Fast 5 Blue Razz Ingredients & Drug Interactions
by VPX
What is this page for?
First and foremost: checking Fast 5 Blue Razz against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Fast 5 Blue Razz is a dietary supplement by VPX with 9 active ingredients. Its ingredients are commonly taken for replacing fluids and electrolytes, preventing dehydration during exercise or illness, treating low blood sodium (under medical care).Based on those ingredients, 828 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Vitamin D3, Sodium, PeptoPro Casein Hydrolysate. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Fast 5 Blue Razz by VPX
Ask about any prescription or over-the-counter medication and we check it for interactions with Fast 5 Blue Razz by VPX — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Fast 5 Blue Razz by VPX
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Partial disclosure
Fast 5 Blue Razz contains 8 active ingredients: sodium, potassium, L-leucine, L-isoleucine, L-valine, vitamin D3, PeptoPro casein hydrolysate, and a proprietary blend of branched-chain amino acids (BCAAs) and peptides. The three free-form amino acids (leucine, isoleucine, valine) and the BCAA blend support muscle metabolism and recovery.
Casein peptides are protein fragments designed for faster absorption. Sodium and potassium are electrolytes that help with fluid balance and muscle function.
The product also contains inactive ingredients: natural and artificial flavors, citric acid, sucralose (a sweetener), and potassium citrate.
Does it work?
Insufficient evidence
Casein peptides in this product are likely effective for atopic dermatitis (eczema) and food allergies. Vitamin D3 is effective for familial hypophosphatemia, osteomalacia, renal osteodystrophy, rickets, and hypoparathyroidism—though those are specialized medical conditions, not general wellness uses.
For the branched-chain amino acids and other components, effectiveness ratings aren't established in our data.
How safe is it?
Well-documented data
Sodium is well tolerated at normal dietary amounts, but high intake is linked to high blood pressure and heart strain. The product's sodium content matters: avoid sodium supplements or very high intake without your doctor's approval, especially if you have blood pressure concerns or kidney disease.
Potassium from food is safe, but potassium supplements can cause dangerously high blood levels in some people, particularly those with kidney problems; use only under medical guidance. Vitamin D is generally safe at recommended doses, but very high doses over time can cause toxicity with symptoms like high blood calcium.
Casein peptides are generally well tolerated in healthy adults but must be avoided by anyone with a milk allergy.
Meds to double-check
Moderate interaction found
Before taking this product, have your doctor or pharmacist review it if you take lithium, blood pressure medications (antihypertensives, ACE inhibitors, ARBs, or thiazide diuretics), potassium-sparing diuretics, heart rhythm medications (verapamil, diltiazem, digoxin), steroids (corticosteroids), atorvastatin, or any sodium-containing drugs or supplements. The sodium, potassium, and vitamin D in this product all carry documented interactions with these medication types.
The bottom line
Scorecard at a glancePartially disclosed formula with insufficient evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
This product is marketed as a workout recovery drink built on branched-chain amino acids and electrolytes. If you take any blood pressure medication, a diuretic, lithium, heart rhythm drugs, or cholesterol medication, you need to check your specific drugs against the interaction tool on this page before using it.
Talk with your doctor or pharmacist about whether Fast 5 Blue Razz is appropriate for you, especially if you have kidney disease, high blood pressure, or heart problems.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 4 of 8 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Oct 22, 2015.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Fast 5 Blue Razz, straight from the product label.
| Brand | VPX |
|---|---|
| Barcode (UPC) | 610764180438 |
| Net contents | 8.05 oz.; 228 Gram(s) |
| Market status | On market |
| Date entered into DSLD | Oct 22, 2015 |
| DSLD ID | 51516 |
| Product type | Amino Acid/protein |
| Supplement form | Powder |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Gluten Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Fast 5 Blue Razz by VPX, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Calories | 15 {Calories} | -- |
| Total Carbohydrates | 0 Gram(s) | -- |
| Protein | 4 Gram(s) | 8% |
| Sodium | 25 mg | 1% |
| Potassium | 55 mg | 2% |
| L-Leucine | 1200 mg | -- |
| L-Isoleucine | 1200 mg | -- |
| L-Valine | 600 mg | -- |
| Vitamin D3 | 1000 IU | 250% |
| PeptoPro Casein Hydrolysate | 0 NP | -- |
| Patent Pending 2:2:1 Ratio BCAAs | 3000 mg | -- |
| L-Leucyl-L-IsoLeucine Peptide | 0 NP | -- |
| Proprietary Designer Peptide Matrix | 1500 mg | -- |
Other ingredients: Natural and Artificial flavors, Citric Acid Anhydrous, Sucralean brand Sucralose, Potassium Citrate Monohydrate
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Statement of Identity
Dietary Supplement
Brand IP Statement(s)
Fast 5 packs the latest scientific research into a potent muscle building powerhouse. Primarily an intra-workout product, Fast 5 can also be used pre-workout or post-workout. It can also be used to enhance any pre-, intra-, or post-workout product. Furthermore, Fast 5 can be added to protein shakes and/or meals to significantly increase muscle protein synthesis.
Fast 5 also reduces whole body protein breakdown, which in turn increases recovery time and reduces Delayed Onset Muscle Soreness (DOMS). Fast 5 was designed with the elite athlete in mind. The revolutionary Fast 5 muscle building cocktail is YOUR scientific secret to packing on rock hard, ripped muscle FAST!
~ Patent Pending: L-Leucyl-L-Isoleucine; Methods of use of Dipeptides and Tripeptides of Branched Chain Amino Acids and Derivatives ~ Patent Pending: 2:2:1 Leucine, Isoleucine, Valine Ratio is Patent Pending Proprietary Blend of BCAAs
ULTRAPURE
PEPTIDEX
2014 Vital Pharmaceuticals, Inc.
General Statements
During training, muscle protein breakdown is increased, the extent of which is dependent on amino acid availability.
It's the mTOR/GLUT4 Bio-Synergistic Sizzle that's going to give you the muscle and performance edge to kick butt on the field or in the gym!
Be sure to get a copy of Jack Owoc's new book, Super Creatine: New Creatine Peptides Ignite Explosive Muscle Growth! For more info visit vpxsports.com.
Product contains heat and moisture sensitive materials which can cause clumping and settling. Shake well before opening.
Made in USA from Domestic & Imported Ingredients in VPX State of the Art GMP Facilities
Natural & Artificial Flavors
Not a significant Source of Vitamin A, Vitamin C, calcium and iron.
All Right Reserved.
Formula
Fast 5 contains a potent combination of PeptoPro (Casein Protein Hydrolysates) along with a 2:2:1 ratio of BCAAs which are used to fuel working muscles and stimulate muscle protein synthesis. This 2:2:1 Leucien, Isoleucine, Valine Ratio is a VPX Patent Pending Proprietary Blend of BCAAs. Consuming the Patent Pending 2:2:1 ratio of Fast 5 allows you to ignite the explosive muscle building power of not only mTOR, but also GLUT4!
