Interactions on record — worth a quick check against your medications. Check your meds →
Dietary supplement

Ergo+ Ingredients & Drug Interactions

by Real Mushrooms

Capsule Category: Botanical With Nutrients
Most serious interaction: Moderate
The interaction bottom line Most serious interaction: Moderate

Ergo+ is a dietary supplement by Real Mushrooms with 2 active ingredients. Its ingredients are commonly taken for antioxidant support, healthy aging and longevity, cellular protection.Based on those ingredients, 293 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Beta-(1,3)(1,6)-Glucans. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

HelloPharmacist Scorecard of Ergo+ by Real Mushrooms

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 2 of its 2 active ingredients.
  • “Golden Oyster Mushroom Extract” is listed as a grouped ingredient — the label gives one combined amount (500 mg) without saying how much of each component you get.

Ergo+ has two active ingredients: L-ergothioneine and beta-(1,3)(1,6)-glucans (beta-glucans, for short), plus a Golden Oyster Mushroom Extract. L-ergothioneine is an amino acid found naturally in mushrooms and other foods, while beta-glucans are compounds in mushroom cell walls believed to support immune and cardiovascular health.

The product also contains inactive ingredients—hypromellose, silicon dioxide, stearic acid, and microcrystalline cellulose—which are common capsule fillers and binders.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: Immune support and antioxidant wellness.
  • We looked for evidence on: Aging, Exercise-induced respiratory infections, Lower respiratory tract infections, Upper respiratory tract infection (URTI), Wound healing, Cellular health — and 1 related terms.
  • The closest evidence on file: Beta-glucans is rated "Insufficient Reliable Evidence To Rate" for Upper respiratory tract infection (URTI) (Natural Medicines).
  • Also on file: Beta-glucans is rated "Insufficient Reliable Evidence To Rate" for Exercise-induced respiratory infections, Lower respiratory tract infections, Wound healing, Aging.

The data shows beta-glucans are likely effective for high cholesterol (dyslipidemia) and coronary heart disease, based on clinical research. L-ergothioneine is being studied for coronary heart disease and joint pain, but there isn't enough reliable evidence yet to rate how well it works for either condition.

If heart health or cholesterol is why you're considering this product, the beta-glucans ingredient has some support; for other uses, the evidence isn't established in our data.

The evidence, ingredient by ingredient Ergothioneine Beta-glucans

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Beta-glucans from food are generally well tolerated, but concentrated supplements (like this one) don't have enough long-term safety data, so use caution. L-ergothioneine appears well tolerated in foods and short-term studies, though long-term supplement safety isn't well established.

For pregnancy: L-ergothioneine should be avoided—there isn't enough safety data on supplement doses. Beta-glucans in pregnancy also lack adequate research, so caution is advised.

For breastfeeding: L-ergothioneine should be avoided, and beta-glucans have little research at supplement doses, so caution applies there too. Talk with your doctor or pharmacist before using Ergo+ if you're pregnant or nursing.

Side effects, ingredient by ingredient Ergothioneine Beta-glucans

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 2 matched ingredients can interact with medications — Beta-glucans.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: immunosuppressants / transplant drugs.
  • For scale: 293 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with your pharmacist before taking Ergo+ if you're on blood pressure medication or drugs that suppress your immune system (such as those used after organ transplant). Both Moderate-severity interactions are in the product.

No interactions are documented for L-ergothioneine.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

Ergo+ is mainly for people interested in supporting heart health or cholesterol levels through beta-glucans, which have research backing. If you take blood pressure medication or immunosuppressants, check with your pharmacist first—this product could affect how they work.

Avoid it if you're pregnant or breastfeeding, and talk to your pharmacist if you have questions about long-term use.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Apr 24, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Ergo+, straight from the product label.

Brand Real Mushrooms
Barcode (UPC) 628110068385
Net contents 60 Capsule(s)
Market status On market
Date entered into DSLD Apr 24, 2025
DSLD ID 327047
Product type Botanical With Nutrients
Supplement form Capsule
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Ergo+ by Real Mushrooms, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
60
UPC/BARCODE
628110068385
IngredientAmount% DV
L-Ergothioneine5 mg--
Beta-(1,3)(1,6)-Glucans125 mg--
Golden Oyster Mushroom Extract500 mg--

Other ingredients: Hypromellose, Silicon Dioxide, Stearic Acid, Microcrystalline Cellulose

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

3rd party lab verified for quality Hot water extracted for improved bioavailability

Vegan

Gluten free Non GMO

Our guarantee: This product is verified for active compounds.

There are no added starch, grains or mycelium.

Quality grown Verified for active compounds

Formula

Guaranteed potency: 25% beta-glucans per capsule

L-ergothioneine Mushroom extract powder

Seals/Symbols

Vegan

Suggested/Recommended/Usage/Directions

Suggested use: Adults take 1 capsule per day.

Storage

Storage: Store in a cool dry place with the lid securely closed.

Precautions

Warning: Keep out of reach of children.

Consult a physician if you are pregnant or nursing; have or had a medical condition; or are taking prescription drugs.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

FDA Statement of Identity

Dietary Supplement

See for yourself

Ergo+ by Real Mushrooms label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

What’s inside

The Ingredients in Ergo+ by Real Mushrooms

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

L-Ergothioneine

No known
interactions
5 mg per serving

Ergothioneine is a naturally occurring amino acid–like compound (an antioxidant) found mostly in mushrooms and made by certain fungi and bacteria. Ear...

L-Ergothioneine monograph & interactions

Golden Oyster Mushroom Extract

500 mg per serving

Other (inactive) ingredients: Hypromellose, Silicon Dioxide, Stearic Acid, Microcrystalline Cellulose. These complete the product’s ingredient list but are not active constituents.

Interaction report

Ergo+ by Real Mushrooms Drug Interactions

Want to check YOUR meds against Ergo+?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

Go to the checker
293Drugs
293 Moderate

Ingredients driving the most interactions

Each ingredient & the kinds of drugs it affects

For each ingredient in Ergo+ with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Beta-(1,3)(1,6)-Glucans2 drug types · 293 drugs

Antihypertensive Drugs

Theoretically, taking beta-glucans with antihypertensive drugs might increase the risk of hypotension.
Clinical research shows that taking beta-glucans may reduce systolic and diastolic blood pressure in some hypertensive individuals.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, beta-glucans might interfere with immunosuppressive therapy.
Some clinical research shows that beta-glucans have immunostimulant effects.

Likelihood Possible Evidence D
The maker

Brand information

Manufacturer and brand details for Ergo+, from the product label.

Real Mushrooms

See all Real Mushrooms products
Name
Real Mushrooms Inc.
Street Address
908 17 Ave SW, Suite 303
City
Calgary
ZipCode
AB T2T 0A3
Phone Number
1-800-263-4387
Web Address
realmushrooms.com
Pharmacist Counseling Corner

Ergo+ by Real Mushrooms: Common Questions

Does Ergo+ by Real Mushrooms interact with any medications?
Yes. Based on its ingredients, Ergo+ has a known interaction with 293 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Ergo+ contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is L-ergothioneine, and what does it do?
L-ergothioneine is an amino acid naturally found in mushrooms and some other foods. In Ergo+, it's being studied for possible benefits in heart disease and joint pain, but we don't have enough reliable evidence yet to say how well it works for either.
What are beta-glucans, and why are they in this product?
Beta-glucans are compounds from mushroom cell walls that research suggests can help lower cholesterol and support heart health. They're included in Ergo+ because clinical studies show they may be effective for both dyslipidemia (high cholesterol) and coronary heart disease.
Is it safe to take Ergo+ long-term?
Long-term safety data for concentrated supplements of either ingredient isn't well established. L-ergothioneine appears well tolerated in foods and short-term studies, and beta-glucans from food are generally well tolerated, but we don't have enough information about taking them as concentrated supplements for years. Talk with your pharmacist about your individual situation.
Can I take Ergo+ if I'm pregnant or breastfeeding?
No. L-ergothioneine should be avoided during pregnancy and breastfeeding because there isn't enough safety data on supplement doses. Beta-glucans also lack adequate research at supplement doses in both pregnancy and breastfeeding. If you're pregnant or nursing, talk with your doctor or pharmacist before taking this product.
Does Ergo+ contain any fillers?
Yes, it contains several inactive ingredients: hypromellose, silicon dioxide, stearic acid, and microcrystalline cellulose. These are standard capsule binders and fillers.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Ergo+ is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Ergo+ label
Sources

Sources & How We Checked

Ergo+'s label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 13 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Ergothioneine 2 references
  1. Benson KF, Ager DM, Landes B, Aruoma OI, Jensen GS. Improvement of joint range of motion (ROM) and reduction of chronic pain after consumption of an ergothioneine-containing nutritional supplement. Prev Med. 2012;54 Suppl:S83-9. PubMed
  2. Smith E, Ottosson F, Hellstrand S, et al. Ergothioneine is associated with reduced mortality and decreased risk of cardiovascular disease. Heart 2019. pii: heartjnl-2019-315485. PubMed

See these in context on the Ergothioneine monograph →

Beta-glucans 11 references
  1. Katz, D. L., Nawaz, H., Boukhalil, J., Giannamore, V., Chan, W., Ahmadi, R., and Sarrel, P. M. Acute effects of oats and vitamin E on endothelial responses to ingested fat. Am.J.Prev.Med. 2001;20(2):124-129. PubMed
  2. Keenan, J. M., Pins, J. J., Frazel, C., Moran, A., and Turnquist, L. Oat ingestion reduces systolic and diastolic blood pressure in patients with mild or borderline hypertension: a pilot trial. J.Fam.Pract. 2002;51(4):369.
  3. Maki, K. C., Galant, R., Samuel, P., Tesser, J., Witchger, M. S., Ribaya-Mercado, J. D., Blumberg, J. B., and Geohas, J. Effects of consuming foods containing oat beta-glucan on blood pressure, carbohydrate metabolism and biomarkers of oxidative stress i
  4. Bergendiova, K., Tibenska, E., and Majtan, J. Pleuran (beta-glucan from Pleurotus ostreatus) supplementation, cellular immune response and respiratory tract infections in athletes. Eur.J.Appl.Physiol 2011;111(9):2033-2040.
  5. Talbott S, Talbott J. Effect of beta 1,3/1,6 glucan on respiratory tract infection symptoms and mood state in marathon athletes. J Sports Sci Med 2009;8(4):509-515.
  6. Feldman S, Schwartz HI Kalman DS Mayers A Kohrman HM Clemens R Krieger DR. Randomized phase II clinical trials of Wellmune WGP® for immune support during cold and flu season. The Journal of Applied Research 2009;9(1-2):30-42.
  7. McFarlin BK, Carpenter KC, Davidson T, McFarlin MA. Baker's yeast beta glucan supplementation increases salivary IgA and decreases cold/flu symptomatic days after intense exercise. J Diet Suppl. 2013;10(3):171-83. PubMed
  8. Jesenak M, Urbancek S, Majtan J, Banovcin P, Hercogova J. ß-Glucan-based cream (containing pleuran isolated from pleurotus ostreatus) in supportive treatment of mild-to-moderate atopic dermatitis. J Dermatolog Treat 2016;27(4):351-4.
  9. Mah E, Kaden VN, Kelley KM, Liska DJ. Beverage containing dispersible yeast ß-glucan decreases cold/flu symptomatic days after intense exercise: a randomized controlled trial. J Diet Suppl 2020;17(2):200-10. PubMed
  10. Zhong K, Liu Z, Lu Y, Xu X. Effects of yeast ß-glucans for the prevention and treatment of upper respiratory tract infection in healthy subjects: a systematic review and meta-analysis. Eur J Nutr. 2021. PubMed
  11. Cardenas FI, Mauguen A, Cheung IY, et al. Phase I trial of oral yeast-derived ß-glucan to enhance anti-GD2 immunotherapy of resistant high-risk neuroblastoma. Cancers (Basel) 2021;13(24):6265. PubMed

See these in context on the Beta-glucans monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring