Distress Remedy Ingredients & Drug Interactions
by Nature's Sunshine Flower Essence Formula
What is this page for?
First and foremost: checking Distress Remedy against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Distress Remedy is a dietary supplement by Nature's Sunshine Flower Essence Formula with 3 active ingredients. Its ingredients are commonly taken for constipation (laxative), dry skin (moisturizer), dry, irritated eyes.Based on those ingredients, 983 medications have a known interaction with it, the most serious rated moderate. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Distress Remedy by Nature's Sunshine Flower Essence Formula
Ask about any prescription or over-the-counter medication and we check it for interactions with Distress Remedy by Nature's Sunshine Flower Essence Formula — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Distress Remedy by Nature's Sunshine Flower Essence Formula
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Low disclosure
This formula contains 9 ingredients, of which 5 are flower essences: red clover (Trifolium pratense), arnica (Arnica mollis), star of Bethlehem (Ornithogalum umbellatum), rock rose (Helianthemum nummularium), and Clematis vitalba, Impatiens glandulifera, and Prunus cerasifera. The base also includes organic vegetable glycerin — a thick sweetener and preservative — and purified water.
There are no inactive fillers or other ingredients listed.
Does it work?
Couldn't assess
The data we hold doesn't establish whether Distress Remedy works for its intended purpose. Red clover has been studied for menopausal symptoms, osteoarthritis, and hair loss, but the evidence was rated insufficient to make a recommendation either way.
Arnica shows possibly effective evidence for osteoarthritis pain, though evidence for the other conditions it's been studied for — acne, hot flashes, postoperative pain, and dry eye — is also insufficient. Star of Bethlehem and rock rose have no effectiveness data on file.
How safe is it?
Well-documented data
Red clover is generally well tolerated short-term in healthy adults but carries caution because of its estrogen-like effects; the most common side effects are muscle pain, nausea, and vaginal spotting. Arnica is unsafe when swallowed in whole-plant form and can cause serious toxicity including heart rhythm problems, but homeopathic dilutions and topical forms are generally well tolerated.
Star of Bethlehem contains toxic cardiac glycosides that pose a real risk of dangerous heart arrhythmias and should be approached with extreme caution. Glycerin is generally well tolerated at normal amounts but can cause bloating, nausea, vomiting, diarrhea, headache, and dizziness at larger doses.
Rock rose has limited human safety data. None of these ingredients should be used during pregnancy or while breastfeeding — the data advises against it.
Meds to double-check
Moderate interaction found
Before taking this product, check with your own doctor or pharmacist if you take digoxin or other heart medications, blood thinners (anticoagulants or antiplatelet drugs), diuretics, stimulant laxatives, macrolide or tetracycline antibiotics, corticosteroids, quinine, estrogen therapy, tamoxifen, methotrexate, or any medications metabolized through CYP1A2, CYP2C19, CYP2C9, or CYP3A4 pathways.
The bottom line
Scorecard at a glanceFormula with limited ingredient disclosure with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
If you take heart medications (especially digoxin), blood thinners, diuretics, certain antibiotics, corticosteroids, estrogen therapy, tamoxifen, methotrexate, or quinine, this product isn't safe to add without clearing it first with your own doctor or pharmacist. Even if you don't take those, the cardiac glycoside risk in star of Bethlehem warrants a conversation with your pharmacist before you start.
The effectiveness for distress or anxiety hasn't been established in the data we hold.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 5 of 9 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Oct 23, 2019.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Distress Remedy, straight from the product label.
| Brand | Nature's Sunshine Flower Essence Formula |
|---|---|
| Barcode (UPC) | 099904087781 |
| Net contents | 1.9 fl. Oz.; 57 mL |
| Market status | On market |
| Date entered into DSLD | Oct 23, 2019 |
| DSLD ID | 208495 |
| Product type | Other Combinations |
| Supplement form | Liquid |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years) |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Distress Remedy by Nature's Sunshine Flower Essence Formula, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| purified Water | 0 NP | -- |
| Proprietary Blend | 1000 mg | -- |
| organic Vegetable Glycerin | 0 NP | -- |
| Infusions of the Flowers of | 0 NP | -- |
| Trifolium pratense | 0 NP | -- |
| Arnica mollis | 0 NP | -- |
| Ornithogalum umbellatum | 0 NP | -- |
| Helianthemum nummularium | 0 NP | -- |
| Impatiens glandulifera | 0 NP | -- |
| Clematis vitalba | 0 NP | -- |
| Prunus cerasifera | 0 NP | -- |
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements
Flower Essence Formulas are liquid infusions using only organic ingredients and those derived from flowers grown in organic gardens and pristine wild habitats. Developed for modern issues of occasional emotional and physical stress. Formulated for direct use.
