Interactions on record — worth a quick check against your medications. Based on 7 of 11 ingredients. Check your meds →
Dietary supplement

Gorilla Mode Nitric Fruit Punch Ingredients & Drug Interactions

by Gorilla Mind

Gorilla Mode Nitric Fruit Punch label
See full label image
Powder Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Gorilla Mode Nitric Fruit Punch against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Gorilla Mode Nitric Fruit Punch is a dietary supplement by Gorilla Mind with 11 active ingredients. Its ingredients are commonly taken for improving high-intensity exercise performance, building muscle strength and size, sports and athletic training.Based on those ingredients, 306 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Agmatine Sulfate, Sodium Nitrate, Malic Acid. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Gorilla Mode Nitric Fruit Punch by Gorilla Mind

Ask about any prescription or over-the-counter medication and we check it for interactions with Gorilla Mode Nitric Fruit Punch by Gorilla Mind — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Gorilla Mode Nitric Fruit Punch by Gorilla Mind

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 6, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 11 of its 11 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

Gorilla Mode Nitric Fruit Punch is a pre-workout powder with 11 active ingredients. The formula includes Creatine Monohydrate for muscle strength and athletic performance, Betaine Anhydrous and Agmatine Sulfate for nitric oxide support, and several other compounds — Malic Acid, L-Citruline, Nitrosigine, Sodium Nitrate, Potassium, GlycerPump (glycerol), and VasoDrive-AP — designed to support blood flow and exercise endurance.

It also contains inactive ingredients like citric acid, sucralose, and natural flavors for taste and texture.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: athletic performance and exercise support.
  • We looked for evidence on: Athletic performance, Physical performance, Muscle strength, Muscle cramps, Postoperative recovery, Chronic fatigue syndrome (CFS) — and 4 related terms.
  • The strongest evidence on file: Glycerol is rated "Possibly Effective" for Athletic performance (Natural Medicines).
  • Also on file: Creatine is rated "Possibly Effective" for Athletic performance, Muscle strength.
  • Also on file: Creatine is rated "Insufficient Reliable Evidence To Rate" for Chronic fatigue syndrome (CFS), Cognitive function, Post-stroke fatigue, Muscle cramps.

The evidence for effectiveness in this product is mixed and limited. Creatine Monohydrate is possibly effective for muscle strength and athletic performance, as well as for sarcopenia and cerebral creatine deficiency syndromes.

Glycerol (GlycerPump) is likely effective for constipation and possibly effective for athletic performance. For the other active ingredients — Malic Acid, Betaine Anhydrous, Agmatine Sulfate, Sodium Nitrate, Potassium, Nitrosigine, L-Citruline, and VasoDrive-AP — we either hold insufficient evidence to rate their effectiveness for these uses, or the data is not on file.

Talk to your doctor if you want to know how these specific compounds may help with your fitness goals.

The evidence, ingredient by ingredient Creatine Malic Acid Betaine Anhydrous Agmatine Sodium Potassium Glycerol

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 7 of the 7 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 7 of 7.
  • General safety write-ups exist for 7 of 7.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Creatine Monohydrate is generally well tolerated in healthy adults, but people with kidney issues should be cautious; it should be avoided in pregnancy and while breastfeeding. Common side effects include dehydration, diarrhea, muscle cramps, and water retention.

Malic Acid is likely safe in pregnancy but has not been well studied in supplement doses; common side effects are GI upset. Agmatine Sulfate appears well tolerated short-term but should be avoided in pregnancy and while breastfeeding; it may cause diarrhea, nausea, or indigestion.

Potassium is generally safe from food but can be dangerous in supplement form, especially for those with kidney disease; high levels can cause heart rhythm problems. Sodium (from Sodium Nitrate and Sodium) in excess is linked to high blood pressure, heart strain, and kidney disease.

Glycerol is generally well tolerated but large doses can cause upset stomach, bloating, nausea, and dizziness. Betaine Anhydrous is generally well tolerated but may cause body odor, nausea, or GI distress.