Allergen Information: Contains Milk
Seals/Symbols
PeptoPro
VPX LIVE POWERFULLY
{Non} GMO
GLUTEN FREE GF
VITAL PHARMACEUTICALS GMP
Precautions
Do not purchase if safety seal is broken or missing.
Allergen Information: Contains Milk
Allergen Warning: Manufactured in a facility that processes milk, eggs, shellfish, tree nuts, peanuts, wheat and soy.
Storage
Store container between 15(0)C to 25(0)C (59(0)F to 77(0)F).
FDA Disclaimer Statement
These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.
Suggested/Recommended/Usage/Directions
Recommended Use: Fast 5 can be mixed with water during your workout, or with mTORC1 Preworkout mTOR Ignitor before your workout. Mix one (1) level scoop of Fast 5 with 6 ounces of water or your favorite beverage.
General
V002 U.S.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Fast 5 Blue Razz by VPX label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Fast 5 Blue Razz by VPX
These are the 9 active ingredients this product is made of. Select any to open its full monograph.
Serving size5.7 Gram(s) Dosage formPowder Servings per container40 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Protein
Sodium
Interacts with205 drugs
Sodium is an essential mineral and electrolyte your body needs to balance fluids, support nerves, and help muscles work. Most people in modern diets g...
Sodium monograph & interactionsPotassium
Interacts with62 drugs
Potassium is an essential mineral your body needs for nerve signals, muscle function, and a steady heartbeat, and most people get enough from a balanc...
Potassium monograph & interactionsVitamin D3
Interacts with715 drugs
Vitamin D is a fat-soluble vitamin that helps your body absorb calcium and is important for healthy bones, muscles, and immune function. Many people,...
Vitamin D3 monograph & interactionsPatent Pending 2:2:1 Ratio BCAAs
- › L-Leucine
- › L-Isoleucine
- › L-Valine
Proprietary Designer Peptide Matrix
- › PeptoPro Casein Hydrolysate
- › L-Leucyl-L-IsoLeucine Peptide
Other (inactive) ingredients: Natural and Artificial flavors, Citric Acid Anhydrous, Sucralean brand Sucralose, Potassium Citrate Monohydrate. These complete the product’s ingredient list but are not active constituents.
Fast 5 Blue Razz by VPX Drug Interactions
HelloPharmacist Interaction Report
Fast 5 Blue Razz by VPX contains sodium, potassium, vitamin D3, and casein peptides—ingredients with documented interactions.
The most serious concern is sodium's effect on lithium (a mood-stabilizing medication): high sodium intake can lower lithium levels and reduce its effectiveness, while low sodium intake can raise lithium levels dangerously high and cause toxicity.
Read the full breakdown — every affected drug type, severity by severity
Sodium also interacts with blood pressure medications (antihypertensive drugs), steroids (corticosteroids), and several other drug types. High sodium intake may reduce how well blood pressure medications work, while steroids combined with sodium can raise sodium levels too high.
Potassium poses a separate risk with blood pressure and heart medications: potassium-sparing diuretics, ACE inhibitors, and ARBs (angiotensin receptor blockers) all raise potassium levels, and adding potassium from this product increases the risk of dangerously high blood levels, especially in people with kidney problems.
Vitamin D3 can interact with thiazide diuretics, certain heart rhythm medications (verapamil, diltiazem, digoxin), cholesterol drugs (atorvastatin), and other medications that affect calcium levels. Casein peptides may theoretically lower blood pressure further when combined with blood pressure medications.
We could not check three other ingredients—L-leucyl-L-isoleucine peptide, L-leucine, L-isoleucine, and L-valine—because we hold no interaction data for them.
Altogether, these interactions span 829 individual medications. Before taking this product, check your exact medications with the tool on this page and talk with your doctor or pharmacist about whether it's right for you.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Fast 5 Blue Razz?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Fast 5 Blue Razz interact with 828 drugs. Click any drug to see the details.
4 of the 9 ingredients in Fast 5 Blue Razz interact with drugs. Each result below shows which ingredient is responsible. Vitamin D3 Sodium PeptoPro Casein Hydrolysate Potassium
Atorvastatin CalciumLipitor
How Atorvastatin Calcium interacts with Fast 5 Blue Razz — through 1 ingredient. Tap an ingredient for the detail:
Vitamin D3Cytochrome P450 3a4 (cyp3a4) Substrates, Atorvastatin (lipitor) Moderate
Interaction Summary
Vitamin D might induce CYP3A4 enzymes and reduce the bioavailability of CYP3A4 substrates.
Read the full Vitamin D3 + Atorvastatin Calcium interactionAzelastine Hydrochloride, Fluticasone PropionateDymista
How Azelastine Hydrochloride, Fluticasone Propionate interacts with Fast 5 Blue Razz — through 2 ingredients. Tap an ingredient for the detail:
SodiumCorticosteroids Moderate
Interaction Summary
Concomitant use of mineralocorticoids and some glucocorticoids with sodium supplements might increase the risk of hypernatremia.
Read the full Sodium + Azelastine Hydrochloride, Fluticasone Propionate interactionVitamin D3Cytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Vitamin D might induce CYP3A4 enzymes and reduce the bioavailability of CYP3A4 substrates.
Read the full Vitamin D3 + Azelastine Hydrochloride, Fluticasone Propionate interactionAzilsartanEdarbi
How Azilsartan interacts with Fast 5 Blue Razz — through 3 ingredients. Tap an ingredient for the detail:
PotassiumAngiotensin Receptor Blockers (arbs) Moderate
Interaction Summary
Using ARBs with high doses of potassium increases the risk of hyperkalemia.
Read the full Potassium + Azilsartan interactionPeptopro Casein HydrolysateAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, combining these casein peptides with antihypertensive drugs might increase the risk of hypotension.
Read the full Peptopro Casein Hydrolysate + Azilsartan interactionSodiumAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.
Read the full Sodium + Azilsartan interactionAzilsartan, ChlorthalidoneEdarbyclor
How Azilsartan, Chlorthalidone interacts with Fast 5 Blue Razz — through 4 ingredients. Tap an ingredient for the detail:
Peptopro Casein HydrolysateAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, combining these casein peptides with antihypertensive drugs might increase the risk of hypotension.
Read the full Peptopro Casein Hydrolysate + Azilsartan, Chlorthalidone interactionSodiumAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.
Read the full Sodium + Azilsartan, Chlorthalidone interactionVitamin D3Thiazide Diuretics Moderate
Interaction Summary
Theoretically, taking thiazide diuretics and high-dose vitamin D can increase the risk of hypercalcemia.
Read the full Vitamin D3 + Azilsartan, Chlorthalidone interactionPotassiumAngiotensin Receptor Blockers (arbs) Moderate
Interaction Summary
Using ARBs with high doses of potassium increases the risk of hyperkalemia.