Emotional balance formula Natural flower essence formula that may assist with: Occasional emotional stress Emotional balance Get well keep well Quality, service, integrity
010087780613
Formulation
Flower Essence Formulas are liquid infusions using only organic ingredients and those derived from flowers grown in organic gardens and pristine wild habitats.
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Brand IP Statement(s)
2013
FDA Statement of Identity
Dietary Supplement
Suggested/Recommended/Usage/Directions
Directions: Take 10-15 drops under the tongue, then swallow, 4 times daily. Avoid any contact with dropper to eliminate product contamination.
Precautions
This bottle was sealed for your protection. Do not use if outer shrink band is missing or damaged.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Distress Remedy by Nature's Sunshine Flower Essence Formula label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Distress Remedy by Nature's Sunshine Flower Essence Formula
These are the 3 active ingredients this product is made of. Select any to open its full monograph.
Serving size1 mL Dosage formLiquid Servings per container57 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Proprietary Blend
- › Purified Water
- › Organic Vegetable Glycerin
- › Infusions of the Flowers of
Distress Remedy by Nature's Sunshine Flower Essence Formula Drug Interactions
HelloPharmacist Interaction Report
Nature's Sunshine Distress Remedy, a 9-ingredient flower essence formula, interacts with medications through its red clover, arnica, and star of Bethlehem content.
The most serious concern is star of Bethlehem's interaction with heart medications: its cardiac glycosides can dangerously combine with digoxin (Lanoxin), potentially causing life-threatening heart rhythm problems (arrhythmias) or toxicity.
Read the full breakdown — every affected drug type, severity by severity
Red clover poses Moderate-severity risks with hormone therapy (estrogens and tamoxifen) and methotrexate, a drug used for psoriasis and other conditions. It also has Minor interactions with several liver-metabolized drug classes: CYP1A2, CYP2C19, CYP2C9, and CYP3A4 substrates — though small clinical studies suggest the real-world effect may be limited.
Red clover also carries a Minor anticoagulant concern, though clinical evidence of harm is lacking.
Arnica raises a Moderate concern with blood thinners (anticoagulants) and antiplatelet drugs. Star of Bethlehem compounds this risk and adds Moderate interactions with diuretics, stimulant laxatives, macrolide and tetracycline antibiotics, corticosteroids, and quinine — all through the same cardiac glycoside mechanism.
Rock rose appears to have no documented interactions, and we could not check purified water, Impatiens glandulifera, Clematis vitalba, or Prunus cerasifera. Altogether, these interactions span 984 individual medications.
Check your exact medications with the search tool on this page before starting.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Distress Remedy?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Distress Remedy interact with 983 drugs. Click any drug to see the details.
0 of the 3 ingredients in Distress Remedy interact with drugs. Each result below shows which ingredient is responsible.
AbciximabReoPro
How Abciximab interacts with Distress Remedy — through 2 ingredients. Tap an ingredient for the detail:
Arnica MollisAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, arnica might have additive effects with anticoagulant and antiplatelet drugs.
Read the full Arnica Mollis + Abciximab interactionTrifolium PratenseAnticoagulant/antiplatelet Drugs Minor
Interaction Summary
Although some laboratory research suggests that red clover may have anticoagulant and antiplatelet activity, clinical research has not shown this effect.
Read the full Trifolium Pratense + Abciximab interactionAbrocitinibCibinqo
How Abrocitinib interacts with Distress Remedy — through 2 ingredients. Tap an ingredient for the detail:
Arnica MollisAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, arnica might have additive effects with anticoagulant and antiplatelet drugs.
Read the full Arnica Mollis + Abrocitinib interactionTrifolium PratenseCytochrome P450 2c19 (cyp2c19) Substrates, Cytochrome P450 2c9 (cyp2c9) Substrates +1 Minor
Interaction Summary
Theoretically, red clover might increase the levels and clinical effects of drugs metabolized by CYP2C19.
Read the full Trifolium Pratense + Abrocitinib interactionAcenocoumarolSintrom
How Acenocoumarol interacts with Distress Remedy — through 2 ingredients. Tap an ingredient for the detail:
Arnica MollisAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, arnica might have additive effects with anticoagulant and antiplatelet drugs.
Read the full Arnica Mollis + Acenocoumarol interactionTrifolium PratenseAnticoagulant/antiplatelet Drugs Minor
Interaction Summary
Although some laboratory research suggests that red clover may have anticoagulant and antiplatelet activity, clinical research has not shown this effect.
