L-Glutamine 5000 mg Unflavored Ingredients & Drug Interactions
What is this page for?
First and foremost: checking L-Glutamine 5000 mg Unflavored against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
L-Glutamine 5000 mg Unflavored is a dietary supplement by GNC Pro Performance with 1 active ingredient. Its ingredients are commonly taken for muscle recovery and sports performance, gut health and 'leaky gut', recovery from severe illness or injury.Based on those ingredients, 50 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are L-Glutamine. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against L-Glutamine 5000 mg Unflavored by GNC Pro Performance
Ask about any prescription or over-the-counter medication and we check it for interactions with L-Glutamine 5000 mg Unflavored by GNC Pro Performance — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of L-Glutamine 5000 mg Unflavored by GNC Pro Performance
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This is a straightforward single-ingredient product: 5,000 mg of L-glutamine per serving, an amino acid your body makes naturally. L-glutamine is used by your cells for energy and immune function, and it plays a role in gut health and muscle recovery.
There are no inactive ingredients listed.
Does it work?
Strong evidence
The evidence for L-glutamine is strongest for sickle cell disease, where it's rated effective. For HIV/AIDS-related wasting, postoperative (after-surgery) recovery, and critical illness from trauma, the evidence is rated possibly effective — meaning the studies suggest it may help, but more research is needed to be sure.
We hold no effectiveness data for other uses.
How safe is it?
Well-documented data
L-glutamine is generally well tolerated in healthy adults. The most common side effects are digestive — belching, bloating, constipation, diarrhea, flatulence, nausea, and vomiting — as well as headache and musculoskeletal pain.
People with kidney or liver disease should only use it under medical supervision. If you have bipolar disorder, know that mania and hypomania have been reported rarely in patients taking glutamine.
Pregnancy and lactation safety is rated likely safe, though not enough data exists for supplemental doses while breastfeeding unless your doctor advises otherwise.
Meds to double-check
Moderate interaction found
If you take anticonvulsant medications (seizure drugs), double-check with your doctor or pharmacist before adding this product — glutamine may theoretically reduce how well they work, though no human cases have been reported yet.
The bottom line
Scorecard at a glanceFully disclosed formula with clinical evidence supporting its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
L-glutamine may be worth considering if you have sickle cell disease or are recovering from surgery or critical illness, but the evidence for other uses isn't established in our data. The main concern is a theoretical interaction with anticonvulsants — if that's you, talk it over with your doctor or pharmacist before starting.
Digestive side effects are common, so start low and see how you feel.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated May 22, 2020.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about L-Glutamine 5000 mg Unflavored, straight from the product label.
| Brand | GNC Pro Performance |
|---|---|
| Barcode (UPC) | 048107169831 |
| Net contents | 32 Oz(s); 2 lb(s); 907 Gram(s) |
| Market status | On market |
| Date entered into DSLD | May 22, 2020 |
| DSLD ID | 220100 |
| Product type | Amino Acid/protein |
| Supplement form | Powder |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Gluten Free, Dairy Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for L-Glutamine 5000 mg Unflavored by GNC Pro Performance, sourced from the NIH Dietary Supplement Label Database.
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation
Pro Performance Results Supplementation may help maintain glutamine levels that have been depleted as a result of intense exercise. Glutamine is involved in protein synthesis and plays a pivotal role in the body's nitrogen balance. It serves as fuel for the immune system and maintenance of proper intestinal function. When used in conjunction with an exercise program.
Pro Performance Quality Pro Performance L-Glutamine is tested and certified Banned Substance Free. It is gluten free, lactose free and mixed easily with your favorite beverage.
Key Amino Acid for muscles Fuels the immune system
Gluten free, lactose free.
Products bearing this logo have been tested for banned substances by LGC Science, Inc., a world-class anti-doping lab. Product was tested for over 145 banned substances on the 2017 World Anti-Doping Agency (WADA) Prohibited List via LGC skip lot testing protocol #ICP0307. See gnc.com for more information.
Precautions
Keep out of reach of children.
Storage
Store in a cool, dry place.
Seals/Symbols
Banned Substance Free
Informedchoice.org Trusted by sport
FDA Statement of Identity
Dietary Supplement
General Statements
181 Servings
Notice: Significant product settling may occur.
