Interactions on record — worth a quick check against your medications. Based on 9 of 12 ingredients. Check your meds →
Dietary supplement

Drachen Ingredients & Drug Interactions

by Drachen

Drachen label
See full label image
Liquid Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Drachen against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Drachen is a dietary supplement by Drachen with 12 active ingredients. Its ingredients are commonly taken for anxiety and stress, sleep problems, relaxation.Based on those ingredients, 665 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Gamma-Aminobutyric Acid, L-Arginine, Moomiyo. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Drachen by Drachen

Ask about any prescription or over-the-counter medication and we check it for interactions with Drachen by Drachen — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Drachen by Drachen

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 12 active ingredients.
  • “Growth Factor Complex” is a proprietary blend — the label gives one combined amount (2,000 mg) without saying how much of each component you get.
  • “HGH Stimulator” is listed as a grouped ingredient — the label gives one combined amount (1,000 mg) without saying how much of each component you get.

Drachen contains 12 active ingredients, most of them amino acids and brain-supporting compounds. The amino acids include L-Glutamine, Glycine, L-Arginine, L-Isoleucine, L-Tyrosine, L-Valine, L-Lysine, and L-Dopa—building blocks your body uses for muscle, brain function, and neurotransmitter production.

You'll also find GABA (a calming brain chemical), Alpha-GPC (which supports memory and cognitive function), Moomiyo (also called shilajit, a mineral-rich compound), and Ornithine Alpha Ketoglutarate (another amino acid derivative). The product also contains inactive ingredients like lecithin, phospholipids, citric acid, and natural flavoring.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded its ingredients' overall clinical evidence instead.

Strong

Strong clinical evidence supports its ingredients for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredients' overall clinical evidence instead.
  • On file: Sickle cell disease — rated "Effective" (Glutamine) (Natural Medicines).
  • On file: Phenylketonuria (PKU) — rated "Effective" (Tyrosine) (Natural Medicines).
  • On file: Athletic performance — rated "Possibly Effective" (Ornithine) (Natural Medicines).
  • On file: Herpes labialis (cold sores) — rated "Possibly Effective" (Lysine) (Natural Medicines).
  • On file: HIV/AIDS-related wasting — rated "Possibly Effective" (Glutamine) (Natural Medicines).

The evidence for these ingredients is mixed. L-Tyrosine is possibly effective for cognitive function and memory, and L-Lysine is possibly effective for cold sores.

L-Glutamine shows promise for sickle cell disease (rated effective) and may help with HIV-related wasting and recovery from surgery or critical illness, though the evidence for those is only possibly effective. Ornithine is possibly effective for athletic performance.

Alpha-GPC is possibly effective for Alzheimer's disease. For most other uses claimed in the ingredient list—like GABA for anxiety or Moomiyo for sexual function—the evidence we hold either isn't established or is insufficient to say whether it works.

None of these ingredients are rated ineffective, but that doesn't mean all the marketing claims pan out.

The evidence, ingredient by ingredient Gamma-aminobutyric Acid (gaba) Alpha-gpc Shilajit Glutamine Glycine L-arginine Tyrosine Lysine

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 8 of the 9 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 9 of 9.
  • General safety write-ups exist for 9 of 9.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

L-Glutamine, L-Arginine, Glycine, L-Tyrosine, and L-Lysine are generally well tolerated short-term in healthy adults, though long-term safety data are limited for several. Common side effects include gastrointestinal upset (bloating, nausea, diarrhea, constipation), headache, and in some cases fatigue or dizziness.

GABA and Alpha-GPC can cause drowsiness, dizziness, and nausea rarely. Moomiyo (shilajit) carries a contamination risk—unpurified products may contain heavy metals, so only use purified, tested brands.

One rare case of anaphylaxis to shilajit has been reported. L-Glutamine, L-Arginine, and L-Tyrosine require caution in people with kidney or liver disease and should only be used under medical supervision in those populations.