Read the full Trifolium Pratense + Acenocoumarol interactionAcetaminophen, AspirinGemnisyn
How Acetaminophen, Aspirin interacts with Distress Remedy — through 2 ingredients. Tap an ingredient for the detail:
Arnica MollisAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, arnica might have additive effects with anticoagulant and antiplatelet drugs.
Read the full Arnica Mollis + Acetaminophen, Aspirin interactionTrifolium PratenseCytochrome P450 1a2 (cyp1a2) Substrates, Anticoagulant/antiplatelet Drugs Minor
Interaction Summary
Theoretically, red clover might increase levels of drugs metabolized by CYP1A2; however, a small clinical study found no effect.
Read the full Trifolium Pratense + Acetaminophen, Aspirin interactionAcetaminophen, Aspirin, CaffeineExcedrin, Excedrin Extra Strength, Excedrin Migraine
How Acetaminophen, Aspirin, Caffeine interacts with Distress Remedy — through 2 ingredients. Tap an ingredient for the detail:
Arnica MollisAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, arnica might have additive effects with anticoagulant and antiplatelet drugs.
Read the full Arnica Mollis + Acetaminophen, Aspirin, Caffeine interactionTrifolium PratenseAnticoagulant/antiplatelet Drugs, Caffeine +2 Minor
Interaction Summary
Although some laboratory research suggests that red clover may have anticoagulant and antiplatelet activity, clinical research has not shown this effect.
Read the full Trifolium Pratense + Acetaminophen, Aspirin, Caffeine interactionAcetaminophen, Caffeine, PyrilamineMidol Max Strength Menstrual
How Acetaminophen, Caffeine, Pyrilamine interacts with Distress Remedy — through 2 ingredients. Tap an ingredient for the detail:
Ornithogalum UmbellatumDiuretic Drugs Moderate
Interaction Summary
Theoretically, taking diuretics with star of Bethlehem might increase the risk of toxicity.
Read the full Ornithogalum Umbellatum + Acetaminophen, Caffeine, Pyrilamine interactionTrifolium PratenseCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates +1 Minor
Interaction Summary
Theoretically, red clover might increase levels of drugs metabolized by CYP1A2; however, a small clinical study found no effect.
Read the full Trifolium Pratense + Acetaminophen, Caffeine, Pyrilamine interactionAcetaminophen, IbuprofenCombogesic
How Acetaminophen, Ibuprofen interacts with Distress Remedy — through 2 ingredients. Tap an ingredient for the detail:
Arnica MollisAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, arnica might have additive effects with anticoagulant and antiplatelet drugs.
Read the full Arnica Mollis + Acetaminophen, Ibuprofen interactionTrifolium PratenseCytochrome P450 2c9 (cyp2c9) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates +1 Minor
Interaction Summary
Theoretically, red clover might increase levels of drugs metabolized by CYP2C9; however, a small clinical study found no effect.
Read the full Trifolium Pratense + Acetaminophen, Ibuprofen interactionAcetaminophen, Pamabrom, PyrilamineMidol Max Strength PMS, Pamprin, Pamprin ES
How Acetaminophen, Pamabrom, Pyrilamine interacts with Distress Remedy — through 2 ingredients. Tap an ingredient for the detail:
Ornithogalum UmbellatumDiuretic Drugs Moderate
Interaction Summary
Theoretically, taking diuretics with star of Bethlehem might increase the risk of toxicity.
Read the full Ornithogalum Umbellatum + Acetaminophen, Pamabrom, Pyrilamine interactionTrifolium PratenseCytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, red clover might increase levels of drugs metabolized by CYP1A2; however, a small clinical study found no effect.
Read the full Trifolium Pratense + Acetaminophen, Pamabrom, Pyrilamine interactionAcetazolamideAk-Zol, Diamox
How Acetazolamide interacts with Distress Remedy — through 1 ingredient. Tap an ingredient for the detail:
Ornithogalum UmbellatumDiuretic Drugs Moderate
Interaction Summary
Theoretically, taking diuretics with star of Bethlehem might increase the risk of toxicity.
Read the full Ornithogalum Umbellatum + Acetazolamide interactionAcetylsalicylic AcidEntrophen
How Acetylsalicylic Acid interacts with Distress Remedy — through 2 ingredients. Tap an ingredient for the detail:
Arnica MollisAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, arnica might have additive effects with anticoagulant and antiplatelet drugs.
Read the full Arnica Mollis + Acetylsalicylic Acid interactionTrifolium PratenseAnticoagulant/antiplatelet Drugs Minor
Interaction Summary
Although some laboratory research suggests that red clover may have anticoagulant and antiplatelet activity, clinical research has not shown this effect.
Read the full Trifolium Pratense + Acetylsalicylic Acid interactionAlteplase, TpaActilyse, Activase
How Alteplase, Tpa interacts with Distress Remedy — through 2 ingredients. Tap an ingredient for the detail:
Arnica MollisAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, arnica might have additive effects with anticoagulant and antiplatelet drugs.
Read the full Arnica Mollis + Alteplase, Tpa interactionTrifolium PratenseAnticoagulant/antiplatelet Drugs Minor
Interaction Summary
Although some laboratory research suggests that red clover may have anticoagulant and antiplatelet activity, clinical research has not shown this effect.
Read the full Trifolium Pratense + Alteplase, Tpa interactionAluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium HydroxideAscriptin Codeine #2
How Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide interacts with Distress Remedy — through 2 ingredients. Tap an ingredient for the detail:
Arnica MollisAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, arnica might have additive effects with anticoagulant and antiplatelet drugs.
Read the full Arnica Mollis + Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide interactionTrifolium PratenseAnticoagulant/antiplatelet Drugs Minor
Interaction Summary
Although some laboratory research suggests that red clover may have anticoagulant and antiplatelet activity, clinical research has not shown this effect.
Read the full Trifolium Pratense + Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide interactionAluminum Hydroxide, Aspirin, Magnesium HydroxideAscriptin
How Aluminum Hydroxide, Aspirin, Magnesium Hydroxide interacts with Distress Remedy — through 2 ingredients. Tap an ingredient for the detail:
Arnica MollisAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, arnica might have additive effects with anticoagulant and antiplatelet drugs.
Read the full Arnica Mollis + Aluminum Hydroxide, Aspirin, Magnesium Hydroxide interactionTrifolium PratenseAnticoagulant/antiplatelet Drugs Minor
Interaction Summary
Although some laboratory research suggests that red clover may have anticoagulant and antiplatelet activity, clinical research has not shown this effect.
Read the full Trifolium Pratense + Aluminum Hydroxide, Aspirin, Magnesium Hydroxide interactionAmiloride, HydrochlorothiazideAmil-Co, Amilzide, Moduret 25, Moduretic
How Amiloride, Hydrochlorothiazide interacts with Distress Remedy — through 1 ingredient. Tap an ingredient for the detail:
Ornithogalum UmbellatumDiuretic Drugs Moderate
Interaction Summary
Theoretically, taking diuretics with star of Bethlehem might increase the risk of toxicity.
Read the full Ornithogalum Umbellatum + Amiloride, Hydrochlorothiazide interactionAmmonium ChlorideAmmonium Chloride
How Ammonium Chloride interacts with Distress Remedy — through 1 ingredient. Tap an ingredient for the detail:
Ornithogalum UmbellatumDiuretic Drugs Moderate
Interaction Summary
Theoretically, taking diuretics with star of Bethlehem might increase the risk of toxicity.
Read the full Ornithogalum Umbellatum + Ammonium Chloride interactionAmphotericin, TetracyclineMysteclin-F
How Amphotericin, Tetracycline interacts with Distress Remedy — through 1 ingredient. Tap an ingredient for the detail:
Ornithogalum UmbellatumTetracycline Antibiotics Moderate
Interaction Summary
Theoretically, taking tetracycline antibiotics with star of Bethlehem might increase the risk of cardiac glycoside toxicity.
Read the full Ornithogalum Umbellatum + Amphotericin, Tetracycline interactionAnacaulase-bcdbNexoBrid
How Anacaulase-bcdb interacts with Distress Remedy — through 2 ingredients. Tap an ingredient for the detail:
Arnica MollisAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, arnica might have additive effects with anticoagulant and antiplatelet drugs.
Read the full Arnica Mollis + Anacaulase-bcdb interactionTrifolium PratenseAnticoagulant/antiplatelet Drugs Minor
Interaction Summary
Although some laboratory research suggests that red clover may have anticoagulant and antiplatelet activity, clinical research has not shown this effect.
Read the full Trifolium Pratense + Anacaulase-bcdb interactionAnagrelideAgrylin
How Anagrelide interacts with Distress Remedy — through 2 ingredients. Tap an ingredient for the detail:
Arnica MollisAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, arnica might have additive effects with anticoagulant and antiplatelet drugs.
