Interactions on record — worth a quick check against your medications. Check your meds →
Dietary supplement

Fiber Advance Gunnies Weight Management Ingredients & Drug Interactions

by Fiber Advance

Fiber Advance Gunnies Weight Management label
See full label image
Gummy Or Jelly Category: Botanical With Nutrients
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Fiber Advance Gunnies Weight Management against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Fiber Advance Gunnies Weight Management is a dietary supplement by Fiber Advance with 3 active ingredients. Its ingredients are commonly taken for replacing fluids and electrolytes, preventing dehydration during exercise or illness, treating low blood sodium (under medical care).Based on those ingredients, 2,069 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Dietary Fiber, Sodium, Chromium. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Fiber Advance Gunnies Weight Management by Fiber Advance

Ask about any prescription or over-the-counter medication and we check it for interactions with Fiber Advance Gunnies Weight Management by Fiber Advance — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Fiber Advance Gunnies Weight Management by Fiber Advance

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 3 of its 3 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

Fiber Advance Gunnies has three active ingredients: sodium, chromium, and soluble fiber. Sodium is an essential mineral your body needs in small amounts for nerve and muscle function; it's naturally present in foods and drinking water.

Chromium is a trace mineral that plays a role in how your body manages blood sugar. Soluble fiber is a type of carbohydrate that dissolves in water and supports digestive health.

The gummies also contain several inactive ingredients — chicory root fiber, cane sugar, citric acid, fruit concentrates, natural flavors, wax, oil, pectin, and sodium citrate — that give the product its taste and texture.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

We hold no graded evidence for this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: Supplement daily fiber intake.
  • Our graded evidence for these ingredients doesn't cover that particular purpose.

Sodium's effectiveness is tied to specific medical uses: it's likely effective for cystic fibrosis and possibly effective for amphotericin B nephrotoxicity (kidney damage from an antifungal drug). For bipolar disorder and congestive heart failure, the evidence isn't clear enough to establish whether sodium helps.

Chromium is likely effective for chromium deficiency and possibly effective for type 2 diabetes, but possibly ineffective for prediabetes, schizophrenia, and high blood pressure. We don't have effectiveness data on file for the soluble fiber in this product.

The evidence, ingredient by ingredient Sodium Black Psyllium Chromium

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 3 of the 3 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 3 of 3.
  • General safety write-ups exist for 3 of 3.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Sodium is generally well tolerated when you consume normal dietary amounts up to the recommended daily limit of 2.3 grams. Too much sodium is linked to high blood pressure, heart strain, and worsening kidney disease — serious but rare when taken by mouth in moderation.

Chromium is generally well tolerated at typical supplement doses; the most common side effects are mild stomach upset, headaches, insomnia, and mood changes. Rare serious effects include kidney or liver damage.

Some people may develop skin rashes or contact dermatitis, especially those with a chromium allergy. For pregnancy and lactation, sodium is likely safe, but chromium safety data during pregnancy and breastfeeding isn't on file — talk with your doctor or pharmacist before taking it if you're pregnant or nursing.

Side effects, ingredient by ingredient Sodium Black Psyllium Chromium

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 3 of the 3 matched ingredients can interact with medications — Black Psyllium, Chromium, Sodium.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications; heart-rhythm medications; lithium.
  • For scale: 2,070 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with your pharmacist if you take blood pressure medication (antihypertensives), lithium, insulin, diabetes medication, levothyroxine (thyroid), corticosteroids, HIV medication (didanosine), or any other sodium-containing drugs or supplements. NSAIDs and aspirin may also affect how much chromium your body absorbs.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

If you take blood pressure medication, lithium, thyroid medication, insulin, or diabetes pills, check your exact drugs with the tool on this page before starting. Normal dietary sodium is fine, but this product is a sodium supplement — your doctor needs to know if you're adding it.

Chromium may lower blood sugar and interfere with some medications. Chat with your pharmacist if you're on any prescription drugs.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 3 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Feb 23, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Fiber Advance Gunnies Weight Management, straight from the product label.

