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Dietary supplement

Fibro-Ease LG Ingredients & Drug Interactions

by Earth Friend Herb Co.

Liquid Category: Botanical
Most serious interaction: Moderate
The interaction bottom line Most serious interaction: Moderate

Fibro-Ease LG is a dietary supplement by Earth Friend Herb Co. with 6 active ingredients. Its ingredients are commonly taken for colds, flu (influenza), other respiratory infections.Based on those ingredients, 289 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Sheep Sorrel, Elderberry, Lobelia. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

HelloPharmacist Scorecard of Fibro-Ease LG by Earth Friend Herb Co.

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 6 active ingredients.

Fibro-Ease LG contains 6 active herbal ingredients: elderberry, lobelia, couch grass, white pond lily, sheep sorrel, and condurango. Beyond those, the liquid form contains alcohol and glycerin as inactive ingredients.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

The label doesn't state a purpose we can grade — see each ingredient's own graded uses on its monograph instead.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The evidence base for this product's ingredients is limited. Elderberry has insufficient evidence for hay fever, heart disease, chronic fatigue, lung disease, memory, and respiratory infections.

Lobelia is rated possibly ineffective for smoking cessation. Sheep sorrel, couch grass, white pond lily, and condurango all have insufficient evidence or no established effectiveness ratings for their traditional uses in our data.

If you're considering this product for a specific condition, talk with your pharmacist about what the research actually shows.

The evidence, ingredient by ingredient Elderberry Lobelia Couch Grass White Lily Sorrel Condurango

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 3 of the 6 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 6 of 6.
  • General safety write-ups exist for 6 of 6.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Properly cooked elderberry is generally well tolerated, but raw or unripe berries and seeds can cause nausea, vomiting, severe diarrhea, weakness, dizziness, and other toxicity symptoms due to naturally occurring cyanide compounds — cooking eliminates this risk. Lobelia carries a caution for toxicity; even doses as low as 50 mg can cause nausea, vomiting, diarrhea, dizziness, and throat irritation, and doses of 600 mg or higher can trigger sweating, rapid heartbeat, convulsions, dangerously low blood pressure, and death.

Sheep sorrel is high in oxalates and at medicinal doses could raise kidney stone risk and cause kidney damage. Couch grass is generally well tolerated but has limited human data.

White pond lily may rarely cause skin reactions. This product should be avoided during pregnancy and breastfeeding — elderberry and lobelia specifically lack enough safety data in pregnancy, and lobelia is rated likely unsafe; sheep sorrel is possibly safe in pregnancy but has limited breastfeeding data, and couch grass, white pond lily, and condurango should be avoided when pregnant or nursing due to insufficient information.

Side effects, ingredient by ingredient Elderberry Lobelia Couch Grass White Lily Sorrel Condurango

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 3 of the 6 matched ingredients can interact with medications — Lobelia, Elderberry, Sorrel.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; lithium.
  • For scale: 289 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check before taking this product if you use immunosuppressants, pazopanib (a cancer medication), lithium, blood thinners or antiplatelet drugs, Allegra (fexofenadine), or any drug that uses OATP transporters to be absorbed — all carry documented moderate-severity interactions with elderberry, lobelia, or sheep sorrel in this formula.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

If you take any immunosuppressants, lithium, blood thinners, or Allegra (fexofenadine), check with your pharmacist before starting Fibro-Ease LG. Lobelia's toxicity risk at higher doses is real, so stick to the label dose.

Pregnant people and those breastfeeding should avoid this product.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 6 of 6 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Dec 21, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Fibro-Ease LG, straight from the product label.

Brand Earth Friend Herb Co.
Net contents 1 Fluid Ounce; 30 Milliliter(s)
Market status On market
Date entered into DSLD Dec 21, 2024
DSLD ID 323593
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Fibro-Ease LG by Earth Friend Herb Co., sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
10 Drop(s)
Maximum serving Sizes:
10 Drop(s)
Servings per container
30
IngredientAmount% DV
Elderberry0 NP--
Lobelia0 NP--
Couch Grass0 NP--
White Pond Lily0 NP--
Sheep Sorrel0 NP--
Condurango0 NP--

Other ingredients: Alcohol, Glycerin

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested Use: Use 10 drops 3x daily. Take straight-then drink water.

Precautions

Keep away from children.

Not for use with pregnancy or nursing.

General Statements

An Elijah Free formula

Formulation

All certified organic or wild crafted herbs.