Read the full Potassium + Azilsartan, Chlorthalidone interactionBeclometasone DipropionateBecotide
How Beclometasone Dipropionate interacts with Fast 5 Blue Razz — through 2 ingredients. Tap an ingredient for the detail:
SodiumCorticosteroids Moderate
Interaction Summary
Concomitant use of mineralocorticoids and some glucocorticoids with sodium supplements might increase the risk of hypernatremia.
Read the full Sodium + Beclometasone Dipropionate interactionVitamin D3Cytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Vitamin D might induce CYP3A4 enzymes and reduce the bioavailability of CYP3A4 substrates.
Read the full Vitamin D3 + Beclometasone Dipropionate interactionBeclomethasoneBeclovent, Vanceril
How Beclomethasone interacts with Fast 5 Blue Razz — through 2 ingredients. Tap an ingredient for the detail:
SodiumCorticosteroids Moderate
Interaction Summary
Concomitant use of mineralocorticoids and some glucocorticoids with sodium supplements might increase the risk of hypernatremia.
Read the full Sodium + Beclomethasone interactionVitamin D3Cytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Vitamin D might induce CYP3A4 enzymes and reduce the bioavailability of CYP3A4 substrates.
Read the full Vitamin D3 + Beclomethasone interactionBeclomethasone DipropionateQNASL, Qvar
How Beclomethasone Dipropionate interacts with Fast 5 Blue Razz — through 2 ingredients. Tap an ingredient for the detail:
SodiumCorticosteroids Moderate
Interaction Summary
Concomitant use of mineralocorticoids and some glucocorticoids with sodium supplements might increase the risk of hypernatremia.
Read the full Sodium + Beclomethasone Dipropionate interactionVitamin D3Cytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Vitamin D might induce CYP3A4 enzymes and reduce the bioavailability of CYP3A4 substrates.
Read the full Vitamin D3 + Beclomethasone Dipropionate interactionBenazeprilLotensin
How Benazepril interacts with Fast 5 Blue Razz — through 3 ingredients. Tap an ingredient for the detail:
SodiumAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.
Read the full Sodium + Benazepril interactionPotassiumAce Inhibitors (aceis) Moderate
Interaction Summary
Using ACEIs with high doses of potassium increases the risk of hyperkalemia.
Read the full Potassium + Benazepril interactionPeptopro Casein HydrolysateAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, combining these casein peptides with antihypertensive drugs might increase the risk of hypotension.
Read the full Peptopro Casein Hydrolysate + Benazepril interactionBenazepril, HydrochlorothiazideLotensin HCT
How Benazepril, Hydrochlorothiazide interacts with Fast 5 Blue Razz — through 4 ingredients. Tap an ingredient for the detail:
Vitamin D3Thiazide Diuretics Moderate
Interaction Summary
Theoretically, taking thiazide diuretics and high-dose vitamin D can increase the risk of hypercalcemia.
Read the full Vitamin D3 + Benazepril, Hydrochlorothiazide interactionPeptopro Casein HydrolysateAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, combining these casein peptides with antihypertensive drugs might increase the risk of hypotension.
Read the full Peptopro Casein Hydrolysate + Benazepril, Hydrochlorothiazide interactionPotassiumAce Inhibitors (aceis) Moderate
Interaction Summary
Using ACEIs with high doses of potassium increases the risk of hyperkalemia.
Read the full Potassium + Benazepril, Hydrochlorothiazide interactionSodiumAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.
Read the full Sodium + Benazepril, Hydrochlorothiazide interactionBendroflumethiazideAprinox, Naturetin, Neo-NaClex
How Bendroflumethiazide interacts with Fast 5 Blue Razz — through 3 ingredients. Tap an ingredient for the detail:
SodiumAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.
Read the full Sodium + Bendroflumethiazide interactionVitamin D3Thiazide Diuretics Moderate
Interaction Summary
Theoretically, taking thiazide diuretics and high-dose vitamin D can increase the risk of hypercalcemia.
Read the full Vitamin D3 + Bendroflumethiazide interactionPeptopro Casein HydrolysateAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, combining these casein peptides with antihypertensive drugs might increase the risk of hypotension.
Read the full Peptopro Casein Hydrolysate + Bendroflumethiazide interactionBendroflumethiazide, NadololCorzide
How Bendroflumethiazide, Nadolol interacts with Fast 5 Blue Razz — through 3 ingredients. Tap an ingredient for the detail:
Vitamin D3Thiazide Diuretics Moderate
Interaction Summary
Theoretically, taking thiazide diuretics and high-dose vitamin D can increase the risk of hypercalcemia.
Read the full Vitamin D3 + Bendroflumethiazide, Nadolol interactionPeptopro Casein HydrolysateAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, combining these casein peptides with antihypertensive drugs might increase the risk of hypotension.
Read the full Peptopro Casein Hydrolysate + Bendroflumethiazide, Nadolol interactionSodiumAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.
Read the full Sodium + Bendroflumethiazide, Nadolol interactionBendroflumethiazide, PotassiumCentyl K, Neo-NaClex-K
How Bendroflumethiazide, Potassium interacts with Fast 5 Blue Razz — through 2 ingredients. Tap an ingredient for the detail:
Vitamin D3Thiazide Diuretics Moderate
Interaction Summary
Theoretically, taking thiazide diuretics and high-dose vitamin D can increase the risk of hypercalcemia.
Read the full Vitamin D3 + Bendroflumethiazide, Potassium interactionPotassiumPotassium-sparing Diuretics Moderate
Interaction Summary
Concomitant use increases the risk of hyperkalemia.
Read the full Potassium + Bendroflumethiazide, Potassium interactionBendroflumethiazide, Rauwolfia SerpentinaRauzide
How Bendroflumethiazide, Rauwolfia Serpentina interacts with Fast 5 Blue Razz — through 3 ingredients. Tap an ingredient for the detail:
Vitamin D3Thiazide Diuretics Moderate
Interaction Summary
Theoretically, taking thiazide diuretics and high-dose vitamin D can increase the risk of hypercalcemia.
Read the full Vitamin D3 + Bendroflumethiazide, Rauwolfia Serpentina interactionPeptopro Casein HydrolysateAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, combining these casein peptides with antihypertensive drugs might increase the risk of hypotension.
Read the full Peptopro Casein Hydrolysate + Bendroflumethiazide, Rauwolfia Serpentina interactionSodiumAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.
Read the full Sodium + Bendroflumethiazide, Rauwolfia Serpentina interactionBenzthiazideExna
How Benzthiazide interacts with Fast 5 Blue Razz — through 3 ingredients. Tap an ingredient for the detail:
SodiumAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.
Read the full Sodium + Benzthiazide interactionVitamin D3Thiazide Diuretics Moderate
Interaction Summary
Theoretically, taking thiazide diuretics and high-dose vitamin D can increase the risk of hypercalcemia.
Read the full Vitamin D3 + Benzthiazide interactionPeptopro Casein HydrolysateAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, combining these casein peptides with antihypertensive drugs might increase the risk of hypotension.
