Interactions on record — worth a quick check against your medications. Based on 4 of 7 ingredients. Check your meds →
Dietary supplement

GRP6 Ingredients & Drug Interactions

by Pro-Nutra

GRP6 label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking GRP6 against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

GRP6 is a dietary supplement by Pro-Nutra with 7 active ingredients. Its ingredients are commonly taken for alcohol cravings and reduction, menopausal symptoms, heart and blood vessel health.Based on those ingredients, 1,015 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Pueraria thunbergiana B., Crocus sativus, Calea zacatechichi. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against GRP6 by Pro-Nutra

Ask about any prescription or over-the-counter medication and we check it for interactions with GRP6 by Pro-Nutra — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of GRP6 by Pro-Nutra

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 6, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 7 active ingredients.
  • “GRP6 MATRIS(TM) Proprietary Blend” is a proprietary blend — the label gives one combined amount (325 mg) without saying how much of each component you get.
  • “DREAM SEQUENCE Proprietary Blend” is a proprietary blend — the label doesn't break down how much of each component you get.
  • “APPETITE CONTROL MATRIX Proprietary Blend” is a proprietary blend — the label doesn't break down how much of each component you get.

Pro-Nutra GRP6 is a capsule containing 7 ingredients, several of them grouped into proprietary blends (GRP6 MATRIS, DREAM SEQUENCE, and APPETITE CONTROL MATRIX) whose exact amounts are not disclosed. The active ingredients we can identify are kudzu (Pueraria thunbergiana B.), Calea zacatechichi, saffron (Crocus sativus), and lychee (Litchi chinensis).

Three other ingredients — Ficus bengalensis, Eucommiae cortex, and Ziziphus spinosa — are also present. The capsule itself contains inactive ingredients: gelatin, microcrystalline cellulose (a filler), magnesium stearate, FD&C Blue No.

1 (a dye), and titanium dioxide.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: appetite control and weight loss with sleep support.
  • We looked for evidence on: Obesity, Insomnia, Anxiety, Stress, Alcohol use disorder, Menopausal symptoms — and 3 related terms.
  • The strongest evidence on file: Kudzu is rated "Possibly Effective" for Alcohol use disorder (Natural Medicines).
  • Also on file: Kudzu is rated "Insufficient Reliable Evidence To Rate" for Menopausal symptoms, Obesity.
  • Also on file: Saffron is rated "Insufficient Reliable Evidence To Rate" for Anxiety, Insomnia, Menopausal symptoms.

The evidence for this product's effects is limited and mixed. Kudzu is possibly effective for alcohol use disorder, but the data for hay fever, chest pain, and back pain is insufficient.

Saffron is possibly effective for chemotherapy-related nerve damage and Alzheimer disease. Calea zacatechichi has insufficient evidence for headache, rheumatoid arthritis, insomnia, stress, or urticaria.

We hold no established effectiveness ratings for lychee or the other ingredients in the data we have.

The evidence, ingredient by ingredient Kudzu Calea Zacatechichi Saffron Lychee

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 4 of the 4 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 4 of 4.
  • General safety write-ups exist for 4 of 4.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Kudzu is generally well tolerated in short-term use, though some trial participants reported nausea, indigestion, bloating, and dizziness — none of these occurred more often than placebo. Calea zacatechichi has limited modern safety data and can cause nausea, vomiting, and drowsiness.

Saffron is generally well tolerated at supplement doses, but common side effects include gastrointestinal complaints, nausea, vomiting, sedation, and rare allergic reactions including anaphylaxis; it has also been reported to cause anxiety and agitation at higher doses. Lychee can trigger allergic reactions (rash, swelling, breathing trouble, anaphylaxis) and has been linked to a serious type of low blood sugar (hypoglycemic encephalopathy) in children, especially in malnourished populations.

Long-term safety data for the product overall is not well established.

