Interactions on record — worth a quick check against your medications. Check your meds →
Dietary supplement

Flora & Flow Ingredients & Drug Interactions

by Shaklee Multi-Taskers

Flora & Flow label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Flora & Flow against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Flora & Flow is a dietary supplement by Shaklee Multi-Taskers with 4 active ingredients. Its ingredients are commonly taken for preventing urinary tract infections (utis), treating mild utis, urinary tract health.Based on those ingredients, 182 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Lactobacillus acidophilus La-14, Lacticaseibacillus rhamnosus HN001. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Flora & Flow by Shaklee Multi-Taskers

Ask about any prescription or over-the-counter medication and we check it for interactions with Flora & Flow by Shaklee Multi-Taskers — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Flora & Flow by Shaklee Multi-Taskers

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Partial disclosure
Ingredient Transparency · database check
Partial

Most active ingredients list an amount, but at least one is hidden in a blend or missing.

Why this rating?
  • The label discloses an exact amount for 2 of its 4 active ingredients.
  • “Women's Probiotic Proprietary Blend” is a proprietary blend — the label gives one combined amount (77 mg) without saying how much of each component you get.

Flora & Flow has 4 active ingredients. Lactobacillus acidophilus La-14 and Lacticaseibacillus rhamnosus HN001 are live beneficial bacteria meant to support gut and immune health.

D-mannose is a simple sugar that may help with urinary tract health. Lactoferrin is an iron-binding protein found naturally in breast milk and other body fluids, with potential roles in immune and iron support.

The capsule itself contains microcrystalline cellulose, hydroxypropyl methylcellulose, and water as inactive ingredients.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: support vaginal and urinary tract health.
  • We looked for evidence on: Bacterial vaginosis, Urinary tract infection, Vaginal microbiome balance, Vaginal pH balance.
  • The strongest evidence on file: Lactobacillus Acidophilus is rated "Possibly Effective" for Bacterial vaginosis (Natural Medicines).
  • Also on file: D-mannose is rated "Possibly Ineffective" for Urinary tract infections (UTIs).
  • Also on file: Lactoferrin is rated "Insufficient Reliable Evidence To Rate" for Bacterial vaginosis.

The evidence is mixed and varies by ingredient and condition. Lactobacillus acidophilus is possibly effective for irritable bowel syndrome (IBS), infections caused by Helicobacter pylori bacteria, antibiotic-associated diarrhea, and bacterial vaginosis—but possibly ineffective for atopic disease and has insufficient evidence for acute respiratory distress syndrome.

Lacticaseibacillus rhamnosus is possibly effective for atopic dermatitis (eczema), antibiotic-associated diarrhea, and atopic disease, though possibly ineffective for ventilator-associated pneumonia. D-mannose is likely effective for carbohydrate-deficient glycoprotein syndrome type 1b but possibly ineffective for urinary tract infections.

Lactoferrin is possibly effective for sepsis and pregnancy-related iron deficiency but likely ineffective for fetal and premature infant mortality and necrotizing enterocolitis.

The evidence, ingredient by ingredient D-mannose Lactoferrin Lactobacillus Acidophilus Lacticaseibacillus Rhamnosus

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 4 of the 4 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 4 of 4.
  • General safety write-ups exist for 4 of 4.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Both Lactobacillus acidophilus and Lacticaseibacillus rhamnosus are generally well tolerated in healthy adults and children, though gastrointestinal side effects—bloating, abdominal pain, flatulence, diarrhea, and burping—are uncommon. Because they contain live organisms, there's a theoretical concern that in very ill or immunocompromised people they might cause serious infection, though this is rare.

D-mannose and lactoferrin are also generally well tolerated short-term, though long-term safety data are limited. D-mannose may cause bloating, diarrhea, and nausea, especially at higher doses.

Lactoferrin at typical doses is well tolerated, but doses of 7.2 grams daily can increase constipation, diarrhea, fatigue, and chills. There is not enough pregnancy and breastfeeding safety data for D-mannose or lactoferrin, so talk with your doctor or pharmacist before use if you are pregnant or nursing.

