Huang Bo Ingredients & Drug Interactions
by Hawaii Pharm
What is this page for?
First and foremost: checking Huang Bo against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Huang Bo is a dietary supplement by Hawaii Pharm with 1 active ingredient. Its ingredients are commonly taken for digestive complaints and diarrhea, inflammation and joint discomfort, stress and weight management (in combination products).Based on those ingredients, 1,160 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Phellodendron chinense Bark Extract, Dry. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Huang Bo by Hawaii Pharm
Ask about any prescription or over-the-counter medication and we check it for interactions with Huang Bo by Hawaii Pharm — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Huang Bo by Hawaii Pharm
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
Huang Bo contains one active ingredient: phellodendron chinense bark extract in dry form. Phellodendron is a traditional herbal remedy used in Asian medicine, and this product delivers it as a liquid extract mixed with alcohol, water, and glycerin as inactive carrier ingredients.
Does it work?
Couldn't assess
The evidence for phellodendron is not established for the uses we have data on — acne, benign prostatic hyperplasia (prostate enlargement), diabetes, obesity, osteoarthritis, and peptic ulcers all show insufficient reliable evidence to rate its effectiveness. We hold no data on how well this product works for any condition.
How safe is it?
Well-documented data
Phellodendron has been used short-term in traditional medicine, but human safety data are limited. Avoid this product during pregnancy — berberine-containing herbs are rated likely unsafe.
Breastfeeding is not safe either, since berberine can pass into breast milk and may harm infants. Adverse effects are rare in the data we hold.
A combination product containing phellodendron and magnolia reported single cases of sexual dysfunction, shaking hands, numbness around the mouth, fatigue, headache, and heartburn in clinical trials, though it's unclear whether phellodendron was the cause.
Meds to double-check
Moderate interaction found
Check with your doctor or pharmacist before taking this product if you use CNS depressants (sedating medications), antihypertensive drugs (blood pressure medications), blood thinners or antiplatelet drugs, diabetes medications or metformin, or any drugs metabolized by CYP2D6, CYP2C9, or CYP3A4 enzymes — these can include many common prescriptions. Use the medication search tool on this page to verify your exact medications.
The bottom line
Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
Huang Bo is a single-ingredient phellodendron extract with substantial interaction potential — especially with blood pressure drugs, blood thinners, diabetes medications, and drugs your liver metabolizes. If you take any prescription medication, check it against this product's interactions before starting.
Pregnant and breastfeeding women should avoid it. Talk with your doctor or pharmacist about whether it's appropriate for you.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Oct 24, 2023.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Huang Bo, straight from the product label.
| Brand | Hawaii Pharm |
|---|---|
| Barcode (UPC) | 840253628275 |
| Net contents | 4 Fluid Ounce(s); 120 mL |
| Market status | On market |
| Date entered into DSLD | Oct 24, 2023 |
| DSLD ID | 301688 |
| Product type | Botanical |
| Supplement form | Liquid |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Gluten Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Huang Bo by Hawaii Pharm, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Phellodendron chinense Bark Extract, Dry | 983 mg | -- |
Other ingredients: Alcohol, Water, Glycerin
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Brand IP Statement(s)
Hawaii Pharm Herbal Extract Highest quality since 2008
Suggested/Recommended/Usage/Directions
Suggested use: Shake well before using. For adults add about 20-30 drops (0.7-1 mL, one full squeeze of the dropper bulb) to some juice or water, up to 4 times a day.
Precautions
Warning: We recommend to seek expert medical advice before taking.
Do not use if you are allergic to any ingredients.
Consult your physician before giving to children under 18, during pregnancy, if nursing or taking medications.
Consult your physician before giving to children under 18, during pregnancy, if nursing or taking medications.
May affect the ability to drive and operate machinery. May have contraindications, can cause side effects and adverse reactions. Do not use if seal is broken or missing.
Keep out of the reach of children!
Storage
Store in a cool dry place.
Seals/Symbols
cGMP Made in compliance with cGMP 21 CFR 111 in an FDA registered and inspected facility.