Read the full Peptopro Casein Hydrolysate + Benzthiazide interactionBetamethasoneCelestone, Diprolene AF, Diprosone
How Betamethasone interacts with Fast 5 Blue Razz — through 1 ingredient. Tap an ingredient for the detail:
SodiumCorticosteroids Moderate
Interaction Summary
Concomitant use of mineralocorticoids and some glucocorticoids with sodium supplements might increase the risk of hypernatremia.
Read the full Sodium + Betamethasone interactionBetamethasone DipropionateSernivo
How Betamethasone Dipropionate interacts with Fast 5 Blue Razz — through 1 ingredient. Tap an ingredient for the detail:
SodiumCorticosteroids Moderate
Interaction Summary
Concomitant use of mineralocorticoids and some glucocorticoids with sodium supplements might increase the risk of hypernatremia.
Read the full Sodium + Betamethasone Dipropionate interactionBetamethasone Dipropionate, CalcipotrieneEnstilar, Wynzora
How Betamethasone Dipropionate, Calcipotriene interacts with Fast 5 Blue Razz — through 2 ingredients. Tap an ingredient for the detail:
SodiumCorticosteroids Moderate
Interaction Summary
Concomitant use of mineralocorticoids and some glucocorticoids with sodium supplements might increase the risk of hypernatremia.
Read the full Sodium + Betamethasone Dipropionate, Calcipotriene interactionVitamin D3Calcipotriene (dovonex) Moderate
Interaction Summary
Taking calcipotriene with vitamin D increases the risk for hypercalcemia.
Read the full Vitamin D3 + Betamethasone Dipropionate, Calcipotriene interactionBetamethasone ValerateLuxiq
How Betamethasone Valerate interacts with Fast 5 Blue Razz — through 1 ingredient. Tap an ingredient for the detail:
SodiumCorticosteroids Moderate
Interaction Summary
Concomitant use of mineralocorticoids and some glucocorticoids with sodium supplements might increase the risk of hypernatremia.
Read the full Sodium + Betamethasone Valerate interactionBetaxololBetoptic, Kerlone
How Betaxolol interacts with Fast 5 Blue Razz — through 2 ingredients. Tap an ingredient for the detail:
Peptopro Casein HydrolysateAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, combining these casein peptides with antihypertensive drugs might increase the risk of hypotension.
Read the full Peptopro Casein Hydrolysate + Betaxolol interactionSodiumAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.
Read the full Sodium + Betaxolol interactionBisoprololZebeta
How Bisoprolol interacts with Fast 5 Blue Razz — through 2 ingredients. Tap an ingredient for the detail:
SodiumAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.
Read the full Sodium + Bisoprolol interactionPeptopro Casein HydrolysateAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, combining these casein peptides with antihypertensive drugs might increase the risk of hypotension.
Read the full Peptopro Casein Hydrolysate + Bisoprolol interactionBisoprolol, HydrochlorothiazideZiac
How Bisoprolol, Hydrochlorothiazide interacts with Fast 5 Blue Razz — through 3 ingredients. Tap an ingredient for the detail:
Vitamin D3Thiazide Diuretics Moderate
Interaction Summary
Theoretically, taking thiazide diuretics and high-dose vitamin D can increase the risk of hypercalcemia.
Read the full Vitamin D3 + Bisoprolol, Hydrochlorothiazide interactionPeptopro Casein HydrolysateAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, combining these casein peptides with antihypertensive drugs might increase the risk of hypotension.
Read the full Peptopro Casein Hydrolysate + Bisoprolol, Hydrochlorothiazide interactionSodiumAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.
Read the full Sodium + Bisoprolol, Hydrochlorothiazide interactionBosentanTracleer
How Bosentan interacts with Fast 5 Blue Razz — through 3 ingredients. Tap an ingredient for the detail:
Peptopro Casein HydrolysateAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, combining these casein peptides with antihypertensive drugs might increase the risk of hypotension.
Read the full Peptopro Casein Hydrolysate + Bosentan interactionSodiumAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.
Read the full Sodium + Bosentan interactionVitamin D3Cytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Vitamin D might induce CYP3A4 enzymes and reduce the bioavailability of CYP3A4 substrates.
Read the full Vitamin D3 + Bosentan interactionBudesonideEntocort EC, Eohilia, Pulmicort, Tarpeyo, Uceris
How Budesonide interacts with Fast 5 Blue Razz — through 2 ingredients. Tap an ingredient for the detail:
SodiumCorticosteroids Moderate
Interaction Summary
Concomitant use of mineralocorticoids and some glucocorticoids with sodium supplements might increase the risk of hypernatremia.
Read the full Sodium + Budesonide interactionVitamin D3Cytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Vitamin D might induce CYP3A4 enzymes and reduce the bioavailability of CYP3A4 substrates.
Read the full Vitamin D3 + Budesonide interactionBumetanideBurinex
How Bumetanide interacts with Fast 5 Blue Razz — through 2 ingredients. Tap an ingredient for the detail:
Peptopro Casein HydrolysateAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, combining these casein peptides with antihypertensive drugs might increase the risk of hypotension.
Read the full Peptopro Casein Hydrolysate + Bumetanide interactionSodiumAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.
Read the full Sodium + Bumetanide interactionBumetanide (iv)Bumex
How Bumetanide (iv) interacts with Fast 5 Blue Razz — through 2 ingredients. Tap an ingredient for the detail:
Peptopro Casein HydrolysateAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, combining these casein peptides with antihypertensive drugs might increase the risk of hypotension.
Read the full Peptopro Casein Hydrolysate + Bumetanide (iv) interactionSodiumAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.
Read the full Sodium + Bumetanide (iv) interactionBumetanide (oral)Bumex
How Bumetanide (oral) interacts with Fast 5 Blue Razz — through 2 ingredients. Tap an ingredient for the detail:
Peptopro Casein HydrolysateAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, combining these casein peptides with antihypertensive drugs might increase the risk of hypotension.
Read the full Peptopro Casein Hydrolysate + Bumetanide (oral) interactionSodiumAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.
Read the full Sodium + Bumetanide (oral) interactionBumetanide, PotassiumBurinex K
How Bumetanide, Potassium interacts with Fast 5 Blue Razz — through 1 ingredient. Tap an ingredient for the detail:
PotassiumPotassium-sparing Diuretics Moderate
Interaction Summary
Concomitant use increases the risk of hyperkalemia.
Read the full Potassium + Bumetanide, Potassium interactionCalcipotrieneDovonex
How Calcipotriene interacts with Fast 5 Blue Razz — through 1 ingredient. Tap an ingredient for the detail:
Vitamin D3Calcipotriene (dovonex) Moderate
Interaction Summary
Taking calcipotriene with vitamin D increases the risk for hypercalcemia.
Read the full Vitamin D3 + Calcipotriene interactionCandesartan CilexetilAmias, Atacand
How Candesartan Cilexetil interacts with Fast 5 Blue Razz — through 3 ingredients. Tap an ingredient for the detail:
Peptopro Casein HydrolysateAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, combining these casein peptides with antihypertensive drugs might increase the risk of hypotension.
