Interactions on record — worth a quick check against your medications. Based on 2 of 3 ingredients. Check your meds →
Dietary supplement

Gut Eze Ingredients & Drug Interactions

by Physician's Signature

Gut Eze label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Gut Eze against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Gut Eze is a dietary supplement by Physician's Signature with 3 active ingredients. Its ingredients are commonly taken for digestive health and regularity, infant colic and gut support, diarrhea (including antibiotic-related).Based on those ingredients, 182 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Bifidobacterium breve CGMCC 6402, Bifidobacterium longum infantis SD-6669. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Gut Eze by Physician's Signature

Ask about any prescription or over-the-counter medication and we check it for interactions with Gut Eze by Physician's Signature — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Gut Eze by Physician's Signature

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 3 active ingredients.
  • “Proprietary Live Culture Blend” is a proprietary blend — the label gives one combined amount (20 mg) without saying how much of each component you get.

Gut Eze contains 3 active probiotic ingredients: a proprietary blend of live cultures and two named bacterial strains—Lactobacillus casei casei SD-5842 and two Bifidobacterium species. These are live microorganisms meant to support your gut flora.

The capsule also contains inactive ingredients (microcrystalline cellulose, hydroxypropyl methylcellulose, magnesium stearate, and silicon dioxide) that serve as fillers and binders.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: promote gut integrity and immune function.
  • We looked for evidence on: Abdominal pain, Antibiotic-associated diarrhea, Colic, Clostridioides difficile infection, Constipation, Diarrhea — and 4 related terms.
  • The closest evidence on file: Bifidobacterium Breve is rated "Insufficient Reliable Evidence To Rate" for Antibiotic-associated diarrhea (Natural Medicines).
  • Also on file: Bifidobacterium Breve is rated "Insufficient Reliable Evidence To Rate" for Constipation, Rotaviral diarrhea, Irritable bowel syndrome (IBS), Clostridioides difficile infection, and more.

The evidence for these probiotics is incomplete. For Bifidobacterium breve, we have insufficient reliable evidence to rate its usefulness for allergic rhinitis (hay fever), antibiotic-associated diarrhea, or atopic disease—and it's been rated possibly ineffective for age-related cognitive decline and sepsis.

For Bifidobacterium longum, the same pattern holds: insufficient evidence for allergic rhinitis, antibiotic-associated diarrhea, anxiety, asthma, and athletic performance. In short, what this product is actually meant to do isn't clearly established in the data we hold.

The evidence, ingredient by ingredient Bifidobacterium Breve Bifidobacterium Longum

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Both Bifidobacterium strains are generally well tolerated in healthy people. However, caution is needed if you're seriously ill or have a weakened immune system—there have been rare cases of these bacteria entering the bloodstream in critically ill infants and adults, especially preterm infants.

Common side effects with probiotic use include bloating and flatulence, though these haven't been specifically reported with B. breve. Rare side effects from B. longum include abdominal discomfort, constipation, and even a dry cough in one trial participant.

Because safety data are limited, check with your doctor before use, especially if you're pregnant, breastfeeding, or seriously ill. Data on pregnancy safety for B. breve are not on file; for B. longum, the evidence suggests it's possibly safe, but talk with your doctor for personalized advice.

Side effects, ingredient by ingredient Bifidobacterium Breve Bifidobacterium Longum

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 2 matched ingredients can interact with medications — Bifidobacterium Breve, Bifidobacterium Longum.
  • The most serious interaction on file is rated Moderate.
  • For scale: 182 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take antibiotic drugs, check with us before starting Gut Eze—you'll need to separate when you take the two so the antibiotics don't reduce the probiotic's effectiveness. That's the main interaction we've documented for the ingredients we could check.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

Gut Eze is a probiotic supplement for people interested in gut flora support, but the evidence for what it actually does isn't well established. If you're healthy, it's generally well tolerated, but if you're seriously ill or immunocompromised, talk to your doctor first.

Most importantly: if you take antibiotics, space them out from this supplement so the bacteria don't get killed off.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Aug 22, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Gut Eze, straight from the product label.

Brand Physician's Signature
Barcode (UPC) 850002325010
Net contents 30 Vegetarian Capsule(s)
Market status On market
Date entered into DSLD Aug 22, 2024
DSLD ID 316961
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegetarian, Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Gut Eze by Physician's Signature, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
30
UPC/BARCODE
850002325010
IngredientAmount% DV
Proprietary Live Culture Blend20 mg--
Lactobacillus casei casei SD-58420 NP--
Bifidobacterium breve CGMCC 64020 NP--
Bifidobacterium longum infantis SD-66690 NP--

Other ingredients: Microcrystalline Cellulose, Hydroxypropyl Methylcellulose, Magnesium Stearate, Silicon Dioxide

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Intended to promote production of Short Chain Fatty Acids (SCFAs) to maintain gut integrity, lipid metabolism, appetite regularity and immune integrity.

Suitable for Vegetarians

Not a significant source of total sugars or added sugars.

Suggested/Recommended/Usage/Directions

Suggested Use: Take one capsule daily preferably with a meal.

Precautions

Caution: Consult your physician prior to using this product if you are pregnant, nursing, or have any pre-existing medical conditions.

Keep out of the reach of children.

Do not use if seal is broken.

Storage

Store in a cool, dry place.

Seals/Symbols

Rawleigh A Friend of the Family Since 1889

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Formula

Gut Eze with Live Cultures 1 Billion CFU/Capsule 1 Billion CFU (Colony Forming Units) per capsule at expiry.

FDA Statement of Identity

Dietary Supplement

Brand IP Statement(s)

Physician's Signature by W.T. Rawleigh

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Gut Eze by Physician's Signature label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Gut Eze label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Gut Eze by Physician's Signature

These are the 3 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Proprietary Live Culture Blend

20 mg per serving

Other (inactive) ingredients: Microcrystalline Cellulose, Hydroxypropyl Methylcellulose, Magnesium Stearate, Silicon Dioxide. These complete the product’s ingredient list but are not active constituents.

Interaction report

Gut Eze by Physician's Signature Drug Interactions

Want to check YOUR meds against Gut Eze?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
182Drugs
182 Moderate

Ingredients driving the most interactions

Bifidobacterium breve CGMCC 6402 182
Bifidobacterium longum infantis SD-6669 182

Individual Drug Interactions

The ingredients in Gut Eze interact with 182 drugs. Click any drug to see the details.

2 of the 3 ingredients in Gut Eze interact with drugs. Each result below shows which ingredient is responsible. Bifidobacterium breve CGMCC 6402 Bifidobacterium longum infantis SD-6669

Each ingredient & the kinds of drugs it affects

For each ingredient in Gut Eze with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Bifidobacterium breve CGMCC 64021 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Bifidobacterium breve with antibiotic drugs might decrease the effectiveness of B. breve.
Since B. breve preparations usually contain live and active organisms, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and B. breve preparations by at least 2 hours.

Likelihood Probable Evidence D
Bifidobacterium breve CGMCC 6402 full monograph & interactions

Bifidobacterium longum infantis SD-66691 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Bifidobacterium longum with antibiotic drugs might decrease the effectiveness of B. longum.
Since B. longum preparations usually contain live and active organisms, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and B. longum preparations by at least 2 hours.

Likelihood Probable Evidence D
Bifidobacterium longum infantis SD-6669 full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Gut Eze, from the product label.

Physician's Signature

See all Physician's Signature products
Name
Vitamins Direct (USA), Inc.
City
West Palm Beach
State
FL
ZipCode
33407
Phone Number
866-354-8384
Web Address
www.wtrawleigh.com
Pharmacist Counseling Corner

Gut Eze by Physician's Signature: Common Questions

Does Gut Eze by Physician's Signature interact with any medications?
Yes. Based on its ingredients, Gut Eze has a known interaction with 182 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Gut Eze contains 3 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Do I need to avoid this if I'm on antibiotics?
Not avoid it, but space it out. Antibiotics can kill off the live bacteria in this supplement if you take them at the same time. Ask your pharmacist about the best timing—usually a few hours apart helps.
What exactly does Gut Eze do?
It contains live probiotic bacteria meant to support your gut flora. However, the evidence for what this specific product actually accomplishes isn't clearly established in the research we have.
Are there any common side effects?
The most common reported effects with probiotics are bloating and flatulence. Rare side effects from the Bifidobacterium strains in here include abdominal discomfort, constipation, and occasionally a dry cough.
Is it safe if I'm immunocompromised or very ill?
No—caution is strongly advised. There have been rare cases of these bacteria entering the bloodstream in critically ill patients, especially infants. Talk to your doctor before using this if you're seriously ill or have a weakened immune system.
Can I take this while pregnant or breastfeeding?
For Bifidobacterium longum, the evidence suggests it's possibly safe. For Bifidobacterium breve, we don't have enough data to say either way. Either way, talk with your doctor or pharmacist about what's right for you personally.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Gut Eze is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Gut Eze label
Go deeper

The Full Monographs Behind Gut Eze’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Bifidobacterium Breve

Interacts with 182 drugs

Bifidobacterium breve is a 'friendly' gut bacterium taken as a probiotic, most often to support digestion and balance the gut microbiome. Some studies suggest possible benefits for certain d...

Read the full Bifidobacterium Breve monograph → Herb & supplement monograph

Bifidobacterium Longum

Interacts with 182 drugs

Bifidobacterium longum is a 'friendly' bacterium found naturally in the human gut and used as a probiotic. It is generally well tolerated and is most studied for digestive issues, though evi...

Read the full Bifidobacterium Longum monograph →
Sources

Sources & How We Checked

Gut Eze's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 30 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Bifidobacterium Breve 9 references
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Xiao JZ, Takahashi S, Odamaki T, et al. Antibiotic susceptibility of bifidobacterial strains distributed in the Japanese market. Biosci Biotechnol Biochem. 2010;74(2):336-42. PubMed
  3. Pruccoli G, Silvestro E, Pace Napoleone C, Aidala E, Garazzino S, Scolfaro C. Are probiotics safe? Bifidobacterium bacteremia in a child with severe heart failure. Infez Med. 2019;27(2):175-178.
  4. Ohishi A, Takahashi S, Ito Y, et al. Bifidobacterium septicemia associated with postoperative probiotic therapy in a neonate with omphalocele. J Pediatr. 2010;156(4):679-81. PubMed
  5. Sakurai Y, Watanabe T, Miura Y, et al. Clinical and bacteriologic characteristics of six cases of Bifidobacterium breve bacteremia due to probiotic administration in the neonatal intensive care unit. Pediatr Infect Dis J 2022;41(1):62-65. PubMed
  6. Esaiassen E, Hjerde E, Cavanagh JP, Simonsen GS, Klingenberg C; Norwegian Study Group on Invasive Bifidobacterial Infections. Bifidobacterium bacteremia: Clinical characteristics and a genomic approach to assess pathogenicity. J Clin Microbiol. 2017;55(7) PubMed
  7. Wakabayashi Y, Nakayama S, Yamamoto A, et al. First case of necrotizing fasciitis and bacteremia caused by Bifidobacteriumbreve. Anaerobe 2022;76:102613.
  8. Takeda Y, Ota K, Kondo A, et al. A case of necrotizing fasciitis caused by Bifidobacterium breve. IDCases 2022;31:e01667. PubMed
  9. Suwantarat N, Romagnoli M, Wakefield T, Carroll KC. Ventriculoperitoneal shunt infection caused by Bifidobacterium breve. Anaerobe 2014;28:1-3. PubMed

See these in context on the Bifidobacterium Breve monograph →

Bifidobacterium Longum 21 references
  1. Ha GY, Yang CH, Kim H, Chong Y. Case of sepsis caused by Bifidobacterium longum. J Clin Microbiol 1999;37:1227-8.
  2. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  3. Xiao JZ, Takahashi S, Odamaki T, et al. Antibiotic susceptibility of bifidobacterial strains distributed in the Japanese market. Biosci Biotechnol Biochem. 2010;74(2):336-42. PubMed
  4. Rautava S, Kainonen E, Salminen S, Isolauri E. Maternal probiotic supplementation during pregnancy and breast-feeding reduces the risk of eczema in the infant. J Allergy Clin Immunol. 2012;130(6):1355-60. PubMed
  5. Pruccoli G, Silvestro E, Pace Napoleone C, Aidala E, Garazzino S, Scolfaro C. Are probiotics safe? Bifidobacterium bacteremia in a child with severe heart failure. Infez Med. 2019;27(2):175-178.
  6. Pellonperä O, Vahlberg T, Mokkala K, et al. Weight gain and body composition during pregnancy: a randomised pilot trial with probiotics and/or fish oil. Br J Nutr. 2020 Nov 4:1-11. PubMed
  7. Pellonperä O, Mokkala K, Houttu N, et al. Efficacy of fish oil and/or probiotic intervention on the incidence of gestational diabetes mellitus in an at-risk group of overweight and obese women: A randomized, placebo-controlled, double-blind clinical trial PubMed
  8. Shahriari A, Karimi E, Shahriari M, Aslani N, Khooshideh M, Arab A. The effect of probiotic supplementation on the risk of gestational diabetes mellitus among high-risk pregnant women: A parallel double-blind, randomized, placebo-controlled clinical trial PubMed
  9. Esaiassen E, Hjerde E, Cavanagh JP, Simonsen GS, Klingenberg C; Norwegian Study Group on Invasive Bifidobacterial Infections. Bifidobacterium bacteremia: Clinical characteristics and a genomic approach to assess pathogenicity. J Clin Microbiol. 2017;55(7) PubMed
  10. Enomoto T, Sowa M, Nishimori K, et al. Effects of bifidobacterial supplementation to pregnant women and infants in the prevention of allergy development in infants and on fecal microbiota. Allergol Int 2014;63(4):575-85. PubMed
  11. US Food and Drug Administration (FDA). Dear Healthcare Provider Letter: Warning Regarding Use of Probiotics in Preterm Infants. September 2023. Available at: https://www.fda.gov/media/172606/download?attachment. Accessed November 1, 2023.
  12. Pillai A, Tan J, Paquette V, Panczuk J. Does probiotic bacteremia in premature infants impact clinically relevant outcomes? A case report and updated review of literature. Clin Nutr ESPEN. 2020;39:255-259. PubMed
  13. Sabaté JM, Iglicki F. Effect of Bifidobacterium longum 35624 on disease severity and quality of life in patients with irritable bowel syndrome. World J Gastroenterol 2022;28(7):732-744.
  14. Malaguarnera M, Greco F, Barone G, Gargante MP, Malaguarnera M, Toscano MA. Bifidobacterium longum with fructo-oligosaccharide (FOS) treatment in minimal hepatic encephalopathy: a randomized, double-blind, placebo-controlled study. Dig Dis Sci 2007;52(11) PubMed
  15. Zbinden A, Zbinden R, Berger C, Arlettaz R. Case series of Bifidobacterium longum bacteremia in three preterm infants on probiotic therapy. Neonatology 2015;107(1):56-9.
  16. Tamaki H, Nakase H, Inoue S, et al. Efficacy of probiotic treatment with Bifidobacterium longum 536 for induction of remission in active ulcerative colitis: A randomized, double-blinded, placebo-controlled multicenter trial. Dig Endosc 2016;28(1):67-74.
  17. Bertelli C, Pillonel T, Torregrossa A, et al. Bifidobacterium longum bacteremia in preterm infants receiving probiotics. Clin Infect Dis 2015;60(6):924-7. PubMed
  18. Esaiassen E, Cavanagh P, Hjerde E, Simonsen GS, Støen R, Klingenberg C. Bifidobacterium longum subspecies infantis bacteremia in 3 extremely preterm infants receiving probiotics. Emerg Infect Dis 2016;22(9):1664-6.
  19. Tena D, Losa C, Medina MJ, Sáez-Nieto JA. Peritonitis caused by Bifidobacterium longum: case report and literature review. Anaerobe 2014;27:27-30. PubMed
  20. Sangkanjanavanich S, Pradubpongsa P, Mitthamsiri W, Sangasapaviliya A, Boonpiyathad T. Bifidobacterium infantis 35624 efficacy in patients with uncontrolled asthma: A randomized placebo-controlled trial. Ann Allergy Asthma Immunol 2022;129(6):790-792. PubMed
  21. Wilson HL, Ong CW. Bifidobacterium longum vertebrodiscitis in a patient with cirrhosis and prostate cancer. Anaerobe 2017;47:47-50. PubMed

See these in context on the Bifidobacterium Longum monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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