Suggested/Recommended/Usage/Directions
Directions: As a dietary supplement, mix one scoop (5 g) twice daily in a beverage or shake. For maximum results, take one serving (5g) post-exercise.
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
L-Glutamine 5000 mg Unflavored by GNC Pro Performance label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in L-Glutamine 5000 mg Unflavored by GNC Pro Performance
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size5 Gram(s) Dosage formPowder Servings per container181 Amounts shown are per serving.
L-Glutamine
Interacts with50 drugs
Glutamine is the most abundant amino acid in the body and is usually made in your muscles. A prescription form is FDA-approved to help reduce sickle c...
L-Glutamine monograph & interactionsOther (inactive) ingredients: None. These complete the product’s ingredient list but are not active constituents.
L-Glutamine 5000 mg Unflavored by GNC Pro Performance Drug Interactions
HelloPharmacist Interaction Report
GNC Pro Performance L-Glutamine 5000 mg has one documented interaction: through its L-glutamine content, it may theoretically reduce how well anticonvulsant medications (drugs that prevent seizures) work.
Glutamine breaks down into glutamate, an excitatory brain chemical that could work against anticonvulsants — but this hasn't yet been reported in actual patients, so the real-world risk remains unclear.
Read the full breakdown — every affected drug type, severity by severity
Although this is the only interaction category in our data, these interactions span 50 individual medications. If you take any anticonvulsant, check your exact medications with the tool on this page before starting this supplement.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against L-Glutamine 5000 mg Unflavored?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in L-Glutamine 5000 mg Unflavored interact with 50 drugs. Click any drug to see the details.
1 of the 1 ingredient in L-Glutamine 5000 mg Unflavored interact with drugs. Each result below shows which ingredient is responsible. L-Glutamine
MephobarbitalMebaral
How Mephobarbital interacts with L-Glutamine 5000 mg Unflavored — through 1 ingredient. Tap an ingredient for the detail:
L-glutamineAnticonvulsants Moderate
Interaction Summary
Theoretically, glutamine might antagonize the effects of anticonvulsant medications.
Read the full L-glutamine + Mephobarbital interactionMethsuximideCelontin
How Methsuximide interacts with L-Glutamine 5000 mg Unflavored — through 1 ingredient. Tap an ingredient for the detail:
L-glutamineAnticonvulsants Moderate
Interaction Summary
Theoretically, glutamine might antagonize the effects of anticonvulsant medications.
Read the full L-glutamine + Methsuximide interactionOxazepamSerax
How Oxazepam interacts with L-Glutamine 5000 mg Unflavored — through 1 ingredient. Tap an ingredient for the detail:
L-glutamineAnticonvulsants Moderate
Interaction Summary
Theoretically, glutamine might antagonize the effects of anticonvulsant medications.
Read the full L-glutamine + Oxazepam interactionOxcarbazepineOxtellar XR, Trileptal
How Oxcarbazepine interacts with L-Glutamine 5000 mg Unflavored — through 1 ingredient. Tap an ingredient for the detail:
L-glutamineAnticonvulsants Moderate
Interaction Summary
Theoretically, glutamine might antagonize the effects of anticonvulsant medications.
Read the full L-glutamine + Oxcarbazepine interactionPentobarbitalNembutal
How Pentobarbital interacts with L-Glutamine 5000 mg Unflavored — through 1 ingredient. Tap an ingredient for the detail:
L-glutamineAnticonvulsants Moderate
Interaction Summary
Theoretically, glutamine might antagonize the effects of anticonvulsant medications.
Read the full L-glutamine + Pentobarbital interactionPentobarbitonePentobarbitone
How Pentobarbitone interacts with L-Glutamine 5000 mg Unflavored — through 1 ingredient. Tap an ingredient for the detail:
L-glutamineAnticonvulsants Moderate
Interaction Summary
Theoretically, glutamine might antagonize the effects of anticonvulsant medications.
Read the full L-glutamine + Pentobarbitone interactionPhenacemidePhenurone
How Phenacemide interacts with L-Glutamine 5000 mg Unflavored — through 1 ingredient. Tap an ingredient for the detail:
L-glutamineAnticonvulsants Moderate
Interaction Summary
Theoretically, glutamine might antagonize the effects of anticonvulsant medications.