Side effects, ingredient by ingredient D-mannose Lactoferrin Lactobacillus Acidophilus Lacticaseibacillus Rhamnosus

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 4 matched ingredients can interact with medications — Lactobacillus Acidophilus, Lacticaseibacillus Rhamnosus.
  • The most serious interaction on file is rated Moderate.
  • For scale: 182 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take antibiotic drugs, separate them from Flora & Flow by a few hours—antibiotics can kill off the live beneficial bacteria in this product and reduce its effectiveness. No other interactions are documented for the ingredients we checked, but run your exact medications through the search tool on this page to be sure.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glancePartially disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Flora & Flow is a four-ingredient probiotic and support blend that may help with specific gut and immune conditions, though evidence is strongest for IBS, antibiotic-associated diarrhea, and some forms of eczema. If you take antibiotics, space them a few hours apart from this product so the beneficial bacteria aren't killed off.

Check your exact medications with the tool on this page, and talk with us before starting if you're pregnant, nursing, or immunocompromised.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 4 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jul 24, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Flora & Flow, straight from the product label.

Brand Shaklee Multi-Taskers
Net contents 50 Capsule(s)
Market status On market
Date entered into DSLD Jul 24, 2025
DSLD ID 334656
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Vegetarian, Kosher, Adult Female (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Flora & Flow by Shaklee Multi-Taskers, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
25
IngredientAmount% DV
Calories5 Calorie(s)--
Total Carbohydrates1 Gram(s)1%
Lactobacillus acidophilus La-140 NP--
D-Mannose700 mg--
Lactoferrin50 mg--
Women's Probiotic Proprietary Blend77 mg--
Lacticaseibacillus rhamnosus HN0010 NP--

Other ingredients: Microcrystalline Cellulose, Hydroxypropyl Methylcellulose, Water

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Let balance bloom A proprietary blend specifically formulated to support vaginal and urinary tract health.

It's time to say goodbye to discomfort and find your flora & flow. Shaklee Since 1956 Safe - Proven 100% Guaranteed

GF Gluten free

Veg Vegetarian

Vaginal & urinary tract health

Formula

These once-daily capsules contain a clinically proven blend of probiotics and lactoferrin to balance your vaginal microbiome and pH levels. A key ingredient, D-mannose, is scientifically shown to guard the urinary tract and help manage unwanted bacteria.

Kosher Dairy

Probiotics Lactoferrin D-mannose

Star-D Kosher Dairy

Precautions

Caution: Discuss use during pregnancy or breastfeeding with your OB health professional.

Contains milk.

Seal under cap for your protection.

Manufactured in a facility that may also process tree nuts, milk, soy, wheat, shellfish, and fish.

Brand IP Statement(s)

Shaklee Since 1956 Safe - Proven 100% Guaranteed

Seals/Symbols

Shaklee Since 1956 Safe - Proven 100% Guaranteed Veg Vegetarian Kosher Dairy

Star-D Kosher Dairy

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Directions: Take 2 capsules daily by mouth for holistic care down there.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Flora & Flow by Shaklee Multi-Taskers label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Flora & Flow label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Flora & Flow by Shaklee Multi-Taskers

These are the 4 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container25 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

D-Mannose

No known
interactions
700 mg per serving

D-mannose is a natural sugar most often used to help prevent urinary tract infections, especially those caused by E. coli. Early research is promising...

D-Mannose monograph & interactions

Lactoferrin

No known
interactions
50 mg per serving

Lactoferrin is an iron-binding protein found naturally in milk and other body fluids, and supplements are usually made from cow's milk or rice. It is...

Lactoferrin monograph & interactions

Women's Probiotic Proprietary Blend

77 mg per serving

Other (inactive) ingredients: Microcrystalline Cellulose, Hydroxypropyl Methylcellulose, Water. These complete the product’s ingredient list but are not active constituents.