Read the full Peptopro Casein Hydrolysate + Candesartan Cilexetil interactionPotassiumAngiotensin Receptor Blockers (arbs) Moderate
Interaction Summary
Using ARBs with high doses of potassium increases the risk of hyperkalemia.
Read the full Potassium + Candesartan Cilexetil interactionSodiumAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.
Read the full Sodium + Candesartan Cilexetil interactionCandesartan Cilexetil, HydrochlorothiazideAtacand HCT
How Candesartan Cilexetil, Hydrochlorothiazide interacts with Fast 5 Blue Razz — through 4 ingredients. Tap an ingredient for the detail:
SodiumAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.
Read the full Sodium + Candesartan Cilexetil, Hydrochlorothiazide interactionVitamin D3Thiazide Diuretics Moderate
Interaction Summary
Theoretically, taking thiazide diuretics and high-dose vitamin D can increase the risk of hypercalcemia.
Read the full Vitamin D3 + Candesartan Cilexetil, Hydrochlorothiazide interactionPeptopro Casein HydrolysateAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, combining these casein peptides with antihypertensive drugs might increase the risk of hypotension.
Read the full Peptopro Casein Hydrolysate + Candesartan Cilexetil, Hydrochlorothiazide interactionPotassiumAngiotensin Receptor Blockers (arbs) Moderate
Interaction Summary
Using ARBs with high doses of potassium increases the risk of hyperkalemia.
Read the full Potassium + Candesartan Cilexetil, Hydrochlorothiazide interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Fast 5 Blue Razz with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
Vitamin D3
Aluminum
Vitamin D might increase aluminum absorption and toxicity, but this has only been reported in people with renal failure.
The protein that transports calcium across the intestinal wall can also bind and transport aluminum. This protein is stimulated by vitamin D, which may therefore increase aluminum absorption. This mechanism may contribute to increased aluminum levels and toxicity in people with renal failure, when they take vitamin D and aluminum-containing phosphate binders chronically.
Atorvastatin (Lipitor)
Vitamin D might reduce absorption of atorvastatin.
A small, low-quality clinical study shows that taking vitamin D reduces levels of atorvastatin and its active metabolites by up to 55%. However, while atorvastatin levels decreased, total cholesterol, low-density lipoprotein (LDL) cholesterol, and high-density lipoprotein (HDL) cholesterol levels did not substantially change. Atorvastatin is metabolized in the gut by CYP3A4 enzymes, and researchers theorized that vitamin D might induce CYP3A4, causing reduced levels of atorvastatin. However, this proposed mechanism was not specifically studied.
Calcipotriene (Dovonex)
Taking calcipotriene with vitamin D increases the risk for hypercalcemia.
Calcipotriene is a vitamin D analog used topically for psoriasis. It can be absorbed in sufficient amounts to cause systemic effects, including hypercalcemia. Theoretically, combining calcipotriene with vitamin D supplements might increase the risk of hypercalcemia.
Digoxin (Lanoxin)
Theoretically, hypercalcemia induced by high-dose vitamin D can increase the risk of arrhythmia from digoxin.
High doses of vitamin D can cause hypercalcemia. Hypercalcemia increases the risk of fatal cardiac arrhythmias with digoxin. Avoid vitamin D doses above the tolerable upper intake level (4000 IU daily for adults) and monitor serum calcium levels in people taking vitamin D and digoxin concurrently.
Diltiazem (Cardizem, Others)
Theoretically, hypercalcemia induced by high-dose vitamin D can reduce the therapeutic effects of diltiazem for arrhythmia.
High doses of vitamin D can cause hypercalcemia. Hypercalcemia can reduce the effectiveness of verapamil in atrial fibrillation. Theoretically this could also occur with diltiazem. Avoid vitamin D doses above the tolerable upper intake level (4000 IU daily for adults) and monitor serum calcium levels in people taking vitamin D and diltiazem concurrently.
Thiazide Diuretics
Theoretically, taking thiazide diuretics and high-dose vitamin D can increase the risk of hypercalcemia.
Thiazide diuretics decrease urinary calcium excretion, which could lead to hypercalcemia if vitamin D supplements are taken concurrently. This has been reported in people being treated with vitamin D for hypoparathyroidism, and also in elderly people with normal parathyroid function who were taking a thiazide, vitamin D, and calcium-containing antacids daily.
Verapamil (Calan, Others)
Hypercalcemia induced by high-dose vitamin D can reduce the therapeutic effects of verapamil for arrhythmia.
Hypercalcemia due to high doses of vitamin D can reduce the effectiveness of verapamil in atrial fibrillation. Avoid vitamin D doses above the tolerable upper intake level (4000 IU daily for adults) and monitor serum calcium levels in people taking vitamin D and verapamil concurrently.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Vitamin D might induce CYP3A4 enzymes and reduce the bioavailability of CYP3A4 substrates.
There is some concern that vitamin D might induce CYP3A4. In vitro research suggests that vitamin D induces CYP3A4 transcription. Additionally, observational research has found that increased UV light exposure and serum vitamin D levels are associated with decreased serum levels of CYP3A4 substrates such as tacrolimus and sirolimus, while no association between UV light exposure or vitamin D levels and levels of mycophenolic acid, a non-CYP3A4 substrate, was found. A small, low-quality clinical study shows that taking vitamin D reduces levels of the CYP3A4 substrate atorvastatin and its active metabolites by up to 55%; however, the clinical effects of atorvastatin were not reduced. While researchers theorized that vitamin D might induce CYP3A4, this proposed mechanism was not specifically studied.
Sodium
Antihypertensive Drugs
Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.
High intake of dietary sodium can increase systolic and diastolic blood pressure. Also, high intake of sodium may necessitate increased use of antihypertensive medications to achieve blood pressure control in some patients, such as those with chronic kidney disease.
Corticosteroids
Concomitant use of mineralocorticoids and some glucocorticoids with sodium supplements might increase the risk of hypernatremia.
Mineralocorticoids and some glucocorticoids (corticosteroids) cause sodium retention. This effect is dose-related and depends on mineralocorticoid potency. It is most common with hydrocortisone, cortisone, and fludrocortisone, followed by prednisone and prednisolone.
Didanosine (Videx)
Concomitant use of didanosine with additional sodium from dietary or supplemental sources may increase the risk of hypernatremia.
Didanosine formulations contain a significant amount of sodium.
Lithium
Altering dietary intake of sodium might alter the levels and clinical effects of lithium.
High sodium intake can reduce plasma concentrations of lithium by increasing lithium excretion. Reducing sodium intake can significantly increase plasma concentrations of lithium and cause lithium toxicity in patients being treated with lithium carbonate. Stabilizing sodium intake is shown to reduce the percentage of patients with lithium level fluctuations above 0.8 mEq/L. Patients taking lithium should avoid significant alterations in their dietary intake of sodium.
