Interactions on record — worth a quick check against your medications. Based on 1 of 3 ingredients. Check your meds →
Dietary supplement

Heart Cholesterol Support Ingredients & Drug Interactions

by BIOVEA

Heart Cholesterol Support label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Heart Cholesterol Support against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Heart Cholesterol Support is a dietary supplement by BIOVEA with 3 active ingredients. Its ingredients are commonly taken for heart and circulatory health, blood clot prevention, high blood pressure.Based on those ingredients, 289 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Nattokinase. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Heart Cholesterol Support by BIOVEA

Ask about any prescription or over-the-counter medication and we check it for interactions with Heart Cholesterol Support by BIOVEA — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Heart Cholesterol Support by BIOVEA

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Partial disclosure
Ingredient Transparency · database check
Partial

Most active ingredients list an amount, but at least one is hidden in a blend or missing.

Why this rating?
  • The label discloses an exact amount for 2 of its 3 active ingredients.

This product has 3 active ingredients. Nattokinase is an enzyme derived from fermented soy that works like a blood thinner in your body — it may help break down clots and thin your blood.

Phytosterols are plant compounds that may support cholesterol levels. Salicin is a compound from willow bark.

The capsules also contain inactive ingredients: rice flour, cellulose, silicon dioxide, and magnesium stearate — these are fillers and binders that hold the capsule together.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Nattokinase's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: Heart health and cholesterol support.
  • We looked for evidence on: Angina, Atherosclerosis, Cardiovascular disease (CVD), Hyperlipidemia, Hypertension, Peripheral arterial disease (PAD) — and 4 related terms.
  • The closest evidence on file: Nattokinase is rated "Insufficient Reliable Evidence To Rate" for Angina (Natural Medicines).
  • Also on file: Nattokinase is rated "Insufficient Reliable Evidence To Rate" for Atherosclerosis, Cardiovascular disease (CVD), Hyperlipidemia, Hypertension, and more.

The evidence we hold doesn't establish that nattokinase works for any of the conditions listed — angina, atherosclerosis, cancer, cardiovascular disease, and chronic fatigue syndrome all show insufficient reliable evidence. We don't have effectiveness ratings on file for phytosterols or salicin in this product either, so we can't speak to how well they may work for heart or cholesterol support.

The evidence, ingredient by ingredient Nattokinase

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Nattokinase is generally well tolerated short-term, but because it thins your blood, it's not suitable if you have a bleeding disorder or high bleeding risk. Rare cases of severe bleeding — including brain bleeding — have been reported, especially when combined with blood thinners.

Nattokinase can trigger allergic reactions in people sensitive to natto (fermented soy), including anaphylaxis in rare cases. Do not use this product during pregnancy — there isn't enough safety data.

Safety while breastfeeding is unknown, so avoid it to be safe. We have no pregnancy or breastfeeding data on file for phytosterols or salicin.

Side effects, ingredient by ingredient Nattokinase

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Nattokinase.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 289 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with us before taking this if you use blood thinners or antiplatelet drugs like warfarin, apixaban, dabigatran, rivaroxaban, clopidogrel, or aspirin — nattokinase raises bleeding risk (Moderate severity). Also double-check if you take antihypertensive drugs (blood pressure medications) — nattokinase may lower your pressure further (Moderate severity).

We hold no interaction data for phytosterols or salicin.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glancePartially disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

This product is mainly for someone interested in natural approaches to heart and cholesterol health who doesn't take blood thinners or blood pressure medications. If you're on any prescription drugs — especially anticoagulants, antiplatelet agents, or blood pressure meds — talk to your pharmacist before adding it.

Anyone with a natto allergy or bleeding disorder should skip it.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Sep 22, 2016.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Heart Cholesterol Support, straight from the product label.

Brand BIOVEA
Barcode (UPC) 689076017480
Net contents 60 Vegetarian Capsule(s)
Market status On market
Date entered into DSLD Sep 22, 2016
DSLD ID 65182
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Heart Cholesterol Support by BIOVEA, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Vegetarian Capsule(s)
Maximum serving Sizes:
2 Vegetarian Capsule(s)
Servings per container
30
UPC/BARCODE
689076017480
IngredientAmount% DV
Nattokinase0 NP--
Phytosterols400 mg--
Salicin81 mg--

Other ingredients: Rice Flour, Cellulose, Silicon Dioxide, Magnesium Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Seals/Symbols

Made in the USA

GMP Compliant

Suggested/Recommended/Usage/Directions

Suggested Daily Intake: Take 2 capsules daily with meals.

General Statements

Guaranteed premium quality

Heart health

FDA Statement of Identity

Dietary Supplement

Formula

Allergen Information: Contains soy ingredients.

Precautions

Allergen Information: Contains soy. Avoid this product if you are allergic to aspirin related compounds.

Warning: If you are pregnant, nursing, have any health condition or are taking any medications, consult a health care professional before using this product.

Keep out of reach of children.

Do not use this product if the safety seal on the bottle is broken.

Storage

Store in a cool, dry place.

General

G15

Formulation

Vegan product

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Heart Cholesterol Support by BIOVEA label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Heart Cholesterol Support label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Heart Cholesterol Support by BIOVEA

These are the 3 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Vegetarian Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Nattokinase

Interacts with
289 drugs
0 NP per serving Form: Soy

Nattokinase is an enzyme from the fermented soybean food natto that may have mild blood-thinning and blood-flow effects. Some small studies hint at be...

Nattokinase monograph & interactions

Phytosterols

400 mg per serving Form: Soy

Salicin

81 mg per serving Form: White Willow bark extract

Other (inactive) ingredients: Rice Flour, Cellulose, Silicon Dioxide, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Heart Cholesterol Support by BIOVEA Drug Interactions

Want to check YOUR meds against Heart Cholesterol Support?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
289Drugs
289 Moderate

Ingredients driving the most interactions

Nattokinase 289

Individual Drug Interactions

The ingredients in Heart Cholesterol Support interact with 289 drugs. Click any drug to see the details.

1 of the 3 ingredients in Heart Cholesterol Support interact with drugs. Each result below shows which ingredient is responsible. Nattokinase

Each ingredient & the kinds of drugs it affects

For each ingredient in Heart Cholesterol Support with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Nattokinase2 drug types · 289 drugs

Anticoagulant/Antiplatelet Drugs

Nattokinase might increase the risk of bleeding when used with anticoagulant/antiplatelet drugs.
Nattokinase has thrombolytic and anticoagulant effects. There is a case report of intracranial hemorrhage in a patient who added nattokinase to aspirin therapy.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, nattokinase might increase the risk of hypotension when used with antihypertensive drugs.
Some clinical research suggests that nattokinase may reduce systolic and diastolic blood pressure.

Likelihood Possible Evidence D
Nattokinase full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Heart Cholesterol Support, from the product label.

BIOVEA

See all BIOVEA products
Name
BIOVEA
Phone Number
1-800-961-4750
Web Address
www.biovea.com
Pharmacist Counseling Corner

Heart Cholesterol Support by BIOVEA: Common Questions

Does Heart Cholesterol Support by BIOVEA interact with any medications?
Yes. Based on its ingredients, Heart Cholesterol Support has a known interaction with 289 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Heart Cholesterol Support contains 3 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm on aspirin?
No — there's a documented case of serious brain bleeding when nattokinase was added to low-dose aspirin. Talk to your doctor or pharmacist before considering this product if you take any blood thinner or antiplatelet medication.
Does this product actually work for cholesterol or heart health?
We don't have reliable evidence that nattokinase works for any of those conditions. The data we hold shows insufficient evidence for angina, atherosclerosis, heart disease, and other conditions this product targets.
What are the side effects I should watch for?
The main risk is bleeding — nattokinase can cause rare but serious bleeding, including brain bleeding. It can also trigger allergic reactions in people sensitive to natto (fermented soy), from mild throat symptoms to anaphylaxis. Vertigo and unsteady gait have also been reported.
Is it safe to take this while pregnant or breastfeeding?
No — there isn't enough safety data for pregnancy, so it's best avoided. Safety while breastfeeding is unknown, so avoid it too. Talk to your doctor about safer options.
What is nattokinase and where does it come from?
Nattokinase is an enzyme made from fermented soy (natto). It works like a blood thinner in your body and may help break down clots, which is why it carries bleeding risk when combined with other thinners.
What if I'm allergic to soy — should I avoid this?
Yes — nattokinase comes from fermented soy and can trigger allergic reactions in people sensitive to natto, ranging from throat swelling to anaphylaxis. If you have a soy allergy, skip this product.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Heart Cholesterol Support is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Heart Cholesterol Support label
Go deeper

The Full Monographs Behind Heart Cholesterol Support’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Nattokinase

Interacts with 289 drugs

Nattokinase is an enzyme from the fermented soybean food natto that may have mild blood-thinning and blood-flow effects. Some small studies hint at benefits for blood pressure and circulatio...

Read the full Nattokinase monograph →
Sources

Sources & How We Checked

Heart Cholesterol Support's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 9 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Nattokinase 9 references
  1. Suzuki Y, Kondo K, Matsumoto Y, et al. Dietary supplementation of fermented soybean, natto, suppresses intimal thickening and modulates the lysis of mural thrombi after endothelial injury in rat femoral artery. Life Sci 2003;73:1289-98.. PubMed
  2. Sumi H, Hamada H, Nakanishi K, Hiratani H. Enchancement of fibrinolytic activity in plasma by oral administration of nattokinase. Acta Haematol 1990;84:139-43.
  3. Chang, Y. Y., Liu, J. S., Lai, S. L., Wu, H. S., and Lan, M. Y. Cerebellar hemorrhage provoked by combined use of nattokinase and aspirin in a patient with cerebral microbleeds. Intern Med 2008;47(5):467-469. PubMed
  4. Kim, J. Y., Gum, S. N., Paik, J. K., Lim, H. H., Kim, K. C., Ogasawara, K., Inoue, K., Park, S., Jang, Y., and Lee, J. H. Effects of nattokinase on blood pressure: a randomized, controlled trial. Hypertens.Res 2008;31(8):1583-1588. PubMed
  5. <p>Maruyama M, Sumi H (eds): Effect of natto diet on blood pressure, in Basic and Clinical Aspects of Japanese Traditional Food Natto II. Japan Technology Transfer Association (JTTAS), 1998, pp 1–3.</p>
  6. Kurosawa Y, Nirengi S, Homma T, et al. A single-dose of oral nattokinase potentiates thrombolysis and anti-coagulation profiles. Sci Rep 2015;5:11601. PubMed
  7. Ramachandran L, Aqeel A, Jafri A, Sidhu Y, Mohamed Djirdeh T. Nattokinase-associated hemoperitoneum in an elderly woman. Cureus 2021;13(12):e20074. PubMed
  8. Awatani-Yoshidome K, Hashimoto T, Satoh T. Anaphylaxis from nattokinase in a patient with fermented soybean (natto) allergy. Allergol Int 2022;71(1):153-4. PubMed
  9. Suzuki K, Nakamura M, Sato N, Futamura K, Matsunaga K, Yagami A. Nattokinase, a subtilisin family serine protease, is a novel allergen contained in the traditional Japanese fermented food natto. Allergol Int 2022.

See these in context on the Nattokinase monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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