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Dietary supplement

Extra Strength Probiotic Juicy Apple Ingredients & Drug Interactions

by OLLY

Extra Strength Probiotic Juicy Apple label
See full label image
Gummy Or Jelly Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Extra Strength Probiotic Juicy Apple against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Extra Strength Probiotic Juicy Apple is a dietary supplement by OLLY with 2 active ingredients. Its ingredients are commonly taken for digestive health and bloating, diarrhea support, immune support.Based on those ingredients, 182 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Bacillus subtilis DE111, Bacillus coagulans MTCC 5856. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Extra Strength Probiotic Juicy Apple by OLLY

Ask about any prescription or over-the-counter medication and we check it for interactions with Extra Strength Probiotic Juicy Apple by OLLY — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Extra Strength Probiotic Juicy Apple by OLLY

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 30, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 2 of its 2 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains two active probiotic ingredients: Bacillus subtilis DE111 and Bacillus coagulans MTCC 5856. These are live microorganisms meant to support digestive health.

The gummy is made with cane sugar, glucose syrup, gelatin, and natural apple flavoring, along with other inactive ingredients like citric acid, tartaric acid, and food colorings.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: support digestive and immune health.
  • We looked for evidence on: Antibiotic-associated diarrhea, Clostridioides difficile infection, Constipation, Diarrhea, Dyspepsia, Flatulence — and 4 related terms.
  • The strongest evidence on file: Bacillus Coagulans is rated "Possibly Effective" for Constipation (Natural Medicines).
  • Also on file: Bacillus Coagulans is rated "Possibly Effective" for Irritable bowel syndrome (IBS).
  • Also on file: Bacillus Subtilis is rated "Possibly Effective" for Antibiotic-associated diarrhea.

Bacillus coagulans MTCC 5856 is rated possibly effective for constipation and irritable bowel syndrome (IBS) based on available evidence. Bacillus subtilis DE111 is rated possibly effective for antibiotic-associated diarrhea.

For other uses — including athletic performance, diabetes, eczema, cirrhosis, and fatty liver disease — the evidence in our data is insufficient to rate either strain.

The evidence, ingredient by ingredient Bacillus Subtilis Bacillus Coagulans

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Both bacterial strains are generally well tolerated in healthy adults, though product quality and safety can vary by brand and strain. In trials, one headache and rare cases of diarrhea have been reported.

There's a theoretical concern about pathogenic infection in severely immunocompromised patients (such as those on life support or with central lines), though this is uncommon in relatively healthy people with intact immune systems. Pregnancy and lactation safety data are not on file for either ingredient — talk with your doctor or pharmacist about whether this product is right for you during pregnancy or while breastfeeding.

Side effects, ingredient by ingredient Bacillus Subtilis Bacillus Coagulans

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 2 matched ingredients can interact with medications — Bacillus Coagulans, Bacillus Subtilis.
  • The most serious interaction on file is rated Moderate.
  • For scale: 182 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Antibiotic drugs are the main medication type to double-check before taking this product — both bacterial strains interact with them at Moderate severity. If you're on an antibiotic, talk with your doctor or pharmacist about how far apart to take each one so the probiotic bacteria survive.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

If you're dealing with constipation, IBS, or antibiotic-related diarrhea, one of these two strains may help — though the evidence is strongest for constipation and IBS. The main thing to watch is spacing this product away from antibiotics so the live bacteria aren't killed off.

If you're immunocompromised or have any serious health concerns, check with your doctor or pharmacist before starting.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jul 23, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Extra Strength Probiotic Juicy Apple, straight from the product label.

Brand OLLY
Barcode (UPC) 852933008437
Net contents 50 Gummy(ies)
Market status On market
Date entered into DSLD Jul 23, 2020
DSLD ID 230149
Product type Non-nutrient/non-botanical
Supplement form Gummy Or Jelly
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Extra Strength Probiotic Juicy Apple by OLLY, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Gummy(ies)
Maximum serving Sizes:
2 Gummy(ies)
Servings per container
25
UPC/BARCODE
852933008437
IngredientAmount% DV
Calories15 Calorie(s)--
Total Carbohydrates4 Gram(s)1%
Added Sugars3 Gram(s)6%
Total Sugars3 Gram(s)--
Bacillus subtilis DE11150 mg--
Bacillus coagulans MTCC 585666 mg--

Other ingredients: Cane Sugar, Glucose Syrup, Water, Gelatin, Lactic Acid, Natural flavors, Citric Acid, Tartaric Acid, Mixed Tocopherols, Coloring

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Double Down Feeling less than extra? Here's a super dose to hep you get back on track. This powerful pair hits your digestive tract alive and ready to roll. Game on!

