Interactions on record — worth a quick check against your medications. Check your meds →
Dietary supplement

Inositol Nicotinate + Cr Ingredients & Drug Interactions

by Genestra Brands

Inositol Nicotinate + Cr label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Inositol Nicotinate + Cr against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Inositol Nicotinate + Cr is a dietary supplement by Genestra Brands with 2 active ingredients. Its ingredients are commonly taken for blood sugar support in type 2 diabetes, weight loss and appetite control, insulin sensitivity.Based on those ingredients, 256 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Inositol Nicotinate, Chromium. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Inositol Nicotinate + Cr by Genestra Brands

Ask about any prescription or over-the-counter medication and we check it for interactions with Inositol Nicotinate + Cr by Genestra Brands — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Inositol Nicotinate + Cr by Genestra Brands

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 13, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 2 of its 2 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains 2 active ingredients: chromium and inositol nicotinate. Chromium is a mineral that plays a role in how your body handles blood sugar and insulin sensitivity.

Inositol nicotinate is a compound your body converts to niacin, a B vitamin involved in energy metabolism and circulation. The capsule also contains inactive ingredients—cellulose, hypromellose, magnesium silicate, and magnesium stearate—which are common binders and fillers that help hold the capsule together.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: support healthy glucose metabolism and carbohydrate fat metabolism.
  • We looked for evidence on: Diabetes, Impaired glucose tolerance (Prediabetes), Hyperlipidemia, Metabolic syndrome, Chromium deficiency, Raynaud syndrome — and 3 related terms.
  • The strongest evidence on file: Chromium is rated "Likely Effective" for Chromium deficiency (Natural Medicines).
  • Also on file: Inositol Nicotinate is rated "Possibly Effective" for Raynaud syndrome.
  • Also on file: Chromium is rated "Possibly Effective" for Diabetes.

For chromium: the evidence shows it's likely effective for chromium deficiency and possibly effective for diabetes. It's rated possibly ineffective for prediabetes, schizophrenia, and high blood pressure.

For inositol nicotinate: it's rated possibly effective for Raynaud syndrome (a circulation condition affecting the fingers and toes). For scleroderma, intermittent claudication (leg pain with walking), psoriasis, restless legs syndrome, and migraine headache, the evidence isn't established well enough in our data to rate it.

The evidence, ingredient by ingredient Chromium Inositol Nicotinate

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Chromium is generally well tolerated at typical supplement doses. Most common side effects are gastrointestinal irritation, headaches, insomnia, irritability, and mood changes.

Rare serious effects include kidney and liver damage and blood cell problems; skin rashes and contact dermatitis have also been reported. High or long-term doses may pose risks, and extra supplement doses should be avoided unless your doctor recommends them—especially in pregnancy and breastfeeding, where only small amounts from diet or prenatal vitamins are considered acceptable.

Inositol nicotinate is generally well tolerated short-term but evidence on long-term safety is limited, and high-dose niacin compounds can affect your liver. Common side effects mirror niacin's: abdominal pain, constipation, diarrhea, flushing, heartburn, nausea, and vomiting—usually worse early on and manageable with meals or antacids.

Because inositol nicotinate converts to niacin, it may impair how your body handles blood sugar. Pregnancy and breastfeeding safety data are not on file for this ingredient.

Side effects, ingredient by ingredient Chromium Inositol Nicotinate

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 2 matched ingredients can interact with medications — Inositol Nicotinate, Chromium.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications.
  • For scale: 256 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, double-check with your doctor or pharmacist if you take any of the following: blood thinners or blood clot preventers (anticoagulant/antiplatelet drugs)—risk of increased bleeding; diabetes medications or insulin—risk of low blood sugar; thyroid hormone (levothyroxine/Synthroid)—may reduce absorption; cholesterol-lowering statins—risk of muscle damage; nicotine patches; or NSAIDs and aspirin regularly.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with clinical evidence supporting its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Inositol nicotinate + chromium may be an option if you're interested in blood sugar support or circulation, but it's not right for everyone. If you take diabetes medications, insulin, blood thinners, thyroid hormone, statins, or nicotine patches, you'll need to check with your doctor or pharmacist first—these combinations carry real interaction risks.

Talk it over with your own healthcare provider before starting.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Feb 23, 2016.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Inositol Nicotinate + Cr, straight from the product label.

Brand Genestra Brands
Barcode (UPC) 88319612491
Net contents 60 Vegetable Capsule(s)
Market status On market
Date entered into DSLD Feb 23, 2016
DSLD ID 55589
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses Nutrient, All Other
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Inositol Nicotinate + Cr by Genestra Brands, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
UPC/BARCODE
88319612491
IngredientAmount% DV
Chromium100 mcg--
Inositol Nicotinate300 mg--

Other ingredients: Cellulose, Hypromellose, Magnesium Silicate, Magnesium Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Recommended Adult Dose: Take one capsule daily with a meal or as recommended by your healthcare practitioner.

Precautions

Risk Information: If you are pregnant or breastfeeding, consult your healthcare practitioner prior to use

Quality Assurance: Safety-sealed for your protection and for product freshness. Do not use if outer seal is missing or broken.

Formulation

Guaranteed to contain no added wheat, starch, yeast, gluten, corn, soy, sodium, sugar, artificial colouring or flavouring, antimicrobial preservatives, dairy or animal products.

Ideal for vegans.

Storage

Store in a cool, dry place.

FDA Statement of Identity

MINERAL SUPPLEMENT

General Statements

Provides support for healthy glucose metabolism and helps the body to metabolize carbohydrates and fats. A factor in the maintenance of good health.

Seals/Symbols

Seroyal

General

V1.0 127

Formula

Inositol Nicotinate + Cr

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Inositol Nicotinate + Cr by Genestra Brands label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Inositol Nicotinate + Cr label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Inositol Nicotinate + Cr by Genestra Brands

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Chromium

Interacts with
178 drugs
100 mcg per serving Form: Chromium Nicotinate

Chromium is an essential trace mineral involved in how the body handles sugar and fat. Some studies suggest it may modestly help blood sugar control i...

Chromium monograph & interactions

Inositol Nicotinate

Interacts with
223 drugs
300 mg per serving

Inositol nicotinate is a 'no-flush' form of niacin marketed for cholesterol and circulation. Evidence that it works as well as regular niacin is weak...

Inositol Nicotinate monograph & interactions

Other (inactive) ingredients: Cellulose, Hypromellose, Magnesium Silicate, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Inositol Nicotinate + Cr by Genestra Brands Drug Interactions

Want to check YOUR meds against Inositol Nicotinate + Cr?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
256Drugs
226 Moderate 30 Minor

Ingredients driving the most interactions

Inositol Nicotinate 223
Chromium 178

Individual Drug Interactions

The ingredients in Inositol Nicotinate + Cr interact with 256 drugs. Click any drug to see the details.

2 of the 2 ingredients in Inositol Nicotinate + Cr interact with drugs. Each result below shows which ingredient is responsible. Inositol Nicotinate Chromium

Each ingredient & the kinds of drugs it affects

For each ingredient in Inositol Nicotinate + Cr with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Inositol Nicotinate4 drug types · 223 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, concomitant use of inositol nicotinate with anticoagulant or antiplatelet drugs might increase the risk of bleeding.
Inositol nicotinate has fibrinolytic effects, which may increase the risk of bleeding when used concomitantly with anticoagulant/antiplatelet drugs.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, inositol nicotinate might increase blood glucose levels and may diminish the effects of antidiabetes drugs.
Inositol nicotinate is metabolized to niacin in the body. Niacin can cause hyperglycemia, abnormal glucose tolerance, and glycosuria. Increased blood glucose monitoring may be necessary, particularly early in the course of treatment.

Likelihood Probable Evidence B
Hmg-Coa Reductase Inhibitors ("Statins")

Theoretically, concomitant use of inositol nicotinate and statins might increase the risk of myopathy and rhabdomyolysis.
Inositol nicotinate is metabolized to niacin in the body. Some case reports have raised concerns that niacin might increase the risk of myopathy and rhabdomyolysis when combined with statins However, a significantly increased risk of myopathy has not been demonstrated in clinical trials.

Likelihood Possible Evidence D
Transdermal Nicotine (Nicoderm)

Theoretically, concomitant use of inositol nicotinate and transdermal nicotine might increase the risk of flushing and dizziness.
Inositol nicotinate is metabolized to niacin in the body. Inositol nicotinate and nicotine can both cause flushing and dizziness.

Likelihood Possible Evidence D
Inositol Nicotinate full monograph & interactions

Chromium5 drug types · 178 drugs

Antidiabetes Drugs

Theoretically, chromium may have additive effects with antidiabetic agents and increase the risk of hypoglycemia.
Some research shows that taking chromium might lower blood glucose levels, especially in patients with poorly controlled type 2 diabetes.

Likelihood Possible Evidence A
Insulin

Theoretically, concomitant use of chromium and insulin might increase the risk of hypoglycemia.
In clinical research, chromium has been shown to increase insulin sensitivity,

Likelihood Possible Evidence B
Levothyroxine (Synthroid, Others)

Chromium might bind levothyroxine in the intestinal tract and decrease levothyroxine absorption.
Clinical research in healthy volunteers shows that taking chromium picolinate 1000 mcg with levothyroxine 1 mg decreases serum levels of levothyroxine by 17% when compared to taking levothyroxine alone. Advise patients to take levothyroxine at least 30 minutes before or 3-4 hours after taking chromium.

Likelihood Probable Evidence B
Aspirin

Theoretically, aspirin might increase chromium absorption.
Animal research suggests that aspirin may increase chromium absorption and chromium levels in the blood.

Likelihood Possible Evidence D
Nonsteroidal Anti-Inflammatory Drugs (Nsaids)

NSAIDs might increase chromium levels in the body.
Drugs that are prostaglandin inhibitors, such as NSAIDs, seem to increase chromium absorption and retention.

Likelihood Possible Evidence D
Chromium full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Inositol Nicotinate + Cr, from the product label.

Genestra Brands

Name
Seroyal International
Street Address
490 Elgin Mills Rd E
City
Richmond Hill
State
ON
ZipCode
L4C 0L8
Pharmacist Counseling Corner

Inositol Nicotinate + Cr by Genestra Brands: Common Questions

Does Inositol Nicotinate + Cr by Genestra Brands interact with any medications?
Yes. Based on its ingredients, Inositol Nicotinate + Cr has a known interaction with 256 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Inositol Nicotinate + Cr contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is inositol nicotinate, and what does it do in the body?
Inositol nicotinate is a compound your body converts to niacin, a B vitamin. It's involved in energy metabolism and may support circulation. This product includes it because it's rated possibly effective for Raynaud syndrome, a condition affecting blood flow to your fingers and toes.
Can I take this if I have diabetes or prediabetes?
Not without checking first. Both ingredients can affect blood sugar: chromium may lower it (increasing low-blood-sugar risk with diabetes drugs or insulin), while inositol nicotinate may raise it. Talk with your doctor or pharmacist before starting, especially if you're on diabetes medication.
Can I take this with my thyroid medication (levothyroxine)?
Chromium can bind to levothyroxine in your gut and reduce how much you absorb—research shows a 17% drop in blood levels. You'd need to talk with your doctor about whether this product is right for you and whether timing doses apart would help.
What are the most common side effects?
Chromium most commonly causes gastrointestinal irritation, headaches, insomnia, irritability, and mood changes. Inositol nicotinate commonly causes abdominal pain, constipation, diarrhea, flushing, heartburn, nausea, and vomiting—though these often improve if you take it with food and usually go away within two weeks.
Is it safe to take this while breastfeeding?
Chromium is rated likely safe for breastfeeding. Inositol nicotinate's breastfeeding safety data aren't on file. Check with your doctor or pharmacist before taking it while nursing so you can get personalized advice.
Can I use this if I'm taking aspirin or NSAIDs like ibuprofen regularly?
Aspirin and NSAIDs may increase how much chromium your body absorbs, which could raise chromium levels. If you take these regularly, mention it to your doctor or pharmacist before starting this product.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Inositol Nicotinate + Cr is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Inositol Nicotinate + Cr label
Go deeper

The Full Monographs Behind Inositol Nicotinate + Cr’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Chromium

Interacts with 178 drugs

Chromium is an essential trace mineral involved in how the body handles sugar and fat. Some studies suggest it may modestly help blood sugar control in certain people with type 2 diabetes, b...

Read the full Chromium monograph → Herb & supplement monograph

Inositol Nicotinate

Interacts with 223 drugs

Inositol nicotinate is a 'no-flush' form of niacin marketed for cholesterol and circulation. Evidence that it works as well as regular niacin is weak and inconsistent, and it is not a proven...

Read the full Inositol Nicotinate monograph →
Sources

Sources & How We Checked

Inositol Nicotinate + Cr's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 74 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Chromium 53 references
  1. Cerulli J, Grabe DW, Gauthier I, et al. Chromium picolinate toxicity. Ann Pharmacother 1998;32:428-31. PubMed
  2. Urberg M, Zemel MB. Evidence for synergism between chromium and nicotinic acid in the control of glucose tolerance in elderly humans. Metabolism 1987;36:896-9. PubMed
  3. Mohamedshah FY, Moser-Veillon PB, Yamini S, et al. Distribution of a stable isotope of chromium (53Cr) in serum, urine, and breast milk in lactating women. Am J Clin Nutr 1998;67:1250-5. PubMed
  4. Wasser WG, Feldman NS, D'Agati VD. Chronic renal failure after ingestion of over-the-counter chromium picolinate. [letter]. Ann Intern Med 1997;126:410. PubMed
  5. Mertz W. Interaction of chromium with insulin: a progress report. Nutr Rev 1998;56:174-7. PubMed
  6. Anderson RA. Chromium, glucose intolerance and diabetes. J Am Coll Nutr 1998;17:548-55. PubMed
  7. McLeod MN, Gaynes BN, Golden RN. Chromium potentiation of antidepressant pharmacotherapy for dysthymic disorder in 5 patients. J Clin Psych 1999;60:237-40. PubMed
  8. Fowler JF Jr. Systemic contact dermatitis caused by oral chromium picolinate. Cutis 2000;65:116. DOI
  9. Trent LK, Thieding-Cancel D. Effects of chromium picolinate on body composition. J Sports Med Phys Fitness 1995;35:273-80.
  10. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002.
  11. Rabinovitz H, Friedensohn A, Leibovitz A, et al. Effect of chromium supplementation on blood glucose and lipid levels in type 2 diabetes mellitus elderly patients. Int J Vitam Nutr Res 2004;74:178-82. PubMed
  12. Lanca S, Alves A, Vieira AI, et al. Chromium-induced toxic hepatitis. Eur J Intern Med 2002;13:518-20. PubMed
  13. Kockler DR, McCarthy MW, Lawson CL. Seizure activity and unresponsiveness after hydroxycut ingestion. Pharmacotherapy 2001;21:647-51.. PubMed
  14. Davidson JR, Abraham K, Connor KM, McLeod MN. Effectiveness of chromium in atypical depression: a placebo-controlled trial. Biol Psychiatry 2003;53:261-4.. PubMed
  15. Food Standards Agency. Medicines and Healthcare products Regulatory Agency (MHRA). Expert Group on Vitamins and Minerals. Available at: http://cot.food.gov.uk/sites/default/files/vitmin2003.pdf.
  16. Mouser JF, Hak EB, Helms RA, et al. Chromium and zinc concentrations in pediatric patients receiving long-term parenteral nutrition. Am J Health Syst Pharm 1999;56:1950-6. PubMed
  17. Stevens T, Qadri A, Zein NN. Two patients with acute liver injury associated with use of the herbal weight-loss supplement hydroxycut. Ann Intern Med 2005;142:477-8. PubMed
  18. Wani S, Weskamp C, Marple J, Spry L. Acute tubular necrosis associated with chromium picolinate-containing dietary supplement. Ann Pharmacother 2006;40:563-6. PubMed
  19. Kleefstra N, Houweling ST, Jansman FG, et al. Chromium treatment has no effect in patients with poorly controlled, insulin-treated type 2 diabetes in an obese Western population: a randomized, double-blind, placebo-controlled trial. Diabetes Care 2006;29: PubMed
  20. Martin J, Wang ZQ, Zhang XH, et al. Chromium picolinate supplementation attenuates body weight gain and increases insulin sensitivity in subjects with type 2 diabetes. Diabetes Care 2006;29:1826-32. PubMed
  21. Singer GM, Geohas J. The effect of chromium picolinate and biotin supplementation on glycemic control in poorly controlled patients with type 2 diabetes mellitus: a placebo-controlled, double-blinded, randomized trial. Diabetes Technol Ther 2006;8:636-43. PubMed
  22. John-Kalarickal J, Pearlman G, Carlson HE. New medications which decrease levothyroxine absorption. Thyroid 2007;17:763-5. PubMed
  23. Yazaki Y, Faridi Z, Ma Y, et al. A pilot study of chromium picolinate for weight loss. J Altern Complement Med 2010;16:291-9. PubMed
  24. Davis ML, Seaborn CD, and Stoecker BJ. Effects of over-the-counter drugs on chromium retention and urinary excretion in rats. Nutrition Research 1995;15(2):201-210.
  25. Young P, Turiansky G, Bonner M, and et al. Acute generalized exanthematous pustulosis induced by chromium picolinate. J.Am Acad.Dermatol. 1999;41(5 Pt 2):820-823. PubMed
  26. Gibb, H. J., Lees, P. S., Pinsky, P. F., and Rooney, B. C. Lung cancer among workers in chromium chemical production. Am J Ind.Med 2000;38(2):115-126. DOI
  27. Gibb, H. J., Lees, P. S., Pinsky, P. F., and Rooney, B. C. Clinical findings of irritation among chromium chemical production workers. Am J Ind.Med 2000;38(2):127-131. PubMed
  28. Pittler, M. H. and Ernst, E. Dietary supplements for body-weight reduction: a systematic review. Am.J.Clin Nutr. 2004;79(4):529-536. PubMed
  29. Pei, D., Hsieh, C. H., Hung, Y. J., Li, J. C., Lee, C. H., and Kuo, S. W. The influence of chromium chloride-containing milk to glycemic control of patients with type 2 diabetes mellitus: a randomized, double-blind, placebo-controlled trial. Metabolism 2 PubMed
  30. Hisatomi, K., Ishii, H., Hashiguchi, K., Seki, M., Ide, M., Sugiyama, K., Ishimoto, H., Nakayama, S., Mukae, H., and Kohno, S. Interstitial pneumonia caused by inhalation of fumes of nickel and chrome. Respirology. 2006;11(6):814-817. PubMed
  31. Kleefstra, N., Houweling, S. T., Bakker, S. J., Verhoeven, S., Gans, R. O., Meyboom-de Jong, B., and Bilo, H. J. Chromium treatment has no effect in patients with type 2 diabetes in a Western population: a randomized, double-blind, placebo-controlled tri DOI
  32. Parsons, A., Ingram, J., Inglis, J., Aveyard, P., Johnstone, E., Brown, K., Franklin, M., and Bermudez, I. A proof of concept randomised placebo controlled factorial trial to examine the efficacy of St John's wort for smoking cessation and chromium to pr
  33. Bagdon RE and Hazen RE. Skin permeation and cutaneous hypersensitivity as a basis for making risk assessments of chromium as a soil contaminant. Environ.Health Perspect. 1991;92:111-119. PubMed
  34. Bharmal, S. V., Moyes, V., Ahmed, S., and Grossman, A. Hypoglycaemia: possible mediation by chromium salt medication. Hormones.(Athens.) 2010;9(2):181-183. PubMed
  35. Krol, E., Krejpcio, Z., Byks, H., Bogdanski, P., and Pupek-Musialik, D. Effects of chromium brewer's yeast supplementation on body mass, blood carbohydrates, and lipids and minerals in type 2 diabetic patients. Biol.Trace Elem.Res. 2011;143(2):726-737.
  36. Unisa, S., Jagannath, P., Dhir, V., Khandelwal, C., Sarangi, L., and Roy, T. K. Population-based study to estimate prevalence and determine risk factors of gallbladder diseases in the rural Gangetic basin of North India. HPB (Oxford) 2011;13(2):117-125. PubMed
  37. Noda, S., Asano, Y., and Sato, S. Lichen planus in a patient with long-term exposure to chrome. Eur.J.Dermatol. 2011;21(3):417-418. PubMed
  38. Xiang, J., Sun, Z., and Huan, J. N. Intensive chromic acid burns and acute chromium poisoning with acute renal failure. Chin Med.J.(Engl.) 7-5-2011;124(13):2071-2073.
  39. Chhabra, D., Oda, K., Jagannath, P., Utsunomiya, H., Takekoshi, S., and Nimura, Y. Chronic heavy metal exposure and gallbladder cancer risk in India, a comparative study with Japan. Asian Pac.J.Cancer Prev. 2012;13(1):187-190. PubMed
  40. Huszonek, J. Over-the-counter chromium picolinate. Am J Psychiatry 1993;150(10):1560-1561. PubMed
  41. Bunner S and McGinnis R. Chromium-induced hypoglycemia. Psychosomatics 1998;39(3):298-299. PubMed
  42. Martin, W. R. and Fuller, R. E. Suspected chromium picolinate-induced rhabdomyolysis. Pharmacotherapy 1998;18(4):860-862. DOI
  43. Proctor, D. M., Fredrick, M. M., Scott, P. K., Paustenbach, D. J., and Finley, B. L. The prevalence of chromium allergy in the United States and its implications for setting soil cleanup: a cost-effectiveness case study. Regul.Toxicol Pharmacol 1998;28(1 PubMed
  44. De Marchi S, Cecchin E, De Marchi SU. Systemic allergic dermatitis resulting from oral administration of chromium with a food supplement. Contact Dermatitis 2014;70(2):123-5. PubMed
  45. Hedberg YS, Gumulka M, Lind ML, Matura M, Lidén C. Severe occupational chromium allergy despite cement legislation. Contact Dermatitis. 2014;70(5):321-3. PubMed
  46. Thyssen JP, Jellesen MS, Møller P, Menné T, Johansen JD. Allergic chromium dermatitis from wearing 'chromium-free' footwear. Contact Dermatitis 2014;70(3):185-7. PubMed
  47. Liu Y, Cotillard A, Vatier C, et al. A Dietary Supplement Containing Cinnamon, Chromium and Carnosine Decreases Fasting Plasma Glucose and Increases Lean Mass in Overweight or Obese Pre-Diabetic Subjects: A Randomized, Placebo-Controlled Trial. PLoS One.
  48. Jamilian M, Asemi Z. Chromium Supplementation and the Effects on Metabolic Status in Women with Polycystic Ovary Syndrome: A Randomized, Double-Blind, Placebo-Controlled Trial. Ann Nutr Metab. 2015;67(1):42-8. PubMed
  49. Guimarães MM, Carvalho AC, Silva MS. Effect of chromium supplementation on the glucose homeostasis and anthropometry of type 2 diabetic patients: Double blind, randomized clinical trial: Chromium, glucose homeostasis and anthropometry. J Trace Elem Med Bi PubMed
  50. Paiva AN, Lima JG, Medeiros AC, et al. Beneficial effects of oral chromium picolinate supplementation on glycemic control in patients with type 2 diabetes: A randomized clinical study. J Trace Elem Med Biol. 2015;32:66-72. PubMed
  51. Yin RV, Phung OJ. Effect of chromium supplementation on glycated hemoglobin and fasting plasma glucose in patients with diabetes mellitus. Nutr J. 2015;14:14. PubMed
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See these in context on the Chromium monograph →

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See these in context on the Inositol Nicotinate monograph →

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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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