Interactions on record — worth a quick check against your medications. Based on 1 of 3 ingredients. Check your meds →
Dietary supplement

UriVarx Ingredients & Drug Interactions

by Innovus Pharmaceuticals

UriVarx label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 30, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking UriVarx against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

UriVarx is a dietary supplement by Innovus Pharmaceuticals with 3 active ingredients. Its ingredients are commonly taken for fluid retention (mild diuretic), urinary and bladder concerns, hair, skin, and nail support.Based on those ingredients, 188 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Horsetail (Equisetum arvense) extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against UriVarx by Innovus Pharmaceuticals

Ask about any prescription or over-the-counter medication and we check it for interactions with UriVarx by Innovus Pharmaceuticals — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of UriVarx by Innovus Pharmaceuticals

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 24, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 3 active ingredients.
  • “UriVarx Proprietary Blend” is a proprietary blend — the label gives one combined amount (840 mg) without saying how much of each component you get.

UriVarx contains 3 active ingredients: horsetail (Equisetum arvense) extract, Lindera (Lindera aggregata) extract, and Three-leaf Caper (Crateva nurvala) extract, along with a proprietary blend. The product is filled with vegetable capsules made with rice flour and silica.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Horsetail's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: promote and support healthy bladder function.
  • We looked for evidence on: Urinary incontinence, Urinary tract infections (UTIs), bladder overactivity, urinary frequency.
  • The closest evidence on file: Horsetail is rated "Insufficient Reliable Evidence To Rate" for Urinary tract infections (UTIs) (Natural Medicines).
  • Also on file: Horsetail is rated "Insufficient Reliable Evidence To Rate" for Urinary incontinence.

The evidence we hold does not establish that horsetail or the other ingredients in this product are effective for urinary incontinence, obesity, tonsillitis, or androgenic alopecia (hair loss). All the effectiveness ratings for these uses show insufficient reliable evidence to rate them — meaning we don't have enough solid clinical data to say whether this product works for these purposes.

The evidence, ingredient by ingredient Horsetail

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Horsetail is generally well tolerated for short-term use in healthy adults, but long-term use carries real risks. The most common side effects from oral horsetail are abdominal bloating, increased bowel movements, and nausea.

Crude horsetail contains thiaminase, which can cause thiamine (vitamin B1) deficiency with prolonged use, though products certified thiaminase-free are available. One case report described seborrheic dermatitis (a skin rash) from topical horsetail, traced to its nicotine content.

Pregnancy: the safety data advises against use during pregnancy. Breastfeeding: the safety data advises against use while breastfeeding.

Side effects, ingredient by ingredient Horsetail

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Horsetail.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications; lithium.
  • For scale: 188 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking UriVarx, double-check with your doctor or pharmacist if you take HIV medications (NRTIs or efavirenz in particular — horsetail may reduce their effectiveness), antidiabetes drugs, diuretics, or lithium. Horsetail may also lower blood sugar, raise lithium levels, and increase potassium loss — all of which can require dose adjustments or careful monitoring.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

If you're considering UriVarx for urinary symptoms or another condition, talk it over with your doctor or pharmacist first — the evidence doesn't yet show it works for the uses listed, and horsetail carries real interactions with HIV medications, diabetes drugs, diuretics, and lithium. If you take any of those, or any other prescription medication, check with your own doctor or pharmacist before starting this product.

Horsetail is best used short-term, not long-term.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Oct 25, 2018.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about UriVarx, straight from the product label.

Brand Innovus Pharmaceuticals
Barcode (UPC) 357483000189
Net contents 60 Veggie Capsule(s)
Market status On market
Date entered into DSLD Oct 25, 2018
DSLD ID 182012
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for UriVarx by Innovus Pharmaceuticals, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
30
UPC/BARCODE
357483000189
IngredientAmount% DV
Lindera (Lindera aggregata) extract0 NP--
UriVarx Proprietary Blend840 mg--
Horsetail (Equisetum arvense) extract0 NP--
Cratevox Three-leaf Caper (Crateva nurvala) extract0 NP--

Other ingredients: Vegetable Capsule, Rice Flour, Silica

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Brand IP Statement(s)

UriVarx is a proprietary patented blend of synergistic herbs designed to promote and support healthy bladder function, help reduce frequency and maintain control.

UriVarx is a trademark of Innovus Pharmaceuticals and Cratevox is a trademark of Seipel Group P/L.

Suggested/Recommended/Usage/Directions

Suggested Use: Take two (2) capsules daily with meals or as instructed by a healthcare professional.

Precautions

Consult a physician before using if pregnant, nursing or on medication.

Do not purchase if seal is broken.

Storage

Store at room temperature.

FDA Disclaimer Statement

These statements have not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

General Statements

U.S. Patent No. 9,453,191

Clinically proven bladder control

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

UriVarx by Innovus Pharmaceuticals label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

UriVarx label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in UriVarx by Innovus Pharmaceuticals

These are the 3 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

UriVarx Proprietary Blend

840 mg per serving

Other (inactive) ingredients: Vegetable Capsule, Rice Flour, Silica. These complete the product’s ingredient list but are not active constituents.

Interaction report

UriVarx by Innovus Pharmaceuticals Drug Interactions

Want to check YOUR meds against UriVarx?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
188Drugs
188 Moderate

Ingredients driving the most interactions

Horsetail (Equisetum arvense) extract 188

Individual Drug Interactions

The ingredients in UriVarx interact with 188 drugs. Click any drug to see the details.

1 of the 3 ingredients in UriVarx interact with drugs. Each result below shows which ingredient is responsible. Horsetail (Equisetum arvense) extract

Each ingredient & the kinds of drugs it affects

For each ingredient in UriVarx with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Horsetail (Equisetum arvense) extract5 drug types · 188 drugs

Antidiabetes Drugs

Theoretically, taking horsetail with antidiabetes drugs might increase the risk of hypoglycemia.
Equisetum myriochaetum has demonstrated hypoglycemic activity in clinical research. In an animal diabetic model, Equisetum giganteum had hypoglycemic effects. It is unclear whether other horsetail species have hypoglycemic effects.

Likelihood Possible Evidence D
Diuretic Drugs

Theoretically, taking horsetail with diuretic drugs might increase potassium loss and the risk of hypokalemia.
Laboratory research shows that various species of horsetail have diuretic properties. Due to its diuretic effects, there has been concern that taking horsetail along with potassium-depleting diuretics might increase the risk for hypokalemia. However, pharmacokinetic research in humans shows that taking horsetail 900 mg daily for 4 days does not affect urinary excretion of electrolytes, including potassium and sodium, despite having a diuretic effect similar to taking hydrochlorothiazide 25 mg daily. It is unclear if taking horsetail for a longer duration would affect electrolyte levels. Until more is known, use with caution.

Likelihood Possible Evidence D
Efavirenz (Sustiva)

Theoretically, horsetail might decrease the levels and clinical effects of efavirenz.
In two case reports, patients were found to have detectable viral loads when taking horsetail-containing supplements along with an antiretroviral regimen that included efavirenz. In one case, the antiretroviral regimen included zidovudine, lamivudine, and efavirenz; in the other case, the regimen consisted of emtricitabine, tenofovir disoproxil fumarate, and efavirenz. One month after discontinuing horsetail, the viral loads became undetectable in both cases. The exact mechanism of this interaction is unknown. It is also unclear if this interaction is specific to efavirenz or if it is related to various components of antiretroviral therapy.

Likelihood Possible Evidence D
Lithium

Theoretically, horsetail might increase the levels and adverse effects of lithium.
Animal research suggests that horsetail has diuretic properties. Theoretically, due to these potential diuretic effects, horsetail might reduce excretion and increase levels of lithium. The dose of lithium might need to be decreased.

Likelihood Possible Evidence D
Nucleoside Reverse Transcriptase Inhibitors (Nrtis)

Theoretically, horsetail might decrease the levels and clinical effects of NRTIs.
In two case reports, patients were found to have detectable viral loads when taking horsetail-containing supplements along with an antiretroviral therapy. In one case, the antiretroviral regimen included zidovudine, lamivudine, and efavirenz; in the other case, the regimen consisted of emtricitabine, tenofovir disoproxil fumarate, and efavirenz. One month after discontinuing the supplement, the viral loads became undetectable in both cases. The exact mechanism of these interactions is unknown. It is also unclear if these interactions are specific to NRTIs or if they are related to various components of antiretroviral therapy.

Likelihood Possible Evidence D
Horsetail (Equisetum arvense) extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for UriVarx, from the product label.

Innovus Pharmaceuticals

See all Innovus Pharmaceuticals products
Name
Innovus Pharmaceuticals, Inc.
Street Address
9171 Towne Centre Drive, Ste 440
City
San Diego
State
CA
ZipCode
92122
Phone Number
1.800.748.6119
Web Address
www.urivarx.com
Pharmacist Counseling Corner

UriVarx by Innovus Pharmaceuticals: Common Questions

Does UriVarx by Innovus Pharmaceuticals interact with any medications?
Yes. Based on its ingredients, UriVarx has a known interaction with 188 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
UriVarx contains 3 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is horsetail supposed to do in this product?
The product lists horsetail for urinary incontinence, obesity, tonsillitis, and androgenic alopecia (hair loss). However, we don't have enough reliable clinical evidence to say whether horsetail actually works for any of these uses.
Can I take UriVarx if I'm pregnant or breastfeeding?
No. The safety data advises against use during pregnancy and while breastfeeding. Talk to your doctor about safer options for your situation.
What are the most common side effects?
Abdominal bloating, increased bowel movements, and nausea are the most common side effects reported. Long-term use of crude horsetail can also cause thiamine deficiency, though some products are certified thiaminase-free.
I take diabetes medication — is UriVarx safe for me?
No, not without checking first. Horsetail may increase the risk of low blood sugar when combined with antidiabetes drugs, and your dose may need adjusting. Talk to your doctor or pharmacist before taking this product.
Does it matter if I'm on a water pill (diuretic)?
Yes, this matters. Horsetail itself has diuretic effects and may increase potassium loss, especially combined with potassium-depleting water pills. Check with your doctor or pharmacist before starting UriVarx.
Can I use this with my HIV medication?
Horsetail has been associated in case reports with reduced effectiveness of NRTIs and efavirenz — patients had detectable viral loads while taking horsetail-containing supplements. Do not start this product without talking to your doctor first.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

UriVarx label
Go deeper

The Full Monographs Behind UriVarx’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Horsetail

Interacts with 188 drugs

Horsetail is a traditional herb most often used as a mild diuretic and for hair, nail, and bone support, but high-quality human evidence is limited. It can cause thiamine (vitamin B1) loss w...

Read the full Horsetail monograph →
Sources

Sources & How We Checked

UriVarx's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 14 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Horsetail 14 references
  1. Sudan BJ. Seborrhoeic dermatitis induced by nicotine of horsetails (Equisetum arvense L.). Contact Dermatitis 1985;13:201-2.
  2. Perez Gutierrez RM, Laguna GY, Walkowski A. Diuretic activity of Mexican equisetum. J Ethnopharmacol 1985;14:269-72. PubMed
  3. Lemus I, Garcia R, Erazo S, et al. Diuretic activity of an Equisetum bogotense tea (Platero herb): evaluation in healthy volunteers. J Ethnopharmacol 1996;54:55-8. PubMed
  4. Revilla MC, Andrade-Cetto A, Islas S, Wiedenfeld H. Hypoglycemic effect of Equisetum myriochaetum aerial parts on type 2 diabetic patients. J Ethnopharmacol 2002;81:117-20. PubMed
  5. Tiktinskii, O. L. and Bablumian, I. A. [Therapeutic action of Java tea and field horsetail in uric acid diathesis]. Urol.Nefrol.(Mosk) 1983;3(1):47-50.
  6. Henderson JA, Evans EV, and McIntosh RA. The antithiamine action of Equisetum. J Amer Vet Med Assoc 1952;120:375-378.
  7. Carneiro DM, Freire RC, Honório TC, Zoghaib I, Cardoso FF, Tresvenzol LM, de Paula JR, Sousa AL, Jardim PC, da Cunha LC. Randomized, Double-Blind Clinical Trial to Assess the Acute Diuretic Effect of Equisetum arvense (Field Horsetail) in Healthy Voluntee
  8. Klnçalp S, Ekiz F, Basar Ö, Coban S, Yüksel O. Equisetum arvense (Field Horsetail)-induced liver injury. Eur J Gastroenterol Hepatol. 2012 Feb;24(2):213-4. PubMed
  9. Ortega García JA, Angulo MG, Sobrino-Najul EJ, Soldin OP, Mira AP, Martínez-Salcedo E, Claudio L. Prenatal exposure of a girl with autism spectrum disorder to 'horsetail' (Equisetum arvense) herbal remedy and alcohol: a case report. J Med Case Rep. 2011 M PubMed
  10. Cordova E, Morganti L, Rodriguez C. Possible Drug-Herb Interaction between Herbal Supplement Containing Horsetail (Equisetum arvense) and Antiretroviral Drugs. J Int Assoc Provid AIDS Care. 2017;16(1):11-13.
  11. García Gavilán MD, Moreno García AM, Rosales Zabal JM, Navarro Jarabo JM, Sánchez Cantos A. Case of drug-induced acute pancreatitis produced by horsetail infusions. Rev Esp Enferm Dig. 2017 Apr;109(4):301-304. PubMed
  12. Vieira GT, de Oliveira TT, Carneiro MAA, et al. Antidiabetic effect of Equisetum giganteum L. extract on alloxan-diabetic rabbit. J Ethnopharmacol. 2020;260:112898. PubMed
  13. Health Canada. Organism-Equisetum arvense. Available at: http://webprod.hc-sc.gc.ca/nhpid-bdipsn/ingredReq.do?id=6117&lang=eng. Accessed 21-July 2021.
  14. Bates D, Duong TB, Kheyson S, Moore K. Hyponatremia Secondary to Decreased Oral Intake and SIADH and Possibly Exacerbated by Horsetail (Equisetum arvense). Can J Hosp Pharm 2021;74(4):386-389. PubMed

See these in context on the Horsetail monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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