Interactions on record — worth a quick check against your medications. Based on 2 of 3 ingredients. Check your meds →
Dietary supplement

GenoFlex Ingredients & Drug Interactions

by P E Science

GenoFlex label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking GenoFlex against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

GenoFlex is a dietary supplement by P E Science with 3 active ingredients. Its ingredients are commonly taken for bone fracture healing, joint pain and bone health, weight management.Based on those ingredients, 1,020 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Boswellia serrata (gum resin) extract, Cissus quadrangularis (stem) extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against GenoFlex by P E Science

Ask about any prescription or over-the-counter medication and we check it for interactions with GenoFlex by P E Science — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of GenoFlex by P E Science

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 3 of its 3 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

GenoFlex contains three active ingredients. Cissus quadrangularis stem extract and Boswellia serrata gum resin extract are both included for joint and bone support.

Passion Fruit seed extract rounds out the formula. The capsule also contains inactive ingredients — gelatin, magnesium stearate, silicon dioxide, titanium dioxide, and FD&C Yellow No.

5 — which help hold the supplement together and give it its color.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: Joint support formulated for athletes.
  • We looked for evidence on: Joint pain, Knee pain, Osteoarthritis, Rheumatoid arthritis (RA), Fractures, Exercise-induced muscle soreness — and 3 related terms.
  • The strongest evidence on file: Boswellia Serrata is rated "Possibly Effective" for Osteoarthritis (Natural Medicines).
  • Also on file: Boswellia Serrata is rated "Insufficient Reliable Evidence To Rate" for Exercise-induced muscle soreness, Rheumatoid arthritis (RA), Knee pain.
  • Also on file: Cissus Quadrangularis is rated "Insufficient Reliable Evidence To Rate" for Fractures, Muscle strength, Joint pain.

The evidence for GenoFlex's ingredients is mixed. Cissus quadrangularis shows possibly effective evidence for obesity, based on small studies suggesting it may lower fasting blood glucose in people who are overweight.

For bone health (osteopenia), inflammation, high cholesterol, and cancer, the data we hold on Cissus is insufficient to rate it. Boswellia serrata is rated possibly effective for osteoarthritis.

For hay fever, Alzheimer's disease, asthma, and cluster headaches, the evidence we hold is insufficient to rate it. We don't have effectiveness data on file for Passion Fruit seed extract.

The evidence, ingredient by ingredient Cissus Quadrangularis Boswellia Serrata

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Cissus quadrangularis has been generally well tolerated in short-term studies, though long-term safety hasn't been well studied. Reported side effects — headache, insomnia, flatulence, diarrhea, upset stomach, and dry mouth — occurred at rates similar to or lower than placebo.

Boswellia serrata is also generally well tolerated orally in the short term, though product quality and doses vary widely. Common side effects include abdominal pain, diarrhea, headache, heartburn, nausea, and itching.

In one study, nearly 11% of people taking a specific extract reported headache. A rare but serious concern: very large amounts of boswellia gum resin can cause bezoar formation (a mass in the GI tract).

Neither ingredient should be used during pregnancy — there isn't enough safety data. Boswellia should also be avoided while breastfeeding.

Side effects, ingredient by ingredient Cissus Quadrangularis Boswellia Serrata

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 2 matched ingredients can interact with medications — Boswellia Serrata, Cissus Quadrangularis.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: immunosuppressants / transplant drugs; diabetes medications.
  • For scale: 1,021 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking GenoFlex, check with your pharmacist if you take any of these: diabetes medications (risk of low blood sugar), drugs processed through liver enzymes like CYP2D6, CYP2C19, CYP1A2, CYP2C9, or CYP3A4 (which include many heart, blood pressure, and antidepressant medications), or immunosuppressant drugs. All of these interactions are Moderate in severity.

Use the medication checker on this page with your full list.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

GenoFlex may be worth considering if you're looking for joint or weight support, but it's not a straightforward add-on if you take prescription medications. The Boswellia in it potentially affects how your liver clears over 1,000 different drugs.

Check your exact medications with our tool before starting, and talk to your pharmacist or doctor if you take diabetes drugs, heart medications, antidepressants, or immunosuppressants.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Feb 23, 2016.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about GenoFlex, straight from the product label.