Read the full L-glutamine + Phenacemide interactionPhenobarbitalLuminal, Phenobarbital, Solfoton
How Phenobarbital interacts with L-Glutamine 5000 mg Unflavored — through 1 ingredient. Tap an ingredient for the detail:
L-glutamineAnticonvulsants Moderate
Interaction Summary
Theoretically, glutamine might antagonize the effects of anticonvulsant medications.
Read the full L-glutamine + Phenobarbital interactionPhenobarbital, PhenytoinDilantin with PB
How Phenobarbital, Phenytoin interacts with L-Glutamine 5000 mg Unflavored — through 1 ingredient. Tap an ingredient for the detail:
L-glutamineAnticonvulsants Moderate
Interaction Summary
Theoretically, glutamine might antagonize the effects of anticonvulsant medications.
Read the full L-glutamine + Phenobarbital, Phenytoin interactionPhensuximideMilontin
How Phensuximide interacts with L-Glutamine 5000 mg Unflavored — through 1 ingredient. Tap an ingredient for the detail:
L-glutamineAnticonvulsants Moderate
Interaction Summary
Theoretically, glutamine might antagonize the effects of anticonvulsant medications.
Read the full L-glutamine + Phensuximide interactionPhentermine, TopiramateQsymia
How Phentermine, Topiramate interacts with L-Glutamine 5000 mg Unflavored — through 1 ingredient. Tap an ingredient for the detail:
L-glutamineAnticonvulsants Moderate
Interaction Summary
Theoretically, glutamine might antagonize the effects of anticonvulsant medications.
Read the full L-glutamine + Phentermine, Topiramate interactionPhenytoinDi-Phen, Dilantin, Dilantin Infatabs, Dilantin injection, Dilantin Kapseals, Phenytek
How Phenytoin interacts with L-Glutamine 5000 mg Unflavored — through 1 ingredient. Tap an ingredient for the detail:
L-glutamineAnticonvulsants Moderate
Interaction Summary
Theoretically, glutamine might antagonize the effects of anticonvulsant medications.
Read the full L-glutamine + Phenytoin interactionPrimidoneMysoline
How Primidone interacts with L-Glutamine 5000 mg Unflavored — through 1 ingredient. Tap an ingredient for the detail:
L-glutamineAnticonvulsants Moderate
Interaction Summary
Theoretically, glutamine might antagonize the effects of anticonvulsant medications.
Read the full L-glutamine + Primidone interactionSodium ValproateEpilim
How Sodium Valproate interacts with L-Glutamine 5000 mg Unflavored — through 1 ingredient. Tap an ingredient for the detail:
L-glutamineAnticonvulsants Moderate
Interaction Summary
Theoretically, glutamine might antagonize the effects of anticonvulsant medications.
Read the full L-glutamine + Sodium Valproate interactionTiagabineGabitril
How Tiagabine interacts with L-Glutamine 5000 mg Unflavored — through 1 ingredient. Tap an ingredient for the detail:
L-glutamineAnticonvulsants Moderate
Interaction Summary
Theoretically, glutamine might antagonize the effects of anticonvulsant medications.
Read the full L-glutamine + Tiagabine interactionTopiramateEprontia, Qudexy XR, Topamax, Trokendi XR
How Topiramate interacts with L-Glutamine 5000 mg Unflavored — through 1 ingredient. Tap an ingredient for the detail:
L-glutamineAnticonvulsants Moderate
Interaction Summary
Theoretically, glutamine might antagonize the effects of anticonvulsant medications.
Read the full L-glutamine + Topiramate interactionTrimethadioneTridione
How Trimethadione interacts with L-Glutamine 5000 mg Unflavored — through 1 ingredient. Tap an ingredient for the detail:
L-glutamineAnticonvulsants Moderate
Interaction Summary
Theoretically, glutamine might antagonize the effects of anticonvulsant medications.
Read the full L-glutamine + Trimethadione interactionValproic AcidDepacon, Depakene, Valproate
How Valproic Acid interacts with L-Glutamine 5000 mg Unflavored — through 1 ingredient. Tap an ingredient for the detail:
L-glutamineAnticonvulsants Moderate
Interaction Summary
Theoretically, glutamine might antagonize the effects of anticonvulsant medications.
