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Dietary supplement

Kefiran Ingredients & Drug Interactions

by LaneInnovative

Kefiran label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Kefiran against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Kefiran is a dietary supplement by LaneInnovative with 2 active ingredients. Its ingredients are commonly taken for digestive health and balance, diarrhea (including antibiotic-related), vaginal yeast and bacterial infections.Based on those ingredients, 182 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Probiotic Culture Blend. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Kefiran by LaneInnovative

Ask about any prescription or over-the-counter medication and we check it for interactions with Kefiran by LaneInnovative — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Kefiran by LaneInnovative

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 13, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 1 of its 8 active ingredients.
  • “Probiotic Culture Blend” is a proprietary blend — the label doesn't break down how much of each component you get.

This product contains 8 active ingredients: a Probiotic Culture Blend made up of six Lactobacillus strains (including L. acidophilus LA-3 and L. helveticus SP-27), plus Kefiran, which is a polysaccharide derived from kefir cultures. These are live microorganisms and compounds intended to support your gut health.

The capsule also contains inactive ingredients—microcrystalline cellulose, hydrolyzed fiber, and water—which are standard binders and fillers.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded its ingredients' overall clinical evidence instead.

Moderate

Some clinical evidence supports its ingredients for:

Why this rating?
  • The label markets general wellness (“healthy digestion and well-being”), not a specific health condition, so there is no single claim to grade against clinical-evidence data.
  • Since the label doesn't commit to one use, we graded the ingredients' overall clinical evidence instead.
  • On file: Antibiotic-associated diarrhea — rated "Possibly Effective" (Lactobacillus Acidophilus) (Natural Medicines).
  • On file: Bacterial vaginosis — rated "Possibly Effective" (Lactobacillus Acidophilus) (Natural Medicines).
  • On file: Helicobacter pylori — rated "Possibly Effective" (Lactobacillus Acidophilus) (Natural Medicines).
  • On file: Irritable bowel syndrome (IBS) — rated "Possibly Effective" (Lactobacillus Acidophilus) (Natural Medicines).

The data we hold shows Lactobacillus acidophilus may be effective for irritable bowel syndrome (IBS), Helicobacter pylori infection, antibiotic-associated diarrhea, and bacterial vaginosis, though the evidence is still developing (rated Possibly Effective). For Lactobacillus helveticus, we don't have enough reliable evidence yet to rate it for any of the conditions it's been studied in, including hay fever, antibiotic-associated diarrhea, cognitive function, mood, rotaviral diarrhea, and exercise-related respiratory infections.

We hold no effectiveness data for Kefiran or the other strains in this product.

The evidence, ingredient by ingredient Lactobacillus Acidophilus Lactobacillus Helveticus

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Lactobacillus acidophilus is generally well tolerated in healthy adults and children, though the safety data advise checking with your doctor before you start. Lactobacillus helveticus is also generally well tolerated in healthy people, but if you're seriously ill or immunocompromised, be cautious—and check with your doctor first either way.

Both strains are live organisms, so there is a small theoretical concern they could cause infection in some patients, though most documented cases appear tied to bacteria already present in your body moving to other sites. Oral use of these probiotics may rarely cause mild gastrointestinal side effects like bloating, gas, abdominal discomfort, or diarrhea; a small number of trial participants reported rash and itching, though it's unclear if these were tied to the probiotics themselves.

Side effects, ingredient by ingredient Lactobacillus Acidophilus Lactobacillus Helveticus

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 2 matched ingredients can interact with medications — Lactobacillus Acidophilus, Lactobacillus Helveticus.
  • The most serious interaction on file is rated Moderate.
  • For scale: 182 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Antibiotic drugs are the main medication type to double-check before taking Kefiran. Because this product contains live probiotic organisms, antibiotics taken at the same time may kill them and make the probiotics less effective.

Space out your doses with your doctor's or pharmacist's help.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.

If you have IBS, antibiotic-associated diarrhea, or certain other gut or bacterial concerns, Lactobacillus acidophilus in this product may be worth trying—the evidence is developing. The other strains haven't been studied enough yet to know.

If you take antibiotics, you'll need to time this carefully to avoid reducing the probiotics' effectiveness. Check your medications and talk with your doctor or pharmacist before starting, especially if you're immunocompromised or seriously ill.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 8 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated May 19, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Kefiran, straight from the product label.

Brand LaneInnovative
Net contents 60 Veggie Capsule(s)
Market status On market
Date entered into DSLD May 19, 2022
DSLD ID 263545
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Kefiran by LaneInnovative, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
30
IngredientAmount% DV
Probiotic Culture Blend0 NP--
Kefiran20 mg--
Lactobacillus plantarum 14D0 NP--
Lactobacillus rhamnosus SP-10 NP--
Lactobacillus casei BGP-930 NP--
Lactobacillus acidophilus LA-30 NP--
Lactobacillus helveticus SP-270 NP--
Lactobacillus rhamnosus CRL-15050 NP--
Lactobacillus paracasei 101/370 NP--

Other ingredients: Microcrystalline Cellulose, Fiber, Hydrolyzed, Water

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Healthy digestion & well-being

The best of Kefir in a veggie capsule

No dairy No lactose No gluten

Vegan

Kefiran is produced through a simple fermentation process of Non-GMO rice. It has no animal sourced ingredient.

Kefiran capsules are very small and easy to swallow.

To ensure Kefiran meets the highest standards of quality, strict controls are applied at every stage of the manufacturing process. Kefiran is manufactured in a GMP facility.

What is Kefir? Kefir is a fermented milk beverage originating from one of the world's top longevity regions. The word Kefir is derived from the Turkish word Keif which translates to "feeling good". This fermented beverage is known for promoting healthy digestion and overall well-being. What is Kefiran? Kefiran is the best of the traditional kefir drink in a veggie capsule.

Kefiran contains no dairy, lactose or gluten.

Kefiran is vegan and low calorie.

During fermentation, the L. kefiranofaciens in traditional kefir produces kefiran, a polysaccharide that - along with the probiotic cultures - is believed to be the primary source of kefir's health benefits. Two Kefiran capsules provide 20 mg of kefiran, plus 50 billion CFU (colony forming units) of active probiotic cultures. Why take Kefiran? Most of the food in our modern diet is devoid of the healthy bacteria found in many traditional foods. Add Kefiran to your daily diet and enjoy the benefits of the traditional fermented beverage for healthy digestion, intestinal health and overall well-being.

Formula

Kefir nutrient +50 billion active probiotic cultures per serving

Kefiran polysaccharide from fermented non-GMO rice

Amount of kefiran, the polysaccharide Two kefiran capsules = One quart kefir milk Two capsules contain 20mg of kefiran, polysaccharide (the same amount found in a quart of traditional milk kefir) and 50 billion live probiotic cultures from 7 different good strains at the date of manufacture.

Two Kefiran capsules daily provides: 20 mg of kefiran, the polysaccharide 50 billion live cultures 7 probiotic strains

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Directions: For best results, take two capsules daily with a light meal.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Seals/Symbols

GMP Good Manufacturing Practices

General Statements

Please recycle

Storage

Store in a dry place at 72 degrees F or below.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Kefiran by LaneInnovative label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Kefiran label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Kefiran by LaneInnovative

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Probiotic Culture Blend

Interacts with
182 drugs
0 NP per serving

Lactobacillus acidophilus is a 'friendly' bacterium used as a probiotic to support gut and vaginal health. It is generally well tolerated in healthy p...

Probiotic Culture Blend monograph & interactions

Kefiran

20 mg per serving Form: Rice

Other (inactive) ingredients: Microcrystalline Cellulose, Fiber, Hydrolyzed, Water. These complete the product’s ingredient list but are not active constituents.

Interaction report

Kefiran by LaneInnovative Drug Interactions

Want to check YOUR meds against Kefiran?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
182Drugs
182 Moderate

Ingredients driving the most interactions

Probiotic Culture Blend 182

Individual Drug Interactions

The ingredients in Kefiran interact with 182 drugs. Click any drug to see the details.

1 of the 2 ingredients in Kefiran interact with drugs. Each result below shows which ingredient is responsible. Probiotic Culture Blend

Each ingredient & the kinds of drugs it affects

For each ingredient in Kefiran with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Probiotic Culture Blend1 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L. acidophilus.
L. acidophilus preparations usually contain live and active organisms. Therefore, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and L. acidophilus preparations by at least two hours.

Likelihood Probable Evidence D
Probiotic Culture Blend full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Kefiran, from the product label.

LaneInnovative

See all LaneInnovative products
Name
LaneInnovative, Inc.
City
Vero Beach
State
FL
ZipCode
32964
Phone Number
1-800-526-3005
Web Address
www.kefiranhealth.com
Pharmacist Counseling Corner

Kefiran by LaneInnovative: Common Questions

Does Kefiran by LaneInnovative interact with any medications?
Yes. Based on its ingredients, Kefiran has a known interaction with 182 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Kefiran contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this product while I'm on antibiotics?
Theoretically, yes, but timing matters. Antibiotics can kill the live organisms in this product and reduce how well they work. Talk to your doctor or pharmacist about separating the doses—they can help you figure out the right schedule.
Does Lactobacillus acidophilus in this product really help with IBS or diarrhea?
The evidence suggests it may help, though research is still ongoing. It's rated Possibly Effective for IBS, antibiotic-associated diarrhea, and a few other conditions. That means some studies show benefit, but we need more proof before we're certain.
Is this safe to take if I'm pregnant or breastfeeding?
Lactobacillus acidophilus is rated Possibly Safe in pregnancy. We don't have enough data on Lactobacillus helveticus in pregnancy or lactation to say either way. Talk with your doctor or pharmacist before starting—they know your full health picture and can give you personalized advice.
What's Kefiran and why is it in this product?
Kefiran is a polysaccharide compound from kefir cultures. We don't have effectiveness or interaction data on file for it, so we can't tell you exactly what role it plays in this formula. Your best bet is to ask the manufacturer directly about their intended use.
Can this product cause side effects?
It's generally well tolerated, but some people experience mild gastrointestinal effects like bloating, gas, or loose stools. These are uncommon. There's also a small theoretical concern about infection in seriously ill or immunocompromised patients, though most documented cases involved bacteria already in the body moving to other areas.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Kefiran is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Kefiran label
Go deeper

The Full Monographs Behind Kefiran’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Lactobacillus Acidophilus

Interacts with 182 drugs

Lactobacillus acidophilus is a 'friendly' bacterium used as a probiotic to support gut and vaginal health. It is generally well tolerated in healthy people, and there is reasonable evidence...

Read the full Lactobacillus Acidophilus monograph → Herb & supplement monograph

Lactobacillus Helveticus

Interacts with 182 drugs

Lactobacillus helveticus is a lactic acid bacterium used as a probiotic, often combined with other strains in mood, gut, and general wellness products. Early research is interesting—especial...

Read the full Lactobacillus Helveticus monograph →
Sources

Sources & How We Checked

Kefiran's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 17 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Lactobacillus Acidophilus 15 references
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Begtrup LM, de Muckadell OB, Kjeldsen J, Christensen RD, Jarbøl DE. Long-term treatment with probiotics in primary care patients with irritable bowel syndrome--a randomised, double-blind, placebo controlled trial. Scand J Gastroenterol 2013;48(10):1127-35 PubMed
  3. Chatterjee S, Kar P, Das T, Ray S, Gangulyt S, Rajendiran C, Mitra M. Randomised placebo-controlled double blind multicentric trial on efficacy and safety of Lactobacillus acidophilus LA-5 and Bifidobacterium BB-12 for prevention of antibiotic-associated
  4. Shavakhi A, Tabesh E, Yaghoutkar A, Hashemi H, Tabesh F, Khodadoostan M,Minakari M, Shavakhi S, Gholamrezaei A. The effects of multistrain probiotic compound on bismuth-containing quadruple therapy for Helicobacter pylori infection: a randomized placebo-c
  5. Karamali M, Dadkhah F, Sadrkhanlou M, et al. Effects of probiotic supplementation on glycaemic control and lipid profiles in gestational diabetes: a randomized, double-blind, placebo-controlled trial. Diabetes Metab 2016;42(4):234-41. PubMed
  6. Badehnoosh B, Karamali M, Zarrati M, et al. The effects of probiotic supplementation on biomarkers of inflammation, oxidative stress and pregnancy outcomes in gestational diabetes. J Matern Fetal Neonatal Med. 2018 May;31(9):1128-1136.
  7. Kumar S, Kumar R, Rohilla L, Jacob N, Yadav J, Sachdeva N. A high potency multi-strain probiotic improves glycemic control in children with new-onset type 1 diabetes mellitus: A randomized, double-blind, and placebo-controlled pilot study. Pediatr Diabete
  8. Shahriari A, Karimi E, Shahriari M, Aslani N, Khooshideh M, Arab A. The effect of probiotic supplementation on the risk of gestational diabetes mellitus among high-risk pregnant women: A parallel double-blind, randomized, placebo-controlled clinical trial PubMed
  9. Xiao SD, Zhang DZ, Lu H, et al. Multicenter, randomized, controlled trial of heat-killed Lactobacillus acidophilus LB in patients with chronic diarrhea. Adv Ther. 2003;20(5):253-60.
  10. Rossi F, Amadoro C, Gasperi M, Colavita G. Lactobacilli infection case reports in the last three years and safety implications. Nutrients. 2022;14(6):1178. PubMed
  11. Ozer M, Goksu SY, Shahverdiani A, Mustafa M. Lactobacillus acidophilus-induced endocarditis and associated splenic abscess. Case Rep Infect Dis 2020;2020:1382709.
  12. Sadrin S, Sennoune S, Gout B, et al. A 2-strain mixture of Lactobacillus acidophilus in the treatment of irritable bowel syndrome: A placebo-controlled randomized clinical trial. Dig Liver Dis 2020;52(5):534-540. PubMed
  13. Stoffer JN, Slingsby TJ, Giuliari GP. Lactobacillus acidophilus endophthalmitis after intravitreal bevacizumab injection requiring intraocular lens explantation. Can J Ophthalmol 2022;57(1):e21-e22. PubMed
  14. Cukovic-Cavka S, Likic R, Francetic I, Rustemovic N, Opacic M, Vucelic B. Lactobacillus acidophilus as a cause of liver abscess in a NOD2/CARD15-positive patient with Crohn's disease. Digestion 2006;73(2-3):107-10.
  15. Hui J, Ren Y, Wang Y, Han Q. Lactobacillus acidophilus endophthalmitis postcataract operation: A case report with a literature review. Ocul Immunol Inflamm 2023.

See these in context on the Lactobacillus Acidophilus monograph →

Lactobacillus Helveticus 2 references
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Rossi F, Amadoro C, Gasperi M, Colavita G. Lactobacilli infection case reports in the last three years and safety implications. Nutrients. 2022;14(6):1178. PubMed

See these in context on the Lactobacillus Helveticus monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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