Side effects, ingredient by ingredient Kudzu Calea Zacatechichi Saffron Lychee

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 4 of the 4 matched ingredients can interact with medications — Kudzu, Saffron, Calea Zacatechichi, Lychee.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; diabetes medications.
  • For scale: 1,016 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check your medications against these types: blood thinners and antiplatelet drugs (Moderate concern from kudzu), diabetes medications (Moderate from kudzu, Calea zacatechichi, saffron, and lychee), sleeping pills and CNS depressants (Minor from Calea zacatechichi, Moderate from saffron), blood pressure medications (Moderate from saffron), hormone therapy including estrogens and tamoxifen (Moderate from kudzu), methotrexate (Moderate from kudzu), immunosuppressants (Minor from lychee), and caffeine supplements or high-caffeine foods (Moderate from kudzu and saffron). Run your exact medications through the checker on this page.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This product brings together several herbal ingredients with some clinical research behind them — kudzu for alcohol use disorder and saffron for nerve damage and Alzheimer disease stand out — but it also carries real interaction risks, especially if you take blood thinners, diabetes medications, blood pressure drugs, or certain psychiatric medications. The safety data for short-term use is generally reassuring, but long-term effects are not well studied, and pregnancy and breastfeeding are not supported by the safety data for most ingredients.

Talk it over with your doctor or pharmacist before you start, particularly if you're on any prescription medication.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 4 of 7 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Oct 1, 2012.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about GRP6, straight from the product label.

Brand Pro-Nutra
Barcode (UPC) 851330004042
Net contents 30 Cap(s)
Market status On market
Date entered into DSLD Oct 1, 2012
DSLD ID 12431
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for GRP6 by Pro-Nutra, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
30
UPC/BARCODE
851330004042
IngredientAmount% DV
GRP6 MATRIS(TM) Proprietary Blend325 mg--
Ficus bengalensis0 NP--
Pueraria thunbergiana B.0 NP--
Eucommiae cortex0 NP--
DREAM SEQUENCE Proprietary Blend0 NP--
Calea zacatechichi0 NP--
Ziziphus spinosa0 NP--
APPETITE CONTROL MATRIX Proprietary Blend0 NP--
Crocus sativus0 NP--
Litchi chinensis0 NP--

Other ingredients: Gelatin, Microcrystalline Cellulose, Magnesium Stearate, FD&C Blue No. 1, Titanium Dioxide

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Brand IP Statement(s)

ZAP2X(TM) APPETITE CONTROL

FOR MAXIMUM RESULTS COMBINE WITH: METHOXYBURN(TM) 1 CAPSULE IN THE MORNING 1 CAPSULE IN THE AFTERNOON GUAVA(TM) SUPER FRUIT 1 CAPSULE IN THE MORNING 1 CAPSULE IN THE AFTERNOON

WEIGHT LOSS Modulates the pituitary growth family, which in turn acts to enhance growth factors responsible for longevity, lean body mass, energy, appearance, performance, well-being, and weight loss. APPETITE CONTROL Helps to regulate brain neuro-chemicals involved in appetite and caloric intake, which promotes normalized weight and healthy appearance. R.E.M. SLEEP Shown to produce a state of relaxation and enhanced sleep, while promoting wellness and enhanced metabolic rate.

General Statements

AVAILABLE WITHOUT A PRESCRIPTION

Growth Factor Releasing Peptides Combined with an Advanced Appetite Control Matrix to Promote Weight Loss, Reduced Food Intake and Healthy R.E.M Sleep.

Weight Loss - Modulates the pituitary growth family, which in turn acts to enhance growth factors responsible for longevity, lean body mass, energy, appearance, performance, well-being, and weight loss.

Appetite Control - Helps to regulate brain neuro-chemicals involved in appetite and caloric intake, which promotes normalized weight and healthy appearance.

R.E.M Sleep - Shown to produce a state of relaxation and enhanced sleep, while promoting wellness and enhanced metabolic rate.

(chart) SHOWN TO CUT FOOD INTAKE BY 220% APPETITE PERCENTAGE [%] REDUCTION Crocus sativus PLACEBO 51%

Dr. Gary Weinberger is a member of Pro Nutra’s scientific advisory board.

When combined with a proper exercise and nutrition regimen. Statements based on early stage independent 3rd party in vivo and / or in vitro model scientific research data findings.

“GRP6 is unlike any other product on the market. Research shows that it contains natural compounds that not only help to support overall longevity, but also how one feels and looks” - Gary I. Weinberger, MD

PHYSICIAN RECOMMENDED

MULTI-PHASE DELIVERY SYSTEM

FDA Disclaimer Statement

THESE STATEMENTS HAVE NOT BEEN EVALUATED BY THE FOOD AND DRUG ADMINISTRATION. THIS PRODUCT IS NOT INTENDED TO DIAGNOSE, TREAT, CURE, OR PREVENT ANY DISEASE.

FDA Statement of Identity

DIETARY SUPPLEMENT

Suggested/Recommended/Usage/Directions

Suggested Use: Take one (1) capsule one (1) hour before bedtime, on an empty stomach, or as directed by a qualified healthcare practitioner.

Precautions

Warnings: Not intended for use by persons under age 18.

Do not exceed recommended dose.

Get the consent of a licensed physician before using this product, especially if you are taking medication, have a medical condition, you are pregnant, nursing or thinking about becoming pregnant.

KEEP THIS PRODUCT AND ALL SUPPLEMENTS OUT OF THE REACH OF CHILDREN.

DO NOT USE IF SAFETY SEAL IS BROKEN.

General

Rev. 01-001-GRP001 04/12

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

GRP6 by Pro-Nutra label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

GRP6 label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in GRP6 by Pro-Nutra

These are the 7 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

GRP6 MATRIS(TM) Proprietary Blend

325 mg per serving

DREAM SEQUENCE Proprietary Blend

0 NP per serving

APPETITE CONTROL MATRIX Proprietary Blend

0 NP per serving

Other (inactive) ingredients: Gelatin, Microcrystalline Cellulose, Magnesium Stearate, FD&C Blue No. 1, Titanium Dioxide. These complete the product’s ingredient list but are not active constituents.

Interaction report

GRP6 by Pro-Nutra Drug Interactions

Want to check YOUR meds against GRP6?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,015Drugs
923 Moderate 92 Minor

Ingredients driving the most interactions

Pueraria thunbergiana B. 584
Crocus sativus 521
Calea zacatechichi 334
Litchi chinensis 207

Individual Drug Interactions

The ingredients in GRP6 interact with 1,015 drugs. Click any drug to see the details.

4 of the 7 ingredients in GRP6 interact with drugs. Each result below shows which ingredient is responsible. Pueraria thunbergiana B. Crocus sativus Calea zacatechichi Litchi chinensis

Each ingredient & the kinds of drugs it affects

For each ingredient in GRP6 with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Pueraria thunbergiana B.7 drug types · 584 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, kudzu may increase the risk of bleeding if used with antiplatelet or anticoagulant drugs.
Kudzu isoflavones are reported to have antiplatelet activity.

Likelihood Possible Evidence D
Caffeine

Theoretically, taking kudzu with caffeine might increase levels of caffeine.
In healthy males injected with the kudzu constituent puerarin, caffeine clearance and metabolism is inhibited. This effect has been attributed to inhibition of cytochrome P450 1A2 (CYP1A2) enzyme, which is involved in caffeine metabolism. It is unclear if taking kudzu orally would have this same effect.

Likelihood Probable Evidence D
Estrogens

Theoretically, kudzu might alter the effects of estrogen therapy.
Some research suggests that kudzu has estrogenic effects. This may enhance or inhibit the effects of estrogen therapy.

Likelihood Possible Evidence B
Hepatotoxic Drugs

Theoretically, concomitant use might have additive hepatotoxic effects.
There is some concern that kudzu can adversely affect the liver.

Likelihood Possible Evidence D
Methotrexate (Trexall, Others)

Theoretically, taking kudzu with methotrexate might increase the risk of methotrexate toxicity.
Preclinical research suggests that kudzu extract greatly reduces the elimination and increases the toxicity of methotrexate. Kudzu might inhibit organic anion transporters (OATs) that are responsible for hepatobiliary and renal excretion of anions, similar to the interaction between methotrexate and non-steroidal anti-inflammatory drugs (NSAIDs).

Likelihood Possible Evidence D
Tamoxifen (Nolvadex)

Theoretically, kudzu might interfere with tamoxifen activity.
Some research suggests that kudzu may have estrogenic effects.

Likelihood Possible Evidence B
Antidiabetes Drugs

Theoretically, taking kudzu with antidiabetes drugs might increase the risk of hypoglycemia.
Kudzu might lower blood glucose levels and have additive effects in patients treated with antidiabetic agents. The dose of diabetes medications might need to be adjusted.

Likelihood Unlikely Evidence D
Pueraria thunbergiana B. full monograph & interactions

Crocus sativus4 drug types · 521 drugs

Antidiabetes Drugs

Theoretically, concomitant use of saffron with antidiabetes drugs might increase the risk of hypoglycemia.
Some clinical research shows that taking saffron extract reduces fasting levels of glucose when used in addition to hypoglycemic agents. However, saffron powder itself has not been shown to reduce fasting glucose levels.

Likelihood Possible Evidence B
Antihypertensive Drugs

Theoretically, concomitant use of saffron with antihypertensive drugs might have additive effects.
Animal and human research suggests that saffron extract can decrease blood pressure.

Likelihood Possible Evidence D
Caffeine

Theoretically, saffron might inhibit the metabolism of caffeine.
A small clinical study suggests that taking saffron powder 300 mg in 150 mL water daily for 5 days and then taking caffeine 200 mg seems to reduce caffeine metabolite levels in the saliva and urine in males, but not females. Theoretically, this may be due to the inhibition of cytochrome P450 1A2 by saffron.

Likelihood Possible Evidence B
Cns Depressants

Theoretically, concomitant use of saffron and CNS depressants might have additive sedative effects.
Clinical research shows that taking saffron extract 60 mg orally daily for 26 weeks can cause drowsiness and sedation. Animal research suggests that adding saffron to hexobarbital further increases sleeping and slows motor activity.

Likelihood Possible Evidence D
Crocus sativus full monograph & interactions

Calea zacatechichi2 drug types · 334 drugs

Antidiabetes Drugs

Theoretically, taking Calea zacatechichi with antidiabetes drugs might increase the risk of hypoglycemia.
Animal research shows that Calea zacatechichi lowers blood glucose levels. Theoretically, combining Calea zacatechichi with antidiabetes drugs might result in additive effects.

Likelihood Possible Evidence D
Cns Depressants

Theoretically, Calea zacatechichi might increase the sedative effects of CNS depressants.
Calea zacatechichi can cause CNS depression in animals and humans.

Likelihood Possible Evidence D
Calea zacatechichi full monograph & interactions

Litchi chinensis2 drug types · 207 drugs

Antidiabetes Drugs

Theoretically, lychee seed might increase the risk of hypoglycemia when used with antidiabetes drugs.
Animal research suggests that an aqueous extract of lychee seed reduces fasting and 2-hour postprandial blood glucose and improves impaired glucose tolerance in rats with type 2 diabetes. Additionally, retrospective research in children has found an association between lychee consumption and increased odds of acute hypoglycemic encephalopathy.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, lychee might reduce the effectiveness of immunosuppressant drugs.
In vitro, flavonoids extracted from lychee show immunostimulant effects. So far, this effect has not been reported in humans.

Likelihood Possible Evidence D
Litchi chinensis full monograph & interactions
The maker

Brand information

Manufacturer and brand details for GRP6, from the product label.

Pro-Nutra

See all Pro-Nutra products
Name
Pro-Nutra
City
Fort Lauderdale
ZipCode
33301
Pharmacist Counseling Corner

GRP6 by Pro-Nutra: Common Questions

Does GRP6 by Pro-Nutra interact with any medications?
Yes. Based on its ingredients, GRP6 has a known interaction with 1,015 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
GRP6 contains 7 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is kudzu, and why is it in this product?
Kudzu (Pueraria thunbergiana B.) is a plant used in traditional medicine. Research suggests it may help with alcohol use disorder, which is why it's included here. However, it does carry interactions with several medication types, so it's important to check before you start.
Can I take this if I'm pregnant or breastfeeding?
No. Saffron in particular is likely unsafe during pregnancy because it may stimulate the uterus. Calea zacatechichi and kudzu lack enough safety data during pregnancy, and there isn't enough information on most ingredients during breastfeeding either. Talk with your doctor before considering this product if you're pregnant or nursing.
What side effects might I notice?
In trials, kudzu users sometimes reported nausea, indigestion, bloating, and dizziness — though these weren't more common than placebo. Calea zacatechichi can cause nausea, vomiting, and drowsiness. Saffron may cause nausea, sedation, and gastrointestinal complaints. Lychee can trigger allergic reactions in some people.
Does saffron in this product actually work for what it's used for?
Saffron is possibly effective for chemotherapy-related nerve damage and Alzheimer disease based on clinical research. However, the other ingredients don't have strong evidence for their claimed uses, and we don't know how well ingredients work in a proprietary blend where their amounts aren't disclosed.
I'm taking methotrexate for my arthritis. Is this product safe for me?
No — kudzu, which is in this product, may increase methotrexate toxicity by interfering with how your body clears the drug. Talk with your rheumatologist or pharmacist before taking any new supplement while on methotrexate.
What's in the proprietary blends, and why won't the label tell me how much?
The GRP6 MATRIS, DREAM SEQUENCE, and APPETITE CONTROL MATRIX blends contain multiple ingredients combined in undisclosed amounts — the manufacturer considers the exact formula proprietary. This means you can't see the dose of any single ingredient, which makes it harder to predict effects or interactions.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