Find you OLLY as OLLY.com Facebook: OLLY Instagram, Pintrest, Twitter: @OLLYnutrition

Proud to be a Certified B Corporation

Formulation

The Goods Inside Bacillus subtilis This native super star promotes peaceful pipes to help keep things running smoothly and on the regular. Bacillus coagulans A hero strain that works with your body's natural bacteria to support a healthy digestive tract and immune system.

A boost to support immune & digestive health

Made in Columbia. Packaged and quality tested in the U.S.A.

No artificial flavors or colors Gluten free

Formula

6 Billion probiotics Juicy apple with other natural flavors

2 Powerful probiotic strains

OLLY Extra Strength Probiotic has 6 billion probiotics per serving compared to 1 billion per serving on OLLY Probiotic.

Naturally tasty Crispy sweet pink lady apple.

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Suggested Use: Take 2 gummies daily. Chew thoroughly before swallowing.

Take only as directed. Do not exceed suggested dosage.

On the daily Chew two gummies daily. No food or water needed.

Precautions

Processed in a facility with products that may contain soy, egg, peanuts, tree nuts, milk, fish, shellfish and wheat.

If you have a medical condition, are on medication or are pregnant or nursing, please seek the advice of a qualified health care professional before using.

Do not use if inner seal is broken or missing.

Keep out of the reach of children

Storage

Store in a cool, dry place.

Seals/Symbols

Certified B Corporation

Brand IP Statement(s)

2019 OLLY PBC

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Extra Strength Probiotic Juicy Apple by OLLY label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Extra Strength Probiotic Juicy Apple label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Extra Strength Probiotic Juicy Apple by OLLY

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Gummy(ies) Dosage formGummy Or Jelly Servings per container25 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Bacillus subtilis DE111

Interacts with
182 drugs
50 mg per serving

Bacillus subtilis is a spore-forming probiotic bacterium found in soil and some fermented foods, and it is used mainly to support gut health and diges...

Bacillus subtilis DE111 monograph & interactions

Bacillus coagulans MTCC 5856

Interacts with
182 drugs
66 mg per serving

Bacillus coagulans is a spore-forming probiotic that survives stomach acid well and may help with some digestive problems such as IBS, constipation, a...

Bacillus coagulans MTCC 5856 monograph & interactions

Other (inactive) ingredients: Cane Sugar, Glucose Syrup, Water, Gelatin, Lactic Acid, Natural flavors, Citric Acid, Tartaric Acid, Mixed Tocopherols, Coloring. These complete the product’s ingredient list but are not active constituents.

Interaction report

Extra Strength Probiotic Juicy Apple by OLLY Drug Interactions

Want to check YOUR meds against Extra Strength Probiotic Juicy Apple?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
182Drugs
182 Moderate

Ingredients driving the most interactions

Bacillus subtilis DE111 182
Bacillus coagulans MTCC 5856 182

Individual Drug Interactions

The ingredients in Extra Strength Probiotic Juicy Apple interact with 182 drugs. Click any drug to see the details.

2 of the 2 ingredients in Extra Strength Probiotic Juicy Apple interact with drugs. Each result below shows which ingredient is responsible. Bacillus subtilis DE111 Bacillus coagulans MTCC 5856

Each ingredient & the kinds of drugs it affects

For each ingredient in Extra Strength Probiotic Juicy Apple with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Bacillus subtilis DE1111 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Bacillus subtilis with antibiotic drugs might decrease the effectiveness of B. subtilis.
Since B. subtilis preparations usually contain live and active organisms, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and B. subtilis preparations by at least 2 hours.

Likelihood Probable Evidence D
Bacillus subtilis DE111 full monograph & interactions

Bacillus coagulans MTCC 58561 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking antibiotics with Bacillus coagulans might decrease the effectiveness of B. coagulans.
B. coagulans preparations usually contain live and active organisms. Therefore, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and B. coagulans preparations by at least two hours.

Likelihood Probable Evidence D
Bacillus coagulans MTCC 5856 full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Extra Strength Probiotic Juicy Apple, from the product label.

OLLY

See all OLLY products
Name
OLLY Public Benefit Corp.
City
San Francisco
State
CA
ZipCode
94129
Phone Number
1-844-439-6559
Web Address
[email protected]
Pharmacist Counseling Corner

Extra Strength Probiotic Juicy Apple by OLLY: Common Questions

Does Extra Strength Probiotic Juicy Apple by OLLY interact with any medications?
Yes. Based on its ingredients, Extra Strength Probiotic Juicy Apple has a known interaction with 182 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Extra Strength Probiotic Juicy Apple contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does this probiotic work for antibiotic-associated diarrhea?
Bacillus subtilis DE111 is rated possibly effective for that specific problem based on available evidence. Bacillus coagulans MTCC 5856 doesn't have enough evidence in our data to say one way or the other for antibiotic-associated diarrhea, though it is possibly effective for constipation and IBS.
Can I take this while I'm on an antibiotic?
Not at the same time. Antibiotics can kill the live bacteria in this product and make it less effective. You'll need to space out when you take the antibiotic and the probiotic — ask your doctor or pharmacist for the right timing based on which antibiotic you're taking.
Is this safe during pregnancy or breastfeeding?
We don't have safety data on file for either of the bacterial strains in pregnancy or lactation. Talk with your doctor or pharmacist about whether this product is appropriate for you during that time.
What's the difference between the two bacteria in this product?
Bacillus coagulans is possibly effective for constipation and IBS. Bacillus subtilis is possibly effective for antibiotic-associated diarrhea. Both are live organisms and need to be spaced away from antibiotics.
Are there any common side effects?
Both strains are generally well tolerated in healthy adults. In trials, one person reported a headache and diarrhea has been reported rarely. If you're immunocompromised or have a serious illness, talk with your doctor first, since there's a theoretical risk of infection in that situation.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Extra Strength Probiotic Juicy Apple is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Extra Strength Probiotic Juicy Apple label
Go deeper

The Full Monographs Behind Extra Strength Probiotic Juicy Apple’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Bacillus Subtilis

Interacts with 182 drugs

Bacillus subtilis is a spore-forming probiotic bacterium found in soil and some fermented foods, and it is used mainly to support gut health and digestion. Early research is promising for ce...

Read the full Bacillus Subtilis monograph → Herb & supplement monograph

Bacillus Coagulans

Interacts with 182 drugs

Bacillus coagulans is a spore-forming probiotic that survives stomach acid well and may help with some digestive problems such as IBS, constipation, and certain types of diarrhea. The eviden...

Read the full Bacillus Coagulans monograph →
Sources

Sources & How We Checked

Extra Strength Probiotic Juicy Apple's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 30 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Bacillus Subtilis 10 references
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Lampropoulos PK, Gkentzi D, Tzifas S, Dimitriou G. Neonatal sepsis due to Bacillus subtilis. Cureus 2021;13(9):e17692. PubMed
  3. La Jeon Y, Yang JJ, Kim MJ, et al. Combined Bacillus licheniformis and Bacillus subtilis infection in a patient with oesophageal perforation. J Med Microbiol 2012;61(Pt 12):1766-1769. PubMed
  4. Wallet F, Crunelle V, Roussel-Delvallez M, Fruchart A, Saunier P, Courcol RJ. Bacillus subtilis as a cause of cholangitis in polycystic kidney and liver disease. Am J Gastroenterol 1996;91(7):1477-8.
  5. Velasco E, Martins CA, Tabak D, Bouzas LF. "Bacillus subtilis" infection in a patient submitted to a bone marrow transplantation. Rev Paul Med 1992;110(3):116-7.
  6. Kato A, Yoshifuji A, Komori K, et al. A case of Bacillus subtilis var. natto bacteremia caused by ingestion of natto during COVID-19 treatment in a maintenance hemodialysis patient with multiple myeloma. J Infect Chemother 2022;28(8):1212-1215. PubMed
  7. Freedman KE, Hill JL, Wei Y, et al. Examining the gastrointestinal and immunomodulatory effects of the novel probiotic Bacillus subtilis DE111. Int J Mol Sci 2021;22(5):2453. PubMed
  8. Lefevre M, Racedo SM, Denayrolles M, et al. Safety assessment of Bacillus subtilis CU1 for use as a probiotic in humans. Regul Toxicol Pharmacol 2017;83:54-65. PubMed
  9. Hanifi A, Culpepper T, Mai V, et al. Evaluation of Bacillus subtilis R0179 on gastrointestinal viability and general wellness: a randomised, double-blind, placebo-controlled trial in healthy adults. Benef Microbes 2015;6(1):19-27. PubMed
  10. Tokano M, Tarumoto N, Imai K, et al. A case of bacterial meningitis caused by Bacillus subtilis var. natto. Intern Med. 2022. Epub ahead of print.

See these in context on the Bacillus Subtilis monograph →

Bacillus Coagulans 20 references
  1. Saxelin M, Chuang NH, Chassy B, et al. Lactobacilli and bacteremia in southern Finland 1989-1992. Clin Infect Dis 1996;22:564-6. PubMed
  2. Tynkkynen S, Singh KV, Varmanen P. Vancomycin resistance factor of Lactobacillus rhamnosus GG in relation to enterococcal vancomycin resistance (van) genes. Int J Food Microbiol 1998;41:195-204. PubMed
  3. Klein G, Zill E, Schindler R, et al. Peritonitis associated with vancomycin-resistant Lactobacillus rhamnosus in a continuous ambulatory peritoneal dialysis patient; organism identification, antibiotic therapy, and case report. J Clin Microbiol 1998;36:
  4. Kalima P, Masterton RG, Roddie PH, et al. Lactobacillus rhamnosus infection in a child following bone marrow transplant. J Infect 1996;32:165-7. PubMed
  5. Goldin BR. Health Benefits of probiotics. Br J Nutr 1998;80:S203-7. DOI
  6. Rautio M, Jousimies-Somer H, Kauma H, et al. Liver abscess due to Lactobacillus rhamnosus strain indistinguishable from L. rhamnosus strain GG. Clin Infect Dis 1999;28:1159-60.
  7. MacGregor G, Smith AJ, Thakker B, Kinsella J. Yoghurt biotherapy: contraindicated in immunosuppressed patients? Postgrad Med J 2002;78:366-7. PubMed
  8. Land MH, Rouster-Stevens K, Woods CR, et al. Lactobacillus sepsis associated with probiotic therapy. Pediatrics 2005;115:178-81.
  9. De Groote MA, Frank DN, Dowell E, et al. Lactobacillus rhamnosus GG bacteremia associated with probiotic use in a child with short gut syndrome. Pediatr Infect Dis J 2005;24:278-80. PubMed
  10. Vahabnezhad E, Mochon AB, Wozniak LJ, Ziring DA. Lactobacillus bacteremia associated with probiotic use in a pediatric patient with ulcerative colitis. J Clin Gastroenterol. 2013;47(5):437-9. PubMed
  11. Pruccoli G, Silvestro E, Pace Napoleone C, Aidala E, Garazzino S, Scolfaro C. Are probiotics safe? Bifidobacterium bacteremia in a child with severe heart failure. Infez Med. 2019;27(2):175-178.
  12. Sendil S, Shrimanker I, Mansoora Q, Goldman J, Nookala VK. Lactobacillus rhamnosus bacteremia in an immunocompromised renal transplant patient. Cureus. 2020;12(2):e6887. PubMed
  13. Albarillo FS, Shah U, Joyce C, Slade D. Lactobacillus rhamnosus Infection: A single-center 4-year descriptive analysis. J Glob Infect Dis. 2020;12(3):119-123. PubMed
  14. Pasala S, Singer L, Arshad T, Roach K. Lactobacillus endocarditis in a healthy patient with probiotic use. IDCases. 2020;22:e00915. PubMed
  15. Agrawal S, Tuchman ES, Bruce MJ, Theodorou ME. Fatal Lactobacillus endocarditis in a patient with transcatheter aortic valve replacement. BMJ Case Rep. 2020;13(11):e236835.
  16. Antoun M, Hattab Y, Akhrass FA, Hamilton LD. Uncommon pathogen, Lactobacillus, causing infective endocarditis: Case report and review. Case Rep Infect Dis. 2020;2020:8833948. PubMed
  17. Rossi F, Amadoro C, Gasperi M, Colavita G. Lactobacilli infection case reports in the last three years and safety implications. Nutrients. 2022;14(6):1178. PubMed
  18. Franko B, Vaillant M, Recule C, Vautrin E, et al. Lactobacillus paracasei endocarditis in a consumer of probiotics. Med Mal Infect. 2013;43(4):171-3. PubMed
  19. Campbell RE, Miller A, Afroze A. Native valve endocarditis secondary to Lactobacillus paracasei bacteremia. Consultant. 2020;60(9):27-8. DOI
  20. Kato K, Funabashi N, Takaoka H, et al. Lactobacillus paracasei endocarditis in a consumer of probiotics with advanced and severe bicuspid aortic valve stenosis complicated with diffuse left ventricular mid-layer fibrosis. Int J Cardiol. 2016;224:157-161. PubMed

See these in context on the Bacillus Coagulans monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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