Side effects, ingredient by ingredient Creatine Malic Acid Betaine Anhydrous Agmatine Sodium Potassium Glycerol

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 4 of the 7 matched ingredients can interact with medications — Potassium, Malic Acid, Sodium, Agmatine.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications; lithium.
  • For scale: 306 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, double-check with your own doctor or pharmacist if you're on blood pressure medications (antihypertensives) — sodium can reduce their effectiveness. Similarly, if you take potassium-sparing diuretics, ACE inhibitors, or ARBs, confirm it's safe, as the potassium content carries a Moderate risk of high potassium levels.

Moderate interactions are also documented with corticosteroids, lithium, antidiabetes drugs, didanosine, sodium phosphates, and tolvaptan. We could not check three ingredients (Nitrosigine, L-Citruline, and VasoDrive-AP) for interactions.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This is a pre-workout designed for strength and endurance; Creatine and glycerol have decent evidence for athletic use. The big catch is the sodium and potassium content — if you take blood pressure meds, heart medications, or any drug affecting potassium or sodium balance, this product needs a conversation with your own doctor or pharmacist before you start.

Steer clear if you're pregnant or breastfeeding, or if you have kidney disease.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 8 of 11 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Dec 14, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Gorilla Mode Nitric Fruit Punch, straight from the product label.

Brand Gorilla Mind
Barcode (UPC) 869269000394
Net contents 1.532 lb(s); 695 Gram(s)
Market status On market
Date entered into DSLD Dec 14, 2023
DSLD ID 301135
Product type Other Combinations
Supplement form Powder
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Gorilla Mode Nitric Fruit Punch by Gorilla Mind, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
8.69 Gram(s)
Maximum serving Sizes:
34.75 Gram(s)
Servings per container
40
UPC/BARCODE
869269000394
IngredientAmount% DV
Creatine Monohydrate5000 mg, 2500 mg--
Malic Acid3000 mg, 1500 mg--
Betaine Anhydrous4000 mg, 2000 mg--
Agmatine Sulfate1500 mg, 750 mg--
Nitrosigine1500 mg, 750 mg--
L-Citruline10000 mg, 5000 mg--
Sodium Nitrate1500 mg, 750 mg--
Potassium75 mg, 37.5 mg2%, 1%
GlycerPump4000 mg, 2000 mg--
Sodium405 mg, 202.5 mg14%, 7%
VasoDrive-AP254 mg, 127 mg--

Other ingredients: Silicon Dioxide, Natural & Artificial flavors, Disodium Phosphate, Citric Acid, Sucralose, Acesulfame Potassium

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested use: as a dietary supplement, mix 1-2 scoops of Gorilla Mode Nitric in 12-14 ounces of water and consume 30 minutes prior to training. Vary the amount of water to achieve your desired flavor level. First time users should begin use with 1/2-1 scoop or less to evaluate tolerance.

Precautions

Do not exceed 2 scoops in any 24 hour period.

Warning: keep out of reach of children.

This product should not be taken by individuals who are pregnant, nursing, have or suspect a medical condition, or taking any medications or are under 18 years of age. Do not use this product with PDE5 inhibitors, nitrites, or other blood pressure lowering medications and/or supplements.

This product should not be taken by individuals who are pregnant, nursing, have or suspect a medical condition, or taking any medications or are under 18 years of age.

Consult a physician before taking this or any other dietary supplement.

Storage

Store in a cool, dry place.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

General Statements

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Seals/Symbols

Made in USA GMP good manufacturing practice

Formulation

Stimulant free pre-workout formula

Raises nitric oxide Intramuscular hyper-hydration Increases power & endurance

Note: due to the very high concentration of ingredients in Gorilla Mode Nitric, clumping of the powder is common. This does not affect the quality of the supplement. Simply break up the clumps and enjoy the results.