Brand P E Science
Barcode (UPC) 040232199356
Net contents 120 Capsule(s)
Market status On market
Date entered into DSLD Feb 23, 2016
DSLD ID 56656
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for GenoFlex by P E Science, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
4 Capsule(s)
Maximum serving Sizes:
4 Capsule(s)
Servings per container
30
UPC/BARCODE
040232199356
IngredientAmount% DV
Cissus quadrangularis (stem) extract2900 mg--
Passion Fruit (seed) extract150 mg--
Boswellia serrata (gum resin) extract100 mg--

Other ingredients: Gelatin, Magnesium Stearate, Silicon Dioxide, Titanium Dioxide, FD&C Yellow No. 5

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Daily values not established

30 Day Supply 3 Powerful Ingredients

Joint Support

~ 30-Day Supply

{Capsule} Not actual size

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Formula

100 mg ApresFlex

Formulated for Athletes

~ Cissus Quadrangularis Extract ~ Passion Fruit Seed Extract

~ ApresFlex

It is designed for individuals interested in bodybuilding who generally do not have health problems.

FDA Statement of Identity

Dietary Supplement

Brand IP Statement(s)

ApresFlex is a registered trademark of Laila Nutraceuticals

Precautions

Pregnant or nursing women should not use this product. Consult with a licensed physician before using this product, especially if you are taking any prescription, over the counter medication, dietary supplement product, or if you have any preexisting medical condition including but not limited to: high or low blood pressure, high or low cholesterol, cardiac arrhythmia, stroke, heart, liver, kidney or thyroid disease, seizure disorder, psychiatric disease, osteoporosis, diabetes, difficulty urinating due to prostate enlargement or if you are taking a MAO-B inhibitor or any other medication.

Do not take this product if you have been diagnosed with prostate cancer, testicular cancer or breast cancer. Discontinue use 2 weeks prior to surgery. Discontinue use and immediately consult your health care professional if you experience any adverse reaction to this product. Do not exceed recommended serving. Do not use if safety seal is broken or missing.

Keep out of reach of children.

Warning: This product is intended to be consumed by healthy adults 18 years of age or older.

Suggested/Recommended/Usage/Directions

Directions: Take 4 capsules daily. For best results, take 2 capsules with each of your two largest meals each day.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

GenoFlex by P E Science label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

GenoFlex label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in GenoFlex by P E Science

These are the 3 active ingredients this product is made of. Select any to open its full monograph.

Serving size4 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Cissus quadrangularis (stem) extract

Interacts with
86 drugs
2900 mg per serving

Cissus quadrangularis is a traditional vine used mainly for bone health, joint pain, and weight management. Most of the supporting evidence comes from...

Cissus quadrangularis (stem) extract monograph & interactions

Passion Fruit (seed) extract

150 mg per serving

Boswellia serrata (gum resin) extract

Interacts with
952 drugs
100 mg per serving

Boswellia serrata is a tree resin used in traditional medicine, mainly for joint pain and inflammation. Some studies suggest it may help with osteoart...

Boswellia serrata (gum resin) extract monograph & interactions

Other (inactive) ingredients: Gelatin, Magnesium Stearate, Silicon Dioxide, Titanium Dioxide, FD&C Yellow No. 5. These complete the product’s ingredient list but are not active constituents.

Interaction report

GenoFlex by P E Science Drug Interactions

Want to check YOUR meds against GenoFlex?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,020Drugs
1,020 Moderate

Ingredients driving the most interactions

Boswellia serrata (gum resin) extract 952
Cissus quadrangularis (stem) extract 86

Individual Drug Interactions

The ingredients in GenoFlex interact with 1,020 drugs. Click any drug to see the details.

2 of the 3 ingredients in GenoFlex interact with drugs. Each result below shows which ingredient is responsible. Boswellia serrata (gum resin) extract Cissus quadrangularis (stem) extract

Each ingredient & the kinds of drugs it affects

For each ingredient in GenoFlex with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Boswellia serrata (gum resin) extract6 drug types · 952 drugs

Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, Boswellia serrata might increase the levels of CYP1A2 substrates.
In vitro research shows that Boswellia serrata gum resin inhibits CYP1A2 enzymes.

Likelihood Possible Evidence D
Cytochrome P450 2C19 (Cyp2C19) Substrates

Theoretically, Boswellia serrata might increase the levels of CYP2C19 substrates.
In vitro research shows that Boswellia serrata gum resin inhibits CYP2C19 enzymes.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, Boswellia serrata might increase the levels of CYP2C9 substrates.
In vitro research shows that Boswellia serrata gum resin inhibits CYP2C9 enzymes.

