Interactions on record — worth a quick check against your medications. Based on 7 of 16 ingredients. Check your meds →
Dietary supplement

Digeryxin OTC Ingredients & Drug Interactions

by Innovus Pharmaceuticals

Digeryxin OTC label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Digeryxin OTC against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Digeryxin OTC is a dietary supplement by Innovus Pharmaceuticals with 16 active ingredients. Its ingredients are commonly taken for lactose intolerance, gas and bloating after dairy, diarrhea from dairy foods.Based on those ingredients, 1,101 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are BioPerine Black Pepper extract, Astragalus membranaceous (root) extracts, Panax notoginseng (root) extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Digeryxin OTC by Innovus Pharmaceuticals

Ask about any prescription or over-the-counter medication and we check it for interactions with Digeryxin OTC by Innovus Pharmaceuticals — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Digeryxin OTC by Innovus Pharmaceuticals

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 23, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 1 of its 16 active ingredients.
  • “Proprietary Enzyme Blend” is a proprietary blend — the label gives one combined amount (391 mg) without saying how much of each component you get.
  • “AstraGin” is listed as a grouped ingredient — the label gives one combined amount (20 mg) without saying how much of each component you get.

Digeryxin OTC contains 16 ingredients, 11 of which are digestive enzymes: lactase (breaks down milk sugar), lipase (breaks down fats), and proteases (break down proteins), along with several others that help digest different food components. It also includes BioPerine (a black pepper extract meant to aid absorption), Panax notoginseng (a traditional herbal extract), and Astragalus (another herbal extract).

The remaining ingredients are inactive fillers and the capsule material itself.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: Promotes healthy digestion and reduces gas.
  • We looked for evidence on: Dyspepsia, Flatulence, Lactose intolerance, Diarrhea, Indigestion, Bloating — and 1 related terms.
  • The strongest evidence on file: Lactase is rated "Effective" for Lactose intolerance (Natural Medicines).
  • Also on file: Lipase is rated "Insufficient Reliable Evidence To Rate" for Dyspepsia.
  • Also on file: Black Pepper is rated "Insufficient Reliable Evidence To Rate" for Diarrhea, Dyspepsia, Flatulence.

The evidence in our data is limited. Lactase is rated effective for lactose intolerance, but the other ingredients—lipase, protease, Panax notoginseng, and Astragalus—either have insufficient evidence to rate their effectiveness or, in the case of the proteases and most other enzymes, no effectiveness ratings on file.

Panax notoginseng is possibly effective for angina and stroke, and possibly ineffective for heart attack. You won't find strong proof here that this blend works for general digestion or the conditions makers often claim it treats.

The evidence, ingredient by ingredient Lactase Lipase Proteolytic Enzymes (proteases) Phytase Black Pepper Panax Notoginseng Astragalus

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 7 of the 7 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 7 of 7.
  • General safety write-ups exist for 7 of 7.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Most of the digestive enzymes in this product are generally well tolerated, though protease may cause digestive upset or allergic reactions in some people. Lactase is likely safe in pregnancy and lactation based on available data.

However, Panax notoginseng is rated likely unsafe in pregnancy and should be avoided if you're pregnant or breastfeeding. Astragalus lacks enough safety data for pregnancy or breastfeeding, so it's best avoided in both.

BioPerine (black pepper) at food levels is likely safe in pregnancy, but the concentrated supplement form hasn't been well studied. Panax notoginseng can cause dry mouth, nausea, vomiting, nervousness, and insomnia orally.

Astragalus has occasionally been linked to dizziness and rash. Rare allergic reactions to protease and phytase have occurred with occupational exposure.