Interaction report

Flora & Flow by Shaklee Multi-Taskers Drug Interactions

Want to check YOUR meds against Flora & Flow?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
182Drugs
182 Moderate

Ingredients driving the most interactions

Lactobacillus acidophilus La-14 182
Lacticaseibacillus rhamnosus HN001 182

Individual Drug Interactions

The ingredients in Flora & Flow interact with 182 drugs. Click any drug to see the details.

2 of the 4 ingredients in Flora & Flow interact with drugs. Each result below shows which ingredient is responsible. Lactobacillus acidophilus La-14 Lacticaseibacillus rhamnosus HN001

Each ingredient & the kinds of drugs it affects

For each ingredient in Flora & Flow with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Lactobacillus acidophilus La-141 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L. acidophilus.
L. acidophilus preparations usually contain live and active organisms. Therefore, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and L. acidophilus preparations by at least two hours.

Likelihood Probable Evidence D
Lactobacillus acidophilus La-14 full monograph & interactions

Lacticaseibacillus rhamnosus HN0011 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Lacticaseibacillus rhamnosus with antibiotic drugs might decrease the effectiveness of L. rhamnosus.
L. rhamnosus preparations usually contain live and active organisms. Therefore, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and L. rhamnosus preparations by at least two hours.

Likelihood Probable Evidence D
Lacticaseibacillus rhamnosus HN001 full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Flora & Flow, from the product label.

Shaklee Multi-Taskers

See all Shaklee Multi-Taskers products
Name
Shaklee Corporation
City
Pleasanton
State
CA
ZipCode
94566
Phone Number
1.800.742.5533
Pharmacist Counseling Corner

Flora & Flow by Shaklee Multi-Taskers: Common Questions

Does Flora & Flow by Shaklee Multi-Taskers interact with any medications?
Yes. Based on its ingredients, Flora & Flow has a known interaction with 182 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Flora & Flow contains 4 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this help with my irritable bowel syndrome (IBS)?
Lactobacillus acidophilus in this product is possibly effective for IBS based on the evidence we have. That said, results vary from person to person, and you should talk with your doctor about whether it's right for your situation and what dose might work best.
Can I take this while I'm on antibiotics?
Yes, but time them apart. Antibiotics can kill the live bacteria in this product if you take them at the same time, which defeats the purpose. Space your antibiotic and this supplement by a few hours—your doctor or pharmacist can give you a schedule that works.
What are the most common side effects?
The probiotics may cause mild bloating, gas, or loose stools, but these are uncommon. D-mannose can cause bloating, diarrhea, or nausea. Most people tolerate this product without problems, but if you notice persistent digestive upset, cut back or talk with us.
Is this safe if I'm pregnant or breastfeeding?
There isn't enough safety data for D-mannose or lactoferrin in pregnancy and breastfeeding. Talk with your doctor before starting this product if you're pregnant or nursing so they can weigh the benefits and risks for your situation.
What is lactoferrin, and why is it in here?
Lactoferrin is a natural protein found in breast milk and other body fluids. It binds iron and has immune support roles. The evidence suggests it's possibly effective for sepsis and pregnancy-related iron deficiency, though it doesn't help prevent premature infant complications.
Will this help with urinary tract infections (UTIs)?
The evidence doesn't support D-mannose being effective for UTIs, so this product isn't the right choice for that. Talk with your doctor about what might work better for you.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Flora & Flow is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Flora & Flow label
Go deeper

The Full Monographs Behind Flora & Flow’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

D-mannose

D-mannose is a natural sugar most often used to help prevent urinary tract infections, especially those caused by E. coli. Early research is promising for prevention, but the evidence is sti...

Read the full D-mannose monograph → Herb & supplement monograph

Lactoferrin

Lactoferrin is an iron-binding protein found naturally in milk and other body fluids, and supplements are usually made from cow's milk or rice. It is being studied for immune support, iron l...

Read the full Lactoferrin monograph → Herb & supplement monograph

Lactobacillus Acidophilus

Interacts with 182 drugs

Lactobacillus acidophilus is a 'friendly' bacterium used as a probiotic to support gut and vaginal health. It is generally well tolerated in healthy people, and there is reasonable evidence...