Read the full Arnica Mollis + Anagrelide interactionTrifolium PratenseAnticoagulant/antiplatelet Drugs, Cytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Although some laboratory research suggests that red clover may have anticoagulant and antiplatelet activity, clinical research has not shown this effect.
Read the full Trifolium Pratense + Anagrelide interactionAnisindioneMiradon
How Anisindione interacts with Distress Remedy — through 2 ingredients. Tap an ingredient for the detail:
Arnica MollisAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, arnica might have additive effects with anticoagulant and antiplatelet drugs.
Read the full Arnica Mollis + Anisindione interactionTrifolium PratenseAnticoagulant/antiplatelet Drugs Minor
Interaction Summary
Although some laboratory research suggests that red clover may have anticoagulant and antiplatelet activity, clinical research has not shown this effect.
Read the full Trifolium Pratense + Anisindione interactionAntithrombin IiiThrombate III
How Antithrombin Iii interacts with Distress Remedy — through 2 ingredients. Tap an ingredient for the detail:
Arnica MollisAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, arnica might have additive effects with anticoagulant and antiplatelet drugs.
Read the full Arnica Mollis + Antithrombin Iii interactionTrifolium PratenseAnticoagulant/antiplatelet Drugs Minor
Interaction Summary
Although some laboratory research suggests that red clover may have anticoagulant and antiplatelet activity, clinical research has not shown this effect.
Read the full Trifolium Pratense + Antithrombin Iii interactionApixabanEliquis
How Apixaban interacts with Distress Remedy — through 2 ingredients. Tap an ingredient for the detail:
Arnica MollisAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, arnica might have additive effects with anticoagulant and antiplatelet drugs.
Read the full Arnica Mollis + Apixaban interactionTrifolium PratenseAnticoagulant/antiplatelet Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Although some laboratory research suggests that red clover may have anticoagulant and antiplatelet activity, clinical research has not shown this effect.
Read the full Trifolium Pratense + Apixaban interactionArgatrobanArgatroban
How Argatroban interacts with Distress Remedy — through 2 ingredients. Tap an ingredient for the detail:
Arnica MollisAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, arnica might have additive effects with anticoagulant and antiplatelet drugs.
Read the full Arnica Mollis + Argatroban interactionTrifolium PratenseAnticoagulant/antiplatelet Drugs Minor
Interaction Summary
Although some laboratory research suggests that red clover may have anticoagulant and antiplatelet activity, clinical research has not shown this effect.
Read the full Trifolium Pratense + Argatroban interactionArmodafinilNuvigil
How Armodafinil interacts with Distress Remedy — through 2 ingredients. Tap an ingredient for the detail:
Ornithogalum UmbellatumStimulant Laxatives Moderate
Interaction Summary
Theoretically, excessive use of stimulant laxatives with star of Bethlehem might increase the risk of toxicity.
Read the full Ornithogalum Umbellatum + Armodafinil interactionTrifolium PratenseCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, red clover might increase levels of drugs metabolized by CYP3A4; however, a small clinical study found no effect.
Read the full Trifolium Pratense + Armodafinil interactionAspirinAngettes 75, ASA, Asaphen, Aspirin, Caprin, Cartia +8 more
How Aspirin interacts with Distress Remedy — through 2 ingredients. Tap an ingredient for the detail:
Arnica MollisAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, arnica might have additive effects with anticoagulant and antiplatelet drugs.
Read the full Arnica Mollis + Aspirin interactionTrifolium PratenseAnticoagulant/antiplatelet Drugs Minor
Interaction Summary
Although some laboratory research suggests that red clover may have anticoagulant and antiplatelet activity, clinical research has not shown this effect.
Read the full Trifolium Pratense + Aspirin interactionAspirin, Aluminum Hydroxide, Codeine Phosphate, Magnesium HydroxideAscriptin Codeine #3
How Aspirin, Aluminum Hydroxide, Codeine Phosphate, Magnesium Hydroxide interacts with Distress Remedy — through 2 ingredients. Tap an ingredient for the detail:
Arnica MollisAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, arnica might have additive effects with anticoagulant and antiplatelet drugs.
Read the full Arnica Mollis + Aspirin, Aluminum Hydroxide, Codeine Phosphate, Magnesium Hydroxide interactionTrifolium PratenseAnticoagulant/antiplatelet Drugs Minor
Interaction Summary
Although some laboratory research suggests that red clover may have anticoagulant and antiplatelet activity, clinical research has not shown this effect.
