Major interaction on record — check this product against your medications before combining. Based on 5 of 8 ingredients. Check your meds →
Dietary supplement

Herbal Laxative Ingredients & Drug Interactions

by Natures Craft

Herbal Laxative label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Herbal Laxative against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Herbal Laxative is a dietary supplement by Natures Craft with 8 active ingredients. Its ingredients are commonly taken for constipation and digestive health, high cholesterol, heart health.Based on those ingredients, 1,214 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Cascara Sagrada extract, Flaxseed powder, Aloe vera. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Herbal Laxative by Natures Craft

Ask about any prescription or over-the-counter medication and we check it for interactions with Herbal Laxative by Natures Craft — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Herbal Laxative by Natures Craft

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 6, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 8 active ingredients.
  • “Proprietary Blend” is a proprietary blend — the label gives one combined amount (1,090 mg) without saying how much of each component you get.

Herbal Laxative contains 8 ingredients total, including a proprietary blend. The active ingredients are flaxseed powder, aloe vera, psyllium husks powder, cascara sagrada extract, senna extract, and lactobacillus acidophilus—all designed to support bowel regularity and digestive health.

Flaxseed is a fiber source; aloe vera and cascara sagrada and senna are all stimulant laxatives that promote bowel movement; psyllium husks add bulk to stool; and lactobacillus acidophilus is a live probiotic that supports gut flora. The product also contains medium chain triglycerides and rice powder.

Inactive ingredients include gelatin (capsule material), vegetable magnesium stearate, stearic acid, and silicon dioxide (fillers and flow agents).

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: bowel function and occasional constipation relief.
  • We looked for evidence on: Constipation, Bowel preparation, Irritable bowel syndrome (IBS), occasional irregularity, digestive regularity.
  • The strongest evidence on file: Senna is rated "Likely Effective" for Constipation (Natural Medicines).
  • Also on file: Aloe is rated "Possibly Effective" for Constipation.
  • Also on file: Senna is rated "Possibly Effective" for Bowel preparation.

Flaxseed is possibly effective for constipation, high cholesterol, diabetes, and high blood pressure. Aloe vera is possibly effective for constipation, psoriasis, burns, diabetes, and acne.

Senna is likely effective for constipation and possibly effective for bowel preparation before procedures. Cascara sagrada has insufficient reliable evidence for constipation and is possibly ineffective for bowel preparation.

Lactobacillus acidophilus is possibly effective for irritable bowel syndrome, antibiotic-associated diarrhea, bacterial vaginosis, and helicobacter pylori infection, though it is possibly ineffective for atopic disease. We hold no effectiveness data for the other ingredients in this product.

The evidence, ingredient by ingredient Flaxseed Aloe Cascara Sagrada Senna Lactobacillus Acidophilus

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 5 of the 5 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 5 of 5.
  • General safety write-ups exist for 5 of 5.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Flaxseed is generally safe when taken as a food, but you should drink plenty of water and start with small amounts to minimize bloating and gas. At supplement doses, flaxseed may have hormone-like effects and should only be used if your doctor approves.

Safety data are insufficient for supplement doses while breastfeeding, so use caution. Aloe vera gel applied topically is generally well tolerated, but oral aloe latex carries serious risks and should be avoided during pregnancy because it may stimulate the uterus and act as a strong laxative, and during breastfeeding because of limited safety data.

Cascara sagrada is not recommended during pregnancy; its active compounds may pass into breast milk. Senna is considered possibly safe in pregnancy and lactation at standard doses, but only for short-term use under medical guidance.

Lactobacillus acidophilus is possibly safe in pregnancy and generally well tolerated in healthy adults, though data are limited. All ingredients may cause digestive side effects—bloating, gas, abdominal discomfort, cramping, and diarrhea are most common—especially at higher doses.

Side effects, ingredient by ingredient Flaxseed Aloe Cascara Sagrada Senna Lactobacillus Acidophilus

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 5 of the 5 matched ingredients can interact with medications — Aloe, Senna, Cascara Sagrada, Lactobacillus Acidophilus, Flaxseed.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications; heart-rhythm medications.
  • For scale: 1,215 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check with your doctor or pharmacist if you take digoxin (Lanoxin) for your heart—the most serious risk is potassium depletion and toxicity. Also check if you take warfarin or other blood thinners, diabetes medications, blood pressure medications, diuretic water pills, corticosteroids, estrogen-based birth control or hormone therapy, antibiotics, or any drug metabolized by the liver.

Separate antibiotics and this product by several hours if you do take them together.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with clinical evidence supporting its stated purpose. Major medication interactions have been identified, and safety information is well characterized.

This product is designed for short-term constipation relief through a combination of fiber, stimulant laxatives, and probiotics. It's not meant for daily long-term use without medical advice, especially because cascara sagrada and senna can cause serious electrolyte imbalances and interact with heart and blood-thinning medications.

If you take digoxin, warfarin, diabetes medications, blood pressure medications, diuretics, corticosteroids, estrogen-based medications, or antibiotics, check your specific medications with your doctor or pharmacist before starting this product.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 5 of 8 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jul 23, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Herbal Laxative, straight from the product label.

Brand Natures Craft
Barcode (UPC) X002AHM3NJ
Net contents 60 Capsule(s)
Market status On market
Date entered into DSLD Jul 23, 2020
DSLD ID 229178
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Herbal Laxative by Natures Craft, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
30
UPC/BARCODE
X002AHM3NJ
IngredientAmount% DV
Proprietary Blend1090 mg--
Medium Chain Triglycerides0 NP--
Rice powder0 NP--
Flaxseed powder0 NP--
Aloe vera0 NP--
Psyllium husks powder0 NP--
Cascara Sagrada extract0 NP--
Senna extract0 NP--
Lactobacillus acidophilus0 NP--

Other ingredients: Gelatin, Vegetable Magnesium Stearate, Stearic Acid, Silicon Dioxide

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested use: For occasional use only: 1 to 2 capsules taken at bedtime with 8 ounces of water or as directed by a healthcare professional. Short-term cleansing program: 1 to 2 capsules taken at bedtime with 8 ounces of water for up to 15 days or as directed by a healthcare professional. Do not repeat cleansing program for at least 6 to 8 weeks.

Precautions

Caution: Do not exceed recommended dose. Taking this product without adequate fluid may cause it to swell and block your throat or esophagus and may cause choking. Do not take this product if you have difficulty swallowing. If you experience chest pain, vomiting, or difficulty in swallowing or breathing after taking this product, seek immediate medical attention. Read and follow directions carefully.

This product contains cascara sagrada and senna leaves.

This product is not intended for pregnant or nursing mothers or children under the age of 18.

This product is not intended for pregnant or nursing mothers or children under the age of 18.

Do not use this product if you have abdominal pain, diarrhea or loose stools. Rectal bleeding and/or failure to have a bowel movement after the use of a laxative formula may be an indication of a more serious condition. Should this occur, or if you have a known medical condition and are taking medication, consult your physician prior to taking this or any dietary supplement.

This product is manufactured and packaged in a facility which may also process milk, soy, wheat, egg, peanuts, tree nuts, fish and crustacean shellfish.

Keep out of the reach of children.

Do not use if safety seal is damaged or missing.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Formulation

Herbal cleansing formula Intestinal system support Supports bowel function

Non-GMO formula

Formula

With psyllium husks powder

FDA Statement of Identity

Dietary Supplement

Storage

Store in a cool, dry place.

General Statements

Please recycle

Seals/Symbols

Formulated in the U.S.A.

Sourced from a GMP Certified Facility

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Herbal Laxative by Natures Craft label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Herbal Laxative label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Herbal Laxative by Natures Craft

These are the 8 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Proprietary Blend

1090 mg per serving

Other (inactive) ingredients: Gelatin, Vegetable Magnesium Stearate, Stearic Acid, Silicon Dioxide. These complete the product’s ingredient list but are not active constituents.

Interaction report

Herbal Laxative by Natures Craft Drug Interactions

Want to check YOUR meds against Herbal Laxative?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,214Drugs
1 Major 648 Moderate 565 Minor

Ingredients driving the most interactions

Cascara Sagrada extract 745
Flaxseed powder 597
Aloe vera 461
Lactobacillus acidophilus 182
Senna extract 140

Individual Drug Interactions

The ingredients in Herbal Laxative interact with 1,214 drugs. Click any drug to see the details.

5 of the 8 ingredients in Herbal Laxative interact with drugs. Each result below shows which ingredient is responsible. Cascara Sagrada extract Flaxseed powder Aloe vera Lactobacillus acidophilus Senna extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Herbal Laxative with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Cascara Sagrada extract6 drug types · 745 drugs

Corticosteroids

Theoretically, cascara sagrada might increase the risk of hypokalemia when taken with corticosteroids.
Cascara sagrada has stimulant laxative effects, and long-term use has been associated with hypokalemia.

Likelihood Possible Evidence D
Digoxin (Lanoxin)

Theoretically, cascara sagrada might cause hypokalemia, potentially increasing the risk of digoxin toxicity.
Cascara sagrada has stimulant laxative effects, and long-term use has been associated with hypokalemia.

Likelihood Possible Evidence D
Diuretic Drugs

Theoretically, cascara sagrada might increase the risk of hypokalemia when taken with diuretic drugs.
Cascara sagrada has stimulant laxative effects, and long-term use has been associated with hypokalemia.

Likelihood Possible Evidence D
Stimulant Laxatives

Theoretically, cascara sagrada might have additive adverse effects when taken with stimulant laxatives.
Cascara sagrada has stimulant laxative effects and might compound fluid and electrolyte losses when taken with stimulant laxatives.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Theoretically, cascara sagrada might increase the risk of bleeding when taken with warfarin.
Cascara sagrada has stimulant laxative effects. In some people, cascara sagrada can cause diarrhea. Diarrhea can increase the effects of warfarin, increase international normalized ratio (INR), and increase the risk of bleeding.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, cascara sagrada might decrease the effects of CYP3A4 substrates.
In vitro research suggests that cascara sagrada can induce CYP3A4 enzymes, albeit to a much lower degree than rifampin, a known CYP3A4 inducer.

Likelihood Possible Evidence D
Cascara Sagrada extract full monograph & interactions

Flaxseed powder5 drug types · 597 drugs

Antibiotic Drugs

Theoretically, antibiotics might interfere with the metabolism of flaxseed constituents, which could potentially alter the effects of flaxseed.
Some potential benefits of flaxseed are thought to be due to its lignan content. Secoisolariciresinol diglucoside (SDG), a major lignan precursor, is found in high concentrations in flaxseed. SDG is converted by bacteria in the colon to the lignans enterolactone and enterodiol. Antibiotics alter the flora of the colon, which could theoretically alter the metabolism of flaxseed.

Likelihood Possible Evidence D
Anticoagulant/Antiplatelet Drugs

Theoretically, using flaxseed in combination with anticoagulant or antiplatelet drugs might have additive effects and increase the risk of bleeding.
Some clinical evidence suggests that the oil contained in flaxseed can decrease platelet aggregation.

Likelihood Possible Evidence B
Antidiabetes Drugs

Theoretically, flaxseed might have additive effects when used with antidiabetes drugs and increase the risk for hypoglycemia.
Some clinical research suggests that flaxseed can lower blood glucose levels.

Likelihood Probable Evidence B
Antihypertensive Drugs

Theoretically, flaxseed might have additive effects when used with antihypertensive drugs and increase the risk of hypotension.
Clinical research shows that daily flaxseed consumption, especially for longer than 12 weeks, modestly reduces blood pressure.

Likelihood Possible Evidence D
Estrogens

Theoretically, taking flaxseed might decrease the effects of estrogens.
Flaxseed contains lignans with mild estrogenic and possible antiestrogenic effects. The lignans seem to compete with circulating endogenous estrogen and might reduce estrogen binding to estrogen receptors, resulting in an anti-estrogen effect. It is unclear if this effect transfers to exogenously administered estrogens.

Likelihood Possible Evidence D
Flaxseed powder full monograph & interactions

Aloe vera7 drug types · 461 drugs

Digoxin (Lanoxin)

Theoretically, aloe latex might increase the risk of adverse effects when taken with cardiac glycosides.
Overuse of aloe latex can increase the risk of adverse effects from cardiac glycoside drugs, such as digoxin, due to potassium depletion. Overuse of aloe, along with cardiac glycoside drugs, can increase the risk of toxicity.

Likelihood Probable Evidence D
Anticoagulant/Antiplatelet Drugs

Theoretically, aloe gel might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
In vitro research shows that aloe gel can inhibit platelet aggregation. This inhibition was greater than that seen with celecoxib, but less than that seen with aspirin.

Likelihood Possible Evidence D
Antidiabetes Drugs

Aloe might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Preliminary clinical research suggests aloe gel might lower blood glucose levels and have additive effects when used with antidiabetes drugs. Monitor blood glucose levels closely.

Likelihood Possible Evidence D
Diuretic Drugs

Theoretically, aloe latex might increase the risk of hypokalemia when taken with diuretic drugs.
Overuse of aloe latex might compound diuretic-induced potassium loss, increasing the risk of hypokalemia.

Likelihood Possible Evidence D
Stimulant Laxatives

Theoretically, aloe latex might increase the risk for fluid and electrolyte loss when taken with stimulant laxatives.
Due to cathartic laxative effects of aloe latex, concomitant use with other stimulant laxatives might compound fluid and electrolyte loss.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Theoretically, aloe latex might increase the risk of bleeding when taken with warfarin.
Aloe latex has stimulant laxative effects. In some people aloe latex can cause diarrhea. Diarrhea can increase the effects of warfarin, increase international normalized ratio (INR), and increase the risk of bleeding. Advise patients who take warfarin not to take excessive amounts of aloe vera.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, aloe might decrease the levels and clinical effects of CYP1A2 substrates.
In vitro research shows that aloe extract induces CYP1A2 enzymes.

Likelihood Possible Evidence D
Aloe vera full monograph & interactions

Lactobacillus acidophilus1 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L. acidophilus.
L. acidophilus preparations usually contain live and active organisms. Therefore, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and L. acidophilus preparations by at least two hours.

Likelihood Probable Evidence D
Lactobacillus acidophilus full monograph & interactions

Senna extract5 drug types · 140 drugs

Digoxin (Lanoxin)

Theoretically, senna might increase the risk of adverse effects when taken with digoxin.
Overuse/abuse of senna increases the risk of adverse effects from cardiac glycosides, such as digoxin, due to potassium depletion.

Likelihood Possible Evidence D
Diuretic Drugs

Theoretically, senna might increase the risk of hypokalemia when taken with diuretic drugs.
Overuse of senna might compound diuretic-induced potassium loss and increase the risk for hypokalemia.

Likelihood Possible Evidence D
Estrogens

Theoretically, taking senna may interfere with the absorption of exogenous estrogens.
Some preliminary clinical evidence suggests that senna reduces the absorption of estradiol and decreases serum concentrations of estrone and estrone sulfate by decreasing intestinal transit time.

Likelihood Possible Evidence B
Stimulant Laxatives

Theoretically, senna might increase the risk for fluid and electrolyte loss when taken with other stimulant laxatives.
Senna is a stimulant laxative; concomitant use with other stimulant laxatives might compound fluid and electrolyte loss.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Theoretically, excessive use of senna might increase the effects of warfarin.
Senna has stimulant laxative effects and can cause diarrhea. Diarrhea can increase the effects of warfarin, increase international normalized ratio (INR), and increase the risk of bleeding. In one case report, excessive use of senna for 3 weeks resulted in diarrhea, bloody stools, and an elevated INR of 11.9.

Likelihood Possible Evidence D
Senna extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Herbal Laxative, from the product label.

Natures Craft

See all Natures Craft products
Name
Nature's Craft
City
Monsey
State
NY
ZipCode
10952
Phone Number
408-599-3841
Web Address
shopnaturescraft.com
Pharmacist Counseling Corner

Herbal Laxative by Natures Craft: Common Questions

Does Herbal Laxative by Natures Craft interact with any medications?
Yes. Based on its ingredients, Herbal Laxative has a known interaction with 1,214 medications, including 1 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Herbal Laxative contains 8 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm pregnant?
The safety data vary by ingredient. Flaxseed and aloe vera are possibly unsafe in pregnancy—aloe especially can stimulate the uterus and act as a strong laxative, so they should be avoided. Cascara sagrada is also not recommended during pregnancy. Senna is considered possibly safe, but only short-term and under your doctor's guidance. Because this product contains multiple ingredients with different safety profiles, talk with your doctor or pharmacist about whether it's right for you.
Is it safe to take this while breastfeeding?
Flaxseed safety data are insufficient for breastfeeding at supplement doses. Aloe vera and cascara sagrada should be avoided—their active compounds may pass into breast milk and have laxative effects on your baby. Senna and lactobacillus acidophilus are considered possibly safe. Check with your doctor or pharmacist for personalized advice.
What's the main side effect I should expect?
Bloating, gas, abdominal cramping, and diarrhea are the most common side effects, especially when you first start or if you take higher doses. These happen because the product contains multiple fiber and laxative ingredients. Start with a small dose, drink plenty of water, and give your digestive system time to adjust.
Why does this product have so many laxative ingredients?
The product combines different types of laxatives—stimulant laxatives (aloe vera, cascara sagrada, senna) work by triggering muscle contractions in the bowel, while fiber sources (flaxseed and psyllium husks) add bulk to stool. A probiotic is also included to support healthy gut bacteria. The combination is designed for broader effect, but it also means more digestive side effects and more drug interactions are possible.
Is it okay to use this long-term?
No. The safety data and product design are for short-term use only. Long-term daily use of stimulant laxatives like cascara sagrada, senna, and aloe vera can cause serious potassium loss, muscle weakness, heart rhythm problems, and organ damage. Use this product occasionally for constipation relief, and talk with your doctor if you need help with ongoing bowel regularity.
What if I take antibiotics—should I skip this product?
Lactobacillus acidophilus in this product is a live organism, and antibiotics can kill it, making the probiotic less effective. If you're taking antibiotics, separate them from this product by a few hours. Talk with your pharmacist about the best timing for your specific antibiotic.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Herbal Laxative label
Go deeper

The Full Monographs Behind Herbal Laxative’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Flaxseed

Interacts with 597 drugs

Flaxseed is a nutritious food rich in fiber, omega-3 fats (ALA), and plant compounds called lignans. It is most reliably helpful for constipation and may modestly lower cholesterol, but evid...

Read the full Flaxseed monograph → Herb & supplement monograph

Aloe

Interacts with 461 drugs

Aloe vera gel is widely used on the skin for minor burns and irritation, and some research suggests it may help. Aloe latex (the yellow part) is a strong laxative that can cause cramping and...

Read the full Aloe monograph → Herb & supplement monograph

Cascara Sagrada

Interacts with 745 drugs

Cascara sagrada is a stimulant laxative made from the aged bark of a Pacific Northwest tree, used mainly for short-term relief of constipation. Because it can cause cramping, dehydration, an...

Read the full Cascara Sagrada monograph → Herb & supplement monograph

Senna

Interacts with 140 drugs

Senna is a plant-based stimulant laxative that is widely used and generally effective for short-term relief of constipation. It is best used occasionally and for only a few days at a time, s...

Read the full Senna monograph → Herb & supplement monograph

Lactobacillus Acidophilus

Interacts with 182 drugs

Lactobacillus acidophilus is a 'friendly' bacterium used as a probiotic to support gut and vaginal health. It is generally well tolerated in healthy people, and there is reasonable evidence...

Read the full Lactobacillus Acidophilus monograph →
Sources

Sources & How We Checked

Herbal Laxative's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 144 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Flaxseed 37 references
  1. Kolonel LN, Nomura AM, Cooney RV. Dietary fat and prostate cancer: current status. J Natl Cancer Inst 1999;91:414-28. PubMed
  2. Ramon JM, Bou R, Romea S, et al. Dietary fat intake and prostate cancer risk: a case-control study in Spain. Cancer Causes Control 2000;11:679-85. PubMed
  3. Thompson LU, Rickard SE, Cheung F, et al. Variability in anticancer lignan levels in flaxseed. Nutr Cancer 1997;27:26-30. PubMed
  4. Nordstrom DC, Honkanen VE, Nasu Y, et al. Alpha-linolenic acid in the treatment of rheumatoid arthritis. A double-blind, placebo-controlled and randomized study: flaxseed vs. safflower seed. Rheumatol Int 1995;14:231-4. PubMed
  5. Cunnane SC, Ganguli S, Menard C, et al. High alpha-linolenic acid flaxseed (Linum usitatissimum): some nutritional properties in humans. Br J Nutr 1993;69:443-53.
  6. Clark WF, Parbtani A, Huff MW, et al. Flaxseed: a potential treatment for lupus nephritis. Kidney Int 1995;48:475-80. PubMed
  7. Cunnane SC, Hamadeh MJ, Liede AC, et al. Nutritional attributes of traditional flaxseed in healthy young adults. Am J Clin Nutr 1995;61:62-8. PubMed
  8. De Stefani E, Deneo-Pellegrini H, Boffetta P, et al. Alpha-linolenic acid and risk of prostate cancer: a case-control study in Uruguay. Cancer Epidemiol Biomarkers Prev 2000;9:335-8.
  9. Giovannucci E, Rimm EB, Colditz GA, et al. A prospective study of dietary fat and risk of prostate cancer. J Natl Cancer Inst 1993;85:1571-9. PubMed
  10. Clark WF, Kortas C, Heidenheim P, et al. Flaxseed in lupus nephritis: a two-year nonplacebo-controlled crossover study. J Am Coll Nutr 2001;20:143-8. PubMed
  11. Serraino M, Thompson LU. The effect of flaxseed supplementation on early risk markers for mammary carcinogenesis. Cancer Lett 1991;60:135-42. PubMed
  12. Rickard SE, Yuan YV, Thompson LU. Plasma insulin-like growth factor I levels in rats are reduced by dietary supplementation of flaxseed or its lignan secoisolariciresinol diglycoside. Cancer Lett 2000;161:47-55. PubMed
  13. Mousavi Y, Adlercreutz H. Enterolactone and estradiol inhibit each other's proliferative effect on MCF-7 breast cancer cells in culture. J Steroid Biochem Mol Biol 1992;41:615-9.. PubMed
  14. Adlercreutz H, Fotsis T, Bannwart C, et al. Determination of urinary lignans and phytoestrogen metabolites, potential antiestrogens and anticarcinogens, in urine of women on various habitual diets. J Steroid Biochem 1986;25:791-7.. PubMed
  15. Rose DP. Dietary fiber and breast cancer. Nutr Cancer 1990;13:1-8.. PubMed
  16. Lemay A, Dodin S, Kadri N, et al. Flaxseed dietary supplement versus hormone replacement therapy in hypercholesterolemic menopausal women. Obstet Gynecol 2002;100:495-504.. DOI
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Aloe 41 references
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Cascara Sagrada 9 references
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Senna 42 references
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Lactobacillus Acidophilus 15 references
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