Likelihood Possible Evidence D
Cytochrome P450 2D6 (Cyp2D6) Substrates

Theoretically, Boswellia serrata might increase the levels of CYP2D6 substrates.
In vitro research shows that Boswellia serrata gum resin inhibits CYP2D6 enzymes.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, Boswellia serrata might increase or decrease the levels and clinical effects of CYP3A4 substrates.
In vitro research shows that Boswellia serrata gum resin inhibits CYP3A4 enzymes. Other in vitro research shows that Boswellia serrata extract inhibits CYP3A4 enzymes at most concentrations, although it may modestly induce enzyme activity at low concentrations.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, Boswellia serrata might alter the effects of immunosuppressive drugs.
Some in vitro research suggests that Boswellia serrata extracts might inhibit mediators of autoimmune disorders such as leukotrienes and reduce production of antibodies and cell-mediated immunity. However, other in vitro research suggests that, when coupled with calcium ions, boswellic acids containing the keto group have immunostimulant properties within specific cell signaling pathways.

Likelihood Possible Evidence D
Boswellia serrata (gum resin) extract full monograph & interactions

Cissus quadrangularis (stem) extract1 drug type · 86 drugs

Antidiabetes Drugs

Theoretically, Cissus quadrangularis might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Small clinical studies suggest that Cissus quadrangularis might reduce fasting blood glucose in individuals with overweight or obesity.

Likelihood Possible Evidence D
Cissus quadrangularis (stem) extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for GenoFlex, from the product label.

P E Science

See all P E Science products
Name
PEScience LLC
Street Address
3665 East Bay Dr #204-155
City
Largo
State
FL
ZipCode
33771
Phone Number
888-885-0195
Web Address
PESCIENCE.COM
Pharmacist Counseling Corner

GenoFlex by P E Science: Common Questions

Does GenoFlex by P E Science interact with any medications?
Yes. Based on its ingredients, GenoFlex has a known interaction with 1,020 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
GenoFlex contains 3 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take GenoFlex if I'm pregnant or breastfeeding?
Not based on the safety data available. There isn't enough information to know whether Cissus quadrangularis or Boswellia serrata are safe during pregnancy, so they're best avoided. Boswellia should also be avoided while breastfeeding. Talk with your doctor or pharmacist about what's right for you.
What side effects might I experience?
Most commonly, headache, nausea, abdominal pain, diarrhea, heartburn, and dry mouth. These were reported in studies at rates similar to or lower than placebo. Rarely, very large amounts of the boswellia ingredient can cause a gastrointestinal blockage.
Is GenoFlex proven to work?
There's possibly effective evidence that Cissus quadrangularis may help with weight management in people who are overweight, and that Boswellia serrata may help with osteoarthritis. For other uses, the evidence we hold is insufficient to say.
Why can't you check the Passion Fruit ingredient?
We don't hold safety or interaction data on Passion Fruit seed extract, so we can't tell you what it interacts with or how well it works on its own.
How long is it safe to take GenoFlex?
Both main ingredients have been generally well tolerated in short-term studies, but long-term safety hasn't been well studied. If you're thinking of taking it long-term, check with your pharmacist or doctor.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

GenoFlex label
Go deeper

The Full Monographs Behind GenoFlex’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Cissus Quadrangularis

Interacts with 86 drugs

Cissus quadrangularis is a traditional vine used mainly for bone health, joint pain, and weight management. Most of the supporting evidence comes from animal studies and a small number of hu...

Read the full Cissus Quadrangularis monograph → Herb & supplement monograph

Boswellia Serrata

Interacts with 952 drugs

Boswellia serrata is a tree resin used in traditional medicine, mainly for joint pain and inflammation. Some studies suggest it may help with osteoarthritis symptoms, but the overall evidenc...

Read the full Boswellia Serrata monograph →
Sources

Sources & How We Checked

GenoFlex's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 21 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Cissus Quadrangularis 5 references
  1. Oben J, Kuate D, Agbor G, et al. The use of a Cissus quadrangularis formulation in the management of weight loss and metabolic syndrome. Lipids Health Dis 2006, 5:24.
  2. Oben JE, Ngondi JL, Momo CN, et al. The use of Cissus quadrangularis/Irvingia gabonensis combination in the management of weight loss: a double-blind placebo-controlled study. Lipids Health Dis 2008;7:12.
  3. Panpimanmas, S., Sithipongsri, S., Sukdanon, C., and Manmee, C. Experimental comparative study of the efficacy and side effects of Cissus quadrangularis L. (Vitaceae) to Daflon (Servier) and placebo in the treatment of acute hemorrhoids. J Med Assoc.Thai
  4. Nash R, Azantsa B, Kuate D, Singh H, Oben J. The use of a stem and leaf aqueous extract of Cissus quadrangularis (CQR-300) to reduce body fat and other components of metabolic syndrome in overweight participants. J Altern Complement Med. 2019;25(1):98-106
  5. Benjawan S, Nimitphong H, Tragulpiankit P, Musigavong O, Prathanturarug S, Pathomwichaiwat T. The effect of Cissus quadrangularis L. on delaying bone loss in postmenopausal women with osteopenia: A randomized placebo-controlled trial. Phytomedicine 2022;1 PubMed