FDA Statement of Identity

Dietary Supplement

Formula

Fruit punch Naturally & artificially flavored

GlycerPump VasoDrive-AP Nitrosigine Bonded Arginine Silicate

Brand IP Statement(s)

GlycerPump is a trademark of Pinnacle Ingredients (Australia) VasoDrive-AP is a trademark of NovaNutra LLC Nitrosigine and the Nitrosigine logo are registered trademarks of Nutrition 21, LLC. Nitrosigine is patent protected.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Gorilla Mode Nitric Fruit Punch by Gorilla Mind label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Gorilla Mode Nitric Fruit Punch label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Gorilla Mode Nitric Fruit Punch by Gorilla Mind

These are the 11 active ingredients this product is made of. Select any to open its full monograph.

Serving size8.69 Gram(s) Dosage formPowder Servings per container40 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Creatine Monohydrate

No known
interactions
5000 mg per serving

Creatine is one of the most studied sports supplements, with solid evidence that it can boost strength and performance during short, high-intensity ac...

Creatine Monohydrate monograph & interactions

Malic Acid

Interacts with
172 drugs
3000 mg per serving

Malic acid is a natural acid found in apples and other fruits, often combined with magnesium in supplements marketed for fibromyalgia and muscle pain....

Malic Acid monograph & interactions

Betaine Anhydrous

No known
interactions
4000 mg per serving

Betaine anhydrous (also called trimethylglycine) is a compound found in foods like beets, spinach, and whole grains, and is sold as a supplement and a...

Betaine Anhydrous monograph & interactions

Agmatine Sulfate

Interacts with
258 drugs
1500 mg per serving

Agmatine is a compound your body makes from the amino acid arginine, and it is sold mainly as a workout and 'pump' supplement. Human evidence for most...

Agmatine Sulfate monograph & interactions

Nitrosigine

1500 mg per serving Form: Inositol-Stabilized Arginine Silicate

L-Citruline

10000 mg per serving

Sodium Nitrate

Interacts with
205 drugs
1500 mg per serving

Sodium is an essential mineral and electrolyte your body needs to balance fluids, support nerves, and help muscles work. Most people in modern diets g...

Sodium Nitrate monograph & interactions

Potassium

Interacts with
62 drugs
75 mg per serving Form: Inositol-Stabilized Arginine Silicate

Potassium is an essential mineral your body needs for nerve signals, muscle function, and a steady heartbeat, and most people get enough from a balanc...

Potassium monograph & interactions

GlycerPump

No known
interactions
4000 mg per serving Form: Glycerol, Powder

Glycerol (glycerin) is a sweet, syrupy compound made naturally in the body and widely used in foods, skin products, and medicines. It is well establis...

GlycerPump monograph & interactions

Sodium

Interacts with
205 drugs
405 mg per serving Form: Sodium Nitrate

Sodium is an essential mineral and electrolyte your body needs to balance fluids, support nerves, and help muscles work. Most people in modern diets g...

Sodium monograph & interactions

VasoDrive-AP

254 mg per serving Form: Isoleucyl-Prolyl-Proline, Valyl-Prolyl-Proline

Other (inactive) ingredients: Silicon Dioxide, Natural & Artificial flavors, Disodium Phosphate, Citric Acid, Sucralose, Acesulfame Potassium. These complete the product’s ingredient list but are not active constituents.

Interaction report

Gorilla Mode Nitric Fruit Punch by Gorilla Mind Drug Interactions

Want to check YOUR meds against Gorilla Mode Nitric Fruit Punch?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
306Drugs
306 Moderate

Ingredients driving the most interactions

Agmatine Sulfate 258
Sodium Nitrate 205
Malic Acid 172
Potassium 62

Individual Drug Interactions

The ingredients in Gorilla Mode Nitric Fruit Punch interact with 306 drugs. Click any drug to see the details.

4 of the 11 ingredients in Gorilla Mode Nitric Fruit Punch interact with drugs. Each result below shows which ingredient is responsible. Agmatine Sulfate Sodium Nitrate Malic Acid Potassium

Each ingredient & the kinds of drugs it affects

For each ingredient in Gorilla Mode Nitric Fruit Punch with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Agmatine Sulfate2 drug types · 258 drugs

Antidiabetes Drugs

Theoretically, agmatine might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Animal and in vitro research suggest that agmatine has mild hypoglycemic effects.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, agmatine might increase the risk of hypotension when taken with antihypertensive drugs.
Animal research suggests that agmatine can modestly decrease heart rate and blood pressure.

