Interactions on record — worth a quick check against your medications. Based on 1 of 2 ingredients. Check your meds →
Dietary supplement

Digestive Daily Probiotic Ingredients & Drug Interactions

by Culturelle

Digestive Daily Probiotic label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Minor
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Digestive Daily Probiotic against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Minor

Digestive Daily Probiotic is a dietary supplement by Culturelle with 2 active ingredients. Its ingredients are commonly taken for constipation and regularity, prebiotic gut health, blood sugar support.Based on those ingredients, 86 medications have a known interaction with it, the most serious rated minor. The ingredients most likely to interact are Inulin. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Digestive Daily Probiotic by Culturelle

Ask about any prescription or over-the-counter medication and we check it for interactions with Digestive Daily Probiotic by Culturelle — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Digestive Daily Probiotic by Culturelle

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 23, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 2 of its 2 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

Culturelle Digestive Daily Probiotic contains 2 active ingredients: Lactobacillus rhamnosus GG, a live probiotic bacteria, and inulin, a type of soluble fiber that feeds beneficial gut bacteria. The capsule also holds inactive ingredients — hydroxypropyl methylcellulose, vegetable magnesium stearate, and titanium dioxide — which are binders and coating materials.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: digestive health and gut microbiome balance.
  • We looked for evidence on: Constipation, Antibiotic-associated diarrhea, irritable bowel syndrome, dysbiosis.
  • The strongest evidence on file: Inulin is rated "Possibly Effective" for Constipation (Natural Medicines).
  • Also on file: Inulin is rated "Insufficient Reliable Evidence To Rate" for Antibiotic-associated diarrhea.

Inulin is possibly effective for obesity, constipation, and diabetes based on the evidence we hold. For nonalcoholic fatty liver disease and iron deficiency anemia, the evidence isn't established enough to rate it.

The effectiveness data we have for Lactobacillus rhamnosus GG isn't on file.

The evidence, ingredient by ingredient Inulin

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Inulin is generally well tolerated, especially in food amounts, but it commonly causes gas, bloating, constipation, diarrhea, and stomach cramping — particularly at doses over 30 grams. Anaphylaxis (a severe allergic reaction) has been reported rarely with foods high in inulin.

Safety of inulin supplements at concentrated doses hasn't been well studied; talk to your doctor before using them. Inulin is likely safe in pregnancy and while breastfeeding.

Side effects, ingredient by ingredient Inulin

Meds to double-check

Minor interactions only
Known Interaction Concern · database check
Minor only

Only Minor-severity interactions are documented for these ingredients.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Inulin.
  • The most serious interaction on file is rated Minor.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 86 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check your exact diabetes medications before taking this product — inulin carries a Minor interaction risk with antidiabetes drugs and may increase the chance of low blood sugar. Lactobacillus rhamnosus GG hasn't been checked in our data.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Only minor medication interactions are documented, and safety information is well characterized.

This probiotic is generally well tolerated and may help with constipation or digestion. If you take diabetes medication, check with your doctor before starting — inulin might lower your blood sugar further.

Gas and bloating are common, especially when you first start. Chat with your pharmacist or doctor about whether it's right for you.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jul 27, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Digestive Daily Probiotic, straight from the product label.

Brand Culturelle
Barcode (UPC) 049100400662
Net contents 14 Once Daily Vegetarian Capsule(s)
Market status On market
Date entered into DSLD Jul 27, 2021
DSLD ID 250853
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Children 4 or More Years of Age, Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Digestive Daily Probiotic by Culturelle, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
UPC/BARCODE
049100400662
IngredientAmount% DV
Calories0 Calorie(s)--
Total Carbohydrates0 Gram(s)--
Added Sugars0 Gram(s)--
Total Sugars0 Gram(s)--
Lactobacillus rhamnosus GG40 mg--
Inulin200 mg--

Other ingredients: Hydroxypropyl Methylcellulose, Vegetable Magnesium Stearate, Titanium Dioxide

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Take charge of your digestive health with Culturelle

Help your digestive system work better & support your gut microbiome with the power of Culturelle Digestive Daily Probiotic.

Keeps your digestive system balanced Helps with occasional diarrhea, gas & bloating Minimizes travel related stomach & digestive issues

Allergy friendly Free from Milk - Wheat - Eggs Tree Nuts - Peanuts

Most clinically researched strain in the world Based on the number of Lactobacillus rhamnosus GG studies as of January 2019. Guaranteed purity & potency Guaranteed potency through date on box when stored as directed.

Dairy - Gluten - Soy - Free Meets the FDA's guidelines for gluten-free.

Supports your gut microbiome & helps your digestive system work better Helps with occasional digestive upset including diarrhea, gas & bloating

Formula

Formulated with 10 billion CFUs of the proven effective LGG probiotic strain to help naturally balance your digestive system, plus the prebiotic inulin. Based on the studies of Lactobacillus rhamnosus GG for a range of benefits throughout the lifespan.

