to reach the motor end plate. A clinical study found that low-dose rocuronium (0.45 mg/kg), when given after administration of magnesium 30 mg/kg over 10 minutes, has an accelerated onset of effect, which matches the onset of effect seen with a full-dose rocuronium regimen (0.6 mg/kg). In another clinical study, onset times for rocuronium doses of 0.3, 0.6, and 1.2 mg/kg were 86, 76, and 50 seconds, respectively, when given alone, but were reduced to 66, 44, and 38 seconds, respectively, when the doses were given after a 15-minute infusion of magnesium sulfate 60 mg/kg. Giving intraoperative intravenous magnesium sulfate, 50 mg/kg loading dose followed by 15 mg/kg/hour, reduces the onset time of rocuronium, enhances its clinical effects, reduces the dose of intraoperative opiates, and prolongs the spontaneous recovery time. It does not affect the activity of subsequently administered neostigmine.
Sulfonylureas
Magnesium increases the systemic absorption of sulfonylureas, increasing their effects and side effects.
Clinical research shows that administration of magnesium hydroxide with glyburide increases glyburide absorption, increases maximal insulin response by 35-fold, and increases the risk of hypoglycemia, when compared with glyburide alone. A similar interaction occurs between magnesium hydroxide and glipizide. The mechanism of this effect appears to be related to the elevation of gastrointestinal pH by magnesium-based antacids, increasing solubility and enhancing absorption of sulfonylureas.
Tetracycline Antibiotics
Magnesium decreases absorption of tetracyclines.
Magnesium can form insoluble complexes with tetracyclines in the gut and decrease their absorption and antibacterial activity. Advise patients to take these drugs 1 hour before or 2 hours after magnesium supplements.
Anticoagulant/Antiplatelet Drugs
Theoretically, magnesium may have antiplatelet effects, but the evidence is conflicting.
In vitro evidence shows that magnesium sulfate inhibits platelet aggregation, even at low concentrations. Some preliminary clinical evidence shows that infusion of magnesium sulfate increases bleeding time by 48% and reduces platelet activity. However, other clinical research shows that magnesium does not affect platelet aggregation, although inhibition of platelet-dependent thrombosis can occur.
Gabapentin (Neurontin)
Gabapentin absorption can be decreased by magnesium.
Clinical research shows that giving magnesium oxide orally along with gabapentin decreases the maximum plasma concentration of gabapentin by 33%, time to maximum concentration by 36%, and area under the curve by 43%. Advise patients to take gabapentin at least 2 hours before, or 4 to 6 hours after, magnesium supplements.
Sevelamer (Renagel, Renvela)
Sevelamer may increase serum magnesium levels.
In patients on hemodialysis, sevelamer use was associated with a 0.28 mg/dL increase in serum magnesium. The mechanism of this interaction remains unclear.
L-Taurine
Antihypertensive Drugs
Theoretically, taurine might increase the risk of hypotension when taken with antihypertensive drugs.
Some clinical evidence suggests that taurine can reduce both systolic and diastolic blood pressure.
Lithium
Theoretically, taurine might reduce excretion and increase plasma levels of lithium.
Taurine is thought to have diuretic properties, which might reduce the excretion of lithium.
Bioenergy Ribose
Antidiabetes Drugs
Theoretically, taking ribose in combination with antidiabetes drugs might increase the risk of hypoglycemia.
In clinical research, ribose decreases serum glucose levels in a dose-dependent manner.
Insulin
Theoretically, taking ribose with insulin could increase the hypoglycemic effect of insulin.
In clinical pharmacokinetic studies, oral administration of ribose modestly increased serum insulin levels.
Brand information
Manufacturer and brand details for Creatine Muscle Complex, from the product label.
Maxi Health
See all Maxi Health products- Name
- Maxi Health
- City
- Brooklyn
- State
- N.Y.
- Phone Number
- 800-544-6294
- Web Address
- www.maxihealth.com
Creatine Muscle Complex by Maxi Health: Common Questions
Does Creatine Muscle Complex by Maxi Health interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Does this product have any fillers or inactive ingredients?
Can I take this if I'm pregnant or breastfeeding?
Will this help me build muscle?
What are the most common side effects?
Is this safe for people with kidney problems?
Can ribose lower my blood sugar?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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The Full Monographs Behind Creatine Muscle Complex’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Taurine
Interacts with 173 drugsTaurine is an amino acid your body makes naturally and that you also get from animal foods. It is widely used in energy drinks and sports supplements, and short-term use appears generally sa...