GRP6 label
Go deeper

The Full Monographs Behind GRP6’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Kudzu

Interacts with 584 drugs

Kudzu is a fast-growing vine whose root has long been used in traditional Chinese medicine and is now studied mostly for reducing alcohol intake. Early research is promising for cutting back...

Read the full Kudzu monograph → Herb & supplement monograph

Calea Zacatechichi

Interacts with 334 drugs

Calea zacatechichi, often called 'dream herb,' is a Mexican plant traditionally used to encourage vivid dreams and to treat digestive complaints and fever. Human research is very limited, so...

Read the full Calea Zacatechichi monograph → Herb & supplement monograph

Saffron

Interacts with 521 drugs

Saffron is a costly spice that has shown promise in early studies for mild-to-moderate depression and some mood and PMS symptoms, but most research uses small trials, so results are not defi...

Read the full Saffron monograph → Herb & supplement monograph

Lychee

Interacts with 207 drugs

Lychee is a sweet tropical fruit that is nutritious and a source of vitamin C and antioxidant plant compounds. While the fruit is a healthy food for most people, supplement-strength extracts...

Read the full Lychee monograph →
Sources

Sources & How We Checked

GRP6's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 57 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Kudzu 21 references
  1. Woo J, Lau E, Ho SC, et al. Comparison of Pueraria lobata with hormone replacement therapy in treating the adverse health consequences of menopause. Menopause 2003;10:352-61. PubMed
  2. Akita H, Sowa J, Makiura M, et al. Maculopapular drug eruption due to the Japanese herbal medicine Kakkonto (kudzu or arrowroot decoction). Contact Dermatitis 2003;48:348-9. PubMed
  3. Luo ZR, Zheng B. [Effect of Puerarin on platelet activating factors CD63 and CD62P, plasminogen activator inhibitor and C-reactive protein in patients with unstable angia pectoris]. Zhongguo Zhong Xi Yi Jie He Za Zhi 2001;21:31-3 .
  4. Lee KT, Sohn IC, Kim DH, et al. Hypoglycemic and hypolipidemic effects of tectorigenin and kaikasaponin III in the streptozotocin-lnduced diabetic rat and their antioxidant activity in vitro. Arch Pharm Res 2000;23:461-6.
  5. Yu Z, Zhang G, Zhao H. [Effects of Puerariae isoflavone on blood viscosity, thrombosis and platelet function]. Zhong Yao Cai 1997;20:468-9.
  6. Hsu FL, Liu IM, Kuo DH, et al. Antihyperglycemic effect of puerarin in streptozotocin-induced diabetic rats. J Nat Prod 2003;66:788-92. PubMed
  7. Chiang HM, Fang SH, Wen KC, et al. Life-threatening interaction between the root extract of Pueraria lobata and methotrexate in rats. Toxicol Appl Pharmacol 2005;209:263-8.
  8. Zheng, J., Chen, B., Jiang, B., Zeng, L., Tang, Z. R., Fan, L., and Zhou, H. H. The effects of puerarin on CYP2D6 and CYP1A2 activities in vivo. Arch Pharm Res 2010;33(2):243-246. PubMed
  9. Hsu, H. H., Chang, C. K., Su, H. C., Liu, I. M., and Cheng, J. T. Stimulatory effect of puerarin on alpha1A-adrenoceptor to increase glucose uptake into cultured C2C12 cells of mice. Planta Med 2002;68(11):999-1003.
  10. Zheng, G., Zhang, X., Zheng, J., Meng, Q., and Zheng, D. [Estrogen-like effects of puerarin and total isoflavones from Pueraria lobata]. Zhong.Yao Cai. 2002;25(8):566-568.
  11. Qi, B. L. and Qi, B. M. [Effect of the purariae-isofiavones on estrogen level in normal and ovariectomized rats]. Zhongguo Zhong.Yao Za Zhi. 2002;27(11):850-852.
  12. Akita, H., Sowa, J., Makiura, M., Akamatsu, H., and Matsunaga, K. Maculopapular drug eruption due to the Japanese herbal medicine Kakkonto (kudzu or arrowroot decoction). Contact Dermatitis 2003;48(6):348-349. PubMed
  13. Manonai, J., Chittacharoen, A., Theppisai, U., and Theppisai, H. Effect of Pueraria mirifica on vaginal health. Menopause. 2007;14(5):919-924. PubMed
  14. Chandeying, V. and Sangthawan, M. Efficacy comparison of Pueraria mirifica (PM) against conjugated equine estrogen (CEE) with/without medroxyprogesterone acetate (MPA) in the treatment of climacteric symptoms in perimenopausal women: phase III study. J M
  15. Virojchaiwong, P., Suvithayasiri, V., and Itharat, A. Comparison of Pueraria mirifica 25 and 50 mg for menopausal symptoms. Arch.Gynecol.Obstet. 2011;284(2):411-419. PubMed
  16. Hou, Q., Ao, X., Li, G., and Zhang, Y. [Puerarin combined with avandia for diabetic nephropathy]. Zhong.Nan.Da.Xue Xue Bao Yi Xue Ban. 2012;37(1):73-77.
  17. Kim HJ, Kim H, Ahn JH, Suk JH. Liver injury induced by herbal extracts containing mistletoe and kudzu. J Altern Complement Med 2015;21(3):180-5. PubMed
  18. Santosh N, Mohan K, Royana S, Yamini TB. Hepatotoxicity of tubers of Indian Kudzu (Pueraria tuberosa) in rats. Food Chem Toxicol. 2010 Apr;48(4):1066-71. PubMed
  19. Teschke R, Zhang L, Long H, Schwarzenboeck A, Schmidt-Taenzer W, Genthner A, Wolff A, Frenzel C, Schulze J, Eickhoff A. Traditional Chinese Medicine and herbal hepatotoxicity: a tabular compilation of reported cases. Ann Hepatol. 2015 Jan-Feb;14(1):7-19. DOI
  20. Wang D, Qiu L, Wu X, Wei H, Xu F. Evaluation of kudzu root extract-induced hepatotoxicity. J Ethnopharmacol. 2015 Dec 24;176:321-6. PubMed
  21. Warinsiriruk P, Tantitham C, Cherdshewasart W, Shobeiri SA, Manonai J. Effects of Pueraria mirifica on vaginal artery vascularization in postmenopausal women with genitourinary syndrome of menopause. Maturitas 2022;160:4-10. PubMed

See these in context on the Kudzu monograph →

Calea Zacatechichi 2 references
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  2. Roman, Ramos R., Alarcon-Aguilar, F., Lara-Lemus, A., and Flores-Saenz, J. L. Hypoglycemic effect of plants used in Mexico as antidiabetics. Arch.Med.Res 1992;23:59-64.

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Saffron 22 references
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  7. Safarinejad MR, Shafiei N, Safarinejad S. A prospective double-blind randomized placebo-controlled study of the effect of saffron (Crocus sativus Linn.) on semen parameters and seminal plasma antioxidant capacity in infertile men with idiopathic oligoasth
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  9. Modaghegh, M. H., Shahabian, M., Esmaeili, H. A., Rajbai, O., and Hosseinzadeh, H. Safety evaluation of saffron (Crocus sativus) tablets in healthy volunteers. Phytomedicine. 2008;15(12):1032-1037. PubMed
  10. Imenshahidi, M., Hosseinzadeh, H., and Javadpour, Y. Hypotensive effect of aqueous saffron extract (Crocus sativus L.) and its constituents, safranal and crocin, in normotensive and hypertensive rats. Phytother.Res 12-9-2009;
  11. Zhang, Y., Shoyama, Y., Sugiura, M., and Saito, H. Effects of Crocus sativus L. on the ethanol-induced impairment of passive avoidance performances in mice. Biol.Pharm Bull. 1994;17(2):217-221. PubMed
  12. Wuthrich, B., Schmid-Grendelmeyer, P., and Lundberg, M. Anaphylaxis to saffron. Allergy 1997;52(4):476-477. PubMed
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  14. Kashani L, Eslatmanesh S, Saedi N, Niroomand N, Ebrahimi M, Hosseinian M, Foroughifar T, Salimi S, Akhondzadeh S. Comparison of Saffron versus Fluoxetine in Treatment of Mild to Moderate Postpartum Depression: A Double-Blind, Randomized Clinical Trial. Ph PubMed
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  17. Safarinejad MR, Shafiei N, Safarinejad S. An open label, randomized, fixed-dose, crossover study comparing efficacy and safety of sildenafil citrate and saffron (Crocus sativus Linn.) for treating erectile dysfunction in men naïve to treatment. Int J Impo PubMed
  18. Talaei A, Hassanpour Moghadam M, Sajadi Tabassi SA, Mohajeri SA. Crocin, the main active saffron constituent, as an adjunctive treatment in major depressive disorder: a randomized, double-blind, placebo-controlled, pilot clinical trial. J Affect Disord. 2 PubMed
  19. Azimi P, Ghiasvand R Feizi A, Hariri M, Abbasi B. Effects of cinnamon, cardamom, saffron, and ginger consumption on markers of glycemic control, lipid profile, oxidative stress, and inflammation in type 2 diabetes. Rev Diabet Stud. 2014 Fall-Winter;11(3-4
  20. Begas E, Bounitsi M, Kilindris T, et al. Effects of short-term saffron (Crocus sativus L.) intake on the in vivo activities of xenobiotic metabolizing enzymes in healthy volunteers. Food Chem Toxicol. 2019;130:32-43. PubMed
  21. Moravej Aleali A, Amani R, Shahbazian H, Namjooyan F, Latifi SM, Cheraghian B. The effect of hydroalcoholic Saffron (Crocus sativus L.) extract on fasting plasma glucose, HbA1c, lipid profile, liver, and renal function tests in patients with type 2 diabet
  22. Abbaszadeh-Mashkani S, Hoque SS, Banafshe HR, Ghaderi A. The effect of crocin (the main active saffron constituent) on the cognitive functions, craving, and withdrawal syndrome in opioid patients under methadone maintenance treatment. Phytother Res. 2021; PubMed

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Lychee 12 references
  1. Niggemann B, Reibel S, Hipler C, Wahn U. Anaphylactic reaction to lychee in a 12-year-old girl: cross-reactivity to latex? Pediatr Allergy Immunol 2002;13(1):64-7. PubMed
  2. Giannattasio M, Serafini M, Guarrera P, et al. Contact urticaria from litchi fruit (Litchi chinensis Sonn.). Contact Dermatitis 1995;33(1):67.
  3. Raap U, Schaefer T, Kapp A, Wedi B. Exotic food allergy: anaphylactic reaction to lychee. J Investig Allergol Clin Immunol 2007;17(3):199-201.
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  6. John TJ, Das M. Outbreaks of Hypoglycemic Encephalopathy in Muzaffarpur, India: Are These Caused by Toxins in Litchi Fruit?: The Point. Indian Pediatr. 2016;53(5):399.
  7. John TJ. Exploration of Association between Litchi Consumption and Seasonal Acute Encephalopathy Syndrome: Pediatric Infectious Disease Specialist's Viewpoint. Indian Pediatr. 2017;54(4):323-325. DOI
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  10. Spencer PS, Palmer VS, Mazumder R. Probable toxic cause for suspected lychee-linked viral encephalitis. Emerg Infect Dis. 2015;21(5):904-5. DOI
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  12. Vashishtha VM. Outbreaks of Hypoglycemic Encephalopathy in Muzaffarpur, India: Are These Caused by Toxins in Litchi Fruit?: The Counterpoint. Indian Pediatr. 2016 May 8;53(5):399-402.

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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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