Brand Fiber Advance
Barcode (UPC) 812785010439
Net contents 150 Vegetarian Gummy(ies)
Market status On market
Date entered into DSLD Feb 23, 2025
DSLD ID 323401
Product type Botanical With Nutrients
Supplement form Gummy Or Jelly
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Fiber Advance Gunnies Weight Management by Fiber Advance, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
3 Gummy(ies)
Maximum serving Sizes:
3 Gummy(ies)
Servings per container
50
UPC/BARCODE
812785010439
IngredientAmount% DV
Calories25 Calorie(s)--
Total Carbohydrates9 Gram(s)3%
Sodium30 mg1%
Added Sugars1 Gram(s)2%
Total Sugars4 Gram(s)--
Dietary Fiber6 Gram(s)21%
Chromium200 mcg571%
Fiber, Soluble6 Gram(s)--

Other ingredients: Chicory Root Fiber, Cane Sugar, Citric Acid, Lo Han fruit concentrate, Natural Flavors, black carrot juice extract, Carnauba Wax, Maqui berry juice concentrate, Sunflower Oil, Pectin, Sodium Citrate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

FiberAdvance is a delicious and easy way to help ensure you get all the daily fiber your body needs. Three great-tasting gummies provide 6 grams of soluble fiber, the same amount as powdered fiber products, without any watery mess. Just grab, chew, and go!

The American dietetic Association defines and adequate amount of daily fiber as 25-38 grams, yet the average American consumes only 15 grams per day.

Formulation

No artificial flavors. Free from gluten, milk, eggs, peanuts.

Made in the USA of US and imported ingredients

Supplements your fiber intake 100% plant-based fiber Great taste & no mess

Sealed for your protection. Do not use if seal under cap is broken or missing.

Gummy colors may change over time due to natural colors. This does not alter the potency of the product. Any clouding of clear bottle is normal. To ensure quality and potency through expiration, this product is manufactured with higher active ingredient levels than the indicated amount per serving.

Increases the feeling of fullness Supports digestive & immune system health

Non GMO Project Verified nongmoproject.org

Precautions

Keep out of reach of children.

Take only as directed. Do not exceed recommended dosage.

Consult a qualified health care professional if you have a medical condition, are taking any prescription medications, or if you are pregnant or nursing.

Storage

Keep in a dry area away from direct light. Store: Tightly closed; in the dark; dry and cool (45 degrees F - 75 degrees F).

Formula

Weight management with Chromium picolinate 6g Fiber per serving

Natural fruit flavors with other natural flavors

All natural fruit flavors Strawberry Cran-Raspberry Blueberry

Seals/Symbols

Non GMO Project Verified nongmoproject.org

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Suggested/Recommended/Usage/Directions

Directions: Adults chew three gummies per day. Reduce daily dosage if minor gas or bloating occurs.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Fiber Advance Gunnies Weight Management by Fiber Advance label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Fiber Advance Gunnies Weight Management label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Fiber Advance Gunnies Weight Management by Fiber Advance

These are the 3 active ingredients this product is made of. Select any to open its full monograph.

Serving size3 Gummy(ies) Dosage formGummy Or Jelly Servings per container50 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Sodium

Interacts with
205 drugs
30 mg per serving

Sodium is an essential mineral and electrolyte your body needs to balance fluids, support nerves, and help muscles work. Most people in modern diets g...

Sodium monograph & interactions

Dietary Fiber

Interacts with
2,025 drugs
6 Gram(s) per serving

Black psyllium is a soluble-fiber supplement made from the seeds of a Plantago plant, used mostly to ease constipation and support digestive health. I...

Dietary Fiber monograph & interactions
  • › Fiber, Soluble

Chromium

Interacts with
178 drugs
200 mcg per serving Form: Chromium Picolinate

Chromium is an essential trace mineral involved in how the body handles sugar and fat. Some studies suggest it may modestly help blood sugar control i...

Chromium monograph & interactions

Other (inactive) ingredients: Chicory Root Fiber, Cane Sugar, Citric Acid, Lo Han fruit concentrate, Natural Flavors, Black carrot juice extract, Carnauba Wax, Maqui berry juice concentrate, Sunflower Oil, Pectin, Sodium Citrate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Fiber Advance Gunnies Weight Management by Fiber Advance Drug Interactions

Want to check YOUR meds against Fiber Advance Gunnies Weight Management?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
2,069Drugs
296 Moderate 1,773 Minor

Ingredients driving the most interactions

Dietary Fiber 2,025
Sodium 205
Chromium 178

Individual Drug Interactions

The ingredients in Fiber Advance Gunnies Weight Management interact with 2,069 drugs. Click any drug to see the details.