Likelihood Possible Evidence D
Agmatine Sulfate full monograph & interactions

Sodium Nitrate7 drug types · 205 drugs

Antihypertensive Drugs

Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.
High intake of dietary sodium can increase systolic and diastolic blood pressure. Also, high intake of sodium may necessitate increased use of antihypertensive medications to achieve blood pressure control in some patients, such as those with chronic kidney disease.

Likelihood Probable Evidence A
Corticosteroids

Concomitant use of mineralocorticoids and some glucocorticoids with sodium supplements might increase the risk of hypernatremia.
Mineralocorticoids and some glucocorticoids (corticosteroids) cause sodium retention. This effect is dose-related and depends on mineralocorticoid potency. It is most common with hydrocortisone, cortisone, and fludrocortisone, followed by prednisone and prednisolone.

Likelihood Possible Evidence D
Didanosine (Videx)

Concomitant use of didanosine with additional sodium from dietary or supplemental sources may increase the risk of hypernatremia.
Didanosine formulations contain a significant amount of sodium.

Likelihood Probable Evidence C
Lithium

Altering dietary intake of sodium might alter the levels and clinical effects of lithium.
High sodium intake can reduce plasma concentrations of lithium by increasing lithium excretion. Reducing sodium intake can significantly increase plasma concentrations of lithium and cause lithium toxicity in patients being treated with lithium carbonate. Stabilizing sodium intake is shown to reduce the percentage of patients with lithium level fluctuations above 0.8 mEq/L. Patients taking lithium should avoid significant alterations in their dietary intake of sodium.

Likelihood Probable Evidence B
Sodium Phosphates

Theoretically, concomitant use of sodium phosphate with sodium supplements might increase the risk of hypernatremia.
Use of high doses (> 45 mL in 24 hours) of sodium phosphate, such as those used for bowel cleansing before surgery, can lead to serious electrolyte disturbances, including hypernatremia. The risk of hypernatremia is highest in the elderly and people with other risk factors for electrolyte disturbances.

Likelihood Possible Evidence D
Sodium-Containing Drugs

Concomitant use of sodium-containing drugs with additional sodium from dietary or supplemental sources may increase the risk of hypernatremia and long-term sodium-related complications.
The Chronic Disease Risk Reduction (CDRR) intake level of 2.3 grams of sodium daily indicates the intake at which it is believed that chronic disease risk increases for the apparently healthy population. Some medications contain high quantities of sodium. When used in conjunction with sodium supplements or high-sodium diets, the CDRR may be exceeded. Additionally, concomitant use may increase the risk for hypernatremia; this risk is highest in the elderly and people with other risk factors for electrolyte disturbances.

Likelihood Possible Evidence D
Tolvaptan (Samsca)

Theoretically, concomitant use of tolvaptan with sodium might increase the risk of hypernatremia.
Tolvaptan is a vasopressin receptor 2 antagonist that is used to increase sodium levels in patients with hyponatremia. Patients taking tolvaptan should use caution with the use of sodium salts such as sodium chloride.

Likelihood Probable Evidence C
Sodium Nitrate full monograph & interactions

Malic Acid1 drug type · 172 drugs

Antihypertensive Drugs

Theoretically, malic acid might increase the risk of hypotension when taken with antihypertensive drugs.
Animal research shows that malic acid isolated from tagetes roots can reduce mean arterial blood pressure.

Likelihood Possible Evidence D
Malic Acid full monograph & interactions

Potassium3 drug types · 62 drugs

Ace Inhibitors (Aceis)

Using ACEIs with high doses of potassium increases the risk of hyperkalemia.
ACEIs block the actions of the renin-angiotensin-aldosterone system and reduce potassium excretion. Concomitant use of these drugs with potassium supplements increases the risk of hyperkalemia. However, concomitant use of these drugs with moderate dietary potassium intake (about 3775-5200 mg daily) does not increase serum potassium levels.

Likelihood Likely Evidence C
Angiotensin Receptor Blockers (Arbs)

Using ARBs with high doses of potassium increases the risk of hyperkalemia.
ARBs block the actions of the renin-angiotensin-aldosterone system and reduce potassium excretion. Concomitant use of these drugs with potassium supplements increases the risk of hyperkalemia. However, concomitant use of these drugs with moderate dietary potassium intake (about 3775-5200 mg daily) does not increase serum potassium levels.

Likelihood Likely Evidence C
Potassium-Sparing Diuretics

Concomitant use increases the risk of hyperkalemia.
Using potassium-sparing diuretics with potassium supplements increases the risk of hyperkalemia.

Likelihood Likely Evidence C
Potassium full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Gorilla Mode Nitric Fruit Punch, from the product label.

Gorilla Mind

See all Gorilla Mind products
Name
Gorilla Mind, LLC
Street Address
7154 W. State Street, STE 138
City
Boise
State
ID
ZipCode
83714
Phone Number
+1 208-757-4423
Web Address
www.gorillamind.com
Pharmacist Counseling Corner

Gorilla Mode Nitric Fruit Punch by Gorilla Mind: Common Questions

Does Gorilla Mode Nitric Fruit Punch by Gorilla Mind interact with any medications?
Yes. Based on its ingredients, Gorilla Mode Nitric Fruit Punch has a known interaction with 306 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Gorilla Mode Nitric Fruit Punch contains 11 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this while pregnant or breastfeeding?
No — safety data advises against Creatine Monohydrate and Agmatine Sulfate during pregnancy and breastfeeding. Malic Acid is likely safe in pregnancy but isn't well studied in breastfeeding. There isn't enough data on file for several other ingredients. Talk with your doctor or pharmacist for personalized advice.
Will Creatine harm my kidneys?
Creatine is generally well tolerated in healthy adults. But if you have kidney disease or kidney issues, you should be careful and check with your doctor first. A small number of rare case reports have raised concerns, though large studies haven't confirmed increased risk.
What are the most common side effects?
From Creatine: dehydration, diarrhea, muscle cramps, and water retention. From Agmatine: diarrhea, nausea, and indigestion — these appeared within a few days in a small number of trial participants and stopped when they quit the supplement. Glycerol can cause bloating, nausea, dizziness, or headache.
Does this actually work for workout performance?
Creatine is possibly effective for muscle strength and athletic performance, and glycerol is possibly effective for athletic performance. The evidence for the other ingredients in this formula is either insufficient to rate or not on file, so we can't say for sure.
Why does the sodium and potassium content matter?
Too much sodium can raise blood pressure and reduce how well blood pressure meds work. Too much potassium — especially when you're on certain heart or blood pressure drugs — can cause dangerously high potassium levels that affect your heartbeat. If you take any of these medications, confirm this product is safe with your own doctor or pharmacist.
What's in this product besides the active ingredients?
The powder also contains inactive ingredients like citric acid, sucralose, artificial flavors, silicon dioxide, acesulfame potassium, and disodium phosphate — these are fillers and flavorings, not active compounds.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Gorilla Mode Nitric Fruit Punch label
Go deeper

The Full Monographs Behind Gorilla Mode Nitric Fruit Punch’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Creatine

Creatine is one of the most studied sports supplements, with solid evidence that it can boost strength and performance during short, high-intensity activities like weightlifting and sprintin...

Read the full Creatine monograph → Herb & supplement monograph

Malic Acid

Interacts with 172 drugs

Malic acid is a natural acid found in apples and other fruits, often combined with magnesium in supplements marketed for fibromyalgia and muscle pain. The evidence for its health benefits is...

Read the full Malic Acid monograph → Herb & supplement monograph

Betaine Anhydrous

Betaine anhydrous (also called trimethylglycine) is a compound found in foods like beets, spinach, and whole grains, and is sold as a supplement and as a prescription medicine for a rare gen...

Read the full Betaine Anhydrous monograph → Herb & supplement monograph

Agmatine

Interacts with 258 drugs

Agmatine is a compound your body makes from the amino acid arginine, and it is sold mainly as a workout and 'pump' supplement. Human evidence for most of its claimed benefits is limited and...

Read the full Agmatine monograph → Herb & supplement monograph

Sodium

Interacts with 205 drugs

Sodium is an essential mineral and electrolyte your body needs to balance fluids, support nerves, and help muscles work. Most people in modern diets get more than enough—often too much—from...

Read the full Sodium monograph → Herb & supplement monograph

Potassium

Interacts with 62 drugs

Potassium is an essential mineral your body needs for nerve signals, muscle function, and a steady heartbeat, and most people get enough from a balanced diet rich in fruits and vegetables. P...

Read the full Potassium monograph → Herb & supplement monograph

Glycerol

Glycerol (glycerin) is a sweet, syrupy compound made naturally in the body and widely used in foods, skin products, and medicines. It is well established as a laxative and a skin and eye moi...

Read the full Glycerol monograph →
Sources

Sources & How We Checked

Gorilla Mode Nitric Fruit Punch's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 165 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Creatine 86 references
  1. Koshy KM, Griswold E, Schneeberger EE. Interstitial nephritis in a patient taking creatine. N Engl J Med 1999;340:814-5. PubMed
  2. Vahedi K, Domingo V, Amarenco P, Bousser MG. Ischemic stroke in a sportsman who consumed MaHuang extract and creatine monohydrate for bodybuilding. J Neurol Neurosurg Psychiatr 2000;68:112-3.
  3. Greenhaff P. Renal dysfunction accompanying oral creatine supplements. Lancet 1998;352:233-4. PubMed
  4. Vandenberghe K, Goris M, Van Hecke P, et al. Long-term creatine intake is beneficial to muscle performance during resistance training (abstract). J Appl Physiol 1997;83:2055-63. PubMed
  5. Hultman E, Soderlund K, Timmons JA, et al. Muscle creatine loading in men. J Appl Physiol 1996;81:232-7. PubMed
  6. Pritchard NR, Kalra PA. Renal dysfunction accompanying oral creatine supplements. Lancet 1998;351:1252-3. PubMed
  7. Poortmans JR, Auquier H, Renaut V, et al. Effect of short-term creatine supplementation on renal responses in men (abstract). Eur J Appl Physiol Occup Physiol 1997;76:566-7. PubMed
  8. Poortmans JR, Francaux M. Long-term oral creatine supplementation does not impair renal function in healthy athletes. Med Sci Sports Exerc 1999;31:1108-10. PubMed
  9. Mihic S, MacDonald JR, McKenzie S, Tarnopolsky MA. Acute creatine loading increases fat-free mass, but does not affect blood pressure, plasma creatinine, or CK activity in men and women. Med Sci Sports Exerc 2000;32:291-6. PubMed
  10. Rawson ES, Wehnert ML, Clarkson PM. Effects of 30 days of creatine ingestion in older men. Eur J Appl Physiol Occup Physiol 1999;80:139-44. PubMed
  11. Earnest CP, Almada AL, Mitchell TL. High-performance capillary electrophoresis-pure creatine monohydrate reduces blood lipids in men and women. Clin Sci (Colch) 1996;91:113-8. PubMed
  12. Juhn MS. Oral creatine supplementation. Separating fact from hype. Phys Sportsmed 1999;27:47-50,53-54,56,61,89. PubMed
  13. Juhn MS, O'Kane JW, Vinci DM. Oral creatine supplementation in male collegiate athletes: a survey of dosing habits and side effects. J Am Diet Assoc 1999;99:593-5.
  14. Green AL, Hultman E, Macdonald IA, et al. Carbohydrate ingestion augments skeletal muscle creatine accumulation during creatine supplementation in humans. Am J Physiol 1996;271:E821-6. PubMed
  15. Balsom PD, Soderlund K, Sjodin B, Ekblom B. Skeletal muscle metabolism during short duration high-intensity exercise: influence of creatine supplementation. Acta Physiol Scand 1995;154:303-10. PubMed
  16. Snow RJ, McKenna MJ, Selig SE, et al. Effect of creatine supplementation on sprint exercise performance and muscle metabolism. (abstract) J Appl Physiol 1998;84:1667-73. PubMed
  17. McNaughton LR, Dalton B, Tarr J. The effects of creatine supplementation on high-intensity exercise performance in elite performers. (abstract) Eur J Appl Physiol Occup Physiol 1998;78:236-40. PubMed
  18. Groeneveld GJ, Veldink JH, van der Tweel I, et al. A randomized sequential trial of creatine in amyotrophic lateral sclerosis. Ann Neurol 2003;53:437-45. . PubMed
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  3. Whelton PK, He J, Cutler JA, et al. Effects of oral potassium on blood pressure. Meta-analysis of randomized controlled clinical trials. JAMA 1997;277:1624-32. PubMed
  4. Phillips, C. O., Kashani, A., Ko, D. K., Francis, G., and Krumholz, H. M. Adverse effects of combination angiotensin II receptor blockers plus angiotensin-converting enzyme inhibitors for left ventricular dysfunction: a quantitative review of data from ra DOI
  5. Altieri, P. I., Herrero, C., Suero, R., and Ortiz, A. Bleeding duodenal ulcer in a patient taking slow-releasing potassium tablets. Bol.Asoc.Med P.R. 1977;69(8):276.
  6. Raf, L. E. Enteric-coated potassium chloride tablets and ulcer of the small intestine. Acta Chir Scand Suppl 1967;(374):1-87.
  7. Potassium chloride oral solution [package insert]. Allentown, PA: Lehigh Valley Technologies, Inc.; 2014.
  8. Potassium chloride injection [package insert]. Lake Forest, IL: Hospira Inc.; 2009.
  9. Patel RB, Tannenbaum S, Viana-Tejedor A, et al. Serum potassium levels, cardiac arrhythmias, and mortality following non-ST-elevation myocardial infarction or unstable angina: insights from MERLIN-TIMI 36. Eur Heart J Acute Cardiovasc Care 2017 Feb;6(1):1 PubMed
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See these in context on the Potassium monograph →