Pregnancy and breastfeeding safety vary by ingredient: L-Glutamine is rated likely safe in pregnancy and lactation; Ornithine and several others lack sufficient safety data, so the safety notes advise avoiding them in pregnancy and lactation unless a doctor directs otherwise. For Glycine, L-Tyrosine, L-Lysine, GABA, Alpha-GPC, and Moomiyo, we have insufficient data on file, so talk with your doctor or pharmacist before use if you're pregnant or nursing.

Side effects, ingredient by ingredient Gamma-aminobutyric Acid (gaba) Alpha-gpc Shilajit Glutamine Glycine L-arginine Tyrosine Lysine

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 8 of the 9 matched ingredients can interact with medications — Lysine, Gamma-aminobutyric Acid (gaba), L-arginine, Glutamine, Tyrosine, among others.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; seizure medications; diabetes medications; Parkinson's medications.
  • For scale: 665 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you start Drachen, double-check with your pharmacist if you take blood pressure medications (antihypertensive drugs, ACE inhibitors, or ARBs)—L-Arginine can lower your blood pressure further. Also check if you're on blood thinners (anticoagulant or antiplatelet drugs), diabetes medications, potassium-sparing diuretics, seizure medications (anticonvulsants), levodopa, thyroid hormones, clozapine, isoproterenol, sildenafil, or sedating drugs.

Moomiyo may increase the risk of low blood sugar with diabetes medications. L-Lysine has a minor interaction with 5-HT4 agonists, and alpha-GPC may reduce effects of scopolamine patches.

If you're not sure whether any of your medications are affected, use the search tool below.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with strong clinical evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.

Drachen is a multi-ingredient amino acid and brain-support formula that may interest people looking to enhance cognitive function or support muscle recovery, since some ingredients have modest evidence behind them. However, this product is not for everyone—if you take blood pressure medications, diabetes drugs, seizure medications, levodopa, thyroid hormones, clozapine, or blood thinners, you need to check your exact medications with the tool on this page before you start.

People with kidney or liver disease should talk to their doctor first. Because of the breadth of interactions, this isn't a supplement to take without running it by your pharmacist.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 9 of 12 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jun 22, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Drachen, straight from the product label.

Brand Drachen
Net contents 1 Fluid Ounce(s); 30 mL
Market status On market
Date entered into DSLD Jun 22, 2023
DSLD ID 297194
Product type Other Combinations
Supplement form Liquid
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Drachen by Drachen, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Spray(s)
Maximum serving Sizes:
4 Spray(s)
Servings per container
30
IngredientAmount% DV
L-Glutamine0 NP--
Glycine0 NP--
L-Arginine0 NP--
L-Isoleucine0 NP--
L-Tyrosine0 NP--
L-Valine0 NP--
L-Lysine0 NP--
Gamma-Aminobutyric Acid0 NP--
Alpha-Glycerylphosphorylcholine0 NP--
Growth Factor Complex2000 mg--
HGH Stimulator1000 mg--
L-Dopa0 NP--
Moomiyo0 NP--
Ornithine Alpha Ketoglutarate0 NP--

Other ingredients: Water, Purified, Lecithin, Phospholipids, Sodium Citrate, Citric Acid, Potassium Sorbate, Maltodextrin, MethylParaben, Propylparaben, Natural & Artificial Flavors

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Directions Shake well and spray under the tongue. Use 2 full sprays in the morning and 4 full sprays before bedtime. Hold 20 seconds then swallow. For maximum absorption, do not eat or drink for 30 minutes before or after taking the formula.

Formulation

This Product Contains No Hormones.

Precautions

Keep out of reach of children.

Do not use if safety seal is damaged or missing.

Storage

Store in a cool, dry place.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Seals/Symbols

Made in the USA

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Drachen by Drachen label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Drachen label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Drachen by Drachen

These are the 12 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Spray(s) Dosage formLiquid Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Growth Factor Complex

2000 mg per serving

HGH Stimulator

1000 mg per serving

Other (inactive) ingredients: Water, Purified, Lecithin, Phospholipids, Sodium Citrate, Citric Acid, Potassium Sorbate, Maltodextrin, MethylParaben, Propylparaben, Natural & Artificial Flavors. These complete the product’s ingredient list but are not active constituents.

Interaction report

Drachen by Drachen Drug Interactions

Want to check YOUR meds against Drachen?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
665Drugs
466 Moderate 199 Minor

Ingredients driving the most interactions

Gamma-Aminobutyric Acid 419
L-Arginine 403
Moomiyo 86
L-Glutamine 50
L-Tyrosine 21

Individual Drug Interactions

The ingredients in Drachen interact with 665 drugs. Click any drug to see the details.

8 of the 12 ingredients in Drachen interact with drugs. Each result below shows which ingredient is responsible. Gamma-Aminobutyric Acid L-Arginine Moomiyo L-Glutamine L-Tyrosine Alpha-Glycerylphosphorylcholine Glycine L-Lysine

Each ingredient & the kinds of drugs it affects

For each ingredient in Drachen with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Gamma-Aminobutyric Acid2 drug types · 419 drugs

Antihypertensive Drugs

Theoretically, taking GABA with antihypertensive drugs might increase the risk of hypotension.
Some clinical research shows that GABA can decrease blood pressure in patients with hypertension.

Likelihood Possible Evidence B
Cns Depressants

Theoretically, GABA might have additive sedative effects when used in conjunction with CNS depressants. However, it is unclear if this concern is clinically relevant.
Endogenous GABA has well-established relaxant effects and GABA(A) receptors have an established physiological role in sleep. However, the effects of GABA supplements are unclear, as it is unknown whether exogenous GABA crosses the blood-brain barrier. Although there have been limited reports of drowsiness or tiredness with GABA supplements, these effects have not been widely reported in clinical studies. Additionally, intravenous GABA 0.1-1 mg/kg has been shown to induce anxiety in a dose-dependent manner.

Likelihood Unlikely Evidence D
Gamma-Aminobutyric Acid full monograph & interactions

L-Arginine9 drug types · 403 drugs

Ace Inhibitors (Aceis)

Theoretically, concomitant use of L-arginine and ACE inhibitors may increase the risk for hypotension and hyperkalemia.
Combining L-arginine with some antihypertensive drugs, especially ACE inhibitors, seems to have additive vasodilating and blood pressure-lowering effects. Furthermore, ACE inhibitors can increase potassium levels. Use of L-arginine has been associated with hyperkalemia in some patients. Theoretically, concomitant use of ACE inhibitors with L-arginine may increases the risk of hyperkalemia.

Likelihood Probable Evidence D
Angiotensin Receptor Blockers (Arbs)

Theoretically, concomitant use of L-arginine and ARBs may increase the risk of hypotension and hyperkalemia.
L-arginine increases nitric oxide, which causes vasodilation. Combining L-arginine with ARBs seems to increase L-arginine-induced vasodilation. Furthermore, ARBs can increase potassium levels. Use of L-arginine has been associated with hyperkalemia in some patients. Theoretically, concomitant use of ARBs with L-arginine may increases the risk of hyperkalemia.

Likelihood Probable Evidence D
Anticoagulant/Antiplatelet Drugs

Theoretically, concomitant use of L-arginine with anticoagulant and antiplatelet drugs might have additive effects and increase the risk of bleeding.
Preliminary research suggests that L-arginine infusions reduce platelet aggregation in humans. The clinical significance of this effect is unclear.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, concomitant use of L-arginine might have additive effects with antidiabetes drugs.
Preliminary clinical research shows that L-arginine decreases blood glucose levels in patients with type 2 diabetes.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, concomitant use of L-arginine and antihypertensive drugs may increase the risk of hypotension.
L-arginine increases nitric oxide, which causes vasodilation. Clinical evidence shows that L-arginine can reduce blood pressure in some individuals with hypertension. Furthermore, combining L-arginine with some antihypertensive drugs seems to have additive vasodilating and blood pressure-lowering effects.

Likelihood Probable Evidence D
Isoproterenol (Isuprel)

Theoretically, concurrent use of isoproterenol and L-arginine might result in additive effects and hypotension.
Preliminary clinical evidence suggests that L-arginine enhances isoproterenol-induced vasodilation in patients with essential hypertension or a family history of essential hypertension.

Likelihood Probable Evidence D
Potassium-Sparing Diuretics

Theoretically concomitant use of potassium-sparing diuretics with L-arginine may increases the risk of hyperkalemia.
Potassium-sparing diuretics can increase potassium levels. Use of L-arginine has been associated with hyperkalemia in some patients.

Likelihood Possible Evidence D
Sildenafil (Viagra)

Theoretically, concurrent use of sildenafil and L-arginine might increase the risk for hypotension.
In vivo, concurrent use of L-arginine and sildenafil has resulted in increased vasodilation. Theoretically, concurrent use might have additive vasodilatory and hypotensive effects. However, in studies evaluating the combined use of L-arginine and sildenafil for erectile dysfunction, hypotension was not reported.

Likelihood Possible Evidence D
Testosterone

Theoretically, concomitant use of L-arginine and testosterone might have additive effects.
In clinical research, L-arginine increases the level of testosterone in male patients with erectile dysfunction. The clinical significance of this finding is unclear.

Likelihood Possible Evidence D
L-Arginine full monograph & interactions

Moomiyo1 drug type · 86 drugs

Antidiabetes Drugs

Taking shilajit with antidiabetes drugs might increase the risk of hypoglycemia.
Most human and animal research shows that shilajit can decrease fasting plasma glucose levels. In an animal model, shilajit 100 mg per kg daily enhanced the glucose-lowering ability of both glibenclamide and metformin when given in combination over a 4 week period. Monitor blood glucose levels closely. Dose adjustments might be necessary.

Likelihood Possible Evidence D
Moomiyo full monograph & interactions

L-Glutamine1 drug type · 50 drugs

Anticonvulsants

Theoretically, glutamine might antagonize the effects of anticonvulsant medications.
Glutamine is metabolized to the excitatory neurotransmitter glutamate. Glutamate might have antagonistic effects with anticonvulsant drugs. However, this interaction has not yet been reported in humans.

Likelihood Possible Evidence D
L-Glutamine full monograph & interactions

L-Tyrosine2 drug types · 21 drugs

Levodopa

Theoretically, tyrosine might decrease the effectiveness of levodopa.
Tyrosine and levodopa compete for absorption in the proximal duodenum by the large neutral amino acid (LNAA) transport system. Advise patients to separate doses of tyrosine and levodopa by at least 2 hours.

Likelihood Probable Evidence D
Thyroid Hormone

Theoretically, tyrosine might have additive effects with thyroid hormone medications.
Tyrosine is a precursor to thyroxine and might increase levels of thyroid hormones.

Likelihood Probable Evidence D
L-Tyrosine full monograph & interactions

Alpha-Glycerylphosphorylcholine1 drug type · 16 drugs

Scopolamine (Transderm Scop)

Theoretically, alpha-GPC might decrease the effects of scopolamine.
A small clinical study shows that alpha-GPC can partially counteract the attention and memory impairment effects caused by scopolamine given intramuscularly. Whether alpha-GPC can decrease the beneficial anti-motion sickness effects of the scopolamine patch (Transderm Scop) is unclear.

Likelihood Possible Evidence B
Alpha-Glycerylphosphorylcholine full monograph & interactions

Glycine1 drug type · 1 drug

Clozapine (Clozaril)

Theoretically, glycine might decrease the effectiveness of clozapine.
One small clinical study in patients with schizophrenia shows that adding glycine to clozapine therapy worsens symptoms of schizophrenia when compared with clozapine alone. The mechanism of this interaction is unclear.

Likelihood Probable Evidence B
Glycine full monograph & interactions

L-Lysine1 drug type · 1 drug

5-Ht4 Agonists

Theoretically, lysine may reduce the effects of 5-HT4 agonists.
Animal research suggests that L-lysine is a partial serotonin receptor 4 (5-HT4) antagonist and inhibits diarrhea induced by the 5-HT4 agonist, 5-hydroxytryptophane.

