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Dietary supplement

DIM Diindolymethane 400 mg Ingredients & Drug Interactions

by Double Wood Supplements

DIM Diindolymethane 400 mg label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking DIM Diindolymethane 400 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

DIM Diindolymethane 400 mg is a dietary supplement by Double Wood Supplements with 1 active ingredient. Its ingredients are commonly taken for estrogen/hormone balance, acne and hormonal skin issues, prostate health support.Based on those ingredients, 269 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Diindolylmethane. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against DIM Diindolymethane 400 mg by Double Wood Supplements

Ask about any prescription or over-the-counter medication and we check it for interactions with DIM Diindolymethane 400 mg by Double Wood Supplements — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of DIM Diindolymethane 400 mg by Double Wood Supplements

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains a single active ingredient: diindolylmethane (DIM), a compound derived from cruciferous vegetables like broccoli and cabbage. DIM is included at 400 mg per capsule.

The capsule itself is made from hypromellose (a plant-based cellulose), and rice flour is added as an inactive filler.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Diindolylmethane's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: energy metabolism and hormonal balance.
  • We looked for evidence on: Benign prostatic hyperplasia (BPH), Mastalgia, Premenstrual syndrome (PMS), Obesity, Estrogen metabolism, Hormone balance — and 1 related terms.
  • The closest evidence on file: Diindolylmethane is rated "Insufficient Reliable Evidence To Rate" for Benign prostatic hyperplasia (BPH) (Natural Medicines).
  • Also on file: Diindolylmethane is rated "Insufficient Reliable Evidence To Rate" for Mastalgia, Obesity, Premenstrual syndrome (PMS).

The evidence for DIM isn't established in the data we hold. We have insufficient reliable evidence to rate whether it works for benign prostatic hyperplasia, breast cancer, colorectal cancer, cervical dysplasia, or breast pain.

If you're considering DIM for any of these conditions, that's a conversation worth having with your doctor or pharmacist about what the current research actually supports.

The evidence, ingredient by ingredient Diindolylmethane

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

DIM is generally well tolerated in short-term studies, though long-term safety hasn't been well established. The most common side effects reported are diarrhea, gas, headache, nausea, rash, and vomiting.

A rare serious side effect — a severe skin reaction called DRESS — has been documented. One case report mentioned a stroke in a 38-year-old woman taking DIM, but she had multiple stroke risk factors and was taking several supplements, so it's unclear whether DIM played a role.

For pregnancy, the safety data rates DIM as likely safe. However, the data for breastfeeding is not adequate — there's not enough information to know whether it's safe, so it's best avoided while nursing.

Talk with your pharmacist or doctor if you're pregnant or breastfeeding and considering this product.

Side effects, ingredient by ingredient Diindolylmethane

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Diindolylmethane.
  • The most serious interaction on file is rated Moderate.
  • For scale: 269 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking DIM, double-check if you're on estrogens (birth control or hormone replacement therapy) — DIM might interfere with their effects. Also mention any diuretic drugs (water pills) you take.

If you're on medications metabolized by the liver enzyme CYP1A2, that's worth a quick discussion too, though this interaction hasn't been seen in humans yet.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

DIM might appeal to you if you're interested in supporting prostate or breast health, but the evidence for those uses isn't solid yet. If you take birth control, hormone replacement therapy, or water pills, check with us before starting — the interactions could affect how your medications work.

Long-term safety data is thin, so this is a short-term support product worth discussing with your pharmacist first.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Oct 24, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about DIM Diindolymethane 400 mg, straight from the product label.

Brand Double Wood Supplements
Barcode (UPC) 850033272758
Net contents 60 Capsule(s)
Market status On market
Date entered into DSLD Oct 24, 2024
DSLD ID 315645
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for DIM Diindolymethane 400 mg by Double Wood Supplements, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
30
UPC/BARCODE
850033272758
IngredientAmount% DV
Diindolylmethane400 mg--

Other ingredients: Hypromellose, Rice Flour

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Product Information: Diindolylmethane is a compound derived from the digestion of indole-3-carbinol, found in cruciferous vegetables, such as broccoli, Brussels sprouts, cabbage and kale.

DIM 400 mg per serving

Suggested/Recommended/Usage/Directions

Suggested use: As a dietary supplement take 1 serving per day, with or without food.

Storage

Storage: Store in a cool, dark place. Do not freeze or expose to moisture or heat above room temperature after opening.