Glycerol 8 references
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  2. Wagner DR. Hyperhydrating with glycerol: implications for athletic performance. J Am Diet Assoc 1999;99:207-12. PubMed
  3. Yu YL, Kumana CR, Lauder IJ, et al. Treatment of acute cortical infarct with intravenous glycerol. A double-blind, placebo-controlled randomized trial. Stroke 1993;24:1119-24. PubMed
  4. Frei A, Cottier C, Wunderlich P, Ludin E. Glycerol and dextran combined in the therapy of acute stroke. A placebo-controlled, double-blind trial with a planned interim analysis. Stroke 1987;18:373-9. PubMed
  5. Balaskas E, Szepietowski JC, Bessis D, Ioannides D, Ponticelli C, Ghienne C, Taberly A, Dupuy P. Randomized, double-blind study with glycerol and paraffin in uremic xerosis. Clin J Am Soc Nephrol. 2011 Apr;6(4):748-52. PubMed
  6. Blanchet-Bardon C, Tadini G, Machado Matos M, Delarue A. Association of glycerol and paraffin in the treatment of ichthyosis in children: an international, multicentric, randomized, controlled, double-blind study. J Eur Acad Dermatol Venereol. 2012 Aug;26 PubMed
  7. Kajita N, Kanamori K, Yamamoto S, Yoshida K. Generalized Urticaria Caused by a Glycerin Enema in an Infant. J Investig Allergol Clin Immunol 2022;32(4):318-319. PubMed
  8. Suzuki R, Fukuyama K, Miyazaki Y, Namiki T. Contact urticaria syndrome and protein contact dermatitis caused by glycerin enema. JAAD Case Reports. 2016;2:108-10. PubMed

See these in context on the Glycerol monograph →

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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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