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Dietary supplement

L-Citrulline DL-Malate 1:1 Ingredients & Drug Interactions

by BulkSupplements.com

L-Citrulline DL-Malate 1:1 label
See full label image
Powder Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking L-Citrulline DL-Malate 1:1 against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

L-Citrulline DL-Malate 1:1 is a dietary supplement by BulkSupplements.com with 2 active ingredients. Its ingredients are commonly taken for exercise performance, muscle soreness and fatigue, blood flow and circulation.Based on those ingredients, 178 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are L-Citrulline, DL-Malate. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against L-Citrulline DL-Malate 1:1 by BulkSupplements.com

Ask about any prescription or over-the-counter medication and we check it for interactions with L-Citrulline DL-Malate 1:1 by BulkSupplements.com — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of L-Citrulline DL-Malate 1:1 by BulkSupplements.com

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 13, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 2 of its 2 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

This powder contains 2 active ingredients: L-citrulline and DL-malate in a 1:1 ratio. L-citrulline is an amino acid your body converts to L-arginine, which plays a role in blood vessel function and circulation.

DL-malate is the salt form of malic acid, a compound found naturally in foods like apples. There are no other inactive ingredients listed.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded its ingredients' overall clinical evidence instead.

Moderate

Some clinical evidence supports its ingredients for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredients' overall clinical evidence instead.
  • On file: Athletic performance — rated "Possibly Effective" (L-citrulline) (Natural Medicines).
  • On file: Dry mouth — rated "Possibly Effective" (Malic Acid) (Natural Medicines).

L-citrulline is possibly effective for athletic performance. For other uses — including heart failure, cardiovascular disease, diabetes, and treating sarcopenia (age-related muscle loss) — the evidence is either insufficient to rate or possibly ineffective.

DL-malate is possibly effective for dry mouth; for acne, GERD, fatigue, fibromyalgia, and psoriasis, evidence is insufficient or not well established. If you're considering this supplement for a specific goal, talk it over with your doctor or pharmacist to see what the current research actually supports.

The evidence, ingredient by ingredient L-citrulline Malic Acid

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

L-citrulline is generally well tolerated in healthy adults, but long-term safety hasn't been fully studied. The most common side effects are gastrointestinal discomfort and heartburn.

A small number of patients with pulmonary hypertension reported cough. DL-malate (malic acid) is generally well tolerated in food amounts, but supplement safety is not well researched — diarrhea and nausea have been reported in one study, though it's unclear whether malic acid alone was responsible.

Because pregnancy safety data for L-citrulline are insufficient, the supplement should be avoided during pregnancy. L-citrulline should also be avoided while breastfeeding due to unknown safety.

DL-malate is likely safe in pregnancy, but supplement doses haven't been studied, so talk with your doctor before use during pregnancy or breastfeeding.

Side effects, ingredient by ingredient L-citrulline Malic Acid

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 2 matched ingredients can interact with medications — L-citrulline, Malic Acid.
  • The most serious interaction on file is rated Moderate.
  • For scale: 178 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check your medications before starting, especially if you take blood pressure medications (antihypertensive drugs) or erectile dysfunction drugs like sildenafil (phosphodiesterase-5 inhibitors). Both L-citrulline and DL-malate may lower blood pressure, and combining them with your medication could cause dizziness, lightheadedness, or unsafe drops in blood pressure.

Talk with your doctor or pharmacist about your specific situation.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.

This product may support athletic performance, but evidence for other uses is weak or unclear. The main concern is its interaction with blood pressure medications and erectile dysfunction drugs — if you take either, check with your doctor or pharmacist before starting.

Gastrointestinal side effects are possible. Because pregnancy and breastfeeding safety are not well studied (or not safe for L-citrulline), pregnant or nursing women should discuss this supplement with their healthcare provider before use.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Nov 19, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about L-Citrulline DL-Malate 1:1, straight from the product label.

Brand BulkSupplements.com
Barcode (UPC) X000HNRXJH
Net contents 100 Gram(s); 3.5 oz
Market status On market
Date entered into DSLD Nov 19, 2021
DSLD ID 253880
Product type Other Combinations
Supplement form Powder
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for L-Citrulline DL-Malate 1:1 by BulkSupplements.com, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
3000 mg
Maximum serving Sizes:
3000 mg
Servings per container
33
UPC/BARCODE
X000HNRXJH
IngredientAmount% DV
L-Citrulline1680 mg--
DL-Malate1320 mg--

Other ingredients: None

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Clean & pure bulk supplements

New - BulkSupplements L-Citrulline DL-Malate 1:1 Powder (100 Grams)

FDA Disclaimer Statement

Warning: This product is not intended to diagnose, treat, cure, or prevent any disease.

Precautions

Always consult a physician before taking any dietary supplement.

Keep out of reach of children.