See these in context on the Cissus Quadrangularis monograph →

Boswellia Serrata 16 references
  1. Gupta I, Gupta V, Parihar A, et al. Effects of Boswellia serrata gum resin in patients with bronchial asthma: results of a double-blind, placebo-controlled, 6-week clinical study. Eur J Med Res 1998;3:511-4.
  2. Electronic Code of Federal Regulations. Title 21. Part 182 -- Substances Generally Recognized As Safe. Available at: https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?CFRPart=182
  3. Kimmatkar N, Thawani V, Hingorani L, et al. Efficacy and tolerability of Boswellia serrata extract in treatment of osteoarthritis of knee--a randomized double blind placebo controlled trial. Phytomedicine 2003;10:3-7. PubMed
  4. Liu JJ, Nilsson A, Oredsson S, et al. Boswellic acids trigger apoptosis via a pathway dependent on caspase-8 activation but independent on Fas/Fas ligand interaction in colon cancer HT-29 cells. Carcinogenesis 2002;23:2087-93. PubMed
  5. Wildfeuer A, Neu IS, Safayhi H, et al. Effects of boswellic acids extracted from a herbal medicine on the biosynthesis of leukotrienes and the course of experimental autoimmune encephalomyelitis. Arzneimittelforschung 1998;48:668-74.
  6. Gupta I, Parihar A, Malhotra P, et al. Effects of gum resin of Boswellia serrata in patients with chronic colitis. Planta Med 2001;67:391-5. PubMed
  7. Sengupta K, Alluri KV, Satish AR, et al. A double blind, randomized, placebo controlled study of the efficacy and safety of 5-Loxin. Arthritis Res Ther 2008;10:R85.
  8. Sengupta K, Krishnaraju AV, Vishal AA, et al. Comparative efficacy and tolerability of 5-Loxin and Aflapin against osteoarthritis of the knee: a double blind, randomized, placebo controlled clinical study. Int J Med Sci 2010;7:366-77.
  9. Ernst E. Frankincense: systematic review. BMJ 2008;337:a2813. PubMed
  10. Kirste S, Treier M, Wehrle SJ, et al. Boswellia serratea extract acts on cerebral edema in patients irradiated for brain tumors: a prospective, randomized, placebo-controlled, double-blind pilot trial. Cancer 2011;117:3788-95.
  11. Frank A, Unger M. Analysis of frankincense from various Boswellia species with inhibitory activity on human drug metabolising cytochrome P450 enzymes using liquid chromatography mass spectrometry after automated on-line extraction. J Chromatogr A 2006;111 PubMed
  12. Altmann A, Poeckel D, Fischer L, et al. Coupling of boswellic acid-incuded Ca2+ mobilisation and MAPK activation to lipid metabolism and peroxide formation in human leucocytes. Br J Pharmacol 2004;141:223-32.
  13. El Fortia, M., Badi, H., Elalem, Kh, Kadiki, O., and Topov, Y. Olibanum bezoar: complication of a traditional popular medicine. East Mediterr.Health J 2006;12(6):927-929.
  14. Meshkat S, Mahmoodi Baram S, Rajaei S, et al. Boswellia serrata extract shows cognitive benefits in a double-blind, randomized, placebo-controlled pilot clinical trial in individuals who suffered traumatic brain injury. Brain Inj 2022;36(4):553-559. PubMed
  15. Haron MH, Dale O, Martin K, et al. Evaluation of the Herb-Drug Interaction Potential of Commonly Used Botanicals on the US Market with Regard to PXR- and AhR-Mediated Influences on CYP3A4 and CYP1A2. J Diet Suppl 2022. PubMed
  16. Valente IVB, Garcia D, Abbott A, et al. The anti-proliferative effects of a frankincense extract in a window of opportunity phase ia clinical trial for patients with breast cancer. Breast Cancer Res Treat 2024;204(3):521-530. PubMed

See these in context on the Boswellia Serrata monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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