See for yourself

Fibro-Ease LG by Earth Friend Herb Co. label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

What’s inside

The Ingredients in Fibro-Ease LG by Earth Friend Herb Co.

These are the 6 active ingredients this product is made of. Select any to open its full monograph.

Serving size10 Drop(s) Dosage formLiquid Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Elderberry

Interacts with
121 drugs
0 NP per serving

Elderberry is a popular herbal supplement, mainly taken to help with colds and flu. Some small studies suggest it may modestly shorten cold or flu sym...

Elderberry monograph & interactions

Lobelia

Interacts with
1 drug
0 NP per serving

Lobelia is a traditional herb once used for breathing problems and to help people quit smoking, but reliable evidence supporting these uses is lacking...

Lobelia monograph & interactions

Couch Grass

No known
interactions
0 NP per serving

Couch grass is a common lawn weed whose rhizome has long been used in traditional European herbal medicine, mainly for urinary and bladder complaints....

Couch Grass monograph & interactions

White Pond Lily

No known
interactions
0 NP per serving

White Lily (Lilium candidum) is a flowering plant used mostly in traditional skin care, where its bulb- or flower-infused oils are applied for minor s...

White Pond Lily monograph & interactions

Sheep Sorrel

Interacts with
169 drugs
0 NP per serving

Sorrel is a tangy, leafy herb used in cooking and traditional medicine, often for congestion, digestion, and inflammation. Solid human evidence for an...

Sheep Sorrel monograph & interactions

Condurango

No known
interactions
0 NP per serving

Condurango is the bark of a South American vine traditionally used as a bitter to stimulate appetite and ease digestive complaints. Modern scientific...

Condurango monograph & interactions

Other (inactive) ingredients: Alcohol, Glycerin. These complete the product’s ingredient list but are not active constituents.

Interaction report

Fibro-Ease LG by Earth Friend Herb Co. Drug Interactions

Want to check YOUR meds against Fibro-Ease LG?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

Go to the checker
289Drugs
289 Moderate

Ingredients driving the most interactions

Each ingredient & the kinds of drugs it affects

For each ingredient in Fibro-Ease LG with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Sheep Sorrel3 drug types · 169 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, sorrel might cause additive effects and side effects when used with anticoagulant or antiplatelet drugs.
In vitro, sorrel has been shown to inhibit platelet aggregation. However, this effect has not been reported in humans.

Likelihood Possible Evidence D
Fexofenadine (Allegra)

Sorrel might reduce the effectiveness of fexofenadine by reducing its absorption from the gut.
In vitro research shows that an ethanol extract of sorrel inhibits organic anion-transporting polypeptide 1A2 (OATP1A2), which transports fexofenadine from the intestine into cells. In rats, concomitant administration of sorrel extract with fexofenadine reduces oral absorption of fexofenadine and the area under the plasma concentration-time curve (AUC).

Likelihood Likely Evidence D
Organic Anion-Transporting Polypeptide Substrates (Oatp)

Sorrel might reduce the effectiveness of OATP substrates by reducing their absorption from the gut.
In vitro research shows that sorrel inhibits OATP1A2. Theoretically it may inhibit other OATPs. The OATPs are expressed in the small intestine and liver and transport drugs into cells. Inhibition of OATP may reduce the bioavailability of oral drugs that are substrates of OATP.

Likelihood Possible Evidence D

Elderberry2 drug types · 121 drugs

Immunosuppressants

Theoretically, elderberry might interfere with immunosuppressant therapy due to its immunostimulant activity.
Elderberry has immunostimulant activity, increasing the production of cytokines, including interleukin and tumor necrosis factor.

Likelihood Possible Evidence B
Pazopanib (Votrient)

Theoretically, elderberry might interact with pazopanib, potentially increasing the risk of adverse effects.
In one case, a 65-year-old patient taking pazopanib for 4 weeks for soft-tissue sarcoma developed severe nausea, loose stools, and elevated alanine transaminase and aspartate transaminase levels and was diagnosed with grade 3 liver injury. The patient reported taking elderberry supplements for 2 years, dose unspecified, and was also taking a multivitamin and a calcium supplement. The patient's symptoms and liver enzyme levels improved upon discontinuation of pazopanib and all supplements. Pazopanib treatment was re-initiated, at a lower dose, with no further evidence of liver injury. It was unclear in this case report if the elderberry supplements were derived from the berry, the flower, or the combination.

Likelihood Possible Evidence D

Lobelia1 drug type · 1 drug

Lithium

Lobelia is thought to have diuretic properties. Theoretically, due to these potential diuretic effects, lobelia might reduce excretion and increase levels of lithium. The dose of lithium might need to be decreased.