Read the full Taurine monograph → Herb & supplement monographMagnesium
Interacts with 295 drugsMagnesium is an essential mineral your body needs for muscles, nerves, blood pressure, and many other functions, and supplements are useful for preventing or correcting deficiency. Some othe...
Read the full Magnesium monograph → Herb & supplement monographCreatine
Creatine is one of the most studied sports supplements, with solid evidence that it can boost strength and performance during short, high-intensity activities like weightlifting and sprintin...
Read the full Creatine monograph → Herb & supplement monographRibose
Interacts with 86 drugsRibose (D-ribose) is a simple sugar your body makes naturally and uses to build energy molecules like ATP. Some people take it for fatigue, fibromyalgia, exercise recovery, or heart conditio...
Read the full Ribose monograph →Sources & How We Checked
Creatine Muscle Complex's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 197 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Taurine 21 references
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- Calabro, R. S., Italiano, D., Gervasi, G., and Bramanti, P. Single tonic-clonic seizure after energy drink abuse. Epilepsy Behav 2012;23(3):384-385. PubMed
- Fujita, T., Ando, K., Noda, H., Ito, Y., and Sato, Y. Effects of increased adrenomedullary activity and taurine in young patients with borderline hypertension. Circulation 1987;75(3):525-532. PubMed
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- Franconi, F., Bennardini, F., Mattana, A., Miceli, M., Ciuti, M., Mian, M., Gironi, A., Anichini, R., and Seghieri, G. Plasma and platelet taurine are reduced in subjects with insulin-dependent diabetes mellitus: effects of taurine supplementation. Am.J. DOI
- Stohs SJ, Miller M. A case study involving allergic reactions to sulfur-containing compounds including, sulfite, taurine, acesulfame potassium and sulfonamides. Food Chem Toxicol. 2014 Jan;63:240-3. PubMed
- Sun Q, Wang B, Li Y, Sun F, et al. Taurine supplementation lowers blood pressure and improves vascular function in prehypertension: randomized, double-blind, placebo-controlled study. Hypertension 2016 Mar;67(3):541-9. PubMed
- Jang ES, Hwang SH, Kim JW, Jeong SH. Effectiveness of 4-week oral taurine treatment for muscle cramps in patients with liver cirrhosis: a single-arm pilot study. Yonsei Med J 2021;62(1):21-8. PubMed
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- Higgins JP, Liras GN, Liras IN, et al. Energy Drink Effects on Hemodynamics and Endothelial Function in Young Adults. Cardiology. 2021;146(2):258-262. PubMed
- Pallangyo P, Bhalia SV, Komba M, et al. Acute Myocardial Infarction Following the Consumption of Energy Drink in a 28-Year-Old Male: A Case Report. J Investig Med High Impact Case Rep. 2023 Jan-Dec;11:23247096231168811. PubMed
Creatine 86 references
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- Volek, J. S., Duncan, N. D., Mazzetti, S. A., Putukian, M., Gomez, A. L., and Kraemer, W. J. No effect of heavy resistance training and creatine supplementation on blood lipids. Int J Sport Nutr.Exerc.Metab 2000;10(2):144-156. PubMed
- Robinson, T. M., Sewell, D. A., Casey, A., Steenge, G., and Greenhaff, P. L. Dietary creatine supplementation does not affect some haematological indices, or indices of muscle damage and hepatic and renal function. Br.J Sports Med 2000;34(4):284-288. PubMed
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- Tarnopolsky, M. A. and MacLennan, D. P. Creatine monohydrate supplementation enhances high-intensity exercise performance in males and females. Int J Sport Nutr.Exerc.Metab 2000;10(4):452-463. PubMed
- Arciero, P. J., Hannibal, N. S., III, Nindl, B. C., Gentile, C. L., Hamed, J., and Vukovich, M. D. Comparison of creatine ingestion and resistance training on energy expenditure and limb blood flow. Metabolism 2001;50(12):1429-1434. PubMed
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- Kilduff, L. P., Vidakovic, P., Cooney, G., Twycross-Lewis, R., Amuna, P., Parker, M., Paul, L., and Pitsiladis, Y. P. Effects of creatine on isometric bench-press performance in resistance-trained humans. Med Sci.Sports Exerc. 2002;34(7):1176-1183. PubMed
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