Likelihood Unlikely Evidence D
L-Lysine full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Drachen, from the product label.

Drachen

See all Drachen products
Name
Drachen
Street Address
4604 49th Street N #67
City
St. Petersburg FL
ZipCode
33709
Phone Number
1-833-882-8559
Pharmacist Counseling Corner

Drachen by Drachen: Common Questions

Does Drachen by Drachen interact with any medications?
Yes. Based on its ingredients, Drachen has a known interaction with 665 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Drachen contains 12 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is Drachen safe to take while I'm pregnant or breastfeeding?
It depends on the ingredient. L-Glutamine is rated likely safe in pregnancy and lactation. For the others—L-Arginine, L-Tyrosine, L-Lysine, Glycine, GABA, Alpha-GPC, and Moomiyo—there isn't enough safety data on file, so the guidance is to avoid them during pregnancy and breastfeeding unless your doctor tells you otherwise. Talk to your doctor or pharmacist before you start.
What does Moomiyo do?
Moomiyo, also called shilajit, is a mineral-rich compound used traditionally as a supplement. The evidence we hold shows it's insufficient to rate for most uses (like sexual function or athletic performance). Just remember: only use purified, tested brands, since unpurified products may contain heavy metals.
Can Drachen help with memory and brain fog?
Some ingredients may help—L-Tyrosine is possibly effective for cognitive function and memory, and Alpha-GPC is possibly effective for Alzheimer's disease. However, the evidence isn't strong for all the brain-support claims, and we can't say for certain this product will work for your specific situation.
What are the most common side effects?
Most common are gastrointestinal upset—bloating, nausea, diarrhea, constipation—plus headache and sometimes fatigue. These tend to be mild and resolve if you stop taking it. If you have kidney or liver disease, talk to your doctor before use, since several ingredients require medical supervision in those cases.
Does this product have fillers?
Yes. Beyond the active ingredients, the liquid contains water, lecithin, phospholipids, citric acid, potassium sorbate, maltodextrin, and parabens (preservatives), plus natural and artificial flavors.
Can I take this if I have high blood pressure?
Not without checking with your pharmacist first. L-Arginine and GABA in this product can lower blood pressure, so if you're already taking blood pressure medication (or ACE inhibitors or ARBs), combining them could drop your blood pressure too far. Get your specific medications checked before you start.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Drachen label
Go deeper

The Full Monographs Behind Drachen’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Gamma-aminobutyric Acid (gaba)

Interacts with 419 drugs

GABA is a calming chemical messenger (neurotransmitter) that your body makes on its own, and it is sold as a supplement for stress, anxiety, and sleep. The science behind oral GABA supplemen...

Read the full Gamma-aminobutyric Acid (gaba) monograph → Herb & supplement monograph

Alpha-gpc

Interacts with 16 drugs

Alpha-GPC is a choline-containing compound used mainly for memory, brain health, and as a choline source. There is some evidence it may help cognition in people with dementia, but evidence i...

Read the full Alpha-gpc monograph → Herb & supplement monograph

Shilajit

Interacts with 86 drugs

Shilajit is a sticky, tar-like substance found in rocks of mountain ranges like the Himalayas, used in traditional Ayurvedic medicine for energy and vitality. Human evidence is limited and m...

Read the full Shilajit monograph → Herb & supplement monograph

Glutamine

Interacts with 50 drugs

Glutamine is the most abundant amino acid in the body and is usually made in your muscles. A prescription form is FDA-approved to help reduce sickle cell disease complications, but for most...

Read the full Glutamine monograph → Herb & supplement monograph

Glycine

Interacts with 1 drug

Glycine is a non-essential amino acid your body makes on its own and that also appears in protein-rich foods. It is most studied for improving sleep quality, where early research is promisin...

Read the full Glycine monograph → Herb & supplement monograph

L-arginine

Interacts with 403 drugs

L-arginine is an amino acid that the body uses to make nitric oxide, a substance that helps blood vessels relax and widen. It is popularly used for blood pressure, erectile dysfunction, and...

Read the full L-arginine monograph → Herb & supplement monograph

Tyrosine

Interacts with 21 drugs

L-tyrosine is an amino acid your body uses to make brain chemicals like dopamine and norepinephrine. Some studies suggest it may help mental performance during short-term stress, sleep loss,...

Read the full Tyrosine monograph → Herb & supplement monograph

Lysine

Interacts with 1 drug

Lysine is an essential amino acid your body cannot make on its own, so it must come from food or supplements. People most often take extra lysine to try to prevent or shorten cold sores, but...

Read the full Lysine monograph → Herb & supplement monograph

Ornithine

Ornithine is a non-essential amino acid your body makes naturally as part of the urea cycle, which helps remove ammonia. It is sold as a supplement for fatigue, exercise recovery, and sleep,...

Read the full Ornithine monograph →
Sources

Sources & How We Checked

Drachen's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 118 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Glutamine 11 references
  1. Miller AL. Therapeutic considerations of L-glutamine: a review of the literature. Altern Med Rev 1999;4:239-48..
  2. Bozzetti F, Biganzoli L, Gavazzi C, et al. Glutamine supplementation in cancer patients receiving chemotherapy: a double-blind randomized study. Nutrition 1997;13:748-51.. PubMed
  3. Mebane AH. L-Glutamine and mania. Am J Psychiatry 984;141:1302-3.
  4. Meldrum BS. Glutamate as a neurotransmitter in the brain: review of physiology and pathology. J Nutr 2000;130:1007S-15S.. PubMed
  5. Garlick PJ. Assessment of the safety of glutamine and other amino acids. J Nutr 2001;131:2556S-61S.. PubMed
  6. Chapman AG. Glutamate and epilepsy. J Nutr 2000;130:1043S-5S.. PubMed
  7. Ziegler TR. Glutamine supplementation in cancer patients receiving bone marrow transplantation and high dose chemotherapy. J Nutr 2001;131:2578S-84S.. PubMed
  8. Laviano A, Molfino A, Lacaria MT, Canelli A, De Leo S, Preziosa I, Rossi Fanelli F. Glutamine supplementation favors weight loss in nondieting obese female patients. A pilot study. Eur J Clin Nutr. 2014 Nov;68(11):1264-6. PubMed
  9. Endari (l-glutamine) [package insert]. Torrance, CA: Emmaus Medical,Inc; 2017.
  10. Niihara Y, Miller ST, Kanter J, et al. A Phase 3 Trial of l-Glutamine in Sickle Cell Disease. N Engl J Med 2018;379(3):226-35. doi: 10.1056/NEJMoa1715971.
  11. Ogden HB, Child RB, Fallowfield JL, et al. Gastrointestinal Tolerance of Low, Medium and High Dose Acute Oral l-Glutamine Supplementation in Healthy Adults: A Pilot Study. Nutrients. 2020;12(10):2953. PubMed

See these in context on the Glutamine monograph →

Glycine 5 references
  1. Heresco-Levy U, Javitt DC, Ermilov M, et al. Efficacy of high-dose glycine in the treatment of enduring negative symptoms of schizophrenia. Arch Gen Psychiatry 1999;56:29-36.. PubMed
  2. Potkin SG, Jin Y, Bunney BG, Costa J, Gulasekaram B. Effect of clozapine and adjunctive high-dose glycine in treatment-resistant schizophrenia. Am J Psychiatry 1999;156:145-7.. PubMed
  3. Gusev EI, Skvortsova VI, Dambinova SA, et al. Neuroprotective effects of glycine for therapy of acute ischaemic stroke. Cerebrovasc Dis 2000;10:49-60. PubMed
  4. Inagawa K, Kawai N, Ono K, Sukegawa E, Tsubuku S, Takahashi M. Assessment of acute adverse effects of glycine ingestion at a high dose in human volunteers. Seikatsu Eisei. 2006; 50:27-32.
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L-arginine 66 references
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Tyrosine 4 references
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Gamma-aminobutyric Acid (gaba) 12 references
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Alpha-gpc 4 references
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Shilajit 8 references
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Ornithine 1 reference
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