Major interaction on record — check this product against your medications before combining. Based on 2 of 9 ingredients. Check your meds →
Dietary supplement

M-P-S Muscle Builder Orange Ingredients & Drug Interactions

by Dymatize Nutrition

M-P-S Muscle Builder Orange label
See full label image
Powder Category: Other Combinations
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking M-P-S Muscle Builder Orange against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

M-P-S Muscle Builder Orange is a dietary supplement by Dymatize Nutrition with 9 active ingredients. Its ingredients are commonly taken for bone health and osteoporosis prevention, dietary calcium deficiency, heartburn relief (calcium carbonate antacids).Based on those ingredients, 173 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Calcium, Whey Protein isolate. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against M-P-S Muscle Builder Orange by Dymatize Nutrition

Ask about any prescription or over-the-counter medication and we check it for interactions with M-P-S Muscle Builder Orange by Dymatize Nutrition — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
Prefer a human? Send your question to our licensed pharmacists — free, answered by email within 24 hours.

HelloPharmacist Scorecard of M-P-S Muscle Builder Orange by Dymatize Nutrition

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 20, 2026

What’s inside

Partial disclosure
Ingredient Transparency · database check
Partial

Most active ingredients list an amount, but at least one is hidden in a blend or missing.

Why this rating?
  • The label discloses an exact amount for 5 of its 8 active ingredients.
  • “instantly soluble BCAAs” is listed as a grouped ingredient — the label gives one combined amount (7 Gram(s)) without saying how much of each component you get.

M-P-S Muscle Builder Orange contains 8 active ingredients. The main players are calcium, whey protein isolate (a complete protein from milk), and three branched-chain amino acids—L-leucine, L-isoleucine, and L-valine—plus a blend called M-P-S MATRIX and two calcium-containing compounds, alpha-hydroxyisocaproic acid calcium and alpha-ketoisocaproic acid calcium.

These are designed to support muscle protein synthesis and recovery. The product also includes inactive ingredients like sweeteners (erythritol, sucralose, acesulfame potassium, stevia), flavor enhancers, acids for taste, and food colorants (beta-carotene, beet powder).

These are the excipients that make up the powder's texture and taste.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: muscle building and anabolic support.
  • We looked for evidence on: Athletic performance, Exercise-induced muscle damage, Sarcopenia, muscle recovery, protein synthesis, lean mass gain.
  • The strongest evidence on file: Whey Protein is rated "Possibly Effective" for Athletic performance (Natural Medicines).
  • Also on file: Calcium is rated "Insufficient Reliable Evidence To Rate" for Exercise-induced muscle damage.
  • Also on file: Whey Protein is rated "Insufficient Reliable Evidence To Rate" for Sarcopenia, Exercise-induced muscle damage.

For calcium, the evidence supports its use for kidney failure, indigestion, low blood calcium (hypocalcemia), and high potassium (hyperkalemia), and it is likely effective for osteoporosis. Whey protein shows possibly effective evidence for athletic performance, but the evidence doesn't support it for osteoporosis, COPD, or age-related cognitive decline—data on those uses is either lacking or leans against benefit.

We don't have effectiveness ratings on file for the other ingredients in this product.

The evidence, ingredient by ingredient Calcium Whey Protein

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Calcium is generally well tolerated at recommended doses, though high amounts can cause problems. The most common side effects are belching, constipation, diarrhea, gas, and stomach upset.

There's theoretical concern that very high calcium intake (over 1500–2000 mg daily) might increase prostate cancer and cardiovascular disease risk, though research remains mixed. Calcium is likely safe in pregnancy and during breastfeeding at recommended amounts—talk to your doctor if you're unsure of the right dose for you.

Whey protein is generally well tolerated by healthy adults. Common side effects are dose-related and include bloating, cramps, diarrhea, nausea, headache, and reflux.

Case reports link whey protein to acne development or worsening, usually reversible after stopping. One rare case report connected whey protein to coronary embolism.

Whey as a food is likely fine, but high-dose concentrated supplements aren't well studied—check with your doctor before starting.

Side effects, ingredient by ingredient Calcium Whey Protein

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 2 of the 2 matched ingredients can interact with medications — Calcium, Whey Protein.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: heart-rhythm medications; lithium; Parkinson's medications.
  • For scale: 173 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with your doctor or pharmacist before taking this product if you use dolutegravir or elvitegravir (HIV integrase inhibitors), ceftriaxone (an antibiotic given intravenously), levodopa (Parkinson's medication), quinolone antibiotics, bisphosphonates, or tetracycline antibiotics. Also check if you take raltegravir, levothyroxine, sotalol, calcipotriene, or diltiazem.