Formulation

Free of: Added sugar, soy, dairy, yeast, gluten, additives

Suggested/Recommended/Usage/Directions

Suggested Use: As a dietary supplement, take 3000 mg (about 1 1/5 tsp) once or twice daily, or as directed by a physician.

Storage

Store in a dry, cool place

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

L-Citrulline DL-Malate 1:1 by BulkSupplements.com label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

L-Citrulline DL-Malate 1:1 label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in L-Citrulline DL-Malate 1:1 by BulkSupplements.com

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size3000 mg Dosage formPowder Servings per container33 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

L-Citrulline

Interacts with
178 drugs
1680 mg per serving

L-citrulline is an amino acid that the body turns into L-arginine to help make nitric oxide, which relaxes blood vessels and may improve blood flow. I...

L-Citrulline monograph & interactions

DL-Malate

Interacts with
172 drugs
1320 mg per serving

Malic acid is a natural acid found in apples and other fruits, often combined with magnesium in supplements marketed for fibromyalgia and muscle pain....

DL-Malate monograph & interactions

Other (inactive) ingredients: None. These complete the product’s ingredient list but are not active constituents.

Interaction report

L-Citrulline DL-Malate 1:1 by BulkSupplements.com Drug Interactions

Want to check YOUR meds against L-Citrulline DL-Malate 1:1?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
178Drugs
178 Moderate

Ingredients driving the most interactions

L-Citrulline 178
DL-Malate 172

Individual Drug Interactions

The ingredients in L-Citrulline DL-Malate 1:1 interact with 178 drugs. Click any drug to see the details.

2 of the 2 ingredients in L-Citrulline DL-Malate 1:1 interact with drugs. Each result below shows which ingredient is responsible. L-Citrulline DL-Malate

Each ingredient & the kinds of drugs it affects

For each ingredient in L-Citrulline DL-Malate 1:1 with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

L-Citrulline2 drug types · 178 drugs

Antihypertensive Drugs

Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
L-citrulline is converted to L-arginine, which can increase nitric oxide and cause vasodilation. However, a meta-analysis of 5 small clinical studies suggests that taking L-citrulline 3-6 grams daily for 1-8 weeks does not lower blood pressure when compared with control.

Likelihood Possible Evidence B
Phosphodiesterase-5 Inhibitors

Theoretically, concurrent use of phosphodiesterase-5 (PDE-5) inhibitors and L-citrulline might result in additive vasodilation.
L-citrulline is converted to L-arginine, which can increase nitric oxide and cause vasodilation. Theoretically, taking L-arginine with PDE-5 inhibitors might have additive vasodilatory and hypotensive effects. However, in studies evaluating the combined use of L-arginine and sildenafil for erectile dysfunction, hypotension was not reported.

Likelihood Possible Evidence D
L-Citrulline full monograph & interactions

DL-Malate1 drug type · 172 drugs

Antihypertensive Drugs

Theoretically, malic acid might increase the risk of hypotension when taken with antihypertensive drugs.
Animal research shows that malic acid isolated from tagetes roots can reduce mean arterial blood pressure.

Likelihood Possible Evidence D
DL-Malate full monograph & interactions
The maker

Brand information

Manufacturer and brand details for L-Citrulline DL-Malate 1:1, from the product label.

BulkSupplements.com

See all BulkSupplements.com products
Name
BulkSupplements.com
Street Address
7511 Eastgate Rd
City
Henderson
State
NV
ZipCode
89011
Web Address
BulkSupplements.com
Pharmacist Counseling Corner

L-Citrulline DL-Malate 1:1 by BulkSupplements.com: Common Questions

Does L-Citrulline DL-Malate 1:1 by BulkSupplements.com interact with any medications?
Yes. Based on its ingredients, L-Citrulline DL-Malate 1:1 has a known interaction with 178 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
L-Citrulline DL-Malate 1:1 contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm pregnant or breastfeeding?
Not without talking to your doctor first. L-citrulline should be avoided during pregnancy and breastfeeding because there isn't enough safety data. DL-malate is likely safe in food amounts during pregnancy, but supplement doses haven't been studied. Your doctor or pharmacist can give you personalized advice.
What are the side effects?
The most common ones are gastrointestinal discomfort and heartburn. A small number of people with pulmonary hypertension reported cough. Diarrhea and nausea have been reported in studies, though it's unclear which ingredient caused them. Stop and talk with your doctor if side effects are bothersome.
Does L-citrulline actually improve athletic performance?
L-citrulline is possibly effective for athletic performance based on available evidence, but the research is still limited. It's one of the better-supported uses for this ingredient. Your results will depend on your training, diet, and overall routine.
What is DL-malate and why is it in this product?
DL-malate is the salt form of malic acid, a compound found in apples and other foods. It's possibly effective for dry mouth. Here it's paired with L-citrulline in a 1:1 ratio, though the reason for that specific combination isn't explained in the product facts.
Is it safe to use long-term?
L-citrulline is generally well tolerated, but long-term safety hasn't been fully studied. DL-malate safety at supplement doses also isn't well researched. If you're thinking of using it regularly, talk with your doctor or pharmacist to make sure it's right for you.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

L-Citrulline DL-Malate 1:1 label
Go deeper

The Full Monographs Behind L-Citrulline DL-Malate 1:1’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

L-citrulline

Interacts with 178 drugs

L-citrulline is an amino acid that the body turns into L-arginine to help make nitric oxide, which relaxes blood vessels and may improve blood flow. It is popular for exercise performance an...

Read the full L-citrulline monograph → Herb & supplement monograph

Malic Acid

Interacts with 172 drugs

Malic acid is a natural acid found in apples and other fruits, often combined with magnesium in supplements marketed for fibromyalgia and muscle pain. The evidence for its health benefits is...

Read the full Malic Acid monograph →
Sources

Sources & How We Checked

L-Citrulline DL-Malate 1:1's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 15 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

L-citrulline 8 references
  1. Cheng JW, Balwin SN. L-arginine in the management of cardiovascular diseases. Ann Pharmacother 2001;35:755-64. PubMed
  2. Schwedhelm E, Maas R, Freese R, et al. Pharmacokinetic and pharmacodynamic properties of oral L-citrulline and L-arginine: impact on nitric oxide metabolism. Br J Clin Pharmacol 2008;65:51-9. PubMed
  3. Romero MJ, Platt DH, Caldwell RB, Caldwell RW. Therapeutic use of citrulline in cardiovascular disease. Cardiovasc Drug Rev 2006;24:275-90. PubMed
  4. Balderas-Munoz K, Castillo-Martínez L, Orea-Tejeda A, et al. Improvement of ventricular function in systolic heart failure patients with oral L-citrulline supplementation. Cardiol J 2012;19:612-7. PubMed
  5. Sharif Kashani B, Tahmaseb Pour P, Malekmohammad M, et al. Oral l-citrulline malate in patients with idiopathic pulmonary arterial hypertension and Eisenmenger Syndrome: a clinical trial. J Cardiol 2014;64:231-5. PubMed
  6. Pérez-Guisado J, Jakeman PM. Citrulline malate enhances athletic anaerobic performance and relieves muscle soreness. J Strength Cond Res 2010;24:1215-22. PubMed
  7. Mirenayat MS, Moradi S, Mohammadi H, Rouhani MH. Effect of L-citrulline supplementation on blood pressure: a systematic review and meta-analysis of clinical trials. Curr Hypertens Rep. 2018;20(11):98. PubMed
  8. Xu Z, Liu C, Liu S, Zhou Z. Comparison of efficacy and safety of daily oral L-arginine and PDE5Is alone or combination in treating erectile dysfunction: A systematic review and meta-analysis of randomised controlled trials. Andrologia. 2021:e14007. PubMed

See these in context on the L-citrulline monograph →

Malic Acid 7 references
  1. Russell IJ, Michalek JE, Flechas JD, Abraham GE. Treatment of fibromyalgia syndrome with Super Malic: a randomized, double blind, placebo controlled, crossover pilot study. J Rheumatol 1995;22:953-8.
  2. Fiume, Z. Final report on the safety assessment of malic acid and sodium malate. Int J Toxicol 2001;20 Suppl 1:47-55. PubMed
  3. Electronic Code of Federal Regulations. Title 21. Part 184 - Direct Food Substances Affirmed as Generally Recognized as Safe. Available at: http://www.ecfr.gov/cgi-bin/text-idx?c=ecfr&sid=786bafc6f6343634fbf79fcdca7061e1&rgn=div5&view=text&node=21:3.0.1.1
  4. Saleem R, Ahmad M, Naz A, et al. Hypotensive and toxicological study of citric acid and other constituents from Tagetes patula roots. Arch Pharm Res 2004;27(10):1037-42.
  5. Chiriac A, Brzezinski P. Topical malic acid in combination with citric acid: an option to treat recalcitrant warts. Dermatol Ther. 2015;28(6):336-8. PubMed
  6. CFR - Code of Federal Regulations Title 21 SUBCHAPTER B. 184.1069 Malic Acid. Food and Drug Administration Department Of Health And Human Services. Updated April 1, 2017. https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=184.1069.
  7. Amended Safety Assessment of Malic Acid and Sodium Malate as Used in Cosmetics. Cosmetic Ingredient Review Expert Panel. Updated May 19, 2017. http://www.cir-safety.org/sites/default/files/malic%20acid.pdf. Accessed January 24, 2018.

See these in context on the Malic Acid monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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