3 of the 3 ingredients in Fiber Advance Gunnies Weight Management interact with drugs. Each result below shows which ingredient is responsible. Dietary Fiber Sodium Chromium

Each ingredient & the kinds of drugs it affects

For each ingredient in Fiber Advance Gunnies Weight Management with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Dietary Fiber7 drug types · 2,025 drugs

Carbamazepine (Tegretol)

Theoretically, black psyllium might reduce the effects of carbamazepine and increase the risk for convulsions.
Theoretically, black psyllium might reduce carbamazepine absorption. A preliminary study using blond psyllium reported decreased carbamazepine bioavailability due to binding of the drug to psyllium, as well as reduction of available fluid in the gut for dissolution of the drug. This interaction may also occur with black psyllium.

Likelihood Probable Evidence D
Lithium

Theoretically, taking black psyllium at the same time as lithium might reduce lithium absorption.
The fiber in black psyllium might reduce lithium absorption and plasma levels. Some case reports describe a reduction in plasma lithium levels with concomitant administration of blond psyllium. This was reversed when psyllium was stopped. This interaction may also occur with black psyllium.

Likelihood Probable Evidence D
Metformin (Glucophage)

Theoretically, black psyllium might increase the therapeutic and adverse effects of metformin.
Animal research shows that concurrent consumption of blond psyllium with metformin slows and increases the absorption of metformin. This interaction may also occur with black psyllium. To avoid changes in absorption, take psyllium 30-60 minutes after metformin.

Likelihood Possible Evidence D
Olanzapine (Zyprexa)

Theoretically, taking black psyllium at the same time as olanzapine might reduce olanzapine absorption.
The fiber in black psyllium might decrease the absorption of olanzapine. A single case report describes a reduction in the effectiveness of olanzapine when it was concomitantly administered with an unspecified type of psyllium 3 grams orally twice daily. This effect was reversed when psyllium was stopped.

Likelihood Possible Evidence D
Digoxin (Lanoxin)

Theoretically, taking black psyllium at the same time as digoxin might reduce digoxin absorption and decrease digoxin levels.
Psyllium might bind digoxin in the gut. However, some clinical evidence suggests that psyllium does not impact digoxin absorption.

Likelihood Unlikely Evidence B
Ethinyl Estradiol

Theoretically, taking black psyllium at the same time as ethinyl estradiol might alter levels of estradiol.
Concurrent use of blond psyllium with ethinyl estradiol results in a slight increase in the extent of ethinyl estradiol absorption and a slower rate of absorption. This is unlikely to be clinically significant.

Likelihood Unlikely Evidence D
Oral Drugs

Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Psyllium seems to have variable effects on drug absorption. To avoid changes in absorption, take psyllium 30-60 minutes after oral medications. Animal research shows that blond psyllium delays and increases the absorption of metformin and ethinyl estradiol. Case reports and animal research suggest that blond psyllium might reduce absorption of lithium, digoxin, olanzapine, and carbamazepine. Finally, some pharmacokinetic studies show that psyllium does not affect the absorption of levothyroxine or warfarin. Although many of these studies evaluated blond psyllium, the fiber content in black psyllium may have similar effects.

Likelihood Possible Evidence B
Dietary Fiber full monograph & interactions

Sodium7 drug types · 205 drugs

Antihypertensive Drugs

Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.
High intake of dietary sodium can increase systolic and diastolic blood pressure. Also, high intake of sodium may necessitate increased use of antihypertensive medications to achieve blood pressure control in some patients, such as those with chronic kidney disease.

Likelihood Probable Evidence A
Corticosteroids

Concomitant use of mineralocorticoids and some glucocorticoids with sodium supplements might increase the risk of hypernatremia.
Mineralocorticoids and some glucocorticoids (corticosteroids) cause sodium retention. This effect is dose-related and depends on mineralocorticoid potency. It is most common with hydrocortisone, cortisone, and fludrocortisone, followed by prednisone and prednisolone.