Not a reduced calorie food.

LGG naturally sourced LGG

With prebiotics 200mg inulin

General Statements

Unleash the power of your microbiome! Your gut microbiome helps support an overall healthy you because it's linked to your digestive health, cognition, mood, nutrition, and immune system. You can trust your gut daily to Culturelle.

Scan to learn more

Our brand values We're on a mission to inspire better health & wellness for you and your family. We believe in integrity, so we hold ourselves to the highest standards of truth. We believe in the natural power of your body's microbiome, & in scientific research & products that will unlock its full potential. We believe in uncompromising quality, safety & proven efficacy. We believe in empowering you to embrace every day with confidence.

The Culturelle difference Excludes gummy formulas.

The most trusted probiotic brand Based on the 2019 BrandSpark American Shopper Study. Culturelle Probiotics

Storage

Storage instructions: Store Culturelle in a cool, dry place away from direct sunlight.

Precautions

Tamper evident: Product is sealed within blisters. Do not use if any part of the blister is torn, open or damaged.

Keep out of reach of children.

Inform a healthcare professional before starting any dietary supplement, particularly if there is a known immune-compromised condition. When first taking a probiotic, your gut microbiome adjusts. You may experience minor bloating, gas or intestinal gurgling which should subside with continued use. Consult your healthcare professional if symptoms continue after two weeks. For questions, concerns or to report an adverse event please call (800) 722-3476.

Brand IP Statement(s)

Culturelle is a trademark of DSM. LGG & LGG logo are trademarks of Chr. Hansen A/S.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

FDA Statement of Identity

Probiotic Supplement

Suggested/Recommended/Usage/Directions

Directions for age 12+ years: Take one capsule daily. Continued use is suggested. When traveling, take two capsules daily [one in the morning and one at night] before and during the trip. During antibiotic use, take one capsule twice daily [as directed above] and continue for 10 days after completion of antibiotics.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Digestive Daily Probiotic by Culturelle label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Digestive Daily Probiotic label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Digestive Daily Probiotic by Culturelle

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Lactobacillus rhamnosus GG

40 mg per serving

Inulin

Interacts with
86 drugs
200 mg per serving Form: Chicory root extract

Inulin is a type of plant fiber (a prebiotic) found naturally in foods like chicory root, onions, and garlic, and it is widely added to supplements an...

Inulin monograph & interactions

Other (inactive) ingredients: Hydroxypropyl Methylcellulose, Vegetable Magnesium Stearate, Titanium Dioxide. These complete the product’s ingredient list but are not active constituents.

Interaction report

Digestive Daily Probiotic by Culturelle Drug Interactions

Want to check YOUR meds against Digestive Daily Probiotic?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
86Drugs
86 Minor

Ingredients driving the most interactions

Inulin 86

Individual Drug Interactions

The ingredients in Digestive Daily Probiotic interact with 86 drugs. Click any drug to see the details.

1 of the 2 ingredients in Digestive Daily Probiotic interact with drugs. Each result below shows which ingredient is responsible. Inulin

Each ingredient & the kinds of drugs it affects

For each ingredient in Digestive Daily Probiotic with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Inulin1 drug type · 86 drugs

Antidiabetes Drugs

Theoretically, inulin might increase the risk of hypoglycemia with antidiabetes drugs.
Some clinical research shows that inulin improves glycemic control in patients with diabetes; however, it is unclear if it has hypoglycemic effects.

Likelihood Unlikely Evidence D
Inulin full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Digestive Daily Probiotic, from the product label.

Culturelle

Name
i-Health, Inc.
Street Address
55 Sebethe Dr.
City
Cromwell
State
CT
ZipCode
06416
Phone Number
800-722-3476
Web Address
www.Culturelle.com
Pharmacist Counseling Corner

Digestive Daily Probiotic by Culturelle: Common Questions

Does Digestive Daily Probiotic by Culturelle interact with any medications?
Yes. Based on its ingredients, Digestive Daily Probiotic has a known interaction with 86 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Digestive Daily Probiotic contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this give me bloating or gas?
Yes, it's common — especially when you first start. Inulin often causes bloating, gas, and stomach cramping, more so at higher doses over 30 grams. You may notice it settle as your gut adjusts.
Is it safe during pregnancy?
Yes, inulin is likely safe in pregnancy. We don't have safety data on file for Lactobacillus rhamnosus GG during pregnancy, so talk to your doctor if you want to be sure.
Can I take it if I have diabetes?
Check with your doctor first. Inulin might theoretically lower blood sugar further with diabetes medication, which could raise the risk of low blood sugar.
What's inulin, and why is it in a probiotic?
Inulin is a soluble fiber that acts as a prebiotic — it feeds the good bacteria in your gut so they can thrive. It's why it's paired with the Lactobacillus bacteria in this product.
Is it safe while breastfeeding?
Inulin is likely safe while breastfeeding. Data on Lactobacillus rhamnosus GG during breastfeeding isn't on file, so ask your pharmacist or doctor if you want to double-check.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Digestive Daily Probiotic is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Digestive Daily Probiotic label
Go deeper

The Full Monographs Behind Digestive Daily Probiotic’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Inulin

Interacts with 86 drugs

Inulin is a type of plant fiber (a prebiotic) found naturally in foods like chicory root, onions, and garlic, and it is widely added to supplements and processed foods. It may help with regu...

Read the full Inulin monograph →
Sources

Sources & How We Checked

Digestive Daily Probiotic's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 17 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Inulin 17 references
  1. Williams CM. Effects of inulin on lipid parameters in humans. J Nutr 1999 Jul;129(7 Suppl):1471S-3S. PubMed
  2. Pedersen A, Sandstrom B, Van Amelsvoort JM. The effect of ingestion of inulin on blood lipids and gastrointestinal symptoms in healthy females. Br J Nutr 1997;78:215-22. PubMed
  3. Cummings JH, Macfarlane GT, Englyst HN. Prebiotic digestion and fermentation. Am J Clin Nutr 2001;73:415S-420S. PubMed
  4. Bonnema AL, Kolberg LW, Thomas W, Slavin JL. Gastrointestinal tolerance of chicory inulin products. J Am Diet Assoc 2010;110(6):865-8. PubMed
  5. Dehghan P, Gargari BP, Jafar-Abadi MA, Aliasgharzadeh A. Inulin controls inflammation and metabolic endotoxemia in women with type 2 diabetes mellitus: a randomized-controlled clinical trial. Int J Food Sci Nutr 2014;65(1):117-23. PubMed
  6. Guess ND, Dornhorst A, Oliver N, Frost GS. A randomised crossover trial: the effect of inulin on glucose homeostasis in subtypes of prediabetes. Ann Nutr Metab 2016;68(1):26-34. PubMed
  7. Marteau P, Jacobs H, Cazaubiel M, Signoret C, Prevel JM, Housez B. Effects of chicory inulin in constipated elderly people: a double-blind controlled trial. Int J Food Sci Nutr 2011;62(2):164-70. PubMed
  8. Mensink MA, Frijlink HW, van der Voort Maarschalk K, Hinrichs WL. Inulin, a flexible oligosaccharide I: review of its physicochemical characteristics. Carbohydr Polym 2015;130:405-19. PubMed
  9. Slavin J, Feirtag J. Chicory inulin does not increase stool weight or speed up intestinal transit time in healthy male subjects. Food Funct. 2011;2(1):72-7. PubMed
  10. Micka A, Siepelmeyer A, Holz A, Theis S, Schön C. Effect of consumption of chicory inulin on bowel function in healthy subjects with constipation: a randomized, double-blind, placebo-controlled trial. Int J Food Sci Nutr. 2017;68(1):82-89. PubMed
  11. Smiljanec K, Mitchell CM, Privitera OF, Neilson AP, Davy KP, Davy BM. Pre-meal inulin consumption does not affect acute energy intake in overweight and obese middle-aged and older adults: A randomized controlled crossover pilot trial. Nutr Health. 2017;23 PubMed
  12. Cai X, Yu H, Liu L, et al. Milk powder co-supplemented with inulin and resistant dextrin improves glycemic control and insulin resistance in elderly type 2 diabetes mellitus: a 12-week randomized, double-blind, placebo-controlled trial. Mol Nutr Food Res PubMed
  13. Rao M, Gao C, Xu L, et al. Effect of inulin-type carbohydrates on insulin resistance in patients with type 2 diabetes and obesity: a systematic review and meta-analysis. J Diabetes Res. 2019;2019:5101423. PubMed
  14. Mitchell CM, Davy BM, Ponder MA, et al. Prebiotic Inulin Supplementation and Peripheral Insulin Sensitivity in adults at Elevated Risk for Type 2 Diabetes: A Pilot Randomized Controlled Trial. Nutrients 2021;13(9):3235. PubMed
  15. Li L, Li P, Xu L. Assessing the effects of inulin-type fructan intake on body weight, blood glucose, and lipid profile: A systematic review and meta-analysis of randomized controlled trials. Food Sci Nutr 2021;9(8):4598-4616. PubMed
  16. Ziaei R, Shahshahan Z, Ghasemi-Tehrani H, Heidari Z, Ghiasvand R. Effects of inulin-type fructans with different degrees of polymerization on inflammation, oxidative stress and endothelial dysfunction in women with polycystic ovary syndrome: A randomized,
  17. Risso D, Kaczmarczyk M, Laurie I, et al. Moderate intakes of soluble corn fibre or inulin do not cause gastrointestinal discomfort and are well tolerated in healthy children. Int J Food Sci Nutr 2022;73(8):1104-1115. PubMed

See these in context on the Inulin monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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