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Dietary supplement

Lion's Mane Capsules Ingredients & Drug Interactions

by Real Mushrooms

Lion's Mane Capsules label
See full label image
Capsule Category: Botanical With Nutrients
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Lion's Mane Capsules against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Lion's Mane Capsules is a dietary supplement by Real Mushrooms with 1 active ingredient. Its ingredients are commonly taken for memory and cognitive support, nerve health, mood and anxiety.Based on those ingredients, 494 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Lion's Mane Mushroom Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Lion's Mane Capsules by Real Mushrooms

Ask about any prescription or over-the-counter medication and we check it for interactions with Lion's Mane Capsules by Real Mushrooms — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Lion's Mane Capsules by Real Mushrooms

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 13, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 1 active ingredient.
  • “Lion's Mane Mushroom Extract” is listed as a grouped ingredient — the label gives one combined amount (1,000 mg) without saying how much of each component you get.

This product contains one active ingredient: beta-glucans derived from Lion's Mane Mushroom Extract. Beta-glucans are a type of soluble fiber found naturally in mushrooms and other sources; they're thought to support heart and immune health.

The capsules also hold four inactive ingredients used as fillers and binders: hypromellose, silicon dioxide, microcrystalline cellulose, and stearic acid.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

We hold no graded evidence for this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: Memory and cognitive support.
  • We looked for evidence on: Memory, Cognitive function, Cognitive impairment, Alzheimer disease, Dementia, Parkinson disease — and 2 related terms.
  • Our graded evidence for these ingredients doesn't cover that particular purpose.

Beta-glucans in this product are rated Likely Effective for two conditions: dyslipidemia (abnormal blood fat levels) and coronary heart disease (CHD). This means clinical evidence supports their use for these purposes.

The data we hold does not include effectiveness ratings for other uses sometimes claimed for Lion's Mane, so we can't speak to those from the facts available here.

The evidence, ingredient by ingredient Lion's Mane Mushroom Beta-glucans

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Beta-glucans from food sources are generally well tolerated by most people. However, concentrated supplements — like this capsule — haven't been studied as thoroughly, so the data advises caution.

In clinical trials, beta-glucans were mostly mild and well handled; one rare case in a high-dose trial of children with neuroblastoma showed temporary elevation of liver enzymes shortly after starting the supplement, which resolved. There isn't enough data on supplement doses during breastfeeding to know either way, so if you're nursing, talk with your doctor or pharmacist about whether this product is right for you.

Side effects, ingredient by ingredient Lion's Mane Mushroom Beta-glucans

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Beta-glucans.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: immunosuppressants / transplant drugs.
  • For scale: 293 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you start Lion's Mane, double-check it with your doctor or pharmacist if you take blood pressure medication or an immunosuppressant (a drug that weakens your immune system on purpose, often used after transplant or for certain autoimmune conditions). Beta-glucans can lower blood pressure and boost immune activity, which may not mix well with these drugs.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

If you have high cholesterol or coronary heart disease, this product may be worth a conversation with your doctor — the evidence backs it for those uses. If you take blood pressure medication or an immunosuppressant, check with your own doctor or pharmacist first, because beta-glucans can affect how those drugs work.

For everyone else, the ingredient is generally well tolerated, but concentrated supplements are less studied than food sources.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Nov 22, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Lion's Mane Capsules, straight from the product label.

Brand Real Mushrooms
Barcode (UPC) 628110068293
Net contents 300 Capsule(s)
Market status On market
Date entered into DSLD Nov 22, 2022
DSLD ID 275751
Product type Botanical With Nutrients
Supplement form Capsule
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Lion's Mane Capsules by Real Mushrooms, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
150
UPC/BARCODE
628110068293
IngredientAmount% DV
Beta-1,3-1,6-Glucan0 NP--
Lion's Mane Mushroom Extract1000 mg--

Other ingredients: Hypromellose, Silicon Dioxide, Microcrystalline Cellulose, Stearic Acid

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Our quality commitment to you Made with organic mushroom extracts

3rd party lab verified for quality

Gluten free Non GMO

Vegan

Our Guarantee: This product is verified for active compounds.

There are no added starch, grains or mycelium.

Cognition

Quality grown Verified for active compounds

Formula

Our quality commitment to you Made with organic mushroom extracts Guaranteed potency: greater than 25% Beta-glucans

Mushroom extract powder

Suggested/Recommended/Usage/Directions

Suggested Use: Adults take 2 capsules per day.

Storage

Storage: Store in a cool dry place with the lid securely closed.

Precautions

Warning: Keep out of reach of children.

Consult a physician if you are pregnant or nursing; have or had a medical condition; or are taking prescription drugs.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

General Statements

NPN#80091143

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Lion's Mane Capsules by Real Mushrooms label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Lion's Mane Capsules label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Lion's Mane Capsules by Real Mushrooms

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container150 Amounts shown are per serving.

Lion's Mane Mushroom Extract

Interacts with
327 drugs
1000 mg per serving

Lion's mane is an edible mushroom that is popular as a 'nootropic' for memory, focus, and nerve health, but solid human evidence is still limited and...

Lion's Mane Mushroom Extract monograph & interactions

Other (inactive) ingredients: Hypromellose, Silicon Dioxide, Microcrystalline Cellulose, Stearic Acid. These complete the product’s ingredient list but are not active constituents.

Interaction report

Lion's Mane Capsules by Real Mushrooms Drug Interactions

Want to check YOUR meds against Lion's Mane Capsules?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
494Drugs
494 Moderate

Ingredients driving the most interactions

Lion's Mane Mushroom Extract 327

Individual Drug Interactions

The ingredients in Lion's Mane Capsules interact with 494 drugs. Click any drug to see the details.

1 of the 1 ingredient in Lion's Mane Capsules interact with drugs. Each result below shows which ingredient is responsible. Lion's Mane Mushroom Extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Lion's Mane Capsules with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Lion's Mane Mushroom Extract3 drug types · 327 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, lion's mane mushroom may increase the risk of bleeding when used with anticoagulant/antiplatelet drugs.
In vitro research suggests that lion's mane mushroom extracts can inhibit platelet aggregation.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, lion's mane mushroom may have additive effects when used with antidiabetes drugs.
Animal research suggests that an aqueous extract of lion's mane mushroom can reduce serum glucose and increase serum insulin.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, concurrent use of lion's mane mushroom might interfere with immunosuppressive therapy.
In animal and in vitro research, lion's mane mushroom polysaccharides stimulate the immune system.

Likelihood Possible Evidence D
Lion's Mane Mushroom Extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Lion's Mane Capsules, from the product label.

Real Mushrooms

See all Real Mushrooms products
Name
Real Mushrooms Inc.
Street Address
Box 77
City
Roberts Creek
State
BC
ZipCode
V0N 2W0
Phone Number
1-800-263-4387
Web Address
realmushrooms.com
Pharmacist Counseling Corner

Lion's Mane Capsules by Real Mushrooms: Common Questions

Does Lion's Mane Capsules by Real Mushrooms interact with any medications?
Yes. Based on its ingredients, Lion's Mane Capsules has a known interaction with 494 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Lion's Mane Capsules contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What exactly is beta-glucan, and why is it in Lion's Mane?
Beta-glucans are a type of soluble fiber found naturally in mushrooms. They're the active compound in this Lion's Mane product, and research shows they may help lower cholesterol and support heart health.
Can I take this if I'm on blood pressure medication?
You'll want to check with your doctor or pharmacist first. Beta-glucans can lower blood pressure on their own, so taking them alongside your medication might push your blood pressure too low. Your provider can tell you if it's safe and whether any timing changes are needed.
Is Lion's Mane safe if I'm breastfeeding?
There isn't enough research on supplement doses during breastfeeding to know either way. Talk with your doctor or pharmacist — they can help you decide based on your individual situation.
What are the most common side effects?
Beta-glucans are generally well tolerated. The trials we have data for didn't report frequent side effects from oral use. One rare case in a high-dose pediatric trial showed temporary liver enzyme changes that resolved on their own.
Does this product actually work for heart health?
Yes — beta-glucans are rated Likely Effective for both high cholesterol (dyslipidemia) and coronary heart disease based on clinical research. That's the strongest evidence rating in the data we hold.
What's in the capsule besides the active ingredient?
The capsule itself is made of hypromellose, and it contains silicon dioxide, microcrystalline cellulose, and stearic acid as inactive fillers and binders. These are standard capsule materials.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Lion's Mane Capsules label
Go deeper

The Full Monographs Behind Lion's Mane Capsules’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Lion's Mane Mushroom

Interacts with 327 drugs

Lion's mane is an edible mushroom that is popular as a 'nootropic' for memory, focus, and nerve health, but solid human evidence is still limited and early. It is generally well tolerated as...

Read the full Lion's Mane Mushroom monograph → Herb & supplement monograph

Beta-glucans

Interacts with 293 drugs

Beta-glucans are natural fibers found in oats, barley, mushrooms, and yeast. The strongest evidence supports the oat and barley types for modestly lowering cholesterol and blood sugar, while...

Read the full Beta-glucans monograph →
Sources

Sources & How We Checked

Lion's Mane Capsules's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 17 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Beta-glucans 11 references
  1. Katz, D. L., Nawaz, H., Boukhalil, J., Giannamore, V., Chan, W., Ahmadi, R., and Sarrel, P. M. Acute effects of oats and vitamin E on endothelial responses to ingested fat. Am.J.Prev.Med. 2001;20(2):124-129. PubMed
  2. Keenan, J. M., Pins, J. J., Frazel, C., Moran, A., and Turnquist, L. Oat ingestion reduces systolic and diastolic blood pressure in patients with mild or borderline hypertension: a pilot trial. J.Fam.Pract. 2002;51(4):369.
  3. Maki, K. C., Galant, R., Samuel, P., Tesser, J., Witchger, M. S., Ribaya-Mercado, J. D., Blumberg, J. B., and Geohas, J. Effects of consuming foods containing oat beta-glucan on blood pressure, carbohydrate metabolism and biomarkers of oxidative stress i
  4. Bergendiova, K., Tibenska, E., and Majtan, J. Pleuran (beta-glucan from Pleurotus ostreatus) supplementation, cellular immune response and respiratory tract infections in athletes. Eur.J.Appl.Physiol 2011;111(9):2033-2040.
  5. Talbott S, Talbott J. Effect of beta 1,3/1,6 glucan on respiratory tract infection symptoms and mood state in marathon athletes. J Sports Sci Med 2009;8(4):509-515.
  6. Feldman S, Schwartz HI Kalman DS Mayers A Kohrman HM Clemens R Krieger DR. Randomized phase II clinical trials of Wellmune WGP® for immune support during cold and flu season. The Journal of Applied Research 2009;9(1-2):30-42.
  7. McFarlin BK, Carpenter KC, Davidson T, McFarlin MA. Baker's yeast beta glucan supplementation increases salivary IgA and decreases cold/flu symptomatic days after intense exercise. J Diet Suppl. 2013;10(3):171-83. PubMed
  8. Jesenak M, Urbancek S, Majtan J, Banovcin P, Hercogova J. ß-Glucan-based cream (containing pleuran isolated from pleurotus ostreatus) in supportive treatment of mild-to-moderate atopic dermatitis. J Dermatolog Treat 2016;27(4):351-4.
  9. Mah E, Kaden VN, Kelley KM, Liska DJ. Beverage containing dispersible yeast ß-glucan decreases cold/flu symptomatic days after intense exercise: a randomized controlled trial. J Diet Suppl 2020;17(2):200-10. PubMed
  10. Zhong K, Liu Z, Lu Y, Xu X. Effects of yeast ß-glucans for the prevention and treatment of upper respiratory tract infection in healthy subjects: a systematic review and meta-analysis. Eur J Nutr. 2021. PubMed
  11. Cardenas FI, Mauguen A, Cheung IY, et al. Phase I trial of oral yeast-derived ß-glucan to enhance anti-GD2 immunotherapy of resistant high-risk neuroblastoma. Cancers (Basel) 2021;13(24):6265. PubMed

See these in context on the Beta-glucans monograph →

Lion's Mane Mushroom 6 references
  1. Product information for <em>Niaspan</em>. Abbott Laboratories. North Chicago, IL 60064. April 2015.
  2. Liang B, Guo Z, Xie F, Zhao A. Antihyperglycemic and antihyperlipidemic activities of aqueous extract of Hericium erinaceus in experimental diabetic rats. BMC Complement Altern Med. 2013;13:253. PubMed
  3. Mori K, Inatomi S, Ouchi K, Azumi Y, Tuchida T. Improving effects of the mushroom Yamabushitake (Hericium erinaceus) on mild cognitive impairment: a double-blind placebo-controlled clinical trial. Phytother Res. 2009;23(3):367-72.
  4. Mori K, Kikuchi H, Obara Y, et al. Inhibitory effect of hericenone B from Hericium erinaceus on collagen-induced platelet aggregation. Phytomedicine. 2010;17(14):1082-5. PubMed
  5. Li IC, Chang HH, Lin CH, et al. Prevention of early Alzheimer's disease by erinacine A-enriched Hericium erinaceus mycelia pilot double-blind placebo-controlled study. Front Aging Neurosci 2020 Jun 3;12:155. doi: 10.3389/fnagi.2020.00155. PubMed
  6. Tian B, Liu R, Xu T, et al. Modulating effects of Hericium erinaceus polysaccharides on the immune response by regulating gut microbiota in cyclophosphamide-treated mice. J Sci Food Agric 2023;103(6):3050-3064.

See these in context on the Lion's Mane Mushroom monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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