Likelihood Probable Evidence D
The maker

Brand information

Manufacturer and brand details for Fibro-Ease LG, from the product label.

Earth Friend Herb Co.

See all Earth Friend Herb Co. products
Name
Exsula Foods Inc.
Street Address
PO Box 44459
City
Tacoma
State
WA
ZipCode
98448
Phone Number
253-874-9092
Web Address
www.exsula.com
Pharmacist Counseling Corner

Fibro-Ease LG by Earth Friend Herb Co.: Common Questions

Does Fibro-Ease LG by Earth Friend Herb Co. interact with any medications?
Yes. Based on its ingredients, Fibro-Ease LG has a known interaction with 289 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Fibro-Ease LG contains 6 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take Fibro-Ease LG if I'm pregnant or breastfeeding?
No, you should avoid this product while pregnant or breastfeeding. Elderberry and lobelia lack enough safety data in pregnancy, and lobelia is rated likely unsafe. Sheep sorrel, couch grass, white pond lily, and condurango don't have reliable safety information for pregnancy or lactation either. Talk with your doctor or pharmacist about what's appropriate for you.
What does lobelia do in this formula, and why is it a concern?
Lobelia is included for its traditional herbal use, but the safety data advises caution. It can cause nausea, vomiting, diarrhea, dizziness, and throat irritation even at low doses (50 mg), and higher doses (600 mg or more) can trigger serious toxicity including rapid heartbeat, dangerously low blood pressure, and seizures. Always follow the label dose and don't exceed it.
Is elderberry in Fibro-Ease LG safe?
The elderberry in this liquid product should be safe if it's properly prepared (cooked). Raw or unripe berries and seeds contain cyanide compounds that cause nausea, vomiting, severe diarrhea, and weakness — cooking eliminates that risk. The main caution is if you take immunosuppressants or pazopanib, where it may cause problems.
What does this product do?
The evidence for what Fibro-Ease LG actually does is limited. Most of its ingredients — including elderberry, sheep sorrel, couch grass, white pond lily, and condurango — lack reliable evidence for their uses, or the evidence is rated insufficient. If you're considering it for a specific condition, ask your pharmacist what the research supports.
Why is sheep sorrel a concern?
Sheep sorrel is high in oxalates. At medicinal doses, it can increase your kidney stone risk and potentially damage your kidneys. It may also thin your blood if combined with blood thinners like warfarin, and it can reduce how well your body absorbs certain allergy and other medications.
Does this product contain any inactive ingredients I should know about?
Yes, the liquid form contains alcohol and glycerin as inactive ingredients. If you need to avoid alcohol, this product may not be right for you.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Fibro-Ease LG is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Fibro-Ease LG label
Go deeper

The Full Monographs Behind Fibro-Ease LG’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Elderberry

Interacts with 121 drugs

Elderberry is a popular herbal supplement, mainly taken to help with colds and flu. Some small studies suggest it may modestly shorten cold or flu symptoms, but the evidence is limited and n...

Read the full Elderberry monograph →
Herb & supplement monograph

Lobelia

Interacts with 1 drug

Lobelia is a traditional herb once used for breathing problems and to help people quit smoking, but reliable evidence supporting these uses is lacking. It can be toxic in higher amounts, cau...

Read the full Lobelia monograph →
Herb & supplement monograph

Couch Grass

Couch grass is a common lawn weed whose rhizome has long been used in traditional European herbal medicine, mainly for urinary and bladder complaints. High-quality human studies are lacking,...

Read the full Couch Grass monograph →
Herb & supplement monograph

White Lily

White Lily (Lilium candidum) is a flowering plant used mostly in traditional skin care, where its bulb- or flower-infused oils are applied for minor skin problems and soothing. Good-quality...

Read the full White Lily monograph →
Herb & supplement monograph

Sorrel

Interacts with 169 drugs

Sorrel is a tangy, leafy herb used in cooking and traditional medicine, often for congestion, digestion, and inflammation. Solid human evidence for any health benefit is limited, and its hig...

Read the full Sorrel monograph →
Herb & supplement monograph

Condurango

Condurango is the bark of a South American vine traditionally used as a bitter to stimulate appetite and ease digestive complaints. Modern scientific evidence supporting any of these uses is...

