Interactions on record — worth a quick check against your medications. Based on 4 of 5 ingredients. Check your meds →
Dietary supplement

Green Ingredients & Drug Interactions

by UP4

Green label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Green against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Green is a dietary supplement by UP4 with 5 active ingredients. Its ingredients are commonly taken for digestive health and regularity, irritable bowel syndrome (ibs), diarrhea (including antibiotic-related).Based on those ingredients, 507 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Spirulina, B. longum, B. bifidum. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Green by UP4

Ask about any prescription or over-the-counter medication and we check it for interactions with Green by UP4 — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Green by UP4

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 6, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 1 of its 5 active ingredients.
  • “A Proprietary Probiotic Blend” is a proprietary blend — the label gives one combined amount (60 mg) without saying how much of each component you get.

UP4 Green contains 5 active ingredients: three Bifidobacterium species (B. longum, B. bifidum, and B. lactis), Lactobacillus acidophilus DDS-1, and spirulina (a blue-green algae). The product also includes a proprietary probiotic blend.

These are live microorganisms intended to support gut health and general wellness. The capsule itself is made from vegetable cellulose, and the formula includes inactive ingredients such as rice dextrin, fructooligosaccharide (a prebiotic fiber), vegetable magnesium stearate, and silica.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: digestive and immune health support.
  • We looked for evidence on: Abdominal pain, Antibiotic-associated diarrhea, Bacterial vaginosis, Clostridioides difficile infection, Colic, Common cold — and 4 related terms.
  • The strongest evidence on file: Lactobacillus Acidophilus is rated "Possibly Effective" for Antibiotic-associated diarrhea (Natural Medicines).
  • Also on file: Lactobacillus Acidophilus is rated "Possibly Effective" for Bacterial vaginosis.
  • Also on file: Lactobacillus Acidophilus is rated "Insufficient Reliable Evidence To Rate" for Constipation, Inflammatory bowel disease (IBD), Radiation-induced diarrhea, Rotaviral diarrhea, and more.

The evidence for individual ingredients is mixed. B. bifidum and L. acidophilus are both rated Possibly Effective for irritable bowel syndrome (IBS) and respiratory tract infections; L. acidophilus is also Possibly Effective for antibiotic-associated diarrhea, H. pylori infection, and bacterial vaginosis.

Spirulina is Possibly Effective for high blood pressure. For most other uses listed—including hay fever, anxiety, asthma, cognitive decline, and other conditions—the evidence we hold is insufficient to rate these ingredients.

The data don't establish that UP4 Green as a whole product works for any particular condition.

The evidence, ingredient by ingredient Bifidobacterium Longum Bifidobacterium Bifidum Lactobacillus Acidophilus Blue-green Algae

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 4 of the 4 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 4 of 4.
  • General safety write-ups exist for 4 of 4.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

The probiotic ingredients (B. longum, B. bifidum, and L. acidophilus) are generally well tolerated in healthy people; however, caution is advised for anyone with a weakened immune system or serious illness, since rare cases of bacterial bloodstream infection (bacteremia and sepsis) have been reported in critically ill patients. Gastrointestinal side effects—bloating, flatulence, abdominal discomfort, and constipation—have been reported rarely.

Spirulina carries greater caution: quality varies widely and some products have been contaminated with toxins or heavy metals. Common side effects from spirulina include abdominal cramps, bloating, diarrhea, nausea, headache, and dizziness; allergic reactions including rash and, rarely, anaphylaxis have occurred.

For B. longum and L. acidophilus, pregnancy data are rated Possibly Safe, though safety during lactation isn't well established—talk with your doctor or pharmacist before using while breastfeeding. B. bifidum is rated Possibly Safe in pregnancy; lactation data are not on file.

For spirulina, pregnancy and lactation safety data are not on file; consult your doctor or pharmacist for personalized advice.

Side effects, ingredient by ingredient Bifidobacterium Longum Bifidobacterium Bifidum Lactobacillus Acidophilus Blue-green Algae

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 4 of the 4 matched ingredients can interact with medications — Lactobacillus Acidophilus, Blue-green Algae, Bifidobacterium Bifidum, Bifidobacterium Longum.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; diabetes medications.
  • For scale: 507 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking UP4 Green, double-check with your doctor or pharmacist if you take antibiotics (the probiotics may lose effectiveness if dosed at the same time), blood thinners or antiplatelet drugs like warfarin or aspirin (spirulina may increase bleeding risk), immune-suppressing medications (spirulina might interfere), or diabetes drugs (spirulina could lower blood sugar). Separating your antibiotic dose from the probiotics by a few hours is standard practice if you use both.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

UP4 Green is a multi-probiotic supplement with some supporting evidence for IBS and respiratory health (particularly through B. bifidum and L. acidophilus), and spirulina for blood pressure. It's generally well tolerated in healthy adults, but anyone taking antibiotics, blood thinners, immune-suppressing drugs, or diabetes medications should check their specific prescriptions with their doctor or pharmacist first—the interactions can affect how well both the supplement and your medications work.

If you're seriously ill, immune-compromised, or pregnant or breastfeeding, discuss this product with your healthcare provider before starting.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 4 of 5 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Dec 24, 2013.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Green, straight from the product label.

Brand UP4
Net contents 60 Vegetable Capsule(s)
Market status On market
Date entered into DSLD Dec 24, 2013
DSLD ID 28840
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Kosher, Halal, Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Green by UP4, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
30
IngredientAmount% DV
B. longum0 Not Present--
B. bifidum0 Not Present--
B. lactis0 Not Present--
A Proprietary Probiotic Blend60 mg--
L. acidophilus DDS(R)-10 Not Present--
Spirulina500 mg--

Other ingredients: Rice Dextrin, Vegetable Cellulose, Fructooligosaccharide, Vegetable Magnesium Stearate, Silica

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Statement of Identity

PROBIOTIC SUPPLEMENT

Brand IP Statement(s)

A HAPPIER INSIDE

Formula

PROBIOTICS with DDS-1

We start with exceptionally resilient, scientically validated strains like Lactobacillus acidophilus DDS(R)-1 as a base for all of our formulas.

General Statements

5 BILLION CFU 1 MONTH SUPPLY ACID & BILE RESISTANT

SUPPORTS DIGESTIVE and IMMUNE HEALTH

~leading ~scientific ~healthy ~trusted UP4 learning more about the art, science and passion that goes into our products?

Laboratory tested to meet strict standards for potency and identity.

MADE IN USA

UP4 health. Our formulas are based on the researched and proven strains that promote the healthy bacteria in your body. With probiotics and your body in balance, the results are a happier inside.

UP4 trust. We stand on our legacy of quality. We’re dedicated to being a leader in the field and guarantee you will always get what is promised on our label. It’s what you’d expect from a company that’s all in for probiotics.

UP4 leading. We’ve been making probiotics in the USA since 1979. And it’s all we do, from creating the formulas and manufacturing to getting our products to you. For us, it’s a science, an art and definitely our passion.

UP4 science. Not all probiotic strains are created equal.

We add additional live cultures that can naturally withstand stomach acid and bile without the need for chemical coatings.

Laboratory tested to meet strict standards for potency and purity. Potency guaranteed at time of expiration.

Formulation

NON-DAIRY NON-GMO GLUTEN FREE SOY FREE PRESERVATIVE FREE

VEGAN

Seals/Symbols

{crescent moon}M(R)

OK D

vitamin angels(R) PROUD SUPPORTER

Suggested/Recommended/Usage/Directions

DIRECTIONS: For best results take 2 capsules per day before or during meals.

Precautions

CAUTION: ~ Do not take if seal is broken

~ Keep out of reach of children

~ As with any supplement, if you are pregnant, nursing, have a medical condition or taking medication, consult your health practitioner before use

Storage

Room temperature stable for two years. Refrigerate after opening.

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Green by UP4 label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Green label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Green by UP4

These are the 5 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

A Proprietary Probiotic Blend

60 mg per serving

Spirulina

Interacts with
327 drugs
500 mg per serving

Blue-green algae are nutrient-rich aquatic microorganisms (such as spirulina and Klamath Lake algae) taken as a supplement for energy, nutrition, and...

Spirulina monograph & interactions

Other (inactive) ingredients: Rice Dextrin, Vegetable Cellulose, Fructooligosaccharide, Vegetable Magnesium Stearate, Silica. These complete the product’s ingredient list but are not active constituents.

Interaction report

Green by UP4 Drug Interactions

Want to check YOUR meds against Green?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
507Drugs
507 Moderate

Ingredients driving the most interactions

Spirulina 327
B. longum 182
B. bifidum 182
L. acidophilus DDS(R)-1 182

Individual Drug Interactions

The ingredients in Green interact with 507 drugs. Click any drug to see the details.

4 of the 5 ingredients in Green interact with drugs. Each result below shows which ingredient is responsible. Spirulina B. longum B. bifidum L. acidophilus DDS(R)-1

Each ingredient & the kinds of drugs it affects

For each ingredient in Green with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Spirulina3 drug types · 327 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, spirulina blue-green algae might increase the risk of bleeding if used with other anticoagulant or antiplatelet drugs. However, this is unlikely.
Spirulina blue-green algae have shown antiplatelet and anticoagulant effects in vitro. However, one preliminary study in 24 patients receiving spirulina blue-green algae 2.3 grams daily for 2 weeks showed no effect on platelet activation or measures of clotting time.

Likelihood Unlikely Evidence D
Antidiabetes Drugs

Theoretically, taking blue-green algae with antidiabetes drugs might increase the risk of hypoglycemia.
Human research shows that spirulina blue-green algae can have hypoglycemic effects in patients with diabetes, at least some of whom were using antidiabetes drugs. However, blue-green algae does not seem to improve glycated hemoglobin (HbA1c) levels in patients with diabetes. A meta-analysis of animal studies also suggests that spirulina blue-green algae have hypoglycemic effects.

Likelihood Possible Evidence B
Immunosuppressants

Theoretically, concurrent use of blue-green algae might interfere with immunosuppressive therapy.
Blue-green algae have been shown to stimulate the immune system.

Likelihood Possible Evidence D
Spirulina full monograph & interactions

B. longum1 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Bifidobacterium longum with antibiotic drugs might decrease the effectiveness of B. longum.
Since B. longum preparations usually contain live and active organisms, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and B. longum preparations by at least 2 hours.

Likelihood Probable Evidence D
B. longum full monograph & interactions

B. bifidum1 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Bifidobacterium. bifidum with antibiotic drugs might decrease the effectiveness of B. bifidum.
Since B. bifidum preparations usually contain live and active organisms, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and B. bifidum preparations by at least 2 hours.

Likelihood Probable Evidence D
B. bifidum full monograph & interactions

L. acidophilus DDS(R)-11 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L. acidophilus.
L. acidophilus preparations usually contain live and active organisms. Therefore, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and L. acidophilus preparations by at least two hours.

Likelihood Probable Evidence D
L. acidophilus DDS(R)-1 full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Green, from the product label.

UP4

See all UP4 products
Name
UASLifeSciences The Probiotic Company(R)
Street Address
555 N 72nd Avenue
City
Wausau
State
WI
ZipCode
54401
Phone Number
715.849.3333
Pharmacist Counseling Corner

Green by UP4: Common Questions

Does Green by UP4 interact with any medications?
Yes. Based on its ingredients, Green has a known interaction with 507 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Green contains 5 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take UP4 Green at the same time as my antibiotic?
No—it's better to separate them. The antibiotic can kill the live bacteria in the probiotics, making the supplement less effective. Ask your doctor or pharmacist how many hours apart to take them; typically a 2–3 hour gap is recommended.
Is spirulina safe for me if I take a blood thinner?
Spirulina may theoretically increase bleeding risk when combined with blood thinners, though human studies suggest this is unlikely. Still, check with your doctor or pharmacist before adding it, especially if you're on warfarin or other anticoagulants.
What are the most common side effects from this product?
From the probiotics, bloating and flatulence are the most common, though still rare. Spirulina can cause abdominal cramps, diarrhea, nausea, headache, and dizziness. Most side effects are mild and short-lived.
Is UP4 Green safe during pregnancy or breastfeeding?
B. longum and L. acidophilus are rated Possibly Safe in pregnancy, and B. bifidum is Possibly Safe as well. But safety data during breastfeeding are limited. Talk with your doctor or pharmacist before using while pregnant or nursing to weigh the benefits and any risks for your situation.
Can someone with a weakened immune system take this?
Anyone who is seriously ill or immune-compromised should check with their doctor first. Rare cases of serious bacterial infection have been reported in critically ill patients taking probiotics, so medical guidance is important.
Does UP4 Green work for IBS or gas?
B. bifidum and L. acidophilus in this product are rated Possibly Effective for IBS, so there's some evidence they may help. But the product as a whole hasn't been tested for gas or bloating—and ironically, probiotics can cause temporary bloating as your gut adjusts.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Green is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Green label
Go deeper

The Full Monographs Behind Green’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Bifidobacterium Longum

Interacts with 182 drugs

Bifidobacterium longum is a 'friendly' bacterium found naturally in the human gut and used as a probiotic. It is generally well tolerated and is most studied for digestive issues, though evi...

Read the full Bifidobacterium Longum monograph → Herb & supplement monograph

Bifidobacterium Bifidum

Interacts with 182 drugs

Bifidobacterium bifidum is a 'friendly' bacteria (probiotic) that naturally lives in the human gut and is taken to support digestion and gut balance. Some evidence suggests probiotics may he...

Read the full Bifidobacterium Bifidum monograph → Herb & supplement monograph

Lactobacillus Acidophilus

Interacts with 182 drugs

Lactobacillus acidophilus is a 'friendly' bacterium used as a probiotic to support gut and vaginal health. It is generally well tolerated in healthy people, and there is reasonable evidence...

Read the full Lactobacillus Acidophilus monograph → Herb & supplement monograph

Blue-green Algae

Interacts with 327 drugs

Blue-green algae are nutrient-rich aquatic microorganisms (such as spirulina and Klamath Lake algae) taken as a supplement for energy, nutrition, and general wellness. Evidence for most heal...

Read the full Blue-green Algae monograph →
Sources

Sources & How We Checked

Green's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 65 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Bifidobacterium Longum 21 references
  1. Ha GY, Yang CH, Kim H, Chong Y. Case of sepsis caused by Bifidobacterium longum. J Clin Microbiol 1999;37:1227-8.
  2. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  3. Xiao JZ, Takahashi S, Odamaki T, et al. Antibiotic susceptibility of bifidobacterial strains distributed in the Japanese market. Biosci Biotechnol Biochem. 2010;74(2):336-42. PubMed
  4. Rautava S, Kainonen E, Salminen S, Isolauri E. Maternal probiotic supplementation during pregnancy and breast-feeding reduces the risk of eczema in the infant. J Allergy Clin Immunol. 2012;130(6):1355-60. PubMed
  5. Pruccoli G, Silvestro E, Pace Napoleone C, Aidala E, Garazzino S, Scolfaro C. Are probiotics safe? Bifidobacterium bacteremia in a child with severe heart failure. Infez Med. 2019;27(2):175-178.
  6. Pellonperä O, Vahlberg T, Mokkala K, et al. Weight gain and body composition during pregnancy: a randomised pilot trial with probiotics and/or fish oil. Br J Nutr. 2020 Nov 4:1-11. PubMed
  7. Pellonperä O, Mokkala K, Houttu N, et al. Efficacy of fish oil and/or probiotic intervention on the incidence of gestational diabetes mellitus in an at-risk group of overweight and obese women: A randomized, placebo-controlled, double-blind clinical trial PubMed
  8. Shahriari A, Karimi E, Shahriari M, Aslani N, Khooshideh M, Arab A. The effect of probiotic supplementation on the risk of gestational diabetes mellitus among high-risk pregnant women: A parallel double-blind, randomized, placebo-controlled clinical trial PubMed
  9. Esaiassen E, Hjerde E, Cavanagh JP, Simonsen GS, Klingenberg C; Norwegian Study Group on Invasive Bifidobacterial Infections. Bifidobacterium bacteremia: Clinical characteristics and a genomic approach to assess pathogenicity. J Clin Microbiol. 2017;55(7) PubMed
  10. Enomoto T, Sowa M, Nishimori K, et al. Effects of bifidobacterial supplementation to pregnant women and infants in the prevention of allergy development in infants and on fecal microbiota. Allergol Int 2014;63(4):575-85. PubMed
  11. US Food and Drug Administration (FDA). Dear Healthcare Provider Letter: Warning Regarding Use of Probiotics in Preterm Infants. September 2023. Available at: https://www.fda.gov/media/172606/download?attachment. Accessed November 1, 2023.
  12. Pillai A, Tan J, Paquette V, Panczuk J. Does probiotic bacteremia in premature infants impact clinically relevant outcomes? A case report and updated review of literature. Clin Nutr ESPEN. 2020;39:255-259. PubMed
  13. Sabaté JM, Iglicki F. Effect of Bifidobacterium longum 35624 on disease severity and quality of life in patients with irritable bowel syndrome. World J Gastroenterol 2022;28(7):732-744.
  14. Malaguarnera M, Greco F, Barone G, Gargante MP, Malaguarnera M, Toscano MA. Bifidobacterium longum with fructo-oligosaccharide (FOS) treatment in minimal hepatic encephalopathy: a randomized, double-blind, placebo-controlled study. Dig Dis Sci 2007;52(11) PubMed
  15. Zbinden A, Zbinden R, Berger C, Arlettaz R. Case series of Bifidobacterium longum bacteremia in three preterm infants on probiotic therapy. Neonatology 2015;107(1):56-9.
  16. Tamaki H, Nakase H, Inoue S, et al. Efficacy of probiotic treatment with Bifidobacterium longum 536 for induction of remission in active ulcerative colitis: A randomized, double-blinded, placebo-controlled multicenter trial. Dig Endosc 2016;28(1):67-74.
  17. Bertelli C, Pillonel T, Torregrossa A, et al. Bifidobacterium longum bacteremia in preterm infants receiving probiotics. Clin Infect Dis 2015;60(6):924-7. PubMed
  18. Esaiassen E, Cavanagh P, Hjerde E, Simonsen GS, Støen R, Klingenberg C. Bifidobacterium longum subspecies infantis bacteremia in 3 extremely preterm infants receiving probiotics. Emerg Infect Dis 2016;22(9):1664-6.
  19. Tena D, Losa C, Medina MJ, Sáez-Nieto JA. Peritonitis caused by Bifidobacterium longum: case report and literature review. Anaerobe 2014;27:27-30. PubMed
  20. Sangkanjanavanich S, Pradubpongsa P, Mitthamsiri W, Sangasapaviliya A, Boonpiyathad T. Bifidobacterium infantis 35624 efficacy in patients with uncontrolled asthma: A randomized placebo-controlled trial. Ann Allergy Asthma Immunol 2022;129(6):790-792. PubMed
  21. Wilson HL, Ong CW. Bifidobacterium longum vertebrodiscitis in a patient with cirrhosis and prostate cancer. Anaerobe 2017;47:47-50. PubMed

See these in context on the Bifidobacterium Longum monograph →

Bifidobacterium Bifidum 7 references
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Xiao JZ, Takahashi S, Odamaki T, et al. Antibiotic susceptibility of bifidobacterial strains distributed in the Japanese market. Biosci Biotechnol Biochem. 2010;74(2):336-42. PubMed
  3. Rerksuppaphol S, Rerksuppaphol L. Randomized controlled trial of probiotics to reduce common cold in schoolchildren. Pediatr Int. 2012;54(5):682-7. PubMed
  4. Karamali M, Dadkhah F, Sadrkhanlou M, et al. Effects of probiotic supplementation on glycaemic control and lipid profiles in gestational diabetes: a randomized, double-blind, placebo-controlled trial. Diabetes Metab 2016;42(4):234-41. PubMed
  5. Badehnoosh B, Karamali M, Zarrati M, et al. The effects of probiotic supplementation on biomarkers of inflammation, oxidative stress and pregnancy outcomes in gestational diabetes. J Matern Fetal Neonatal Med. 2018 May;31(9):1128-1136.
  6. Pruccoli G, Silvestro E, Pace Napoleone C, Aidala E, Garazzino S, Scolfaro C. Are probiotics safe? Bifidobacterium bacteremia in a child with severe heart failure. Infez Med. 2019;27(2):175-178.
  7. Esaiassen E, Hjerde E, Cavanagh JP, Simonsen GS, Klingenberg C; Norwegian Study Group on Invasive Bifidobacterial Infections. Bifidobacterium bacteremia: Clinical characteristics and a genomic approach to assess pathogenicity. J Clin Microbiol. 2017;55(7) PubMed

See these in context on the Bifidobacterium Bifidum monograph →

Lactobacillus Acidophilus 15 references
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Begtrup LM, de Muckadell OB, Kjeldsen J, Christensen RD, Jarbøl DE. Long-term treatment with probiotics in primary care patients with irritable bowel syndrome--a randomised, double-blind, placebo controlled trial. Scand J Gastroenterol 2013;48(10):1127-35 PubMed
  3. Chatterjee S, Kar P, Das T, Ray S, Gangulyt S, Rajendiran C, Mitra M. Randomised placebo-controlled double blind multicentric trial on efficacy and safety of Lactobacillus acidophilus LA-5 and Bifidobacterium BB-12 for prevention of antibiotic-associated
  4. Shavakhi A, Tabesh E, Yaghoutkar A, Hashemi H, Tabesh F, Khodadoostan M,Minakari M, Shavakhi S, Gholamrezaei A. The effects of multistrain probiotic compound on bismuth-containing quadruple therapy for Helicobacter pylori infection: a randomized placebo-c
  5. Karamali M, Dadkhah F, Sadrkhanlou M, et al. Effects of probiotic supplementation on glycaemic control and lipid profiles in gestational diabetes: a randomized, double-blind, placebo-controlled trial. Diabetes Metab 2016;42(4):234-41. PubMed
  6. Badehnoosh B, Karamali M, Zarrati M, et al. The effects of probiotic supplementation on biomarkers of inflammation, oxidative stress and pregnancy outcomes in gestational diabetes. J Matern Fetal Neonatal Med. 2018 May;31(9):1128-1136.
  7. Kumar S, Kumar R, Rohilla L, Jacob N, Yadav J, Sachdeva N. A high potency multi-strain probiotic improves glycemic control in children with new-onset type 1 diabetes mellitus: A randomized, double-blind, and placebo-controlled pilot study. Pediatr Diabete
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See these in context on the Lactobacillus Acidophilus monograph →

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See these in context on the Blue-green Algae monograph →

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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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