Side effects, ingredient by ingredient Lactase Lipase Proteolytic Enzymes (proteases) Phytase Black Pepper Panax Notoginseng Astragalus

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 3 of the 7 matched ingredients can interact with medications — Black Pepper, Panax Notoginseng, Astragalus.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; diabetes medications; lithium.
  • For scale: 1,102 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, have your doctor or pharmacist check whether you take any seizure medications (especially phenytoin/Dilantin), blood thinners like warfarin, heart or blood pressure drugs (propranolol, atorvastatin), HIV or TB medications (nevirapine, rifampin), immunosuppressants (cyclosporine, cyclophosphamide), diabetes drugs, lithium, or any drug that depends on caffeine metabolism. All of these are documented Moderate interactions with ingredients in this product.

No interactions are documented in our data for the digestive enzymes alone (lactase, lipase, and protease), but several other enzyme components we could not check.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with clinical evidence supporting its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This is a multi-enzyme digestive supplement with herbal additions. If you're not pregnant or breastfeeding and don't take seizure drugs, blood thinners, heart medications, diabetes drugs, or immunosuppressants, it may be worth a try—but the evidence that it actually improves digestion is unclear.

If you take any prescription medication, check your exact drugs against the interactions listed here or use the search tool before you start. Talk with your doctor or pharmacist about whether it fits your situation.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 9 of 16 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Sep 22, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Digeryxin OTC, straight from the product label.

Brand Innovus Pharmaceuticals
Barcode (UPC) 357483001605
Net contents 60 Capsule(s)
Market status On market
Date entered into DSLD Sep 22, 2022
DSLD ID 270232
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Digeryxin OTC by Innovus Pharmaceuticals, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
30
UPC/BARCODE
357483001605
IngredientAmount% DV
Lactase0 NP--
Lipase0 NP--
Protease0 NP--
Beta-Glucanase0 NP--
Cellulase0 NP--
Phytase0 NP--
Hemicellulase0 NP--
Amylase0 NP--
Glucoamylase0 NP--
Alpha-Galactosidase0 NP--
Invertase0 NP--
Proprietary Enzyme Blend391 mg--
BioPerine Black Pepper extract10 mg--
Protease 3.00 NP--
Protease 6.00 NP--
AstraGin20 mg--
Panax notoginseng (root) extract0 NP--
Astragalus membranaceous (root) extracts0 NP--

Other ingredients: Microcrystalline Cellulose, Gelatin Capsule, Rice powder, Magnesium Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Recommended dose: As a dietary supplement, adults take two (2) capsules daily. Take with food a few hours before or after taking other medication.

Precautions

Caution: Keep out of the reach of children.

If you are pregnant, nursing, or are taking any prescription medicine, consult your physician before taking this product.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Formulation

Promotes healthy digestion Helps reduce occasional post-meal gas Helps process difficult to digest foods Supports proper nutrient uptake

Formula

PHD formulated digestive enzyme

FDA Statement of Identity

Dietary Supplement

Brand IP Statement(s)

BioPerine is a registered trademark of Sabinsa Corporation. AstraGin is a registered trademark of Nuliv Science USA, Inc.

General Statements

Innovus Pharmaceuticals, Inc. 8845 Rehco Road San Diego, CA 92121

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Digeryxin OTC by Innovus Pharmaceuticals label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Digeryxin OTC label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Digeryxin OTC by Innovus Pharmaceuticals

These are the 16 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Proprietary Enzyme Blend

391 mg per serving

BioPerine Black Pepper extract

Interacts with
1,019 drugs
10 mg per serving

Black pepper is a common kitchen spice that is generally safe in the amounts used in food. Its extract, piperine, is mostly added to supplements to he...

BioPerine Black Pepper extract monograph & interactions

Other (inactive) ingredients: Microcrystalline Cellulose, Gelatin Capsule, Rice powder, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Digeryxin OTC by Innovus Pharmaceuticals Drug Interactions

Want to check YOUR meds against Digeryxin OTC?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,101Drugs
1,099 Moderate 2 Minor

Ingredients driving the most interactions

BioPerine Black Pepper extract 1,019
Astragalus membranaceous (root) extracts 208
Panax notoginseng (root) extract 207

Individual Drug Interactions

The ingredients in Digeryxin OTC interact with 1,101 drugs. Click any drug to see the details.

