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Dietary supplement

GL3-750 L-Glutamine Ingredients & Drug Interactions

by AST Sports Science

GL3-750 L-Glutamine label
See full label image
Capsule Category: Amino Acid/protein
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking GL3-750 L-Glutamine against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

GL3-750 L-Glutamine is a dietary supplement by AST Sports Science with 1 active ingredient. Its ingredients are commonly taken for muscle recovery and sports performance, gut health and 'leaky gut', recovery from severe illness or injury.Based on those ingredients, 50 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are L-Glutamine GL3, Micronized. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against GL3-750 L-Glutamine by AST Sports Science

Ask about any prescription or over-the-counter medication and we check it for interactions with GL3-750 L-Glutamine by AST Sports Science — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of GL3-750 L-Glutamine by AST Sports Science

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 30, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

GL3-750 L-Glutamine is a single-ingredient supplement containing 750 mg of micronized L-glutamine per capsule. L-glutamine is an amino acid your body naturally produces; it plays a role in muscle recovery, immune function, and gut health.

The product also contains inactive ingredients—stearic acid and a gelatin capsule—that help deliver the active ingredient.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: muscle strength recovery and lean mass.
  • We looked for evidence on: Athletic performance, Exercise-induced muscle damage, Postoperative recovery, Critical illness (trauma), HIV/AIDS-related wasting, Muscular dystrophy — and 4 related terms.
  • The strongest evidence on file: Glutamine is rated "Possibly Effective" for HIV/AIDS-related wasting (Natural Medicines).
  • Also on file: Glutamine is rated "Possibly Effective" for Critical illness (trauma), Postoperative recovery.
  • Also on file: Glutamine is rated "Possibly Ineffective" for Athletic performance, Burns, Muscular dystrophy.

The evidence is strongest for sickle cell disease, where L-glutamine is rated effective. For HIV/AIDS-related wasting, postoperative recovery, and critical illness from trauma, the evidence is rated possibly effective—meaning there's some promising data, but more research is needed to confirm benefit.

If you're considering this supplement for a specific condition, talk it through with your doctor or pharmacist to see if the evidence applies to your situation.

The evidence, ingredient by ingredient Glutamine

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

L-glutamine is generally well tolerated in healthy adults. The most common side effects from oral use are gastrointestinal: belching, bloating, constipation, diarrhea, flatulence, nausea, vomiting, and stomach pain.

Headache and musculoskeletal pain have also been reported. A small number of cases have linked high-dose glutamine to dizziness and, in people with bipolar disorder, to episodes of mania or hypomania—so mention this supplement to your doctor if you have a history of mood disorders.

If you have kidney or liver disease, use this supplement only under medical supervision. Pregnancy is rated likely safe, but not enough reliable data exists for breastfeeding, so talk with your doctor or pharmacist before using it while nursing.

Side effects, ingredient by ingredient Glutamine

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Glutamine.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: seizure medications.
  • For scale: 50 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking GL3-750 L-Glutamine, check with your doctor or pharmacist if you take anticonvulsant medications (seizure drugs). The interaction is moderate in severity—glutamine may theoretically interfere with how these drugs work—though it hasn't been confirmed in humans.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

GL3-750 L-Glutamine may be worth considering if you have sickle cell disease or are recovering from surgery or critical illness, though the evidence for the latter two is still developing. If you take anticonvulsant medications, check your exact drugs before starting—the interaction is theoretical but documented.

People with kidney or liver disease, or a history of bipolar disorder, should discuss this with their doctor or pharmacist first.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated May 24, 2017.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about GL3-750 L-Glutamine, straight from the product label.

Brand AST Sports Science
Barcode (UPC) 705077002680
Net contents 500 Capsule(s); 750 mg
Market status On market
Date entered into DSLD May 24, 2017
DSLD ID 74119
Product type Amino Acid/protein
Supplement form Capsule
Dietary claims / uses Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for GL3-750 L-Glutamine by AST Sports Science, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
4 Capsule(s)
Maximum serving Sizes:
4 Capsule(s)
Servings per container
125
UPC/BARCODE
705077002680
IngredientAmount% DV
L-Glutamine GL3, Micronized3 Gram(s)--

Other ingredients: Stearic Acid, Gelatin Capsule

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

3g Per serving 125 Total servings 20x Particle micronization technology

Strength Recovery Lean mass Easy-to-swallow capsules

This allows for ultra-fast absorption and utilization in a convenient capsule. Glutamine is the most abundant amino acid in your body making up over 63% of the amino acid content in the amino acid pool of your muscle cells. Glutamine is key to the metabolism and maintenance of muscle tissue and acts as primary shuttle for nitrogen from the bloodstream to inside the muscle cell. Intense training and exercise put greater demands on your body's need for glutamine, making it a conditionally essential amino acid. Glutamine plays a multiple role in human nutrition and is essential for the support of lean muscle tissue and immune function.

Made in USA

FDA Statement of Identity

Dietary Supplement

Brand IP Statement(s)

Micronized GL3 750 represents a lead forward in glutamine supplementation. GL3 750 uses a state-of-the-art particle micronization technology (PMT). Each tiny particle of GL3 750 is 20 times smaller than regular glutamine powder.

Copyright 2016 AST Sports Science

FDA Disclaimer Statement

These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.

Suggested/Recommended/Usage/Directions

Recommended Use: As a dietary supplement, take 4 capsules 2-4 times daily. For best results, take 1 serving upon waking, 1 serving right before bedtime, and 1 serving before and after your workout.

General

REV# GL3-750816

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

GL3-750 L-Glutamine by AST Sports Science label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

GL3-750 L-Glutamine label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in GL3-750 L-Glutamine by AST Sports Science

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size4 Capsule(s) Dosage formCapsule Servings per container125 Amounts shown are per serving.

L-Glutamine GL3, Micronized

Interacts with
50 drugs
3 Gram(s) per serving

Glutamine is the most abundant amino acid in the body and is usually made in your muscles. A prescription form is FDA-approved to help reduce sickle c...

L-Glutamine GL3, Micronized monograph & interactions

Other (inactive) ingredients: Stearic Acid, Gelatin Capsule. These complete the product’s ingredient list but are not active constituents.

Interaction report

GL3-750 L-Glutamine by AST Sports Science Drug Interactions

Want to check YOUR meds against GL3-750 L-Glutamine?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
50Drugs
50 Moderate

Ingredients driving the most interactions

L-Glutamine GL3, Micronized 50

Individual Drug Interactions

The ingredients in GL3-750 L-Glutamine interact with 50 drugs. Click any drug to see the details.

1 of the 1 ingredient in GL3-750 L-Glutamine interact with drugs. Each result below shows which ingredient is responsible. L-Glutamine GL3, Micronized

Each ingredient & the kinds of drugs it affects

For each ingredient in GL3-750 L-Glutamine with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

L-Glutamine GL3, Micronized1 drug type · 50 drugs

Anticonvulsants

Theoretically, glutamine might antagonize the effects of anticonvulsant medications.
Glutamine is metabolized to the excitatory neurotransmitter glutamate. Glutamate might have antagonistic effects with anticonvulsant drugs. However, this interaction has not yet been reported in humans.

Likelihood Possible Evidence D
L-Glutamine GL3, Micronized full monograph & interactions
The maker

Brand information

Manufacturer and brand details for GL3-750 L-Glutamine, from the product label.

AST Sports Science

See all AST Sports Science products
Name
AST Sports Science
Street Address
120 Capital Drive
City
Golden
State
CO
ZipCode
80401
Phone Number
1-800-627-2788
Web Address
www.ast-ss.com
Pharmacist Counseling Corner

GL3-750 L-Glutamine by AST Sports Science: Common Questions

Does GL3-750 L-Glutamine by AST Sports Science interact with any medications?
Yes. Based on its ingredients, GL3-750 L-Glutamine has a known interaction with 50 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
GL3-750 L-Glutamine contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is L-glutamine and what does it do?
L-glutamine is an amino acid your body makes naturally. It supports muscle recovery, immune function, and gut health. This supplement provides an extra 750 mg per capsule in micronized form, which means it's broken into very small particles for better absorption.
Is GL3-750 L-Glutamine safe to take every day?
It's generally well tolerated in healthy adults when taken as directed. The most common side effects are digestive—bloating, nausea, diarrhea, or stomach discomfort. If you have kidney or liver disease, use only under medical supervision. If you develop mood changes or other concerning symptoms, stop and talk to your doctor.
Can I take this while pregnant or breastfeeding?
Pregnancy is rated likely safe, so it's considered acceptable during pregnancy. Breastfeeding is different—there isn't enough safety data to know either way, so talk with your doctor or pharmacist before using it while nursing to get personalized advice.
Will this help me recover faster after surgery?
The evidence for postoperative recovery is rated possibly effective, meaning there's some promise but more research is needed. Whether it's right for your situation is something to discuss with your doctor, especially if you're already following a recovery plan.
What are the most common side effects?
Most people who take L-glutamine orally experience some digestive upset: belching, bloating, constipation, diarrhea, nausea, or stomach pain. Headache and muscle aches have also been reported. These tend to be mild, but if they're bothersome or don't settle, mention them to your pharmacist.
Can I take this if I have bipolar disorder?
A small number of people with bipolar disorder taking high-dose glutamine have reported episodes of mania or hypomania. If you have bipolar disorder, talk with your doctor or psychiatrist before starting this supplement so they can monitor you or advise against it.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

GL3-750 L-Glutamine label
Go deeper

The Full Monographs Behind GL3-750 L-Glutamine’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Glutamine

Interacts with 50 drugs

Glutamine is the most abundant amino acid in the body and is usually made in your muscles. A prescription form is FDA-approved to help reduce sickle cell disease complications, but for most...

Read the full Glutamine monograph →
Sources

Sources & How We Checked

GL3-750 L-Glutamine's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 11 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Glutamine 11 references
  1. Miller AL. Therapeutic considerations of L-glutamine: a review of the literature. Altern Med Rev 1999;4:239-48..
  2. Bozzetti F, Biganzoli L, Gavazzi C, et al. Glutamine supplementation in cancer patients receiving chemotherapy: a double-blind randomized study. Nutrition 1997;13:748-51.. PubMed
  3. Mebane AH. L-Glutamine and mania. Am J Psychiatry 984;141:1302-3.
  4. Meldrum BS. Glutamate as a neurotransmitter in the brain: review of physiology and pathology. J Nutr 2000;130:1007S-15S.. PubMed
  5. Garlick PJ. Assessment of the safety of glutamine and other amino acids. J Nutr 2001;131:2556S-61S.. PubMed
  6. Chapman AG. Glutamate and epilepsy. J Nutr 2000;130:1043S-5S.. PubMed
  7. Ziegler TR. Glutamine supplementation in cancer patients receiving bone marrow transplantation and high dose chemotherapy. J Nutr 2001;131:2578S-84S.. PubMed
  8. Laviano A, Molfino A, Lacaria MT, Canelli A, De Leo S, Preziosa I, Rossi Fanelli F. Glutamine supplementation favors weight loss in nondieting obese female patients. A pilot study. Eur J Clin Nutr. 2014 Nov;68(11):1264-6. PubMed
  9. Endari (l-glutamine) [package insert]. Torrance, CA: Emmaus Medical,Inc; 2017.
  10. Niihara Y, Miller ST, Kanter J, et al. A Phase 3 Trial of l-Glutamine in Sickle Cell Disease. N Engl J Med 2018;379(3):226-35. doi: 10.1056/NEJMoa1715971.
  11. Ogden HB, Child RB, Fallowfield JL, et al. Gastrointestinal Tolerance of Low, Medium and High Dose Acute Oral l-Glutamine Supplementation in Healthy Adults: A Pilot Study. Nutrients. 2020;12(10):2953. PubMed

See these in context on the Glutamine monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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