If you take any other medications, use the search tool on this page to make sure they're safe to combine with this product.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glancePartially disclosed formula with some supporting evidence for its stated purpose. Major medication interactions have been identified, and safety information is well characterized.

This is a muscle-support powder centered on protein and branched-chain amino acids. It's most relevant if you're doing strength training and want a convenient protein source.

Before you take it, check your medications against the list on this page—particularly if you take HIV drugs, antibiotics, thyroid medication, heart medications, or Parkinson's medication. Talk with your own doctor or pharmacist to confirm it's right for you and your health history.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 8 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Nov 24, 2015.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about M-P-S Muscle Builder Orange, straight from the product label.

Brand Dymatize Nutrition
Barcode (UPC) 705016190102
Net contents 0.59 oz.; 17 Gram(s)
Market status On market
Date entered into DSLD Nov 24, 2015
DSLD ID 53235
Product type Other Combinations
Supplement form Powder
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for M-P-S Muscle Builder Orange by Dymatize Nutrition, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
17 Gram(s)
Maximum serving Sizes:
17 Gram(s)
Servings per container
1
UPC/BARCODE
705016190102
IngredientAmount% DV
Calories15 {Calories}--
Total Carbohydrates3 Gram(s)1%
Calcium110 mg11%
L-Leucine0 NP--
L-Isoleucine0 NP--
Protein2 Gram(s)4%
L-Valine0 NP--
instantly soluble BCAAs7 Gram(s)--
M-P-S MATRIX10.2 Gram(s)--
Whey Protein isolate2.4 Gram(s)--
Alpha-Hydroxyisocaproic Acid Calcium500 mg--
Alpha-Ketoisocaproic Acid Calcium250 mg--

Other ingredients: Erythritol, Citric Acid, Natural and Artificial flavors, Tartaric Acid, Malic Acid, Phosphoric Acid, Silicon Dioxide, Acesulfame Potassium, Sucralose, Beta-Carotene, Soy Lecithin, Beet powder, Stevia leaf extract

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

NEW

PerformanceDriven

Anabolic Support

NATURALLY & ARTIFICIALLY FLAVORED

We know that you are performance driven, whether that be to improve lean body mass or compete at a higher level. Dymatize developed the new PerformanceDriven line with your goals in mind via Pre, Intra and Post training support. Dymatize M-P-S is designed to accelerate your fitness gains by both triggering muscle protein synthesis (anabolism) and minimizing muscle protein breakdown in response to training (catabolism) for faster recovery.

Great tasting and refreshing, M-P-S is the perfect muscle builder to take after your workouts.

DYMATIZE ENTERPRISES, LLC EEC APPROVED - PLANT# 3005816913

POST PRE INTRA

Formula

7g of Instantly Soluble BCAAs 2.4g of Whey Protein Isolate HICA & KIC

Contains Milk and Soy.

~ 7g of instantly soluble BCAAs (2:1:1) which provides enough L-Leucine to trigger muscle protein synthesis for faster muscle rebuild, recovery and growth ~ Added HICA & KIC (Leucine metabolites) further support muscle protein synthesis and help limit muscle protein breakdown caused by strenuous training ~ 2.4g of whey protein isolate supports muscle protein synthesis

FDA Statement of Identity

DIETARY SUPPLEMENT

Precautions

Contains Milk and Soy.

Warning: Consult a physician before using this or any other product, if you are pregnant, lactating, or have any medical condition.

KEEP OUT OF REACH OF CHILDREN.

Suggested/Recommended/Usage/Directions

DIRECTIONS: As a dietary supplement, add one packet to 10 oz. of water. Mix/Shake until dissolved. Foaming may occur initially with agitation, but will subside.

One scoop post-workout is all you need.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Seals/Symbols

INFORMED-CHOICE.org Trusted by sport

General

8828

Storage

Store in a cool, dry place.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

M-P-S Muscle Builder Orange by Dymatize Nutrition label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

M-P-S Muscle Builder Orange label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in M-P-S Muscle Builder Orange by Dymatize Nutrition

These are the 9 active ingredients this product is made of. Select any to open its full monograph.

Serving size17 Gram(s) Dosage formPowder Servings per container1 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Calcium

Interacts with
168 drugs
110 mg per serving

Calcium is an essential mineral your body needs for strong bones, nerve signaling, and muscle function, and supplements can help fill gaps when diet f...

Calcium monograph & interactions

Protein

2 Gram(s) per serving

Instantly soluble BCAAs

7 Gram(s) per serving
  • › L-Leucine
  • › L-Isoleucine
  • › L-Valine

M-P-S MATRIX

10.2 Gram(s) per serving

Whey Protein isolate

Interacts with
53 drugs
2.4 Gram(s) per serving

Whey protein is a high-quality, complete protein made from cow's milk that can help people meet protein needs and support muscle growth when combined...