Organic Alcohol Based USA Made in United States of America
FDA Disclaimer Statement
This product has not been evaluated by the FDA and is not intended to diagnose, treat, cure or prevent any disease.
General Statements
Scan this QR-code to get 15% discount on your next purchase. Limited time deal.
Formula
Phellodendron chinense
Organic Alcohol Based
Formulation
Only natural ingredients Purity is laboratory tested and verified
All the raw materials are gluten-free by their nature No artificial colors, flavors, or preservatives
Not tested on animals
Organic Alcohol Based
Made in USA, Hawaii
FDA Statement of Identity
Herbal Supplement
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Huang Bo by Hawaii Pharm label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Huang Bo by Hawaii Pharm
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size0.7 mL Dosage formLiquid Servings per container120 Amounts shown are per serving.
Phellodendron chinense Bark Extract, Dry
Interacts with1,160 drugs
Phellodendron is a traditional Chinese medicine bark (Huang Bai) that contains berberine and other plant compounds with antimicrobial and anti-inflamm...
Phellodendron chinense Bark Extract, Dry monograph & interactionsOther (inactive) ingredients: Alcohol, Water, Glycerin. These complete the product’s ingredient list but are not active constituents.
Huang Bo by Hawaii Pharm Drug Interactions
HelloPharmacist Interaction Report
Huang Bo by Hawaii Pharm interacts with medications through its phellodendron chinense bark extract content.
The most serious documented interaction is with CNS depressants (sedating drugs) — phellodendron may add to their sedative effects because the extract contains berberine, which animal research suggests has sedative properties.
Read the full breakdown — every affected drug type, severity by severity
Phellodendron may also interact with antihypertensive drugs (blood pressure medications) by adding to their blood-pressure-lowering effects. It can affect how your body metabolizes several classes of medications: drugs broken down by CYP2D6, CYP2C9, and CYP3A4 enzymes — meaning the supplement could raise their levels in your bloodstream.
Blood thinners and antiplatelet drugs (like warfarin or aspirin) may have a higher bleeding risk when combined with phellodendron because berberine can slow platelet clumping.
The extract may also increase the risk of low blood sugar (hypoglycemia) if you take diabetes medications or metformin, since berberine research shows it can lower blood glucose. With metformin specifically, the combination may increase both the drug's benefits and its side effects.
Altogether, these interactions span 1,161 individual medications. Use the search tool below to check your exact prescriptions before starting this product.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Huang Bo?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Huang Bo interact with 1,160 drugs. Click any drug to see the details.
1 of the 1 ingredient in Huang Bo interact with drugs. Each result below shows which ingredient is responsible. Phellodendron chinense Bark Extract, Dry
Ado-trastuzumab EmtansineKadcyla
How Ado-trastuzumab Emtansine interacts with Huang Bo — through 1 ingredient. Tap an ingredient for the detail:
Phellodendron Chinense Bark Extract, DryCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, phellodendron might increase serum levels of drugs metabolized by CYP3A4.
Read the full Phellodendron Chinense Bark Extract, Dry + Ado-trastuzumab Emtansine interactionAbciximabReoPro
How Abciximab interacts with Huang Bo — through 1 ingredient. Tap an ingredient for the detail:
Phellodendron Chinense Bark Extract, DryAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, phellodendron might increase the risk of bleeding when used with anticoagulant or antiplatelet drugs.
Read the full Phellodendron Chinense Bark Extract, Dry + Abciximab interactionAbemaciclibVerzenio
How Abemaciclib interacts with Huang Bo — through 1 ingredient. Tap an ingredient for the detail:
Phellodendron Chinense Bark Extract, DryCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, phellodendron might increase serum levels of drugs metabolized by CYP3A4.
Read the full Phellodendron Chinense Bark Extract, Dry + Abemaciclib interactionAbiraterone
How Abiraterone interacts with Huang Bo — through 1 ingredient. Tap an ingredient for the detail:
Phellodendron Chinense Bark Extract, DryCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, phellodendron might increase serum levels of drugs metabolized by CYP3A4.
Read the full Phellodendron Chinense Bark Extract, Dry + Abiraterone interactionAbiraterone AcetateYonsa, Zytiga
How Abiraterone Acetate interacts with Huang Bo — through 1 ingredient. Tap an ingredient for the detail:
Phellodendron Chinense Bark Extract, DryCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, phellodendron might increase serum levels of drugs metabolized by CYP3A4.
Read the full Phellodendron Chinense Bark Extract, Dry + Abiraterone Acetate interactionAbrocitinibCibinqo
How Abrocitinib interacts with Huang Bo — through 1 ingredient. Tap an ingredient for the detail:
Phellodendron Chinense Bark Extract, DryAnticoagulant/antiplatelet Drugs, Cytochrome P450 2c9 (cyp2c9) Substrates Moderate
Interaction Summary
Theoretically, phellodendron might increase the risk of bleeding when used with anticoagulant or antiplatelet drugs.
Read the full Phellodendron Chinense Bark Extract, Dry + Abrocitinib interactionAcalabrutinibCalquence
How Acalabrutinib interacts with Huang Bo — through 1 ingredient. Tap an ingredient for the detail:
Phellodendron Chinense Bark Extract, DryCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, phellodendron might increase serum levels of drugs metabolized by CYP3A4.
Read the full Phellodendron Chinense Bark Extract, Dry + Acalabrutinib interactionAcarboseGlucobay, Prandase, Precose
How Acarbose interacts with Huang Bo — through 1 ingredient. Tap an ingredient for the detail:
Phellodendron Chinense Bark Extract, DryAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, phellodendron may increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Phellodendron Chinense Bark Extract, Dry + Acarbose interactionAcebutololRhotral, Sectral
How Acebutolol interacts with Huang Bo — through 1 ingredient. Tap an ingredient for the detail:
Phellodendron Chinense Bark Extract, DryAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, phellodendron might have additive effects with antihypertensive drugs.
Read the full Phellodendron Chinense Bark Extract, Dry + Acebutolol interactionAcenocoumarolSintrom
How Acenocoumarol interacts with Huang Bo — through 1 ingredient. Tap an ingredient for the detail:
Phellodendron Chinense Bark Extract, DryAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, phellodendron might increase the risk of bleeding when used with anticoagulant or antiplatelet drugs.
Read the full Phellodendron Chinense Bark Extract, Dry + Acenocoumarol interactionAcepromazineAtravet
How Acepromazine interacts with Huang Bo — through 1 ingredient. Tap an ingredient for the detail:
Phellodendron Chinense Bark Extract, DryCns Depressants Moderate
Interaction Summary
Theoretically, phellodendron might increase the sedative effects of CNS depressants.
Read the full Phellodendron Chinense Bark Extract, Dry + Acepromazine interactionAcetaminophen, AspirinGemnisyn
How Acetaminophen, Aspirin interacts with Huang Bo — through 1 ingredient. Tap an ingredient for the detail:
Phellodendron Chinense Bark Extract, DryAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, phellodendron might increase the risk of bleeding when used with anticoagulant or antiplatelet drugs.
Read the full Phellodendron Chinense Bark Extract, Dry + Acetaminophen, Aspirin interactionAcetaminophen, Aspirin, CaffeineExcedrin, Excedrin Extra Strength, Excedrin Migraine
How Acetaminophen, Aspirin, Caffeine interacts with Huang Bo — through 1 ingredient. Tap an ingredient for the detail:
Phellodendron Chinense Bark Extract, DryAnticoagulant/antiplatelet Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, phellodendron might increase the risk of bleeding when used with anticoagulant or antiplatelet drugs.
Read the full Phellodendron Chinense Bark Extract, Dry + Acetaminophen, Aspirin, Caffeine interactionAcetaminophen, Butalbital, CaffeineEsgic, Esgic Plus, Fiogesic, Fioricet, Repan, Tecnal +1 more
How Acetaminophen, Butalbital, Caffeine interacts with Huang Bo — through 1 ingredient. Tap an ingredient for the detail:
Phellodendron Chinense Bark Extract, DryCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, phellodendron might increase serum levels of drugs metabolized by CYP3A4.
Read the full Phellodendron Chinense Bark Extract, Dry + Acetaminophen, Butalbital, Caffeine interactionAcetaminophen, Butalbital, Caffeine, CodeineEsgic with Codeine, Fioricet w/ Codeine
How Acetaminophen, Butalbital, Caffeine, Codeine interacts with Huang Bo — through 1 ingredient. Tap an ingredient for the detail:
Phellodendron Chinense Bark Extract, DryCytochrome P450 3a4 (cyp3a4) Substrates, Cns Depressants +1 Moderate
Interaction Summary
Theoretically, phellodendron might increase serum levels of drugs metabolized by CYP3A4.
Read the full Phellodendron Chinense Bark Extract, Dry + Acetaminophen, Butalbital, Caffeine, Codeine interactionAcetaminophen, Butalbital, CodeineBancap w/ Codeine
How Acetaminophen, Butalbital, Codeine interacts with Huang Bo — through 1 ingredient. Tap an ingredient for the detail:
Phellodendron Chinense Bark Extract, DryCytochrome P450 2d6 (cyp2d6) Substrates, Cns Depressants Moderate
Interaction Summary
Theoretically, phellodendron might increase serum levels of drugs metabolized by CYP2D6.
Read the full Phellodendron Chinense Bark Extract, Dry + Acetaminophen, Butalbital, Codeine interactionAcetaminophen, Butalbital, Codeine PhosphatePhrenilin #3
How Acetaminophen, Butalbital, Codeine Phosphate interacts with Huang Bo — through 1 ingredient. Tap an ingredient for the detail:
Phellodendron Chinense Bark Extract, DryCns Depressants, Cytochrome P450 2d6 (cyp2d6) Substrates Moderate
Interaction Summary
Theoretically, phellodendron might increase the sedative effects of CNS depressants.
Read the full Phellodendron Chinense Bark Extract, Dry + Acetaminophen, Butalbital, Codeine Phosphate interactionAcetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, PhenylephrineHycomine Compound
How Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interacts with Huang Bo — through 1 ingredient. Tap an ingredient for the detail:
Phellodendron Chinense Bark Extract, DryCns Depressants, Cytochrome P450 3a4 (cyp3a4) Substrates +1 Moderate
Interaction Summary
Theoretically, phellodendron might increase the sedative effects of CNS depressants.
Read the full Phellodendron Chinense Bark Extract, Dry + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interactionAcetaminophen, Caffeine, CodeineGesic C15, Gesic C30, Gesic C8, Lenoltec 1, Lenoltec 2, Lenoltec 3 +1 more
How Acetaminophen, Caffeine, Codeine interacts with Huang Bo — through 1 ingredient. Tap an ingredient for the detail:
Phellodendron Chinense Bark Extract, DryCytochrome P450 2d6 (cyp2d6) Substrates, Cns Depressants +1 Moderate
Interaction Summary
Theoretically, phellodendron might increase serum levels of drugs metabolized by CYP2D6.
Read the full Phellodendron Chinense Bark Extract, Dry + Acetaminophen, Caffeine, Codeine interactionAcetaminophen, Caffeine, Codeine, SalicylamideCodalan No.1, Codalan No.2, Codalan No.3
How Acetaminophen, Caffeine, Codeine, Salicylamide interacts with Huang Bo — through 1 ingredient. Tap an ingredient for the detail:
Phellodendron Chinense Bark Extract, DryCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 2d6 (cyp2d6) Substrates +1 Moderate
Interaction Summary
Theoretically, phellodendron might increase serum levels of drugs metabolized by CYP3A4.
Read the full Phellodendron Chinense Bark Extract, Dry + Acetaminophen, Caffeine, Codeine, Salicylamide interactionAcetaminophen, Caffeine, DihydrocodeineDHC Plus, Panlor DC, Panlor SS
How Acetaminophen, Caffeine, Dihydrocodeine interacts with Huang Bo — through 1 ingredient. Tap an ingredient for the detail:
Phellodendron Chinense Bark Extract, DryCns Depressants, Cytochrome P450 3a4 (cyp3a4) Substrates +1 Moderate
Interaction Summary
Theoretically, phellodendron might increase the sedative effects of CNS depressants.
Read the full Phellodendron Chinense Bark Extract, Dry + Acetaminophen, Caffeine, Dihydrocodeine interactionAcetaminophen, Caffeine, IsomethepteneMigralam
How Acetaminophen, Caffeine, Isometheptene interacts with Huang Bo — through 1 ingredient. Tap an ingredient for the detail:
Phellodendron Chinense Bark Extract, DryCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, phellodendron might increase serum levels of drugs metabolized by CYP3A4.
Read the full Phellodendron Chinense Bark Extract, Dry + Acetaminophen, Caffeine, Isometheptene interactionAcetaminophen, Caffeine, PyrilamineMidol Max Strength Menstrual
How Acetaminophen, Caffeine, Pyrilamine interacts with Huang Bo — through 1 ingredient. Tap an ingredient for the detail:
Phellodendron Chinense Bark Extract, DryCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, phellodendron might increase serum levels of drugs metabolized by CYP3A4.
Read the full Phellodendron Chinense Bark Extract, Dry + Acetaminophen, Caffeine, Pyrilamine interactionAcetaminophen, Chlorpheniramine Maleate, Dextromethorphan HbrVicks Formula 44M Cough, Cold & Flu Relief
How Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interacts with Huang Bo — through 1 ingredient. Tap an ingredient for the detail:
Phellodendron Chinense Bark Extract, DryDextromethorphan (robitussin Dm, Others), Cytochrome P450 3a4 (cyp3a4) Substrates +1 Moderate
Interaction Summary
Theoretically, phellodendron may increase serum levels of dextromethorphan.
Read the full Phellodendron Chinense Bark Extract, Dry + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interactionAcetaminophen, Chlorpheniramine, Codeine, PhenylephrineColrex
How Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interacts with Huang Bo — through 1 ingredient. Tap an ingredient for the detail:
Phellodendron Chinense Bark Extract, DryCytochrome P450 2d6 (cyp2d6) Substrates, Cns Depressants +1 Moderate
Interaction Summary
Theoretically, phellodendron might increase serum levels of drugs metabolized by CYP2D6.
Read the full Phellodendron Chinense Bark Extract, Dry + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionAcetaminophen, Chlorpheniramine, DextromethorphanCoricidin II Extra Strength Cold and Flu
How Acetaminophen, Chlorpheniramine, Dextromethorphan interacts with Huang Bo — through 1 ingredient. Tap an ingredient for the detail:
Phellodendron Chinense Bark Extract, DryCytochrome P450 2d6 (cyp2d6) Substrates, Dextromethorphan (robitussin Dm, Others) +1 Moderate
Interaction Summary
Theoretically, phellodendron might increase serum levels of drugs metabolized by CYP2D6.
Read the full Phellodendron Chinense Bark Extract, Dry + Acetaminophen, Chlorpheniramine, Dextromethorphan interactionAcetaminophen, Chlorpheniramine, Dextromethorphan HydrobromideCoricidin HBP Maximum Strength Flu
How Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interacts with Huang Bo — through 1 ingredient. Tap an ingredient for the detail:
Phellodendron Chinense Bark Extract, DryCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 2d6 (cyp2d6) Substrates +1 Moderate
Interaction Summary
Theoretically, phellodendron might increase serum levels of drugs metabolized by CYP3A4.
Read the full Phellodendron Chinense Bark Extract, Dry + Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interactionAcetaminophen, Chlorpheniramine, Dextromethorphan, PhenylpropanolamineMulti Symptom Cold Relief
How Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interacts with Huang Bo — through 1 ingredient. Tap an ingredient for the detail:
Phellodendron Chinense Bark Extract, DryCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 2d6 (cyp2d6) Substrates +1 Moderate
Interaction Summary
Theoretically, phellodendron might increase serum levels of drugs metabolized by CYP3A4.
Read the full Phellodendron Chinense Bark Extract, Dry + Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interactionAcetaminophen, Chlorpheniramine, Dextromethorphan, PseudoephedrineChildren's Tylenol Cold Plus Cough, Tylenol Cold Ex Strength
How Acetaminophen, Chlorpheniramine, Dextromethorphan, Pseudoephedrine interacts with Huang Bo — through 1 ingredient. Tap an ingredient for the detail:
Phellodendron Chinense Bark Extract, DryDextromethorphan (robitussin Dm, Others), Cytochrome P450 3a4 (cyp3a4) Substrates +1 Moderate
Interaction Summary
Theoretically, phellodendron may increase serum levels of dextromethorphan.
Read the full Phellodendron Chinense Bark Extract, Dry + Acetaminophen, Chlorpheniramine, Dextromethorphan, Pseudoephedrine interactionAcetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, SalicylamideRhinogesic GG
How Acetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, Salicylamide interacts with Huang Bo — through 1 ingredient. Tap an ingredient for the detail:
Phellodendron Chinense Bark Extract, DryCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, phellodendron might increase serum levels of drugs metabolized by CYP3A4.
Read the full Phellodendron Chinense Bark Extract, Dry + Acetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, Salicylamide interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Huang Bo with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
Phellodendron chinense Bark Extract, Dry
Anticoagulant/Antiplatelet Drugs
Theoretically, phellodendron might increase the risk of bleeding when used with anticoagulant or antiplatelet drugs.
Phellodendron contains berberine. In vitro and in vivo research suggest that berberine can inhibit platelet aggregation. Theoretically, phellodendron might also inhibit platelet aggregation.
Antidiabetes Drugs
Theoretically, phellodendron may increase the risk of hypoglycemia when taken with antidiabetes drugs.
Phellodendron contains berberine. Clinical research shows that berberine may lower blood glucose levels. Theoretically, phellodendron might also lower blood glucose levels.
Antihypertensive Drugs
Theoretically, phellodendron might have additive effects with antihypertensive drugs.
Phellodendron contains berberine. Animal research suggests that berberine can have hypotensive effects. Also, a clinical study suggests that taking berberine in combination with amlodipine can lower systolic and diastolic blood pressure when compared with amlodipine alone. Theoretically, phellodendron might also reduce blood pressure.
Cns Depressants
Theoretically, phellodendron might increase the sedative effects of CNS depressants.
Phellodendron contains berberine. Animal research suggests that berberine may have sedative effects. Theoretically, phellodendron might also have CNS depressants effects.
Cyclosporine (Neoral, Sandimmune)
Theoretically, phellodendron might increase blood levels of cyclosporine.
Phellodendron contains berberine. Preliminary clinical research shows that berberine can reduce metabolism of cyclosporine and increase serum levels, likely through inhibition of cytochrome P450 3A4 (CYP3A4), which metabolizes cyclosporine. Theoretically, phellodendron might also reduce the metabolism of cyclosporine.
Cytochrome P450 2C9 (Cyp2C9) Substrates
Theoretically, phellodendron might increase serum levels of drugs metabolized by CYP2C9.
Phellodendron contains berberine. Preliminary clinical research shows that berberine can inhibit CYP2C9. Theoretically, phellodendron might also inhibit CYP2C9.
Cytochrome P450 2D6 (Cyp2D6) Substrates
Theoretically, phellodendron might increase serum levels of drugs metabolized by CYP2D6.
Phellodendron contains berberine. In vitro research and preliminary clinical evidence show that berberine can inhibit CYP2D6. Theoretically, phellodendron might also inhibit CYP2D6.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Theoretically, phellodendron might increase serum levels of drugs metabolized by CYP3A4.
Phellodendron contains berberine. In vitro research and preliminary clinical research show that berberine moderately inhibits CYP3A4. Theoretically, phellodendron might also inhibit CYP3A4.
Dextromethorphan (Robitussin Dm, Others)
Theoretically, phellodendron may increase serum levels of dextromethorphan.
Phellodendron contains berberine. Preliminary clinical research shows that berberine can inhibit cytochrome P450 2D6 (CYP2D6) activity and reduce the metabolism of dextromethorphan. Theoretically, phellodendron may also inhibit the metabolism of dextromethorphan.
Losartan (Cozaar)
Theoretically, phellodendron might reduce the therapeutic effects of losartan by decreasing its conversion to its active form.
Phellodendron contains berberine. Preliminary clinical research suggests that berberine can inhibit cytochrome P450 2C9 (CYP2C9) activity and reduce metabolism of losartan. Theoretically, phellodendron might also inhibit the metabolism of losartan.
Metformin (Glucophage)
Theoretically, phellodendron might increase the therapeutic and adverse effects of metformin.
Phellodendron contains berberine. In vitro and animal studies show that berberine can increase the systemic exposure and half-life of metformin, potentially increasing metformin's effects and side effects. This interaction seems to be most apparent when berberine is administered 2 hours prior to metformin. Taking berberine and metformin at the same time does not appear to increase systemic exposure to metformin. It is unclear if phellodendron might have this same effect.
Midazolam (Versed)
Theoretically, phellodendron might reduce metabolism of midazolam, which might increase the risk of severe adverse effects.
Phellodendron contains berberine. Preliminary clinical research shows that berberine can inhibit cytochrome P450 3A4 (CYP3A4) activity and reduce metabolism of midazolam. Theoretically, phellodendron might also inhibit the metabolism of midazolam.
Pentobarbital (Nembutal)
Theoretically, phellodendron might increase the sedative effect of pentobarbital.
Phellodendron contains berberine. Animal research shows that berberine can prolong pentobarbital-induced sleeping time. Theoretically, phellodendron might increase the sedative effects of pentobarbital.
Tacrolimus (Prograf)
Theoretically, phellodendron might increase blood levels of tacrolimus.
Phellodendron contains berberine. In a 16-year-old patient with idiopathic nephrotic syndrome who was being treated with tacrolimus 6.5 mg twice daily, intake of berberine 200 mg three times daily increased the blood concentration of tacrolimus from 8 to 22 ng/mL. Following a reduction of the tacrolimus dose to 3 mg daily, blood levels of tacrolimus decreased to 12 ng/mL. It is unclear if phellodendron might have this same effect.
Brand information
Manufacturer and brand details for Huang Bo, from the product label.
Hawaii Pharm
See all Hawaii Pharm products- Name
- Hawaii Pharm LLC
- Street Address
- 510 Sumner St. Ste. 613
- City
- Honolulu
- State
- HI
- ZipCode
- 96817
- Phone Number
- 888-854-2924
- Web Address
- www.hawaiipharm.com
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Sources & How We Checked
Huang Bo's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 22 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Phellodendron 22 references
- Chan E. Displacement of bilirubin from albumin by berberine. Biol Neonate 1993;63:201-8. PubMed
- Janbaz KH, Gilani AH. Studies on preventive and curative effects of berberine on chemical-induced hepatotoxicity in rodents. Fitoterapia 2000;71:25-33.. PubMed
- Wu X, Li Q, Xin H, Yu A, Zhong M. Effects of berberine on the blood concentration of cyclosporin A in renal transplanted recipients: clinical and pharmacokinetic study. Eur J Clin Pharmacol 2005;61:567-72. PubMed
- Garrison R, Chambliss WG. Effect of a proprietary Magnolia and Phellodendron extract on weight management: a pilot, double-blind, placebo-controlled clinical trial. Altern Ther Health Med 2006;12:50-4.
- Zhang Y, Li X, Zou D, et al. Treatment of type 2 diabetes and dyslipidemia with the natural plant alkaloid berberine. J Clin Endocrinol Metab 2008;93:2559-65. PubMed
- Budzinski JW, Foster BC, Vandenhoek S, Arnason JT. An in vitro evaluation of human cytochrome P450 3A4 inhibition by selected commercial herbal extracts and tinctures. Phytomedicine 2000;7:273-82. PubMed
- Chatterjee P, Franklin MR. Human cytochrome p450 inhibition and metabolic-intermediate complex formation by goldenseal extract and its methylenedioxyphenyl components. Drug Metab Dispos 2003;31:1391-7. PubMed
- Shanbhag, S. M., Kulkarni, H. J., and Gaitonde, B. B. Pharmacological actions of berberine on the central nervous system. Jpn.J Pharmacol 1970;20(4):482-487. PubMed
- Wu, J. F. and Liu, T. P. [Effects of berberine on platelet aggregation and plasma levels of TXB2 and 6-keto-PGF1 alpha in rats with reversible middle cerebral artery occlusion]. Yao Xue.Xue.Bao. 1995;30(2):98-102.
- Peng, W. H., Hsieh, M. T., and Wu, C. R. Effect of long-term administration of berberine on scopolamine-induced amnesia in rats. Jpn J Pharmacol 1997;74(3):261-266. DOI
- Sabir M and Bhide NK. Study of some pharmacological actions of berberine. Ind J Physiol & Pharmac 1971;15(3):111-132.
- Tripathi YB and Shukla SD. Berberis artistata inhibits PAF induced aggregation of rabbit platelets. Phytotherapy Research 1996;10:628-630.
- Yin, J., Xing, H., and Ye, J. Efficacy of berberine in patients with type 2 diabetes mellitus. Metabolism 2008;57(5):712-717. PubMed
- Zhang, H., Wei, J., Xue, R., Wu, J. D., Zhao, W., Wang, Z. Z., Wang, S. K., Zhou, Z. X., Song, D. Q., Wang, Y. M., Pan, H. N., Kong, W. J., and Jiang, J. D. Berberine lowers blood glucose in type 2 diabetes mellitus patients through increasing insulin re
- Guo, Y., Chen, Y., Tan, Z. R., Klaassen, C. D., and Zhou, H. H. Repeated administration of berberine inhibits cytochromes P450 in humans. Eur J Clin Pharmacol 2012;68(2):213-217. PubMed
- Wei, W., Zhao, H., Wang, A., Sui, M., Liang, K., Deng, H., Ma, Y., Zhang, Y., Zhang, H., and Guan, Y. A clinical study on the short-term effect of berberine in comparison to metformin on the metabolic characteristics of women with polycystic ovary syndro
- Hermann, R. and von, Richter O. Clinical evidence of herbal drugs as perpetrators of pharmacokinetic drug interactions. Planta Med 2012;78(13):1458-1477. PubMed
- Chun YT, Yip TT, Lau KL, and et al. A biochemical study on the hypotensive effect of berberine in rats. Gen Pharmac 1979;10:177-182. PubMed
- Hou Q, Han W, Fu X. Pharmacokinetic interaction between tacrolimus and berberine in a child with idiopathic nephrotic syndrome. Eur J Clin Pharmacol 2013;69(10):1861-2. PubMed
- Lan J, Zhao Y, Dong F, et al. Meta-analysis of the effect and safety of berberine in the treatment of type 2 diabetes mellitus, hyperlipemia and hypertension. J Ethnopharmacol. 2015;161:69-81. PubMed
- Kalman DS, Feldman S, Feldman R, et al. Effect of a proprietary magnolia and phellodendron extract on stress levels in healthy women: a pilot, double-blind, placebo-controlled clinical trial. Nutr J 2008;7:11.
- Lyu Y, Zhang Y, Yang M, et al. Pharmacokinetic interactions between metformin and berberine in rats: Role of oral administration sequences and microbiota. Life Sci. 2019;235:116818. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
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