Interaction check not available yet — this product's ingredients haven't been matched to our database.
Dietary supplement

Herb 360 Grape Seed Ingredients & Drug Interactions

by GNC Earth Genius

Herb 360 Grape Seed label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Herb 360 Grape Seed against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Herb 360 Grape Seed is a dietary supplement by GNC Earth Genius with 3 active ingredients.Based on those ingredients, 86 medications have a known interaction with it, the most serious rated moderate. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Herb 360 Grape Seed by GNC Earth Genius

Ask about any prescription or over-the-counter medication and we check it for interactions with Herb 360 Grape Seed by GNC Earth Genius — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
Prefer a human? Send your question to our licensed pharmacists — free, answered by email within 24 hours.

HelloPharmacist Scorecard of Herb 360 Grape Seed by GNC Earth Genius

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 6, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 2 of its 6 active ingredients.
  • “Fatty Acids” is listed as a grouped ingredient — the label gives one combined amount (225 mg) without saying how much of each component you get.
  • “Herb 360 Grape seed extract blend” is a proprietary blend — the label gives one combined amount (500 mg) without saying how much of each component you get.

This product contains 6 active ingredients: oleic acid, stearic acid, linoleic acid, palmitic acid, polyphenols, and proanthocyanidins—a mix sourced from a grape seed extract blend. Oleic acid is a fatty acid that may support cholesterol and heart health.

The polyphenols and proanthocyanidins are the plant compounds in grape seed extract that give it its antioxidant reputation, though the evidence we hold is limited to oleic acid alone. The product also contains two inactive ingredients (fillers/capsule materials): hydroxypropyl methylcellulose and silicon dioxide.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded Oleic Acid's overall clinical evidence instead.

Moderate

Some clinical evidence supports Oleic Acid for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredient's overall clinical evidence instead.
  • On file: Coronary heart disease (CHD) — rated "Possibly Effective" (Natural Medicines).
  • On file: Hypercholesterolemia — rated "Possibly Effective" (Natural Medicines).

The only ingredient in this product with established effectiveness data is oleic acid, which is rated possibly effective for high cholesterol and coronary heart disease. The grape seed extract compounds—polyphenols and proanthocyanidins—are often promoted for antioxidant benefits, but we hold no effectiveness ratings for them in our data.

If you're taking this mainly for those grape seed compounds, talk with your doctor about what the evidence actually supports for your situation.

How safe is it?

Some data gaps
Safety Information · database check
Some gaps

Safety data exists for these ingredients, but with some important gaps.

Why this rating?
  • We hold adverse-effect (side-effect) data for 0 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Oleic acid itself is generally well tolerated in normal food amounts (like olive oil). At supplement-level doses, though, safety data in pregnancy and breastfeeding is limited.

Food amounts are considered safe during these periods, but concentrated supplements haven't been well studied. We hold no safety information for the other active ingredients in this product.

If you're pregnant or breastfeeding, discuss this supplement with your doctor or pharmacist before starting.

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Oleic Acid.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 86 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check antidiabetes drugs (blood sugar medications) with your pharmacist before starting—oleic acid may increase their effects and lower your blood sugar more than intended. Several other ingredients in this product we could not fully assess for interactions, so run your complete medication list through the search tool on this page.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence behind its ingredients' uses. Moderate medication interactions have been identified, and some safety-information gaps remain.

This product may be worth considering if you're interested in grape seed extract and oleic acid for heart and cholesterol support, though the evidence is strongest for oleic acid alone. If you take blood sugar medications, be cautious—oleic acid may boost their effect.

Before starting, check your exact medications with your doctor or pharmacist, especially if you take any prescription drugs.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 6 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Apr 22, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Herb 360 Grape Seed, straight from the product label.

Brand GNC Earth Genius
Barcode (UPC) 048107187668
Net contents 30 Vegetarian Capsule(s)
Market status On market
Date entered into DSLD Apr 22, 2021
DSLD ID 243132
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Herb 360 Grape Seed by GNC Earth Genius, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
UPC/BARCODE
048107187668
IngredientAmount% DV
Stearic Acid0 NP--
Linoleic Acid0 NP--
Oleic Acid0 NP--
Palmitic Acid0 NP--
Polyphenols60 mg--
Proanthocyanidins30 mg--
Fatty Acids225 mg--
Herb 360 Grape seed extract blend500 mg--

Other ingredients: Hydroxypropyl Methylcellulose, Silicon Dioxide

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Precautions

Keep out of reach of children.

Warning: Consult your physician prior to using this product if you are pregnant, nursing, taking medication, or have a medical condition.

Discontinue use two weeks prior to surgery.

Storage

Store in a cool, dry place.

Brand IP Statement(s)

HERB 360 is a trademark of US Pharma Lab, Inc.

Formula

Delivers the benefits of whole grape seed the way nature intended

Formulation

GF Gluten free Non GMO

Vegan

FDA Statement of Identity

Herbal Supplement

Suggested/Recommended/Usage/Directions

Directions: As an herbal supplement, take one capsule daily.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Herb 360 Grape Seed by GNC Earth Genius label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Herb 360 Grape Seed label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Herb 360 Grape Seed by GNC Earth Genius

These are the 3 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Herb 360 Grape seed extract blend

500 mg per serving Form: Grape seed aqueous extract, Grape seed CO2 extract, Grape seed ethanol extract
  • › Polyphenols
  • › Proanthocyanidins
  • › Fatty Acids

Other (inactive) ingredients: Hydroxypropyl Methylcellulose, Silicon Dioxide. These complete the product’s ingredient list but are not active constituents.

Interaction report

Herb 360 Grape Seed by GNC Earth Genius Drug Interactions

Want to check YOUR meds against Herb 360 Grape Seed?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
86Drugs
86 Moderate

Ingredients driving the most interactions

Individual Drug Interactions

The ingredients in Herb 360 Grape Seed interact with 86 drugs. Click any drug to see the details.

0 of the 3 ingredients in Herb 360 Grape Seed interact with drugs. Each result below shows which ingredient is responsible.

Each ingredient & the kinds of drugs it affects

For each ingredient in Herb 360 Grape Seed with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

The maker

Brand information

Manufacturer and brand details for Herb 360 Grape Seed, from the product label.

GNC Earth Genius

See all GNC Earth Genius products
Name
General Nutrition Corporation
City
Pittsburgh
State
PA
ZipCode
15222
Phone Number
1-888-462-2548
Web Address
gnc.com
Pharmacist Counseling Corner

Herb 360 Grape Seed by GNC Earth Genius: Common Questions

Does Herb 360 Grape Seed by GNC Earth Genius interact with any medications?
Yes. Based on its ingredients, Herb 360 Grape Seed has a known interaction with 86 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Herb 360 Grape Seed contains 3 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this help my cholesterol?
Oleic acid, one ingredient here, is rated possibly effective for high cholesterol and heart disease. The other compounds (polyphenols, proanthocyanidins) are often marketed for antioxidant power, but we don't have effectiveness data for them. Talk with your doctor about whether this product fits your cholesterol plan.
Is this safe if I'm pregnant or breastfeeding?
Food amounts of oleic acid are considered safe during pregnancy and breastfeeding, but concentrated supplement doses haven't been well studied. We also don't have safety data on file for the other active ingredients at this dose level. Discuss this with your doctor or pharmacist before taking it.
What are proanthocyanidins and polyphenols?
They're plant compounds found naturally in grape seeds and known for antioxidant properties. They're the reason grape seed extract is popular in supplements, though the specific health benefits at supplement doses aren't well documented in our data.
I take metformin for diabetes—is this okay?
Oleic acid in this product may increase how well your blood sugar medication works, which could lower your blood sugar more than expected. Check with your pharmacist or doctor before starting to make sure it's safe with your specific dose and health situation.
Does this have any fillers?
Yes—it contains hydroxypropyl methylcellulose and silicon dioxide as inactive ingredients (the capsule material and flow agents). These are standard in supplements and generally well tolerated.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Herb 360 Grape Seed is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Herb 360 Grape Seed label
Sources

Sources & How We Checked

Herb 360 Grape Seed's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 19 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Oleic Acid 19 references
  1. Madigan C, Ryan M, Owens D, et al. Dietary unsaturated fatty acids in type 2 diabetes: higher levels of postprandial lipoprotein on a linoleic acid-rich sunflower oil diet compared with an oleic acid-rich olive oil diet. Diabetes Care 2000;23:1472-7. PubMed
  2. Gillingham, L. G., Gustafson, J. A., Han, S. Y., Jassal, D. S., and Jones, P. J. High-oleic rapeseed (canola) and flaxseed oils modulate serum lipids and inflammatory biomarkers in hypercholesterolaemic subjects. Br J Nutr 2011;105(3):417-427. PubMed
  3. Jones PJ, Senanayake VK, Pu S, Jenkins DJ, Connelly PW, Lamarche B, Couture P, Charest A, Baril-Gravel L, West SG, Liu X, Fleming JA, McCrea CE, Kris-Etherton PM. DHA-enriched high-oleic acid canola oil improves lipid profile and lowers predicted cardiova
  4. Cater, N. B., Heller, H. J., and Denke, M. A. Comparison of the effects of medium-chain triacylglycerols, palm oil, and high oleic acid sunflower oil on plasma triacylglycerol fatty acids and lipid and lipoprotein concentrations in humans. Am.J Clin.Nutr PubMed
  5. Mozaffarian D, Clarke R. Quantitative effects on cardiovascular risk factors and coronary heart disease risk of replacing partially hydrogenated vegetable oils with other fats and oils. Eur J Clin Nutr. 2009;63(Suppl 2):S22-33. PubMed
  6. Cao Y, Hou L, Wang W. Dietary total fat and fatty acids intake, serum fatty acids and risk of breast cancer: A meta-analysis of prospective cohort studies. Int J Cancer. 2016;138(8):1894-904. doi: 10.1002/ijc.29938. PubMed
  7. FDA completes review of qualified health claim petition for oleic acid and the risk of coronary heart disease. November 2018. Available at: www.fda.gov/Food/NewsEvents/ConstituentUpdates/ucm624758.htm. Accessed January 25, 2019.
  8. Liu X, Kris-Etherton PM, West SG, et al. Effects of canola and high-oleic-acid canola oils on abdominal fat mass in individuals with central obesity. Obesity. 2016;24(11):2261-2268. PubMed
  9. Bowen KJ, Kris-Etherton PM, West SG, et al. Diets enriched with conventional or high-oleic acid canola oils lower atherogenic lipids and lipoproteins compared to a diet with a western fatty acid profile in adults with central adiposity. J Nutr. 2019;149(3 PubMed
  10. Steffen BT, Duprez D, Szklo M, Guan W, Tsai MY. Circulating oleic acid levels are related to greater risks of cardiovascular events and all-cause mortality: The Multi-Ethnic Study of Atherosclerosis. J Clin Lipidol. 2018;12(6):1404-1412. PubMed
  11. Banim PJ, Luben R, Khaw KT, Hart AR. Dietary oleic acid is inversely associated with pancreatic cancer - Data from food diaries in a cohort study. Pancreatology. 2018;18(6):655-660. PubMed
  12. Morin SJ, Gaziano JM, Djoussé L. Relation between plasma phospholipid oleic acid and risk of heart failure. Eur J Nutr. 2018;57(8):2937-2942. PubMed
  13. Samieri C, Féart C, Proust-Lima C, et al. Olive oil consumption, plasma oleic acid, and stroke incidence: the Three-City Study. Neurology. 2011;77(5):418-25. PubMed
  14. Compher CW, Kinosian BP, Rubesin SE, Ratcliffe SJ, Metz DC. Energy absorption is reduced with oleic acid supplements in human short bowel syndrome. JPEN J Parenter Enteral Nutr. 2009;33(1):102-8. PubMed
  15. Ben Fradj MK, Ouanes Y, Hadj-Taieb S, et al. Decreased oleic acid and marine n?-?3 polyunsaturated fatty acids in Tunisian patients with urothelial bladder cancer. Nutr Cancer. 2018;70(7):1043-1050.
  16. de Silva PS, Luben R, Shrestha SS, Khaw KT, Hart AR. Dietary arachidonic and oleic acid intake in ulcerative colitis etiology: a prospective cohort study using 7-day food diaries. Eur J Gastroenterol Hepatol. 2014;26(1):11-8. PubMed
  17. Higashi K, Shige H, Ito T, et al. Effect of a low-fat diet enriched with oleic acid on postprandial lipemia in patients with type 2 diabetes mellitus. Lipids. 2001;36(1):1-6. PubMed
  18. Lin HC, van Citters GW, Heimer F, Bonorris G. Slowing of gastrointestinal transit by oleic acid: a preliminary report of a novel, nutrient-based treatment in humans. Dig Dis Sci. 2001;46(2):223-9. PubMed
  19. Li D, Tong Y, Li Y. Associations between dietary oleic acid and linoleic acid and depressive symptoms in perimenopausal women: The Study of Women's Health Across the Nation. Nutrition. 2020 Mar;71:110602. PubMed

See these in context on the Oleic Acid monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Supplement interaction checker › Check any supplement or product against your medications Drug–drug interactions › Check two or more of your medications against each other Browse medications A–Z › Every drug we've checked against herbs & supplements NDC & pricing lookup › Find a drug’s NDCs, packaging and costs Ask a pharmacist › Free, personal answer from our licensed team