Read the full L-glutamine + Valproic Acid interactionVigabatrinSabril
How Vigabatrin interacts with L-Glutamine 5000 mg Unflavored — through 1 ingredient. Tap an ingredient for the detail:
L-glutamineAnticonvulsants Moderate
Interaction Summary
Theoretically, glutamine might antagonize the effects of anticonvulsant medications.
Read the full L-glutamine + Vigabatrin interactionZonisamideZonegran, Zonisade
How Zonisamide interacts with L-Glutamine 5000 mg Unflavored — through 1 ingredient. Tap an ingredient for the detail:
L-glutamineAnticonvulsants Moderate
Interaction Summary
Theoretically, glutamine might antagonize the effects of anticonvulsant medications.
Read the full L-glutamine + Zonisamide interactionEach ingredient & the kinds of drugs it affects
For each ingredient in L-Glutamine 5000 mg Unflavored with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
L-Glutamine
Anticonvulsants
Theoretically, glutamine might antagonize the effects of anticonvulsant medications.
Glutamine is metabolized to the excitatory neurotransmitter glutamate. Glutamate might have antagonistic effects with anticonvulsant drugs. However, this interaction has not yet been reported in humans.
Brand information
Manufacturer and brand details for L-Glutamine 5000 mg Unflavored, from the product label.
GNC Pro Performance
See all GNC Pro Performance products- Name
- General Nutrition Corporation
- City
- Pittsburgh
- State
- PA
- ZipCode
- 15222
- Phone Number
- 1-888-462-2548
- Web Address
- gnc.com
L-Glutamine 5000 mg Unflavored by GNC Pro Performance: Common Questions
Does L-Glutamine 5000 mg Unflavored by GNC Pro Performance interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
What is L-glutamine and why would I take it?
What side effects should I expect?
Is it safe if I'm pregnant or breastfeeding?
Can I take this if I have kidney or liver disease?
Does this product have any fillers or other ingredients?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if L-Glutamine 5000 mg Unflavored is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind L-Glutamine 5000 mg Unflavored’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
L-Glutamine 5000 mg Unflavored's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 11 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Glutamine 11 references
- Miller AL. Therapeutic considerations of L-glutamine: a review of the literature. Altern Med Rev 1999;4:239-48..
- Bozzetti F, Biganzoli L, Gavazzi C, et al. Glutamine supplementation in cancer patients receiving chemotherapy: a double-blind randomized study. Nutrition 1997;13:748-51.. PubMed
- Mebane AH. L-Glutamine and mania. Am J Psychiatry 984;141:1302-3.
- Meldrum BS. Glutamate as a neurotransmitter in the brain: review of physiology and pathology. J Nutr 2000;130:1007S-15S.. PubMed
- Garlick PJ. Assessment of the safety of glutamine and other amino acids. J Nutr 2001;131:2556S-61S.. PubMed
- Chapman AG. Glutamate and epilepsy. J Nutr 2000;130:1043S-5S.. PubMed
- Ziegler TR. Glutamine supplementation in cancer patients receiving bone marrow transplantation and high dose chemotherapy. J Nutr 2001;131:2578S-84S.. PubMed
- Laviano A, Molfino A, Lacaria MT, Canelli A, De Leo S, Preziosa I, Rossi Fanelli F. Glutamine supplementation favors weight loss in nondieting obese female patients. A pilot study. Eur J Clin Nutr. 2014 Nov;68(11):1264-6. PubMed
- Endari (l-glutamine) [package insert]. Torrance, CA: Emmaus Medical,Inc; 2017.
- Niihara Y, Miller ST, Kanter J, et al. A Phase 3 Trial of l-Glutamine in Sickle Cell Disease. N Engl J Med 2018;379(3):226-35. doi: 10.1056/NEJMoa1715971.
- Ogden HB, Child RB, Fallowfield JL, et al. Gastrointestinal Tolerance of Low, Medium and High Dose Acute Oral l-Glutamine Supplementation in Healthy Adults: A Pilot Study. Nutrients. 2020;12(10):2953. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC