Interactions on record — worth a quick check against your medications. Check your meds →
Dietary supplement

Tremella Ingredients & Drug Interactions

by Real Mushrooms

Tremella label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Tremella against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Tremella is a dietary supplement by Real Mushrooms with 1 active ingredient. Its ingredients are commonly taken for high cholesterol, heart health, immune support.Based on those ingredients, 293 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Beta-1,3/1,6-Glucan. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Tremella by Real Mushrooms

Ask about any prescription or over-the-counter medication and we check it for interactions with Tremella by Real Mushrooms — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Tremella by Real Mushrooms

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • “Tremella Mushroom Extract” is listed as a grouped ingredient — the label gives one combined amount (1,000 mg) without saying how much of each component you get.

This supplement contains one active ingredient: beta-glucans from Tremella mushroom extract. Beta-glucans are a type of soluble fiber naturally found in mushrooms, and they're thought to support heart and cholesterol health.

The capsule also contains inactive ingredients (hypromellose, microcrystalline cellulose, silicon dioxide, and stearic acid) that help form and stabilize the capsule.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: Immune support and general wellness.
  • We looked for evidence on: Exercise-induced respiratory infections, Lower respiratory tract infections, Upper respiratory tract infection (URTI), Wound healing, Critical illness (trauma), Coronary heart disease (CHD) — and 4 related terms.
  • The strongest evidence on file: Beta-glucans is rated "Likely Effective" for Coronary heart disease (CHD) (Natural Medicines).
  • Also on file: Beta-glucans is rated "Likely Effective" for Dyslipidemia.
  • Also on file: Beta-glucans is rated "Insufficient Reliable Evidence To Rate" for Upper respiratory tract infection (URTI), Diabetes, Exercise-induced respiratory infections, Lower respiratory tract infections, and more.

Beta-glucans from this product are rated likely effective for helping with cholesterol levels (dyslipidemia) and coronary heart disease. That said, the evidence comes from clinical research on beta-glucans in general — not specifically tested on this exact Tremella product in your hand.

If heart or cholesterol support is your goal, the ingredient has some solid science behind it.

The evidence, ingredient by ingredient Beta-glucans

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Beta-glucans from food sources are generally well tolerated, but concentrated supplements like this one lack the safety data that whole foods have, so use some caution. In oral studies, most people did fine with no side effects.

One child in a trial developed temporary liver enzyme elevations, which reversed on its own. There's little research on supplement doses during breastfeeding, so talk with your pharmacist or doctor if you're nursing before starting this.

Side effects, ingredient by ingredient Beta-glucans

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Beta-glucans.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: immunosuppressants / transplant drugs.
  • For scale: 293 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check your medications against this product if you take blood pressure drugs (antihypertensive medications) — there's a moderate risk of blood pressure dropping too low. Also check if you take any immunosuppressants (drugs that weaken your immune system on purpose, like those after an organ transplant or for autoimmune conditions) — beta-glucans may interfere with how well they work.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with clinical evidence supporting its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Tremella may be worth considering if you're looking to support cholesterol or heart health and don't take blood pressure or immune-suppressing medications. If you take either type of drug, check with your pharmacist first — the interaction risk is real.

Anyone nursing should ask their pharmacist or doctor before use.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Mar 25, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Tremella, straight from the product label.

Brand Real Mushrooms
Barcode (UPC) 628110068453
Net contents 300 Capsule(s)
Market status On market
Date entered into DSLD Mar 25, 2025
DSLD ID 327054
Product type Botanical
Supplement form Capsule
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Tremella by Real Mushrooms, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
150
UPC/BARCODE
628110068453
IngredientAmount% DV
Beta-1,3/1,6-Glucan100 mg--
Tremella Mushroom Extract1000 mg--

Other ingredients: Hypromellose, Microcrystalline Cellulose, Silicon Dioxide, Stearic Acid

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Our quality commitment to you 3rd party lab verified for quality Hot water extracted for improved bioavailability

Gluten free Non GMO There are no added starch, grains or mycelium.

Our guarantee: This product is verified for active compounds.

Vegan

Rejuvenation

Quality grown Verified for active compounds

Formula

Guaranteed potency: 10% Beta-glucans per capsule

Mushroom extract powder

Suggested/Recommended/Usage/Directions

Suggested use: Adults take 2 capsules per day.

Storage

Storage: Store in a cool dry place with the lid securely closed.

Precautions

Warning: Keep out of reach of children.

Consult a physician if you are pregnant or nursing; have or had a medical condition; or are taking prescription drugs.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Seals/Symbols

Vegan

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Tremella by Real Mushrooms label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Tremella label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Tremella by Real Mushrooms

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container150 Amounts shown are per serving.

Tremella Mushroom Extract

1000 mg per serving

Other (inactive) ingredients: Hypromellose, Microcrystalline Cellulose, Silicon Dioxide, Stearic Acid. These complete the product’s ingredient list but are not active constituents.

Interaction report

Tremella by Real Mushrooms Drug Interactions

Want to check YOUR meds against Tremella?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
293Drugs
293 Moderate

Ingredients driving the most interactions

Beta-1,3/1,6-Glucan 293

Individual Drug Interactions

The ingredients in Tremella interact with 293 drugs. Click any drug to see the details.

1 of the 1 ingredient in Tremella interact with drugs. Each result below shows which ingredient is responsible. Beta-1,3/1,6-Glucan

Each ingredient & the kinds of drugs it affects

For each ingredient in Tremella with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Beta-1,3/1,6-Glucan2 drug types · 293 drugs

Antihypertensive Drugs

Theoretically, taking beta-glucans with antihypertensive drugs might increase the risk of hypotension.
Clinical research shows that taking beta-glucans may reduce systolic and diastolic blood pressure in some hypertensive individuals.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, beta-glucans might interfere with immunosuppressive therapy.
Some clinical research shows that beta-glucans have immunostimulant effects.

Likelihood Possible Evidence D
Beta-1,3/1,6-Glucan full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Tremella, from the product label.

Real Mushrooms

See all Real Mushrooms products
Name
Real Mushrooms Inc.
Street Address
908 17 Ave SW, Suite 303
City
Calgary
ZipCode
AB T2T 0A3
Phone Number
1-800-263-4387
Web Address
realmushrooms.com
Pharmacist Counseling Corner

Tremella by Real Mushrooms: Common Questions

Does Tremella by Real Mushrooms interact with any medications?
Yes. Based on its ingredients, Tremella has a known interaction with 293 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Tremella contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this help my cholesterol or heart health?
Beta-glucans in this product are rated likely effective for both high cholesterol (dyslipidemia) and coronary heart disease. The evidence is solid, though it's important to remember that supplements work best alongside diet and lifestyle changes — talk with your doctor or pharmacist about whether it's right for your situation.
What are beta-glucans and why are they in this mushroom supplement?
Beta-glucans are a type of fiber found naturally in mushrooms. They're included because research suggests they may help support heart and cholesterol health. Your body doesn't make them, so you get them from food or supplements.
Are there any common side effects I should know about?
Beta-glucans are generally well tolerated, and most people experience no side effects. In clinical trials, oral beta-glucans caused no problems for the vast majority of users. One rare case of temporary liver enzyme elevations was reported in a child, which reversed on its own.
Is this safe to take if I'm breastfeeding?
There isn't enough research on concentrated beta-glucan supplement doses during breastfeeding to say either way. Talk with your pharmacist or doctor before starting — they can help you decide based on your situation.
What are the inactive ingredients, and will they bother me?
The capsule contains hypromellose, microcrystalline cellulose, silicon dioxide, and stearic acid — standard capsule materials that most people tolerate fine. If you have sensitivities to any of these, let your pharmacist know.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Tremella label
Go deeper

The Full Monographs Behind Tremella’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Beta-glucans

Interacts with 293 drugs

Beta-glucans are natural fibers found in oats, barley, mushrooms, and yeast. The strongest evidence supports the oat and barley types for modestly lowering cholesterol and blood sugar, while...

Read the full Beta-glucans monograph →
Sources

Sources & How We Checked

Tremella's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 11 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Beta-glucans 11 references
  1. Katz, D. L., Nawaz, H., Boukhalil, J., Giannamore, V., Chan, W., Ahmadi, R., and Sarrel, P. M. Acute effects of oats and vitamin E on endothelial responses to ingested fat. Am.J.Prev.Med. 2001;20(2):124-129. PubMed
  2. Keenan, J. M., Pins, J. J., Frazel, C., Moran, A., and Turnquist, L. Oat ingestion reduces systolic and diastolic blood pressure in patients with mild or borderline hypertension: a pilot trial. J.Fam.Pract. 2002;51(4):369.
  3. Maki, K. C., Galant, R., Samuel, P., Tesser, J., Witchger, M. S., Ribaya-Mercado, J. D., Blumberg, J. B., and Geohas, J. Effects of consuming foods containing oat beta-glucan on blood pressure, carbohydrate metabolism and biomarkers of oxidative stress i
  4. Bergendiova, K., Tibenska, E., and Majtan, J. Pleuran (beta-glucan from Pleurotus ostreatus) supplementation, cellular immune response and respiratory tract infections in athletes. Eur.J.Appl.Physiol 2011;111(9):2033-2040.
  5. Talbott S, Talbott J. Effect of beta 1,3/1,6 glucan on respiratory tract infection symptoms and mood state in marathon athletes. J Sports Sci Med 2009;8(4):509-515.
  6. Feldman S, Schwartz HI Kalman DS Mayers A Kohrman HM Clemens R Krieger DR. Randomized phase II clinical trials of Wellmune WGP® for immune support during cold and flu season. The Journal of Applied Research 2009;9(1-2):30-42.
  7. McFarlin BK, Carpenter KC, Davidson T, McFarlin MA. Baker's yeast beta glucan supplementation increases salivary IgA and decreases cold/flu symptomatic days after intense exercise. J Diet Suppl. 2013;10(3):171-83. PubMed
  8. Jesenak M, Urbancek S, Majtan J, Banovcin P, Hercogova J. ß-Glucan-based cream (containing pleuran isolated from pleurotus ostreatus) in supportive treatment of mild-to-moderate atopic dermatitis. J Dermatolog Treat 2016;27(4):351-4.
  9. Mah E, Kaden VN, Kelley KM, Liska DJ. Beverage containing dispersible yeast ß-glucan decreases cold/flu symptomatic days after intense exercise: a randomized controlled trial. J Diet Suppl 2020;17(2):200-10. PubMed
  10. Zhong K, Liu Z, Lu Y, Xu X. Effects of yeast ß-glucans for the prevention and treatment of upper respiratory tract infection in healthy subjects: a systematic review and meta-analysis. Eur J Nutr. 2021. PubMed
  11. Cardenas FI, Mauguen A, Cheung IY, et al. Phase I trial of oral yeast-derived ß-glucan to enhance anti-GD2 immunotherapy of resistant high-risk neuroblastoma. Cancers (Basel) 2021;13(24):6265. PubMed

See these in context on the Beta-glucans monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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