3 of the 16 ingredients in Digeryxin OTC interact with drugs. Each result below shows which ingredient is responsible. BioPerine Black Pepper extract Astragalus membranaceous (root) extracts Panax notoginseng (root) extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Digeryxin OTC with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

BioPerine Black Pepper extract17 drug types · 1,019 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, black pepper might increase the risk of bleeding when taken with antiplatelet or anticoagulant drugs.
In vitro research shows that piperine, a constituent of black pepper, seems to inhibit platelet aggregation. This has not been reported in humans.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, black pepper might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Animal research shows that piperine, a constituent of black pepper, can reduce blood glucose levels. Monitor blood glucose levels closely. Dose adjustments might be necessary.

Likelihood Possible Evidence D
Atorvastatin (Lipitor)

Theoretically, black pepper might increase blood levels of atorvastatin.
Animal research shows that taking piperine, a constituent of black pepper, 35 mg/kg can increase the maximum serum concentration of atorvastatin three-fold. This has not been reported in humans.

Likelihood Possible Evidence D
Cyclosporine (Neoral, Sandimmune)

Theoretically, black pepper might increase the effects and side effects of cyclosporine.
In vitro research shows that piperine, a constituent of black pepper, increases the bioavailability of cyclosporine. This has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2D6 (Cyp2D6) Substrates

Theoretically, black pepper might increase levels of drugs metabolized by CYP2D6.
In vitro research suggests that some constituents of black pepper inhibit CYP2D6. This has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, black pepper might increase levels of drugs metabolized by CYP3A4.
In vitro research and pharmacokinetic simulation data suggest that piperine, a constituent of black pepper, as well as the pepper fruit seem to inhibit CYP3A4. This has not been reported in humans.

Likelihood Possible Evidence D
Lithium

Theoretically, black pepper might increase blood levels of lithium due to its diuretic effects. The dose of lithium might need to be reduced.
Black pepper is thought to have diuretic properties.

Likelihood Probable Evidence D
Nevirapine (Viramune)

Black pepper might increase blood levels of nevirapine.
Clinical research shows that piperine, a constituent of black pepper, increases the plasma concentration of nevirapine. However, no adverse effects were observed in this study.

Likelihood Probable Evidence D
P-Glycoprotein Substrates

Theoretically, black pepper might increase levels of P-glycoprotein substrates.
In vitro research shows that piperine, a constituent of black pepper, seems to inhibit P-glycoprotein.

Likelihood Possible Evidence D
Pentobarbital (Nembutal)

Theoretically, black pepper might increase the sedative effects of pentobarbital.
Animal research shows that piperine, a constituent of black pepper, increases pentobarbital-induced sleeping time.

Likelihood Possible Evidence D
Phenytoin (Dilantin)

Black pepper might increase blood levels of phenytoin.
Clinical research shows that piperine, a constituent of black pepper, seems to increase absorption, slow elimination, and increase levels of phenytoin. Taking a single dose of black pepper 1 gram along with phenytoin seems to double the serum concentration of phenytoin. Consuming a soup with black pepper providing piperine 44 mg/200 mL of soup along with phenytoin also seems to increase phenytoin levels when compared with consuming the same soup without black pepper.

Likelihood Possible Evidence B
Propranolol (Inderal)

Black pepper might increase blood levels of propranolol.
Clinical research shows that piperine, a constituent of black pepper, seems to increase absorption and slow elimination of propranolol.

Likelihood Possible Evidence B
Rifampin (Rifadin)

Black pepper might increase blood levels of rifampin.
Clinical research shows that piperine, a constituent of black pepper, seems to increase absorption and serum levels of rifampin.

Likelihood Possible Evidence B
Theophylline

Black pepper might increase blood levels of theophylline.
Clinical research shows that piperine, a constituent of black pepper, seems to increase absorption and slow elimination of theophylline.

Likelihood Possible Evidence D
Amoxicillin (Amoxil, Trimox)

Theoretically, black pepper might increase the effects and side effects of amoxicillin.
Animal research shows that taking piperine, a constituent of black pepper, with amoxicillin increases plasma levels of amoxicillin. This has not been reported in humans.

Likelihood Possible Evidence D
Carbamazepine (Tegretol)

Theoretically, black pepper might increase blood levels of carbamazepine, potentially increasing the effects and side effects of carbamazepine.
One clinical study in patients taking carbamazepine 300 mg or 500 mg twice daily shows that taking a single 20 mg dose of purified piperine, a constituent of black pepper, increases carbamazepine levels. Piperine may increase carbamazepine absorption by increasing blood flow to the GI tract, increasing the surface area of the small intestine, or inhibiting cytochrome P450 3A4 (CYP3A4) in the gut wall. Absorption was significantly increased by 7-10 mcg/mL/hour. The time to eliminate carbamazepine was also increased by 4-8 hours. Although carbamazepine levels were increased, this did not appear to increase side effects. In vitro research also shows that piperine can increase carbamazepine levels by 11% in a time-dependent manner.

Likelihood Possible Evidence B
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, black pepper might decrease levels and clinical effects of drugs metabolized by CYP1A2.
In vitro research suggests that black pepper induces CYP1A2. This has not been reported in humans.

Likelihood Possible Evidence D
BioPerine Black Pepper extract full monograph & interactions

Astragalus membranaceous (root) extracts4 drug types · 208 drugs

Antidiabetes Drugs

Theoretically, taking astragalus with antidiabetes drugs might increase the risk of hypoglycemia.
Clinical research in humans shows that astragalus might have hypoglycemic effects. Theoretically, taking astragalus, especially in combination with other hypoglycemic agents, might increase the risk of hypoglycemia.

Likelihood Probable Evidence A
Cyclophosphamide

Theoretically, astragalus might interfere with cyclophosphamide therapy.
Evidence regarding the effect of astragalus on immunosuppression caused by cyclophosphamide is conflicting. Some animal research suggests that astragalus reverses cyclophosphamide-induced immunosuppression. However, other animal research shows no effect.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, astragalus might interfere with immunosuppressive therapy.
Astragalus seems to stimulate immune function. Theoretically, taking astragalus might decrease the effects of immunosuppressive therapy.

Likelihood Possible Evidence D
Lithium

Theoretically, astragalus might increase levels and adverse effects of lithium.
Animal research suggests that astragalus has diuretic properties. Theoretically, due to this diuretic effect, astragalus might reduce excretion and increase levels of lithium.

Likelihood Probable Evidence D
Astragalus membranaceous (root) extracts full monograph & interactions

Panax notoginseng (root) extract4 drug types · 207 drugs

Aspirin

Theoretically, taking Panax notoginseng concomitantly with aspirin may increase the risk of adverse effects from both products.
Animal research shows that taking Panax notoginseng extract with aspirin increases blood levels of salicylic acid by approximately 50% and blood levels of Panax notoginseng by 75% to 196%. This effect may be due to increased absorption of both products.

Likelihood Possible Evidence D
Caffeine

Theoretically, taking Panax notoginseng may decrease the levels and clinical effects of caffeine.
Animal research shows that administering Panax notoginseng intravenously for 7 days before intraperitoneal injection of caffeine can decrease maximal blood levels of caffeine by 37%. This interaction is attributed to the ability of Panax notoginseng to increase the activity of cytochrome P450 1A2 (CYP1A2) enzymes.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, taking Panax notoginseng might reduce the levels and clinical effects of CYP1A2 substrates.
Animal research shows that administering Panax notoginseng intravenously for 7 days before intraperitoneal injection of caffeine can decrease maximal blood levels of caffeine by 37%. This interaction was attributed to the ability of Panax notoginseng to increase the activity of CYP1A2.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Theoretically, taking Panax notoginseng concomitantly with warfarin may increase the risk of bleeding.
Animal research shows that taking Panax notoginseng concomitantly with warfarin increases plasma warfarin levels, prothrombin time, and international normalized ratio when compared with control. In vitro research also suggests that Panax notoginseng may downregulate expression of cytochrome P450 3A4 enzymes, which may affect warfarin metabolism.

Likelihood Possible Evidence D
Panax notoginseng (root) extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Digeryxin OTC, from the product label.

Innovus Pharmaceuticals

See all Innovus Pharmaceuticals products
Name
Innovus Pharmaceuticals, Inc.
City
San Diego
State
CA
ZipCode
92121
Phone Number
1-800-996-5122
Web Address
www.innovuspharma.com
Pharmacist Counseling Corner

Digeryxin OTC by Innovus Pharmaceuticals: Common Questions

Does Digeryxin OTC by Innovus Pharmaceuticals interact with any medications?
Yes. Based on its ingredients, Digeryxin OTC has a known interaction with 1,101 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Digeryxin OTC contains 16 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does this actually help me digest food better?
The data we have shows no proven effectiveness for general digestion. Lactase, which breaks down milk sugar, is rated effective for lactose intolerance—so if that's your issue, this ingredient may help. For the other enzymes and extracts, the evidence isn't strong enough to call them effective.
Can I take this while pregnant?
Lactase is likely safe, but Panax notoginseng in this product is rated likely unsafe in pregnancy, so you should not take it if you're pregnant. BioPerine at food levels is likely safe, but as a supplement it hasn't been well studied. Talk with your doctor or pharmacist before starting this product if you're pregnant.
Can I take this while breastfeeding?
Lactase appears safe, and BioPerine at normal dietary levels is likely safe, but Panax notoginseng and Astragalus lack enough data and are best avoided while breastfeeding. Check with your doctor or pharmacist first.
What side effects might I experience?
Most people tolerate the digestive enzymes without problems. Common side effects from Panax notoginseng include dry mouth, nausea, vomiting, nervousness, and insomnia. BioPerine may cause a burning aftertaste or indigestion. Allergic reactions are rare but have been reported with both protease and Panax notoginseng in sensitive individuals.
Is this safe for a 17-year-old?
The safety data don't specify age limits, but one case report involved a 17-month-old who had an allergic reaction to black pepper in food. A teenager would likely tolerate it better, but any person considering this product should check their medications with a doctor or pharmacist first, especially if they take seizure drugs or blood thinners.
What is BioPerine, and why is it in here?
BioPerine is a concentrated extract from black pepper that contains a compound called piperine. It's added to supplements because it may help your body absorb other ingredients more efficiently. However, this same effect means it can raise blood levels of certain medications, which is why it requires caution if you take prescription drugs.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Digeryxin OTC is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Digeryxin OTC label
Go deeper

The Full Monographs Behind Digeryxin OTC’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Lactase

Lactase is a digestive enzyme supplement that helps people who lack enough natural lactase break down lactose, the sugar in milk and dairy. It can reduce gas, bloating, cramping, and diarrhe...

Read the full Lactase monograph → Herb & supplement monograph

Lipase

Lipase is a digestive enzyme that helps your body break down dietary fats. It is well established as part of prescription pancreatic enzyme therapy for people who cannot make enough of their...

Read the full Lipase monograph → Herb & supplement monograph

Proteolytic Enzymes (proteases)

Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), trypsin, chymotrypsin, and pancreatin. Peo...

Read the full Proteolytic Enzymes (proteases) monograph → Herb & supplement monograph

Phytase

Phytase is an enzyme that breaks down phytic acid (phytate) found in grains, beans, nuts, and seeds, which can free up minerals like iron, zinc, and calcium for absorption. It is widely used...