Seals/Symbols

Proudly manufactured in the USA

Formulation

Made with Non GMO Ingredients Gluten Free

Energy, metabolism, balance

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

FDA Statement of Identity

Dietary Supplement

Precautions

Warning: Consult your physician before use. Discontinue use and consult your doctor immediately if any adverse reactions occur. Do not use DIM and operate heavy machinery until you know how it affects you. Do not exceed capsules per day.

Do not use DIM if you are pregnant, nursing, or are under 18 years of age.

Do not use DIM if you are pregnant, nursing, or are under 18 years of age.

Keep out of reach of children.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

DIM Diindolymethane 400 mg by Double Wood Supplements label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

DIM Diindolymethane 400 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in DIM Diindolymethane 400 mg by Double Wood Supplements

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Diindolylmethane

Interacts with
269 drugs
400 mg per serving

Diindolylmethane (DIM) is a compound made when your body digests cruciferous vegetables, and it is sold as a supplement mainly for hormone balance and...

Diindolylmethane monograph & interactions

Other (inactive) ingredients: Hypromellose, Rice Flour. These complete the product’s ingredient list but are not active constituents.

Interaction report

DIM Diindolymethane 400 mg by Double Wood Supplements Drug Interactions

Want to check YOUR meds against DIM Diindolymethane 400 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
269Drugs
116 Moderate 153 Minor

Ingredients driving the most interactions

Diindolylmethane 269

Individual Drug Interactions

The ingredients in DIM Diindolymethane 400 mg interact with 269 drugs. Click any drug to see the details.

1 of the 1 ingredient in DIM Diindolymethane 400 mg interact with drugs. Each result below shows which ingredient is responsible. Diindolylmethane

Each ingredient & the kinds of drugs it affects

For each ingredient in DIM Diindolymethane 400 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Diindolylmethane3 drug types · 269 drugs

Diuretic Drugs

Theoretically, diindolylmethane might increase the risk of hyponatremia if used with sodium-depleting diuretics.
Large doses of diindolylmethane (600 mg daily) have been associated with two cases of asymptomatic hyponatremia in clinical research.

Likelihood Possible Evidence B
Estrogens

Theoretically, diindolylmethane might increase or decrease the effects of estrogens.
Diindolylmethane might have mild estrogenic or antiestrogenic effects. Theoretically, large amounts of diindolylmethane might interfere with hormone replacement therapy.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, diindolylmethane might lower serum levels of CYP1A2 substrates.
In vitro evidence suggests that diindolylmethane can induce CYP1A2. Theoretically, it might increase metabolism of CYP1A2 substrates and lower serum concentrations. This interaction has not been reported in humans.

Likelihood Unlikely Evidence D
Diindolylmethane full monograph & interactions
The maker

Brand information

Manufacturer and brand details for DIM Diindolymethane 400 mg, from the product label.

Double Wood Supplements

See all Double Wood Supplements products
Name
Double Wood LLC
Street Address
205 Elmwood Ave
City
Sharon Hill
State
PA
ZipCode
19079
Pharmacist Counseling Corner

DIM Diindolymethane 400 mg by Double Wood Supplements: Common Questions

Does DIM Diindolymethane 400 mg by Double Wood Supplements interact with any medications?
Yes. Based on its ingredients, DIM Diindolymethane 400 mg has a known interaction with 269 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
DIM Diindolymethane 400 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm on birth control?
You should check with us first. DIM can theoretically increase or decrease how estrogens work in your body, and that includes hormonal contraceptives. We need to look at your specific pill to make sure DIM won't interfere.
What side effects should I expect?
Most people who take DIM experience diarrhea, gas, headache, nausea, or a rash. These are mild and temporary for most. Serious side effects are rare, but a severe skin reaction (DRESS) has been documented very occasionally.
Is DIM safe to take long-term?
Short-term studies show it's generally well tolerated, but we don't have solid data on long-term safety. If you're thinking about using it regularly for months, that's worth discussing with your pharmacist.
Can I breastfeed while taking this?
There isn't enough safety data to know whether it's safe during breastfeeding, so it's best to avoid it while nursing. Talk with your doctor or pharmacist if you're nursing and considering DIM.
Does DIM actually work for prostate or breast health?
The evidence isn't established yet. We don't have reliable data showing it works for benign prostate problems, breast cancer, or breast pain. It's an area people are interested in, but the science isn't there to confirm it.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

DIM Diindolymethane 400 mg label
Go deeper

The Full Monographs Behind DIM Diindolymethane 400 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Diindolylmethane

Interacts with 269 drugs

Diindolylmethane (DIM) is a compound made when your body digests cruciferous vegetables, and it is sold as a supplement mainly for hormone balance and cancer prevention. Although early lab s...

Read the full Diindolylmethane monograph →
Sources

Sources & How We Checked

DIM Diindolymethane 400 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 14 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Diindolylmethane 14 references
  1. Natl Inst Health, Natl Inst Environmental Health Sci. Indole-3-carbinol. Available at: http://ntp-server.niehs.nih.gov.
  2. Balk JL. Indole-3-carbinol for cancer prevention. Altern Med Alert 2000; 3:105-7.
  3. Riby JE, Chang GHF, Firestone GL, Bjeldanes LF. Ligand-independent activation of estrogen receptor function by 3,3'-diindolylmethane in human breast cancer cells. Biochem Pharmacol 2000;60:167-77. PubMed
  4. Lake BG, Tredger JM, Renwick AB, et al. 3'3-diindolylmethane induces CYP1A2 in cultured precision-cut human liver slices. Xenobiotica 1998;28:803-11. PubMed
  5. Dalessandri, K. M., Firestone, G. L., Fitch, M. D., Bradlow, H. L., and Bjeldanes, L. F. Pilot study: effect of 3,3'-diindolylmethane supplements on urinary hormone metabolites in postmenopausal women with a history of early-stage breast cancer. Nutr Canc PubMed
  6. Reed, G. A., Arneson, D. W., Putnam, W. C., Smith, H. J., Gray, J. C., Sullivan, D. K., Mayo, M. S., Crowell, J. A., and Hurwitz, A. Single-dose and multiple-dose administration of indole-3-carbinol to women: pharmacokinetics based on 3,3'-diindolylmetha
  7. Reed, G. A., Sunega, J. M., Sullivan, D. K., Gray, J. C., Mayo, M. S., Crowell, J. A., and Hurwitz, A. Single-dose pharmacokinetics and tolerability of absorption-enhanced 3,3'-diindolylmethane in healthy subjects. Cancer Epidemiol.Biomarkers Prev. 2008; PubMed
  8. Del Priore G., Gudipudi, D. K., Montemarano, N., Restivo, A. M., Malanowska-Stega, J., and Arslan, A. A. Oral diindolylmethane (DIM): pilot evaluation of a nonsurgical treatment for cervical dysplasia. Gynecol.Oncol. 2010;116(3):464-467. PubMed
  9. Heath, E. I., Heilbrun, L. K., Li, J., Vaishampayan, U., Harper, F., Pemberton, P., and Sarkar, F. H. A phase I dose-escalation study of oral BR-DIM (BioResponse 3,3'- Diindolylmethane) in castrate-resistant, non-metastatic prostate cancer. Am.J.Transl.R
  10. Jellinck, P. H., Forkert, P. G., Riddick, D. S., Okey, A. B., Michnovicz, J. J., and Bradlow, H. L. Ah receptor binding properties of indole carbinols and induction of hepatic estradiol hydroxylation. Biochem.Pharmacol. 3-9-1993;45(5):1129-1136. PubMed
  11. Bui PV, Moualla M, Upson DJ. A Possible Association of Diindolylmethane with Pulmonary Embolism and Deep Venous Thrombosis. Case Rep Med. 2016;2016:7527098. PubMed
  12. Castañon A, Tristram A, Mesher D, Powell N, Beer H, Ashman S, Rieck G, Fielder H, Fiander A, Sasieni P. Effect of diindolylmethane supplementation on low-grade cervical cytological abnormalities: double-blind, randomised, controlled trial. Br J Cancer. 20 PubMed
  13. Le TM, Sanders CJ, van de Corput L, van Erpecum KJ, Röckmann H. Drug rash with eosinophilia and systemic symptoms caused by the dietary supplement diindolylmethane. J Allergy Clin Immunol Pract. 2016 Jan-Feb;4(1):175-6. PubMed
  14. Pence ST, Mehta K, Crum-Bailey J. The Serious Side of Supplements: An Ischemic Stroke in a Healthy 38-year-old Female. Mil Med 2022. PubMed

See these in context on the Diindolylmethane monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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