Read the full Trifolium Pratense + Aspirin, Aluminum Hydroxide, Codeine Phosphate, Magnesium Hydroxide interactionAspirin, ButalbitalAxotal
How Aspirin, Butalbital interacts with Distress Remedy — through 2 ingredients. Tap an ingredient for the detail:
Arnica MollisAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, arnica might have additive effects with anticoagulant and antiplatelet drugs.
Read the full Arnica Mollis + Aspirin, Butalbital interactionTrifolium PratenseAnticoagulant/antiplatelet Drugs Minor
Interaction Summary
Although some laboratory research suggests that red clover may have anticoagulant and antiplatelet activity, clinical research has not shown this effect.
Read the full Trifolium Pratense + Aspirin, Butalbital interactionAspirin, Butalbital, CaffeineFiorinal
How Aspirin, Butalbital, Caffeine interacts with Distress Remedy — through 2 ingredients. Tap an ingredient for the detail:
Arnica MollisAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, arnica might have additive effects with anticoagulant and antiplatelet drugs.
Read the full Arnica Mollis + Aspirin, Butalbital, Caffeine interactionTrifolium PratenseCaffeine, Cytochrome P450 3a4 (cyp3a4) Substrates +2 Minor
Interaction Summary
Theoretically, soy might reduce the clearance of caffeine; however, a small clinical study found no effect.
Read the full Trifolium Pratense + Aspirin, Butalbital, Caffeine interactionAspirin, Butalbital, Caffeine, Codeine PhosphateFiorinal w/ Codeine
How Aspirin, Butalbital, Caffeine, Codeine Phosphate interacts with Distress Remedy — through 2 ingredients. Tap an ingredient for the detail:
Arnica MollisAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, arnica might have additive effects with anticoagulant and antiplatelet drugs.
Read the full Arnica Mollis + Aspirin, Butalbital, Caffeine, Codeine Phosphate interactionTrifolium PratenseCytochrome P450 1a2 (cyp1a2) Substrates, Caffeine +2 Minor
Interaction Summary
Theoretically, red clover might increase levels of drugs metabolized by CYP1A2; however, a small clinical study found no effect.
Read the full Trifolium Pratense + Aspirin, Butalbital, Caffeine, Codeine Phosphate interactionAspirin, Butalbital, Caffeine, PhenacetinMarnal
How Aspirin, Butalbital, Caffeine, Phenacetin interacts with Distress Remedy — through 2 ingredients. Tap an ingredient for the detail:
Arnica MollisAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, arnica might have additive effects with anticoagulant and antiplatelet drugs.
Read the full Arnica Mollis + Aspirin, Butalbital, Caffeine, Phenacetin interactionTrifolium PratenseCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates +2 Minor
Interaction Summary
Theoretically, red clover might increase levels of drugs metabolized by CYP3A4; however, a small clinical study found no effect.
Read the full Trifolium Pratense + Aspirin, Butalbital, Caffeine, Phenacetin interactionAspirin, CaffeineAnacin
How Aspirin, Caffeine interacts with Distress Remedy — through 2 ingredients. Tap an ingredient for the detail:
Arnica MollisAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, arnica might have additive effects with anticoagulant and antiplatelet drugs.
Read the full Arnica Mollis + Aspirin, Caffeine interactionTrifolium PratenseCaffeine, Cytochrome P450 3a4 (cyp3a4) Substrates +2 Minor
Interaction Summary
Theoretically, soy might reduce the clearance of caffeine; however, a small clinical study found no effect.
Read the full Trifolium Pratense + Aspirin, Caffeine interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Distress Remedy with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
Brand information
Manufacturer and brand details for Distress Remedy, from the product label.
Nature's Sunshine Flower Essence Formula
See all Nature's Sunshine Flower Essence Formula products- Name
- Nature's Sunshine Products, Inc.