Read the full Phytase monograph → Herb & supplement monograph

Black Pepper

Interacts with 1,019 drugs

Black pepper is a common kitchen spice that is generally safe in the amounts used in food. Its extract, piperine, is mostly added to supplements to help the body absorb other ingredients (li...

Read the full Black Pepper monograph → Herb & supplement monograph

Panax Notoginseng

Interacts with 207 drugs

Panax notoginseng (sanqi or tienchi ginseng) is a traditional Chinese herb most often used to help with bleeding, bruising, and circulation. Human evidence for these uses is limited and most...

Read the full Panax Notoginseng monograph → Herb & supplement monograph

Astragalus

Interacts with 208 drugs

Astragalus is a root used for centuries in traditional Chinese medicine, mainly to support the immune system and help the body cope with stress. While early studies are interesting, strong h...

Read the full Astragalus monograph →
Sources

Sources & How We Checked

Digeryxin OTC's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 69 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Lactase 1 reference
  1. Laukkanen A, Ruoppi P, Remes S, Koistinen T, Mäkinen-Kiljunen S. Lactase-induced occupational protein contact dermatitis and allergic rhinoconjunctivitis. Contact Dermatitis. 2007;57(2):89-93. PubMed

See these in context on the Lactase monograph →

Lipase 1 reference
  1. Casper C, Hascoet JM, Ertl T, et al. Recombinant bile salt-stimulated lipase in preterm infant feeding: A randomized phase 3 study. PLoS One. 2016;11(5):e0156071. PubMed

See these in context on the Lipase monograph →

Proteolytic Enzymes (proteases) 3 references
  1. Weeks JA, Harper RA, Simon RA, Burdick JD. Assessment of sensitization risk of a laundry pre-spotter containing protease. Cutan Ocul Toxicol. 2011;30(4):272-9. PubMed
  2. Marquès LI, Lara S, Abós T, Bartolomé B. Occupational rhinitis due to pepsin. J Investig Allergol Clin Immunol. 2006;16(2):136-7. DOI
  3. Cartier A, Malo JL, Pineau L, Dolovich J. Occupational asthma due to pepsin. J Allergy Clin Immunol. 1984;73(5 Pt 1):574-7. PubMed

See these in context on the Proteolytic Enzymes (proteases) monograph →

Phytase 7 references
  1. Lei XG, Weaver JD, Mullaney E, Ullah AH, Azain MJ. Phytase, a new life for an "old" enzyme. Annu Rev Anim Biosci. 2013;1:283-309. PubMed
  2. Smuts CM, Matsungo TM, Malan L, et al. Effect of small-quantity lipid-based nutrient supplements on growth, psychomotor development, iron status, and morbidity among 6- to 12-mo-old infants in South Africa: a randomized controlled trial. Am J Clin Nutr. 2 PubMed
  3. van Heemst RC, Sander I, Rooyackers J, et al. Hypersensitivity pneumonitis caused by occupational exposure to phytase. Eur Respir J. 2009;33(6):1507-9. PubMed
  4. Baur X, Melching-Kollmuss S, Koops F, Strassburger K, Zober A. IgE-mediated allergy to phytase -- a new animal feed additive. Allergy. 2002;57(10):943-5. PubMed
  5. Doekes G, Kamminga N, Helwegen L, Heederik D. Occupational IgE sensitisation to phytase, a phosphatase derived from Aspergillus niger. Occup Environ Med. 1999;56(7):454-9. PubMed
  6. Brnic M, Hurrell RF, Songré-Ouattara LT, et al. Effect of phytase on zinc absorption from a millet-based porridge fed to young Burkinabe children. Eur J Clin Nutr. 2017;71(1):137-141. PubMed
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Black Pepper 29 references
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Panax Notoginseng 15 references
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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