Sodium Phosphates
Theoretically, concomitant use of sodium phosphate with sodium supplements might increase the risk of hypernatremia.
Use of high doses (> 45 mL in 24 hours) of sodium phosphate, such as those used for bowel cleansing before surgery, can lead to serious electrolyte disturbances, including hypernatremia. The risk of hypernatremia is highest in the elderly and people with other risk factors for electrolyte disturbances.
Sodium-Containing Drugs
Concomitant use of sodium-containing drugs with additional sodium from dietary or supplemental sources may increase the risk of hypernatremia and long-term sodium-related complications.
The Chronic Disease Risk Reduction (CDRR) intake level of 2.3 grams of sodium daily indicates the intake at which it is believed that chronic disease risk increases for the apparently healthy population. Some medications contain high quantities of sodium. When used in conjunction with sodium supplements or high-sodium diets, the CDRR may be exceeded. Additionally, concomitant use may increase the risk for hypernatremia; this risk is highest in the elderly and people with other risk factors for electrolyte disturbances.
Tolvaptan (Samsca)
Theoretically, concomitant use of tolvaptan with sodium might increase the risk of hypernatremia.
Tolvaptan is a vasopressin receptor 2 antagonist that is used to increase sodium levels in patients with hyponatremia. Patients taking tolvaptan should use caution with the use of sodium salts such as sodium chloride.
PeptoPro Casein Hydrolysate
Antihypertensive Drugs
Theoretically, combining these casein peptides with antihypertensive drugs might increase the risk of hypotension.
Clinical research shows that some casein peptides, including the lactotripeptides isoleucine-proline-proline (IPP) and valine-proline-proline (VPP), can modestly reduce blood pressure in patients with hypertension.
Potassium
Ace Inhibitors (Aceis)
Using ACEIs with high doses of potassium increases the risk of hyperkalemia.
ACEIs block the actions of the renin-angiotensin-aldosterone system and reduce potassium excretion. Concomitant use of these drugs with potassium supplements increases the risk of hyperkalemia. However, concomitant use of these drugs with moderate dietary potassium intake (about 3775-5200 mg daily) does not increase serum potassium levels.
Angiotensin Receptor Blockers (Arbs)
Using ARBs with high doses of potassium increases the risk of hyperkalemia.
ARBs block the actions of the renin-angiotensin-aldosterone system and reduce potassium excretion. Concomitant use of these drugs with potassium supplements increases the risk of hyperkalemia. However, concomitant use of these drugs with moderate dietary potassium intake (about 3775-5200 mg daily) does not increase serum potassium levels.
Potassium-Sparing Diuretics
Concomitant use increases the risk of hyperkalemia.
Using potassium-sparing diuretics with potassium supplements increases the risk of hyperkalemia.
Brand information
Manufacturer and brand details for Fast 5 Blue Razz, from the product label.
Fast 5 Blue Razz by VPX: Common Questions
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Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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The Full Monographs Behind Fast 5 Blue Razz’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sodium
Interacts with 205 drugsSodium is an essential mineral and electrolyte your body needs to balance fluids, support nerves, and help muscles work. Most people in modern diets get more than enough—often too much—from...
Read the full Sodium monograph → Herb & supplement monographPotassium
Interacts with 62 drugsPotassium is an essential mineral your body needs for nerve signals, muscle function, and a steady heartbeat, and most people get enough from a balanced diet rich in fruits and vegetables. P...
Read the full Potassium monograph → Herb & supplement monographVitamin D
Interacts with 715 drugsVitamin D is a fat-soluble vitamin that helps your body absorb calcium and is important for healthy bones, muscles, and immune function. Many people, especially those with low sun exposure,...
Read the full Vitamin D monograph → Herb & supplement monographCasein Peptides
Interacts with 172 drugsCasein peptides are small protein fragments made from milk casein, often studied for mild blood pressure support and relaxation. The evidence is limited and mostly modest, so they should not...
Read the full Casein Peptides monograph →Sources & How We Checked
Fast 5 Blue Razz's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 80 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Sodium 38 references
- Garabedian-Ruffalo SM, Ruffalo RL. Drug and nutrient interactions. Am Fam Physician 1986;33:165-74.
- Food and Drug Administration Science Background: Safety of Sodium Phosphates Oral Solution. September 17, 2001. Available at: http://www.fda.gov/cder/drug/safety/sodiumphospate.htm
- Coton T, Mallaret C, Coilliot C, Carre D, Guisset M. Severe acute ulcerated gastritis induced by salt. Presse Med 2009;38(3):499-500. PubMed
- Frings-Meuthen P, Buehlmeier J, Baecker N, et al. High sodium chloride intake exacerbates immobilization-induced bone resorption and protein losses. J Appl Physiol 2011;111(2):537-542. PubMed
- Frings-Meuthen P, Baecker N, Heer M. Low-grade metabolic acidosis may be the cause of sodium chloride-induced exaggerated bone resorption. J Bone Miner Res 2008;23(4):517-524. PubMed
- Alam S, Johnson AG. A meta-analysis of randomised controlled trials (RCT) among healthy normotensive and essential hypertensive elderly patients to determine the effect of high salt (NaCl) diet of blood pressure. J Hum Hypertens 1999;13(6):367-74.
- Boudville N, Ward S, Benaroia M, House AA. Increased sodium intake correlates with greater use of antihypertensive agents by subjects with chronic kidney disease. Am J Hypertens 2005;18(10):1300-5. PubMed
- Bennett WM. Drug interactions and consequences of sodium restriction. Am J Clin Nutr 1997;65(2 Suppl):678S-681S. PubMed
- Okusa MD, Crystal LJ. Clinical manifestations and management of acute lithium intoxication. Am J Med 1994;97(4):383-9. PubMed
- Food and Nutrition Board, Institute of Medicine. Dietary reference intakes for water, potassium, sodium, chloride, and sulfate. Washington, DC: National Academy Press, 2005. Available at: http://www.nap.edu/openbook.php?record_id=10925. DOI
- D'Elia L, Rossi G, Ippolito R, Cappuccio FP, Strazzullo P. Habitual salt intake and risk of gastric cancer: a meta-analysis of prospective studies. Clin Nutr 2012;31(4):489-98. PubMed
- Goldsmith SR. Hyponatremia in heart failure: time for a trial. J Card Fail 2013;19(6):398-400. PubMed
- Willocks L, Brettle R, Keen J, Valentine C, Pinching AJ. Formulations of didanosine (ddI) and salt overload. Lancet 1992;339(8786):190.
- Chen L, Zhang Z, Chen W, Whelton PK, Appel LJ. Lower Sodium Intake and Risk of Headaches: Results From the Trial of Nonpharmacologic Interventions in the Elderly. Am J Public Health. 2016;106(7):1270-5. PubMed
- Cook NR, Appel LJ, Whelton PK. Lower levels of sodium intake and reduced cardiovascular risk. Circulation. 2014;129(9):981-9. PubMed
- Cook NR, Appel LJ, Whelton PK. Sodium Intake and All-Cause Mortality Over 20 Years in the Trials of Hypertension Prevention. J Am Coll Cardiol. 2016;68(15):1609-1617. PubMed
- Mente A, O'Donnell M, Rangarajan S, et al. Associations of urinary sodium excretion with cardiovascular events in individuals with and without hypertension: a pooled analysis of data from four studies. Lancet. 2016;388(10043):465-75. PubMed
- Moosavian SP, Haghighatdoost F, Surkan PJ, Azadbakht L. Salt and obesity: a systematic review and meta-analysis of observational studies. Int J Food Sci Nutr. 2017;68(3):265-277. PubMed
- O'Donnell M, Mente A, Rangarajan S, et al. Urinary sodium and potassium excretion, mortality, and cardiovascular events. N Engl J Med. 2014;371(7):612-23. DOI
- Poggio R, Gutierrez L, Matta MG, Elorriaga N, Irazola V, Rubinstein A. Daily sodium consumption and CVD mortality in the general population: systematic review and meta-analysis of prospective studies. Public Health Nutr. 2015;18(4):695-704. PubMed
- Stallings VA, Harrison M, Oria M; Committee to Review the Dietary Reference Intakes for Sodium and Potassium, Food and Nutrition Board, Health and Medicine Division, National Academies of Sciences, Engineering, and Medicine. Washington (DC): National Acad
- Mahtani KR, Heneghan C, Onakpoya I, et al. Reduced Salt Intake for Heart Failure: A Systematic Review. JAMA Intern Med. 2018 Dec 1;178(12):1693-1700. PubMed
- Yancy CW. Sodium Restriction in Heart Failure: Too Much Uncertainty-Do the Trials. JAMA Intern Med. 2018 Dec 1;178(12):1700-1701. PubMed
- He FJ, Campbell NRC, Ma Y, MacGregor GA, Cogswell ME, Cook NR. Errors in estimating usual sodium intake by the Kawasaki formula alter its relationship with mortality: implications for public health. Int J Epidemiol. 2018;47(6):1784-1795. PubMed
- Murthy K, Ondrey GJ, Malkani N, et al. THE EFFECTS OF HYPONATREMIA ON BONE DENSITY AND FRACTURES: A SYSTEMATIC REVIEW AND META-ANALYSIS. Endocr Pract. 2019;25(4):366-378. PubMed
- Messerli FH, Hofstetter L, Syrogiannouli L, et al. Sodium intake, life expectancy, and all-cause mortality. Eur Heart J 2021;42(21):2103-2112. PubMed
- Graudal NA, Hubeck-Graudal T, Jurgens G. Effects of low sodium diet versus high sodium diet on blood pressure, renin, aldosterone, catecholamines, cholesterol, and triglyceride. Cochrane Database Syst Rev 2020;12(12):CD004022. PubMed
- Giatti S, Santos RB, Aielo AN, et al. Association of sodium with obstructive sleep apnea. The ELSA-Brasil study. Ann Am Thorac Soc 2021;18(3):502-510. PubMed
- Nan X, Lu H, Wu J, et al. The interactive association between sodium intake, alcohol consumption and hypertension among elderly in northern China: a cross-sectional study. BMC Geriatr 2021;21(1):135. PubMed
- Kyozuka H, Fukusda T, Murata T, et al. Impact of preconception sodium intake on hypertensive disorders of pregnancy: The Japan Environment and Children's study. Pregnancy Hypertens 2021;23:66-72. PubMed
- Zhao L, Ogden CL, Yang Q, et al. Association of usual sodium intake with obesity among US children and adolescents, NHANES 2009-2016. Obesity (Silver Spring) 2021;29(3):587-594. PubMed
- Ma Y, He FJ, Sun Q, et al. 24-Hour urinary sodium and potassium excretion and cardiovascular risk. N Engl J Med 2022;386(3):252-263. PubMed
- Liu J, Yang X, Zhang P, et al. Association of urinary sodium excretion and left ventricular hypertrophy in people with type 2 diabetes mellitus: A cross-sectional study. Front Endocrinol (Lausanne) 2021;12:728493. PubMed
- Filippini T, Malavolti M, Whelton PK, Vinceti M. Sodium intake and risk of hypertension: A systematic review and dose-response meta-analysis of observational cohort studies. Curr Hypertens Rep 2022;24(5):133-144. PubMed
- Wang DD, Li Y, Nguyen XT, et al. Dietary sodium and potassium intake and risk of non-fatal cardiovascular diseases: The million veteran program. Nutrients 2022;14(5):1121. PubMed
- Kwak JH, Park CH, Eun CS, et al. The associations of dietary intake of high sodium and low zinc with gastric cancer mortality: A prospective cohort study in Korea. Nutr Cancer 2022;74(10):3501-3508. PubMed
- George S, Maiti R, Mishra BR, Jena M, Mohapatra D. Effect of regulated add-on sodium chloride intake on stabilization of serum lithium concentration in bipolar disorder: A randomized controlled trial. Bipolar Disord 2023;25(1):66-75. PubMed
- Zhou TL, Schütten MTJ, Kroon AA, et al. Urinary Sodium Excretion and Salt Intake Are Not Associated With Blood Pressure Variability in a White General Population. J Am Heart Assoc 2023;12(1):e026578. PubMed
Potassium 12 references
- McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
- Gennaro A. Remington: The Science and Practice of Pharmacy. 19th ed. Lippincott: Williams & Wilkins, 1996.
- Whelton PK, He J, Cutler JA, et al. Effects of oral potassium on blood pressure. Meta-analysis of randomized controlled clinical trials. JAMA 1997;277:1624-32. PubMed
- Phillips, C. O., Kashani, A., Ko, D. K., Francis, G., and Krumholz, H. M. Adverse effects of combination angiotensin II receptor blockers plus angiotensin-converting enzyme inhibitors for left ventricular dysfunction: a quantitative review of data from ra DOI
- Altieri, P. I., Herrero, C., Suero, R., and Ortiz, A. Bleeding duodenal ulcer in a patient taking slow-releasing potassium tablets. Bol.Asoc.Med P.R. 1977;69(8):276.
- Raf, L. E. Enteric-coated potassium chloride tablets and ulcer of the small intestine. Acta Chir Scand Suppl 1967;(374):1-87.
- Potassium chloride oral solution [package insert]. Allentown, PA: Lehigh Valley Technologies, Inc.; 2014.
- Potassium chloride injection [package insert]. Lake Forest, IL: Hospira Inc.; 2009.