- City
- Spanish Fork
- State
- UT
- ZipCode
- 84660
- Phone Number
- 1-800-223-8225
- Web Address
- www.naturessunshine.com
Distress Remedy by Nature's Sunshine Flower Essence Formula: Common Questions
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Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Distress Remedy’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Distress Remedy's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 52 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Glycerol 8 references
- McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
- Wagner DR. Hyperhydrating with glycerol: implications for athletic performance. J Am Diet Assoc 1999;99:207-12. PubMed
- Yu YL, Kumana CR, Lauder IJ, et al. Treatment of acute cortical infarct with intravenous glycerol. A double-blind, placebo-controlled randomized trial. Stroke 1993;24:1119-24. PubMed
- Frei A, Cottier C, Wunderlich P, Ludin E. Glycerol and dextran combined in the therapy of acute stroke. A placebo-controlled, double-blind trial with a planned interim analysis. Stroke 1987;18:373-9. PubMed
- Balaskas E, Szepietowski JC, Bessis D, Ioannides D, Ponticelli C, Ghienne C, Taberly A, Dupuy P. Randomized, double-blind study with glycerol and paraffin in uremic xerosis. Clin J Am Soc Nephrol. 2011 Apr;6(4):748-52. PubMed
- Blanchet-Bardon C, Tadini G, Machado Matos M, Delarue A. Association of glycerol and paraffin in the treatment of ichthyosis in children: an international, multicentric, randomized, controlled, double-blind study. J Eur Acad Dermatol Venereol. 2012 Aug;26 PubMed
- Kajita N, Kanamori K, Yamamoto S, Yoshida K. Generalized Urticaria Caused by a Glycerin Enema in an Infant. J Investig Allergol Clin Immunol 2022;32(4):318-319. PubMed
- Suzuki R, Fukuyama K, Miyazaki Y, Namiki T. Contact urticaria syndrome and protein contact dermatitis caused by glycerin enema. JAAD Case Reports. 2016;2:108-10. PubMed
Red Clover 24 references
- Kurzer MS, Xu X. Dietary phytoestrogens. Annu Rev Nutr 1997;17:353-81. PubMed
- Electronic Code of Federal Regulations. Title 21. Part 182 -- Substances Generally Recognized As Safe. Available at: https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?CFRPart=182
- Budzinski JW, Foster BC, Vandenhoek S, Arnason JT. An in vitro evaluation of human cytochrome P450 3A4 inhibition by selected commercial herbal extracts and tinctures. Phytomedicine 2000;7:273-82. PubMed
- This P, De La Rochefordiere A, Clough K, et al. Phytoestrogens after breast cancer. Endocr Relat Cancer 2001;8:129-34. PubMed
- Tice J, Cummings SR, Ettinger B, et al. Few adverse effects of two red clover extracts rich in phytoestrogens: a multicenter, placebo-controlled trial. Alt Ther 2001;7:S33.
- Ingram DM, Hickling C, West L, et al. A double-blind randomized controlled trial of isoflavones in the treatment of cyclical mastalgia. The Breast 2002;11:170-4. PubMed
- Unger M, Frank A. Simultaneous determination of the inhibitory potency of herbal extracts on the activity of six major cytochrome P450 enzymes using liquid chromatography/mass spectrometry and automated online extraction. Rapid Commun Mass Spectrom 2004;1 PubMed
- Cheong JL, Bucknall R. Retinal vein thrombosis associated with a herbal phytoestrogen preparation in a susceptible patient. Postgrad Med J 2005;81:266-7.. PubMed
- Geller SE, Shulman LP, van Breemen RB, et al. Safety and efficacy of black cohosh and red clover for the management of vasomotor symptoms: a randomized controlled trial. Menopause 2009;16:1156-66. PubMed
- Hidalgo LA, Chedraui PA, Morocho N, et al. The effect of red clover isoflavones on menopausal symptoms, lipids and vaginal cytology in menopausal women: a randomized, double-blind, placebo-controlled study. Gynecol Endocrinol 2005;21(5):257-264. PubMed
- Campbell MJ, Woodside JV, Honour JW, et al. Effect of red clover-derived isoflavone supplementation on insulin-like growth factor, lipid and antioxidant status in healthy female volunteers: a pilot study. Eur J Clin Nutr 2004;58(1):173-179. PubMed
- Guerrero JA, Lozano ML, Castillo J, et al. Flavonoids inhibit platelet function through binding to the thromboxane A2 receptor. J Thromb Haemost 2005;3(2):369-376. PubMed
- Kondo K, Suzuki Y, Ikeda Y, Umemura K. Genistein, an isoflavone included in soy, inhibits thrombotic vessel occlusion in the mouse femoral artery and in vitro platelet aggregation. Eur J Pharmacol 2002;455(1):53-57. PubMed
- Polini N, Rauschemberger MB, Mendiberri J, et al. Effect of genistein and raloxifene on vascular dependent platelet aggregation. Mol Cell Endocrinol 2007;267(1-2):55-62. PubMed
- Wuttke W, Jarry H, Seidlova-Wuttke D. Plant-derived alternative treatments for the aging male: facts and myths. Aging Male 2010;13(2):75-81. PubMed
- Villaseca P. Non-estrogen conventional and phytochemical treatments for vasomotor symptoms: what needs to be known for practice. Climacteric 2012;15(2):115-124. PubMed
- Chen, Y., Xiao, C. Q., He, Y. J., Chen, B. L., Wang, G., Zhou, G., Zhang, W., Tan, Z. R., Cao, S., Wang, L. P., and Zhou, H. H. Genistein alters caffeine exposure in healthy female volunteers. Eur.J Clin.Pharmacol. 2011;67(4):347-353. PubMed
- Friedman, J. A., Taylor, S. A., McDermott, W., and Alikhani, P. Multifocal and recurrent subarachnoid hemorrhage due to an herbal supplement containing natural coumarins. Neurocrit.Care 2007;7(1):76-80. PubMed
- Hooper, L., Madhavan, G., Tice, J. A., Leinster, S. J., and Cassidy, A. Effects of isoflavones on breast density in pre- and post-menopausal women: a systematic review and meta-analysis of randomized controlled trials. Hum.Reprod.Update. 2010;16(6):745-7 PubMed
- Orr A and Parker R. Red clover causing symptoms suggestive of methotrexate toxicity in a patient on high-dose methotrexate. Menopause Int. 2013;19(3):133-134. PubMed
- Clifton-Bligh PB, et al. Red cover isoflavones enriched with formononetin lower serum LDL cholesterol- a randomized, double-blind, placebo-controlled trial. Eur J Clin Nutr. 2015;69(1):134-142.
- Risk assessment for peri- and post-menopausal women taking food supplements containing isolated isoflavones. EFSA Panel on Food Additives and Nutrient Sources added to Food (ANS). 2015. DOI
- Ferraris C, Ballestra B, Listorti C, et al. Red clover and lifestyle changes to contrast menopausal symptoms in premenopausal patients with hormone-sensitive breast cancer receiving tamoxifen. Breast Cancer Res Treat 2020;180(1):157-65. doi: 10.1007/s1054 PubMed
- Chen L, Choi J, Leonard SW, et al. No Clinically Relevant Pharmacokinetic Interactions of a Red Clover Dietary Supplement with Cytochrome P450 Enzymes in Women. J Agric Food Chem. 2020;68(47):13929-13939. PubMed
Arnica 10 references
- Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.
- McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
- Schroder H, Losche W, Strobach H, et al. Helenalin and 11 alpha, 13-dihydrohelenalin, two constituents from Arnica montana L., inhibit human platelet function via thiol-dependent pathways. Thromb Res 1990;57:839-45.
- Adkison JD, Bauer DW, Chang T. The effect of topical arnica on muscle pain. Ann Pharmacother 2010;44:1579-84. PubMed
- No authors listed. Final report on the safety assessment of Arnica montana extract and Arnica montana. Int.J.Toxicol. 2001;20:1-11. DOI
- Karow JH, Abt HP, Frohling M, and Ackermann H. Efficacy of Arnica montana D4 for healing of wounds after Hallux valgus surgery compared to diclofenac. J Altern Complement Med 2008;14:17-25.
- Venkatramani DV, Goel S, Ratra V, et al. Toxic optic neuropathy following ingestion of homeopathic medication Arnica-30. Cutan.Ocul.Toxicol. 2013;32:95-97. PubMed
- Moghadam BK, Gier R, and Thurlow T. Extensive oral mucosal ulcerations caused by misuse of a commercial mouthwash. Cutis 1999;64:131-134.
- Stevinson C, Devaraj VS, Fountain-Barber A, et al. Homeopathic arnica for prevention of pain and bruising: randomized placebo-controlled trial in hand surgery. J R Soc Med 2003;96:60-65. PubMed
- Canders CP, Stanford SR, Chiem AT. A dangerous cup of tea. Wilderness Environ Med. 2014 Mar;25(1):111-2. PubMed
Star Of Bethlehem 8 references
- Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
- Ellenhorn MJ, et al. Ellenhorn's Medical Toxicology: Diagnoses and Treatment of Human Poisoning. 2nd ed. Baltimore, MD: Williams & Wilkins, 1997.
- Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
- Burnham TH, ed. Drug Facts and Comparisons, Updated Monthly. Facts and Comparisons, St. Louis, MO.
- Waud RA. The action of Ornithogalum umbellatum on the heart. J Pharmacol Exp Ther 1954;111:147-51. DOI
- Vogelsang A. Ornithogalum umbellatum in the treatment of congestive heart failure: progress report. J Am Geriatr Soc 1961;9:1096-9.
- Vogelsang A. Clinical trial of Ornithogalum umbellatum on the human heart; preliminary report. Can Med Assoc J 1955;73:295-6.
- Smith JA, Paterson GR. Rhodexin A and rhodexoside in Ornithogalum umbellatum. J Pharm Pharmacol 1967;19:221-5.
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC