Major interaction on record — check this product against your medications before combining. Based on 2 of 5 ingredients. Check your meds →
Dietary supplement

Gluten Enzymes Ingredients & Drug Interactions

by Dr. Mercola

Gluten Enzymes label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Gluten Enzymes against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Gluten Enzymes is a dietary supplement by Dr. Mercola with 5 active ingredients. Its ingredients are commonly taken for energy and cellular function support, athletic performance and muscle energy, circulation support.Based on those ingredients, 47 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Adenosine Triphosphate. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Gluten Enzymes by Dr. Mercola

Ask about any prescription or over-the-counter medication and we check it for interactions with Gluten Enzymes by Dr. Mercola — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Gluten Enzymes by Dr. Mercola

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 30, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 5 active ingredients.
  • “Optimal pH Proteases” is listed as a grouped ingredient — the label doesn't break down how much of each component you get.

This product has 5 active ingredients: amylase, peptidase, protease 3, adenosine triphosphate (ATP), and protease 7. These are digestive enzymes meant to break down proteins and carbohydrates.

The inactive ingredients are organic rice, a capsule material, and medium chain triglycerides (a type of fat).

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded its ingredients' overall clinical evidence instead.

Strong

Strong clinical evidence supports its ingredients for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredients' overall clinical evidence instead.
  • On file: Cardiovascular disease diagnosis — rated "Effective" (Adenosine) (Natural Medicines).
  • On file: Paroxysmal supraventricular tachycardia — rated "Effective" (Adenosine) (Natural Medicines).
  • On file: Cachexia — rated "Possibly Effective" (Adenosine) (Natural Medicines).

The data we hold on this product doesn't include effectiveness ratings for its digestive enzyme ingredients — the evidence isn't established in what we have. Adenosine triphosphate does show effectiveness for specific heart rhythm problems and cardiovascular diagnosis, but that's in its prescription injectable form, not as an oral supplement in a digestive aid.

The evidence, ingredient by ingredient Adenosine Proteolytic Enzymes (proteases)

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

The proteolytic enzymes in this product are generally well tolerated for most adults but may cause digestive upset or allergic reactions in some people. Rarely, protease can trigger allergic responses; occupational exposure to airborne protease has caused allergic rhinitis and asthma in case reports.

During pregnancy, protease safety hasn't been established — avoid unless prescribed by your doctor. Breastfeeding mothers should not use without medical advice due to limited safety data.

Adenosine triphosphate as an oral supplement has limited evidence; the injectable prescription form is potent and must only be given by healthcare professionals.

Side effects, ingredient by ingredient Adenosine Proteolytic Enzymes (proteases)

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 1 of the 2 matched ingredients can interact with medications — Adenosine.
  • The most serious interaction on file is rated Major.
  • For scale: 47 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check your medications if you're on dipyridamole (Persantine) — this is a Major interaction. Also confirm carbamazepine (Tegretol) use, which carries a Moderate risk of heart block.

If you take any methylxanthines (caffeine supplements, aminophylline, theophylline), mention that too, and avoid this product for 24 hours before using them for heart stress tests.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with strong clinical evidence behind its ingredients' uses. Major medication interactions have been identified, and safety information is well characterized.

If you take dipyridamole, carbamazepine, or methylxanthine medications (caffeine, theophylline, aminophylline), talk with your doctor or pharmacist before starting this product — the interactions documented here are real. If you're pregnant or breastfeeding, check with your doctor first.

For everyone else, the main concern is potential digestive upset or allergic reaction to the enzymes.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 3 of 5 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated May 22, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Gluten Enzymes, straight from the product label.

Brand Dr. Mercola
Barcode (UPC) 810487030939
Net contents 30 Capsule(s)
Market status On market
Date entered into DSLD May 22, 2021
DSLD ID 250214
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Gluten Enzymes by Dr. Mercola, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
30
UPC/BARCODE
810487030939
IngredientAmount% DV
Amylase0 NP--
Peptidase0 NP--
Protease 30 NP--
Adenosine Triphosphate0 NP--
Protease 70 NP--
Optimal pH Proteases0 NP--

Other ingredients: organic Rice, Capsule, Medium Chain Triglycerides

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested Use: Adults, as a dietary supplement, take one (1) capsule daily before a meal containing gluten. For best results, take with Dr. Mercola's Full Spectrum Enzymes.

Precautions

Keep out of reach of children.

Do not use if safety seal is broken.

If you are nursing, pregnant, taking medication or have a medical condition, consult your physician before taking this product.

General Statements

Dr. Mercola has been providing quality products since 2001.

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Gluten Enzymes by Dr. Mercola label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Gluten Enzymes label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Gluten Enzymes by Dr. Mercola

These are the 5 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Amylase

0 NP per serving

Peptidase

0 NP per serving

Adenosine Triphosphate

Interacts with
47 drugs
0 NP per serving

Adenosine is a natural building block your body uses for energy and cell signaling, and a prescription injectable version is used by doctors to treat...

Adenosine Triphosphate monograph & interactions

Optimal pH Proteases

0 NP per serving

Other (inactive) ingredients: Organic Rice, Capsule, Medium Chain Triglycerides. These complete the product’s ingredient list but are not active constituents.

Interaction report

Gluten Enzymes by Dr. Mercola Drug Interactions

Want to check YOUR meds against Gluten Enzymes?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
47Drugs
2 Major 1 Moderate 44 Minor

Ingredients driving the most interactions

Adenosine Triphosphate 47

Individual Drug Interactions

The ingredients in Gluten Enzymes interact with 47 drugs. Click any drug to see the details.

1 of the 5 ingredients in Gluten Enzymes interact with drugs. Each result below shows which ingredient is responsible. Adenosine Triphosphate

Each ingredient & the kinds of drugs it affects

For each ingredient in Gluten Enzymes with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Adenosine Triphosphate3 drug types · 47 drugs

Dipyridamole (Persantine)

Dipyridamole can increase the therapeutic and toxic effects of adenosine.
Dipyridamole decreases the metabolism of adenosine. Intravenous infusion of adenosine in patients who are taking dipyridamole can cause dizziness, bradycardia, and syncope. Dipyridamole should be discontinued for several days prior to a cardiac stress test using adenosine.

Likelihood Likely Evidence D
Carbamazepine (Tegretol)

Carbamazepine might increase the risk of heart block when used concomitantly with adenosine.
Carbamazepine and adenosine can both cause heart block. Giving them concurrently might produce an additive effect.

Likelihood Possible Evidence D
Methylxanthines

Methylxanthines are competitive antagonists of adenosine and can block its pharmacologic effects.
The methylxanthines, aminophylline, caffeine, and theophylline, can block the effects of adenosine by acting as competitive antagonists at adenosine cell surface receptors. It is recommended that methylxanthines be avoided for 24 hours prior to cardiac stress tests.

Likelihood Possible Evidence D
Adenosine Triphosphate full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Gluten Enzymes, from the product label.

Dr. Mercola

See all Dr. Mercola products
Name
NHP
Street Address
125 SW 3rd Place
City
Cape Coral
State
FL
ZipCode
33991
Phone Number
(877) 985-2696
Pharmacist Counseling Corner

Gluten Enzymes by Dr. Mercola: Common Questions

Does Gluten Enzymes by Dr. Mercola interact with any medications?
Yes. Based on its ingredients, Gluten Enzymes has a known interaction with 47 medications, including 2 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Gluten Enzymes contains 5 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What are the enzymes in here supposed to do?
They're digestive enzymes designed to help break down proteins and carbohydrates in food. Amylase works on carbs, and the proteases and peptidase target proteins.
Can I take this if I'm on a heart medication?
It depends which one. If you take dipyridamole (Persantine) or carbamazepine (Tegretol), you need to talk with your doctor or pharmacist before starting — we've documented interactions. For other heart meds, check them against the tool on this page.
Is it safe to take during pregnancy?
The protease enzymes and adenosine in this product haven't been tested enough in pregnancy to say it's safe. Talk with your doctor before taking it if you're pregnant or planning to be.
What are the side effects?
Most commonly, digestive upset. Rarely, the proteases can trigger allergic reactions — and occupational exposure to airborne protease has caused allergic rhinitis or asthma in some cases.
Does it have fillers or anything else I should know about?
The active ingredients are the enzymes and ATP. The inactive ingredients are organic rice, the capsule itself, and medium chain triglycerides — no artificial additives.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Gluten Enzymes is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Gluten Enzymes label
Go deeper

The Full Monographs Behind Gluten Enzymes’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Adenosine

Interacts with 47 drugs

Adenosine is a natural building block your body uses for energy and cell signaling, and a prescription injectable version is used by doctors to treat certain fast heart rhythms. As an over-t...

Read the full Adenosine monograph → Herb & supplement monograph

Proteolytic Enzymes (proteases)

Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), trypsin, chymotrypsin, and pancreatin. Peo...

Read the full Proteolytic Enzymes (proteases) monograph →
Sources

Sources & How We Checked

Gluten Enzymes's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 13 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Proteolytic Enzymes (proteases) 3 references
  1. Weeks JA, Harper RA, Simon RA, Burdick JD. Assessment of sensitization risk of a laundry pre-spotter containing protease. Cutan Ocul Toxicol. 2011;30(4):272-9. PubMed
  2. Marquès LI, Lara S, Abós T, Bartolomé B. Occupational rhinitis due to pepsin. J Investig Allergol Clin Immunol. 2006;16(2):136-7. DOI
  3. Cartier A, Malo JL, Pineau L, Dolovich J. Occupational asthma due to pepsin. J Allergy Clin Immunol. 1984;73(5 Pt 1):574-7. PubMed

See these in context on the Proteolytic Enzymes (proteases) monograph →

Adenosine 10 references
  1. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
  2. Agteresch HJ, Dagnelie PC, van den Berg JW, Wilson JH. Adenosine triphosphate: established and potential clinical applications. Drugs 1999;58:211-32.. PubMed
  3. Agteresch HJ, Dagnelie PC, van der Gaast A, et al. Randomized clinical trial of adenosine 5'-triphosphate in patients with advanced non-small-cell lung cancer. J Natl Cancer Inst 2000;92:321-8.. PubMed
  4. Haskell CM, Wong M, Williams A, Lee LY. Phase I trial of extracellular adenosine 5'-triphosphate in patients with advanced cancer. Med Pediatr Oncol 1996;27:165-73.. DOI
  5. Haskell CM, Mendoza E, Pisters KM, et al. Phase II study of intravenous adenosine 5'-triphosphate in patients with previously untreated stage IIIB and stage IV non-small cell lung cancer. Invest New Drugs 1998;16:81-5.. PubMed
  6. Eisenach JC, Curry R, Hood DD. Dose response of intrathecal adenosine in experimental pain and allodynia. Anesthesiology 2002;97:938-42.. PubMed
  7. Agteresch HJ, Dagnelie PC, Rietveld T, et al. Pharmacokinetics of intravenous ATP in cancer patients. Eur J Clin Pharmacol 2000;56:49-55.. PubMed
  8. Underwood DA. Which medications should be held before a pharmacologic or exercise stress test? Cleve Clin J Med 2002;69:449-50. PubMed
  9. Litmann L, Anderson JD, Monroe MH. Adenosine and Aggrenox: A hazardous combination. Ann Intern Med 2002;137:E-76. PubMed
  10. Faghihi G, Iraji F, Rajaee Harandi M, et al. Comparison of the efficacy of topical minoxidil 5% and adenosine 0.75% solutions on male androgenic alopecia and measuring patient satisfaction rate. Acta Dermatovenerol Croat 2013;21(3):155-9.

See these in context on the Adenosine monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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