Read the full Lactobacillus Acidophilus monograph → Herb & supplement monograph

Lacticaseibacillus Rhamnosus

Interacts with 182 drugs

Lacticaseibacillus rhamnosus (often labeled L. rhamnosus GG) is a well-studied probiotic bacterium used mainly for diarrhea and general gut health. It is considered safe for most healthy peo...

Read the full Lacticaseibacillus Rhamnosus monograph →
Sources

Sources & How We Checked

Flora & Flow's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 61 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Lactobacillus Acidophilus 15 references
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Begtrup LM, de Muckadell OB, Kjeldsen J, Christensen RD, Jarbøl DE. Long-term treatment with probiotics in primary care patients with irritable bowel syndrome--a randomised, double-blind, placebo controlled trial. Scand J Gastroenterol 2013;48(10):1127-35 PubMed
  3. Chatterjee S, Kar P, Das T, Ray S, Gangulyt S, Rajendiran C, Mitra M. Randomised placebo-controlled double blind multicentric trial on efficacy and safety of Lactobacillus acidophilus LA-5 and Bifidobacterium BB-12 for prevention of antibiotic-associated
  4. Shavakhi A, Tabesh E, Yaghoutkar A, Hashemi H, Tabesh F, Khodadoostan M,Minakari M, Shavakhi S, Gholamrezaei A. The effects of multistrain probiotic compound on bismuth-containing quadruple therapy for Helicobacter pylori infection: a randomized placebo-c
  5. Karamali M, Dadkhah F, Sadrkhanlou M, et al. Effects of probiotic supplementation on glycaemic control and lipid profiles in gestational diabetes: a randomized, double-blind, placebo-controlled trial. Diabetes Metab 2016;42(4):234-41. PubMed
  6. Badehnoosh B, Karamali M, Zarrati M, et al. The effects of probiotic supplementation on biomarkers of inflammation, oxidative stress and pregnancy outcomes in gestational diabetes. J Matern Fetal Neonatal Med. 2018 May;31(9):1128-1136.
  7. Kumar S, Kumar R, Rohilla L, Jacob N, Yadav J, Sachdeva N. A high potency multi-strain probiotic improves glycemic control in children with new-onset type 1 diabetes mellitus: A randomized, double-blind, and placebo-controlled pilot study. Pediatr Diabete
  8. Shahriari A, Karimi E, Shahriari M, Aslani N, Khooshideh M, Arab A. The effect of probiotic supplementation on the risk of gestational diabetes mellitus among high-risk pregnant women: A parallel double-blind, randomized, placebo-controlled clinical trial PubMed
  9. Xiao SD, Zhang DZ, Lu H, et al. Multicenter, randomized, controlled trial of heat-killed Lactobacillus acidophilus LB in patients with chronic diarrhea. Adv Ther. 2003;20(5):253-60.
  10. Rossi F, Amadoro C, Gasperi M, Colavita G. Lactobacilli infection case reports in the last three years and safety implications. Nutrients. 2022;14(6):1178. PubMed
  11. Ozer M, Goksu SY, Shahverdiani A, Mustafa M. Lactobacillus acidophilus-induced endocarditis and associated splenic abscess. Case Rep Infect Dis 2020;2020:1382709.
  12. Sadrin S, Sennoune S, Gout B, et al. A 2-strain mixture of Lactobacillus acidophilus in the treatment of irritable bowel syndrome: A placebo-controlled randomized clinical trial. Dig Liver Dis 2020;52(5):534-540. PubMed
  13. Stoffer JN, Slingsby TJ, Giuliari GP. Lactobacillus acidophilus endophthalmitis after intravitreal bevacizumab injection requiring intraocular lens explantation. Can J Ophthalmol 2022;57(1):e21-e22. PubMed
  14. Cukovic-Cavka S, Likic R, Francetic I, Rustemovic N, Opacic M, Vucelic B. Lactobacillus acidophilus as a cause of liver abscess in a NOD2/CARD15-positive patient with Crohn's disease. Digestion 2006;73(2-3):107-10.
  15. Hui J, Ren Y, Wang Y, Han Q. Lactobacillus acidophilus endophthalmitis postcataract operation: A case report with a literature review. Ocul Immunol Inflamm 2023.