Likelihood Possible Evidence D
Didanosine (Videx)

Concomitant use of didanosine with additional sodium from dietary or supplemental sources may increase the risk of hypernatremia.
Didanosine formulations contain a significant amount of sodium.

Likelihood Probable Evidence C
Lithium

Altering dietary intake of sodium might alter the levels and clinical effects of lithium.
High sodium intake can reduce plasma concentrations of lithium by increasing lithium excretion. Reducing sodium intake can significantly increase plasma concentrations of lithium and cause lithium toxicity in patients being treated with lithium carbonate. Stabilizing sodium intake is shown to reduce the percentage of patients with lithium level fluctuations above 0.8 mEq/L. Patients taking lithium should avoid significant alterations in their dietary intake of sodium.

Likelihood Probable Evidence B
Sodium Phosphates

Theoretically, concomitant use of sodium phosphate with sodium supplements might increase the risk of hypernatremia.
Use of high doses (> 45 mL in 24 hours) of sodium phosphate, such as those used for bowel cleansing before surgery, can lead to serious electrolyte disturbances, including hypernatremia. The risk of hypernatremia is highest in the elderly and people with other risk factors for electrolyte disturbances.

Likelihood Possible Evidence D
Sodium-Containing Drugs

Concomitant use of sodium-containing drugs with additional sodium from dietary or supplemental sources may increase the risk of hypernatremia and long-term sodium-related complications.
The Chronic Disease Risk Reduction (CDRR) intake level of 2.3 grams of sodium daily indicates the intake at which it is believed that chronic disease risk increases for the apparently healthy population. Some medications contain high quantities of sodium. When used in conjunction with sodium supplements or high-sodium diets, the CDRR may be exceeded. Additionally, concomitant use may increase the risk for hypernatremia; this risk is highest in the elderly and people with other risk factors for electrolyte disturbances.

Likelihood Possible Evidence D
Tolvaptan (Samsca)

Theoretically, concomitant use of tolvaptan with sodium might increase the risk of hypernatremia.
Tolvaptan is a vasopressin receptor 2 antagonist that is used to increase sodium levels in patients with hyponatremia. Patients taking tolvaptan should use caution with the use of sodium salts such as sodium chloride.

Likelihood Probable Evidence C
Sodium full monograph & interactions

Chromium5 drug types · 178 drugs

Antidiabetes Drugs

Theoretically, chromium may have additive effects with antidiabetic agents and increase the risk of hypoglycemia.
Some research shows that taking chromium might lower blood glucose levels, especially in patients with poorly controlled type 2 diabetes.

Likelihood Possible Evidence A
Insulin

Theoretically, concomitant use of chromium and insulin might increase the risk of hypoglycemia.
In clinical research, chromium has been shown to increase insulin sensitivity,

Likelihood Possible Evidence B
Levothyroxine (Synthroid, Others)

Chromium might bind levothyroxine in the intestinal tract and decrease levothyroxine absorption.
Clinical research in healthy volunteers shows that taking chromium picolinate 1000 mcg with levothyroxine 1 mg decreases serum levels of levothyroxine by 17% when compared to taking levothyroxine alone. Advise patients to take levothyroxine at least 30 minutes before or 3-4 hours after taking chromium.

Likelihood Probable Evidence B
Aspirin

Theoretically, aspirin might increase chromium absorption.
Animal research suggests that aspirin may increase chromium absorption and chromium levels in the blood.

Likelihood Possible Evidence D
Nonsteroidal Anti-Inflammatory Drugs (Nsaids)

NSAIDs might increase chromium levels in the body.
Drugs that are prostaglandin inhibitors, such as NSAIDs, seem to increase chromium absorption and retention.

Likelihood Possible Evidence D
Chromium full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Fiber Advance Gunnies Weight Management, from the product label.