Read the full Condurango monograph →
Sources

Sources & How We Checked

Fibro-Ease LG's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 23 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Elderberry 6 references
  1. Barak V, Halperin T, Kalickman I. The effect of Sambucol, a black elderberry-based, natural product, on the production of human cytokines: I. Inflammatory cytokines. Eur Cytokine Netw 2001;12:290-6..
  2. Elderberry (Sambucus species). The Poison Plant Patch, Novia Scotia Museum, 2007. Available at: http://museum.gov.ns.ca/poison/?section=species&id=117 (Accessed 16 October 2009).
  3. European elder. Canadian Poisonous Plants Information System. Available at: http://www.cbif.gc.ca/pls/pp/ppack.jump?p_null=all&p_psn=121&p_type=all&p_sci=comm&p_x=px (Accessed 16 October 2009).
  4. Raus K, Pleschka S, Klein P, Schoop R, Fisher P. Effect of an echinacea-based hot drink versus oseltamivir in Influenza treatment: a randomized, double-blind, double-dummy, multicenter, noninferiority clinical trial. . Curr Ther Res Clin Exp. 2015;20;77:6 PubMed
  5. Ramachandran A, Antala D, Pudasainee P, Panginikkod S, Gupta H. A Plausible Association Between the Use of Elderberry and Autoimmune Hepatitis. Cureus 2022;14(4):e24250. PubMed
  6. Agarwal N, Mangla A. Elderberry interaction with pazopanib in a patient with soft-tissue sarcoma: A case report and literature review. Mol Clin Oncol 2024;20(5):36. PubMed

See these in context on the Elderberry monograph →

Lobelia 6 references
  1. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
  2. Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.
  3. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  4. McChargue DE, Collins FL Jr, Cohen LM. Effect of non-nicotinic moist snuff replacement and lobeline on withdrawal symptoms during 48-h smokeless tobacco deprivation. Nicotine Tob Res 2002;4:195-200. PubMed
  5. Stead LF, Hughes JR. Lobeline for smoking cessation. Cochrane Database Syst Rev 2000;2:CD000124. PubMed
  6. Plakun, A. L., Ambrus, J., Bross, I., Graham, S., Levin, M. L., and Ross, C. A. Clinical factors in smoking withdrawal: preliminary report. Am J Public Health Nations.Health 1966;56(3):434-441. PubMed

See these in context on the Lobelia monograph →

White Lily 2 references
  1. Poisonous Plants — MedlinePlus (U.S. National Library of Medicine) Source
  2. Using Dietary Supplements Wisely — NIH National Center for Complementary and Integrative Health (NCCIH) Source

See these in context on the White Lily monograph →

Sorrel 8 references
  1. Neubauer N, Marz RW. Placebo-controlled, randomized, double-blind, clincal trial with Sinupret sugar coated tablets on the basis of a therapy with antibiotics and decongestant nasal drops in acute sinusitis. Phytomedicine 1994;1:177-81.
  2. Marz RW, Ismail C, Popp MA. Action profile and efficacy of a herbal combination preparation for the treatment of sinusitis. Wien Med Wochenschr 1999;149:202-8.
  3. Zick, S. M., Sen, A., Feng, Y., Green, J., Olatunde, S., and Boon, H. Trial of Essiac to ascertain its effect in women with breast cancer (TEA-BC). J Altern Complement Med 2006;12(10):971-980. PubMed
  4. Sanz, P. and Reig, R. Clinical and pathological findings in fatal plant oxalosis. A review. Am J Forensic Med Pathol. 1992;13(4):342-345. PubMed
  5. Gniazdowska, B., Doroszewska, G., and Doroszewski, W. [Hypersensitivity to weed pollen allergens in the region of Bygdoszcz]. Pneumonol.Alergol.Pol. 1993;61(7-8):367-372.
  6. Selçuk SN, Gülhan B, Düzova A, Teksam Ö. Acute tubulointerstitial nephritis due to large amount of sorrel (Rumex acetosa) intake. Clin Toxicol (Phila) 2015;53(5):497. PubMed
  7. Ahn JH, Kim J, Rehman NU, Kim HJ, Ahn MJ, Chung HJ. Effect of Rumex Acetosa Extract, a Herbal Drug, on the Absorption of Fexofenadine. Pharmaceutics. 2020;12(6):E547. PubMed
  8. Jeong D, Irfan M, Lee DH, Hong SB, Oh JW, Rhee MH. Rumex acetosa modulates platelet function and inhibits thrombus formation in rats. BMC Complement Med Ther. 2020;20(1):98. PubMed

See these in context on the Sorrel monograph →

Condurango 1 reference
  1. Herbs at a Glance — NIH NCCIH Source

See these in context on the Condurango monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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