- Patel RB, Tannenbaum S, Viana-Tejedor A, et al. Serum potassium levels, cardiac arrhythmias, and mortality following non-ST-elevation myocardial infarction or unstable angina: insights from MERLIN-TIMI 36. Eur Heart J Acute Cardiovasc Care 2017 Feb;6(1):1 PubMed
- Malta D, Arcand J, Ravindran A, Floras V, Allard JP, Newton GE. Adequate intake of potassium does not cause hyperkalemia in hypertensive individuals taking medications that antagonize the renin angiotensin aldosterone system. Am J Clin Nutr 2016 Oct;104(4 PubMed
- Keskin M, Kaya A, Tatlisu MA, et al. The effect of serum potassium level on in-hospital and long-term mortality in ST elevation myocardial infarction. Int J cardiol. 2016 Oct 15;221:505-10.
- Stallings VA, Harrison M, Oria M; Committee to Review the Dietary Reference Intakes for Sodium and Potassium, Food and Nutrition Board, Health and Medicine Division, National Academies of Sciences, Engineering, and Medicine. Washington (DC): National Acad
Vitamin D 26 references
- McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
- Tatro DS, ed. Drug Interactions Facts. Facts and Comparisons Inc., St. Louis, MO. 1999.
- Koutkia P, Chen TC, Holick MF. Vitamin D intoxication associated with an over-the-counter supplement. N Engl J Med 2001;345:66-7. PubMed
- Bar-Or D, Yoel G. Calcium and calciferol antagonize effect of verapamil in atrial fibrillation. Br Med J 1981;282:1585-6.
- Demontis R, Leflon A, Fournier A, et al. 1 alpha(OH) vitamin D3 increases plasma aluminum in hemodialyzed patients taking AI(OH)3. Clin Nephrol 1986;26:146-9.
- Crowe M, Wollner L, Griffiths RA. Hypercalcemia following vitamin D and thiazide therapy in the elderly. Practitioner 1984;228:312-3.
- Parfitt AM. Thiazide-induced hypercalcemia in vitamin D-treated hypoparathyroidism. Ann Intern Med 1972;77:557-63. PubMed
- Thiazide diuretics and the risk of osteoporosis. Pharmacist's Letter/Prescriber's Letter 2003;19(11):191105.
- Moon J. The role of vitamin D in toxic metal absorption. J Am Coll Nutr 1994;13:559-64.
- Demontis R, Reissi D, Noel C, et al. Indirect clinical evidence that 1alphaOH vitamin D<SUB>3</SUB> increases the intestinal absorption of aluminum. Clin Nephrol 1989;31:123-7.
- Adler AJ, Berlyne GM. Duodenal aluminum absorption in the rat: effect of vitamin D. Am J Physiol 1985;249:G209-13. PubMed
- Schwartz JB. Effects of vitamin D supplementation in atorvastatin-treated patients: A new drug interaction with an unexpected consequence. Clin Pharmacol Ther 2009;85:198-203. PubMed
- Dietary reference intakes for calcium and vitamin D. Institute of Medicine, November 30, 2010. Available at: http://www.iom.edu/~/media/Files/Report%20Files/2010/Dietary-Reference-Intakes-for-Calcium-and-Vitamin-D/Vitamin%20D%20and%20Calcium%202010%20Repo
- Cox KA, Dunn MA. Aluminum toxicity alters the regulation of calbindin-D28k protein and mRNA expression in chick intestine. J Nutr 2001;131:2007-13. PubMed
- Escribano, J., Balaguer, A., Pagone, F., Feliu, A., and Roque, I. Figuls. Pharmacological interventions for preventing complications in idiopathic hypercalciuria. Cochrane.Database.Syst.Rev. 2009;(1):CD004754. PubMed
- Carlton, S., Clopton, D., and Cappuzzo, K. A. Vitamin D deficiency: appropriate replenishment therapies and the effects of vitamin D toxicity. Consult Pharm 2010;25(3):171-177. PubMed
- Wang, H., Xia, N., Yang, Y., and Peng, D. Q. Influence of vitamin D supplementation on plasma lipid profiles: a meta-analysis of randomized controlled trials. Lipids Health Dis. 2012;11:42. PubMed
- Turner AN, Carr Reese P, Fields KS, Anderson J, Ervin M, Davis JA, Fichorova RN, Roberts MW, Klebanoff MA, Jackson RD. A blinded, randomized controlled trial of high-dose vitamin D supplementation to reduce recurrence of bacterial vaginosis. Am J Obstet G PubMed
- Weiner M, Epstein FH. Signs and symptoms of electrolyte disorders. Yale J Biol Med. 1970;43(2):76-109.
- Lappe J, Watson P, Travers-Gustafson D, Recker R, Garland C, Gorham E, Baggerly K, McDonnell SL. Effect of Vitamin D and Calcium Supplementation on Cancer Incidence in Older Women: A Randomized Clinical Trial. JAMA. 2017 Mar 28;317(12):1234-1243. PubMed
- Roth DE, Leung M, Mesfin E, Qamar H, Watterworth J, Papp E. Vitamin D supplementation during pregnancy: state of the evidence from a systematic review of randomised trials. BMJ. 2017;359:j5237. PubMed
- Murai IH, Fernandes AL, Sales LP, et al. Effect of a single high dose of vitamin D3 on hospital length of stay in patients with moderate to severe COVID-19: A randomized clinical trial. JAMA. 2021.
- Wang Z, Schuetz EG, Xu Y, Thummel KE. Interplay between vitamin D and the drug metabolizing enzyme CYP3A4. J Steroid Biochem Mol Biol 2013;136:54-8. PubMed
- Doyle D, Browne U, Brickley A, Murphy D. Vitamin D-induced hypercalcaemia and acute kidney injury in sarcoidosis. BMJ Case Rep 2023;16(1):e250580. PubMed
- Williamson A, Martineau AR, Sheikh A, Jolliffe D, Griffiths CJ. Vitamin D for the management of asthma. Cochrane Database Syst Rev 2023;2(2):CD011511. PubMed
- Kinesya E, Santoso D, Gde Arya N, et al. Vitamin D as adjuvant therapy for diabetic foot ulcers: Systematic review and meta-analysis approach. Clin Nutr ESPEN 2023;54:137-143. PubMed
Casein Peptides 4 references
- Cicero AFG, Aubin F, Azais-Braesco V, Borghi C. Do the lactotripeptides isoleucine-proline-proline and valine-proline-proline reduce systolic blood pressure in European subjects? A meta-analysis of randomized controlled trials. Am J Hypertens. 2013;26(3): PubMed
- Fekete AA, Givens DA, Lovegrove JA. Casein-derived lactotripeptides reduce systolic and diastolic blood pressure in a meta-analysis of randomised clinical trials. Nutrients. 2015;7(1):659-81. PubMed
- Qin LQ, Xu JY, Dong JY, Zhao Y, van Bladeren P, Zhang W. Lactotripeptides intake and blood pressure management: a meta-analysis of randomised controlled clinical trials. Nutr Metab Cardiovasc Dis. 2013;23(5):395-402. PubMed
- Turpeinen AM, Järvenpää S, Kautiainen H, Korpela R, Vapaatalo H. Antihypertensive effects of bioactive tripeptides-a random effects meta-analysis. Ann Med. 2013;45(1):51-6. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
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