See these in context on the Lactobacillus Acidophilus monograph →

D-mannose 6 references
  1. Westphal V, Kjaergaard S, Davis JA, et al. Genetic and metabolic analysis of the first adult with congenital disorder of glycosylation type Ib: long-term outcome and effects of mannose supplementation. Mol Genet Metab 2001;73:77-85. PubMed
  2. Kranjcec B, Papes D, Altarac S. D-mannose powder for prophylaxis of recurrent urinary tract infections in women: a randomized clinical trial. World J Urol. 2014 Feb;32(1):79-84.
  3. de Lonlay P, Seta N. The clinical spectrum of phosphomannose isomerase deficiency, with an evaluation of mannose treatment for CDG-Ib. Biochim Biophys Acta. 2009;1792(9):841-3. PubMed
  4. Harms HK, Zimmer KP, Kurnik K, Bertele-Harms RM, Weidinger S, Reiter K. Oral mannose therapy persistently corrects the severe clinical symptoms and biochemical abnormalities of phosphomannose isomerase deficiency. Acta Paediatr. 2002;91(10):1065-72. DOI
  5. . Damen G, de Klerk H, Huijmans J, den Hollander J, Sinaasappel M. Gastrointestinal and other clinical manifestations in 17 children with congenital disorders of glycosylation type Ia, Ib, and Ic. J Pediatr Gastroenterol Nutr. 2004;38(3):282-7. DOI
  6. Lenger SM, Bradley MS, Thomas DA, Bertolet MH, Lowder JL, Sutcliffe S. D-mannose vs other agents for recurrent urinary tract infection prevention in adult women: a systematic review and meta-analysis. Am J Obstet Gynecol. 2020;223(2):265.e1-265.e13. PubMed

See these in context on the D-mannose monograph →

Lactoferrin 6 references
  1. Food and Drug Administration, CFSAN/Office of Food Additive Safety. Agency Response Letter GRAS Notice No. GRN 000130. 2003. Available at: http://www.cfsan.fda.gov/~rdb/opa-g130.html (Accessed 29 June 2005).
  2. Okada S, Tanaka K, Sato T, et al. Dose-response trial of lactoferrin in patients with chronic hepatitis C. Jpn J Cancer Res 2002;93:1063-9. PubMed
  3. Abu Hashim H, Foda O, Ghayaty E. Lactoferrin or ferrous salts for iron deficiency anemia in pregnancy: A meta-analysis of randomized trials. Eur J Obstet Gynecol Reprod Biol. 2017;219:45-52. PubMed
  4. Tarnow-Mordi WO, Abdel-Latif ME, Martin A, et al. The effect of lactoferrin supplementation on death or major morbidity in very low birthweight infants (LIFT): a multicentre, double-blind, randomised controlled trial. Lancet Child Adolesc Health. 2020 Jun PubMed
  5. ELFIN trial investigators group. Enteral lactoferrin supplementation for very preterm infants: a randomised placebo-controlled trial. Lancet. 2019 Feb 2;393(10170):423-433. doi: 10.1016/S0140-6736(18)32221-9.
  6. Lepanto MS, Rosa L, Cutone A, Conte MP, Paesano R, Valenti P. Efficacy of lactoferrin oral administration in the treatment of anemia and anemia of inflammation in pregnant and non-pregnant women: An interventional study. Front Immunol. 2018 Sep 21;9:2123. PubMed

See these in context on the Lactoferrin monograph →

Lacticaseibacillus Rhamnosus 34 references
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Saxelin M, Chuang NH, Chassy B, et al. Lactobacilli and bacteremia in southern Finland 1989-1992. Clin Infect Dis 1996;22:564-6. PubMed
  3. Klein G, Zill E, Schindler R, et al. Peritonitis associated with vancomycin-resistant Lactobacillus rhamnosus in a continuous ambulatory peritoneal dialysis patient; organism identification, antibiotic therapy, and case report. J Clin Microbiol 1998;36:
  4. Kalima P, Masterton RG, Roddie PH, et al. Lactobacillus rhamnosus infection in a child following bone marrow transplant. J Infect 1996;32:165-7. PubMed
  5. Rautio M, Jousimies-Somer H, Kauma H, et al. Liver abscess due to Lactobacillus rhamnosus strain indistinguishable from L. rhamnosus strain GG. Clin Infect Dis 1999;28:1159-60.
  6. Rautava S, Kalliomaki M, Isolauri E. Probiotics during pregnancy and breast-feeding might confer immunomodulatory protection against atopic disease in the infant. J Allergy Clin Immunol 2002;109:119-21. PubMed
  7. Kalliomaki M, Salminen S, Arvilommi H et al. Probiotics in primary prevention of atopic disease: a randomised placebo-controlled trial. Lancet 2001;357:1076-1079. PubMed
  8. MacGregor G, Smith AJ, Thakker B, Kinsella J. Yoghurt biotherapy: contraindicated in immunosuppressed patients? Postgrad Med J 2002;78:366-7. PubMed
  9. Land MH, Rouster-Stevens K, Woods CR, et al. Lactobacillus sepsis associated with probiotic therapy. Pediatrics 2005;115:178-81.
  10. De Groote MA, Frank DN, Dowell E, et al. Lactobacillus rhamnosus GG bacteremia associated with probiotic use in a child with short gut syndrome. Pediatr Infect Dis J 2005;24:278-80. PubMed
  11. Beerepoot MA, ter Riet G, Nys S, van der Wal WM, de Borgie CA, de Reijke TM,Prins JM, Koeijers J, Verbon A, Stobberingh E, Geerlings SE. Lactobacilli vs antibiotics to prevent urinary tract infections: a randomized, double-blind, noninferiority trial in p DOI
  12. Rautava S, Kainonen E, Salminen S, Isolauri E. Maternal probiotic supplementation during pregnancy and breast-feeding reduces the risk of eczema in the infant. J Allergy Clin Immunol. 2012;130(6):1355-60. PubMed
  13. Vahabnezhad E, Mochon AB, Wozniak LJ, Ziring DA. Lactobacillus bacteremia associated with probiotic use in a pediatric patient with ulcerative colitis. J Clin Gastroenterol. 2013;47(5):437-9. PubMed
  14. Wickens KL, Barthow CA, Murphy R, et al. Early pregnancy probiotic supplementation with Lactobacillus rhamnosus HN001 may reduce the prevalence of gestational diabetes mellitus: a randomised controlled trial. Br J Nutr. 2017;117(6):804-813.
  15. Topcuoglu S, Gursoy T, Ovali F, Serce O, Karatekin G. A new risk factor for neonatal vancomycin-resistant Enterococcus colonisation: bacterial probiotics. J Matern Fetal Neonatal Med. 2015;28(12):1491-4. PubMed
  16. Wickens K, Barthow C, Mitchell EA, et al. Maternal supplementation alone with Lactobacillus rhamnosus HN001 during pregnancy and breastfeeding does not reduce infant eczema. Pediatr Allergy Immunol. 2018 May;29(3):296-302.
  17. Husain S, Allotey J, Drymoussi Z, et al. Effects of oral probiotic supplements on vaginal microbiota during pregnancy: a randomised, double-blind, placebo-controlled trial with microbiome analysis. BJOG. 2020;127(2):275-284. PubMed
  18. Sendil S, Shrimanker I, Mansoora Q, Goldman J, Nookala VK. Lactobacillus rhamnosus bacteremia in an immunocompromised renal transplant patient. Cureus. 2020;12(2):e6887. PubMed
  19. Pellonperä O, Vahlberg T, Mokkala K, et al. Weight gain and body composition during pregnancy: a randomised pilot trial with probiotics and/or fish oil. Br J Nutr. 2020 Nov 4:1-11. PubMed
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See these in context on the Lacticaseibacillus Rhamnosus monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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