Fiber Advance

See all Fiber Advance products
Name
SCN BestCo
Street Address
2200 Delaware Avenue
City
Santa Cruz
State
CA
ZipCode
95060
Phone Number
866-942-2429
Pharmacist Counseling Corner

Fiber Advance Gunnies Weight Management by Fiber Advance: Common Questions

Does Fiber Advance Gunnies Weight Management by Fiber Advance interact with any medications?
Yes. Based on its ingredients, Fiber Advance Gunnies Weight Management has a known interaction with 2,069 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Fiber Advance Gunnies Weight Management contains 3 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does this product actually help with weight management?
The product facts we have don't include effectiveness data on weight management for this specific formula. The soluble fiber may support digestive health, and the chromium is possibly effective for type 2 diabetes, but we can't tell you whether the combination works for weight loss. Ask your pharmacist or doctor if it might fit your goals.
Can I take this if I'm on blood pressure pills?
Sodium can work against blood pressure medications and make them less effective. You need to talk with your doctor or pharmacist first — they'll know your dose and your blood pressure history and can advise you.
What's the sodium in these gummies for?
Sodium is an essential mineral your body uses for nerve and muscle function, and it occurs naturally in foods and water. In this supplement, it's included as an active ingredient, but normal dietary sodium is fine — avoid adding a sodium supplement without medical advice.
Is chromium safe if I have diabetes?
Chromium is possibly effective for type 2 diabetes, but it can lower blood sugar on its own. If you take insulin or diabetes medication, combining it with chromium may drop your levels too low. Always run this past your doctor or pharmacist first.
Can I take these while I'm pregnant?
Sodium is rated likely safe in pregnancy, but chromium safety data during pregnancy isn't on file — we don't have enough information. Talk with your doctor or pharmacist before taking this product if you're pregnant or breastfeeding.
Are there any common side effects from chromium?
Chromium is generally well tolerated. The most common side effects are mild — stomach upset, headaches, insomnia, and mood changes. Serious side effects are rare.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Fiber Advance Gunnies Weight Management is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Fiber Advance Gunnies Weight Management label
Go deeper

The Full Monographs Behind Fiber Advance Gunnies Weight Management’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Sodium

Interacts with 205 drugs

Sodium is an essential mineral and electrolyte your body needs to balance fluids, support nerves, and help muscles work. Most people in modern diets get more than enough—often too much—from...

Read the full Sodium monograph → Herb & supplement monograph

Black Psyllium

Interacts with 2,025 drugs

Black psyllium is a soluble-fiber supplement made from the seeds of a Plantago plant, used mostly to ease constipation and support digestive health. It is best known and most studied for rel...

Read the full Black Psyllium monograph → Herb & supplement monograph

Chromium

Interacts with 178 drugs

Chromium is an essential trace mineral involved in how the body handles sugar and fat. Some studies suggest it may modestly help blood sugar control in certain people with type 2 diabetes, b...

Read the full Chromium monograph →
Sources

Sources & How We Checked

Fiber Advance Gunnies Weight Management's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 109 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Sodium 38 references
  1. Garabedian-Ruffalo SM, Ruffalo RL. Drug and nutrient interactions. Am Fam Physician 1986;33:165-74.
  2. Food and Drug Administration Science Background: Safety of Sodium Phosphates Oral Solution. September 17, 2001. Available at: http://www.fda.gov/cder/drug/safety/sodiumphospate.htm
  3. Coton T, Mallaret C, Coilliot C, Carre D, Guisset M. Severe acute ulcerated gastritis induced by salt. Presse Med 2009;38(3):499-500. PubMed
  4. Frings-Meuthen P, Buehlmeier J, Baecker N, et al. High sodium chloride intake exacerbates immobilization-induced bone resorption and protein losses. J Appl Physiol 2011;111(2):537-542. PubMed
  5. Frings-Meuthen P, Baecker N, Heer M. Low-grade metabolic acidosis may be the cause of sodium chloride-induced exaggerated bone resorption. J Bone Miner Res 2008;23(4):517-524. PubMed
  6. Alam S, Johnson AG. A meta-analysis of randomised controlled trials (RCT) among healthy normotensive and essential hypertensive elderly patients to determine the effect of high salt (NaCl) diet of blood pressure. J Hum Hypertens 1999;13(6):367-74.
  7. Boudville N, Ward S, Benaroia M, House AA. Increased sodium intake correlates with greater use of antihypertensive agents by subjects with chronic kidney disease. Am J Hypertens 2005;18(10):1300-5. PubMed
  8. Bennett WM. Drug interactions and consequences of sodium restriction. Am J Clin Nutr 1997;65(2 Suppl):678S-681S. PubMed
  9. Okusa MD, Crystal LJ. Clinical manifestations and management of acute lithium intoxication. Am J Med 1994;97(4):383-9. PubMed
  10. Food and Nutrition Board, Institute of Medicine. Dietary reference intakes for water, potassium, sodium, chloride, and sulfate. Washington, DC: National Academy Press, 2005. Available at: http://www.nap.edu/openbook.php?record_id=10925. DOI
  11. D'Elia L, Rossi G, Ippolito R, Cappuccio FP, Strazzullo P. Habitual salt intake and risk of gastric cancer: a meta-analysis of prospective studies. Clin Nutr 2012;31(4):489-98. PubMed
  12. Goldsmith SR. Hyponatremia in heart failure: time for a trial. J Card Fail 2013;19(6):398-400. PubMed
  13. Willocks L, Brettle R, Keen J, Valentine C, Pinching AJ. Formulations of didanosine (ddI) and salt overload. Lancet 1992;339(8786):190.
  14. Chen L, Zhang Z, Chen W, Whelton PK, Appel LJ. Lower Sodium Intake and Risk of Headaches: Results From the Trial of Nonpharmacologic Interventions in the Elderly. Am J Public Health. 2016;106(7):1270-5. PubMed
  15. Cook NR, Appel LJ, Whelton PK. Lower levels of sodium intake and reduced cardiovascular risk. Circulation. 2014;129(9):981-9. PubMed
  16. Cook NR, Appel LJ, Whelton PK. Sodium Intake and All-Cause Mortality Over 20 Years in the Trials of Hypertension Prevention. J Am Coll Cardiol. 2016;68(15):1609-1617. PubMed
  17. Mente A, O'Donnell M, Rangarajan S, et al. Associations of urinary sodium excretion with cardiovascular events in individuals with and without hypertension: a pooled analysis of data from four studies. Lancet. 2016;388(10043):465-75. PubMed
  18. Moosavian SP, Haghighatdoost F, Surkan PJ, Azadbakht L. Salt and obesity: a systematic review and meta-analysis of observational studies. Int J Food Sci Nutr. 2017;68(3):265-277. PubMed
  19. O'Donnell M, Mente A, Rangarajan S, et al. Urinary sodium and potassium excretion, mortality, and cardiovascular events. N Engl J Med. 2014;371(7):612-23. DOI
  20. Poggio R, Gutierrez L, Matta MG, Elorriaga N, Irazola V, Rubinstein A. Daily sodium consumption and CVD mortality in the general population: systematic review and meta-analysis of prospective studies. Public Health Nutr. 2015;18(4):695-704. PubMed
  21. Stallings VA, Harrison M, Oria M; Committee to Review the Dietary Reference Intakes for Sodium and Potassium, Food and Nutrition Board, Health and Medicine Division, National Academies of Sciences, Engineering, and Medicine. Washington (DC): National Acad
  22. Mahtani KR, Heneghan C, Onakpoya I, et al. Reduced Salt Intake for Heart Failure: A Systematic Review. JAMA Intern Med. 2018 Dec 1;178(12):1693-1700. PubMed
  23. Yancy CW. Sodium Restriction in Heart Failure: Too Much Uncertainty-Do the Trials. JAMA Intern Med. 2018 Dec 1;178(12):1700-1701. PubMed
  24. He FJ, Campbell NRC, Ma Y, MacGregor GA, Cogswell ME, Cook NR. Errors in estimating usual sodium intake by the Kawasaki formula alter its relationship with mortality: implications for public health. Int J Epidemiol. 2018;47(6):1784-1795. PubMed
  25. Murthy K, Ondrey GJ, Malkani N, et al. THE EFFECTS OF HYPONATREMIA ON BONE DENSITY AND FRACTURES: A SYSTEMATIC REVIEW AND META-ANALYSIS. Endocr Pract. 2019;25(4):366-378. PubMed
  26. Messerli FH, Hofstetter L, Syrogiannouli L, et al. Sodium intake, life expectancy, and all-cause mortality. Eur Heart J 2021;42(21):2103-2112. PubMed
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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