Whey Protein isolate monograph & interactions

Alpha-Hydroxyisocaproic Acid Calcium

500 mg per serving

Alpha-Ketoisocaproic Acid Calcium

250 mg per serving

Other (inactive) ingredients: Erythritol, Citric Acid, Natural and Artificial flavors, Tartaric Acid, Malic Acid, Phosphoric Acid, Silicon Dioxide, Acesulfame Potassium, Sucralose, Beta-Carotene, Soy Lecithin, Beet powder, Stevia leaf extract. These complete the product’s ingredient list but are not active constituents.

Interaction report

M-P-S Muscle Builder Orange by Dymatize Nutrition Drug Interactions

Want to check YOUR meds against M-P-S Muscle Builder Orange?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
173Drugs
12 Major 143 Moderate 18 Minor

Ingredients driving the most interactions

Calcium 168
Whey Protein isolate 53

Individual Drug Interactions

The ingredients in M-P-S Muscle Builder Orange interact with 173 drugs. Click any drug to see the details.

2 of the 9 ingredients in M-P-S Muscle Builder Orange interact with drugs. Each result below shows which ingredient is responsible. Calcium Whey Protein isolate

Each ingredient & the kinds of drugs it affects

For each ingredient in M-P-S Muscle Builder Orange with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Calcium18 drug types · 168 drugs

Ceftriaxone (Rocephin)

Co-administration of intravenous calcium and ceftriaxone can result in precipitation of a ceftriaxone-calcium salt in the lungs and kidneys.
Avoid administering intravenous calcium in any form, such as parenteral nutrition or Lactated Ringers, within 48 hours of intravenous ceftriaxone. Case reports in neonates show that administering intravenous ceftriaxone and calcium can result in precipitation of a ceftriaxone-calcium salt in the lungs and kidneys. In several cases, neonates have died as a result of this interaction. So far there are no reports in adults; however, there is still concern that this interaction might occur in adults.

Likelihood Probable Evidence D
Dolutegravir (Tivicay)

Calcium seems to reduce levels of dolutegravir.
Advise patients to take dolutegravir either 2 hours before or 6 hours after taking calcium supplements. Pharmacokinetic research suggests that taking calcium carbonate 1200 mg concomitantly with dolutegravir 50 mg reduces plasma levels of dolutegravir by almost 40%. Calcium appears to decrease levels of dolutegravir through chelation.

Likelihood Probable Evidence B
Elvitegravir (Vitekta)

Calcium seems to reduce levels of elvitegravir.
Advise patients to take elvitegravir either 2 hours before or 2 hours after taking calcium supplements. Pharmacokinetic research suggests that taking calcium along with elvitegravir can reduce blood levels of elvitegravir through chelation.

Likelihood Probable Evidence B
Aluminum

Calcium citrate might increase aluminum absorption and toxicity. Other types of calcium do not increase aluminum absorption.
Calcium citrate can increase the absorption of aluminum when taken with aluminum hydroxide. The increase in aluminum levels may become toxic, particularly in individuals with kidney disease. However, the effect of calcium citrate on aluminum absorption is due to the citrate anion rather than calcium cation. Calcium acetate does not appear to increase aluminum absorption.

Likelihood Possible Evidence B
Bictegravir/Emtricitabine/Tenofovir Alafenamide (Biktarvy)

Calcium might decrease levels of bictegravir/emtricitabine/tenofovir alafenamide by reducing its absorption when taken in a fasting state.
Advise patients that bictegravir/emtricitabine/tenofovir alafenamide and calcium can be taken together if taken with food. However, if taken on an empty stomach, bictegravir/emtricitabine/tenofovir alafenamide should not be taken with, or 2 hours after, calcium containing products.

Likelihood Probable Evidence D
Bisphosphonates

Calcium reduces the absorption of bisphosphonates.
Advise patients to take bisphosphonates at least 30 minutes before calcium, but preferably at a different time of day. Calcium supplements decrease absorption of bisphosphonates.

Likelihood Probable Evidence C
Calcipotriene (Dovonex)

Taking calcipotriene with calcium might increase the risk for hypercalcemia.
Calcipotriene is a vitamin D analog used topically for psoriasis. It can be absorbed in sufficient amounts to cause systemic effects, including hypercalcemia. Theoretically, combining calcipotriene with calcium supplements might increase the risk of hypercalcemia.

Likelihood Possible Evidence B
Digoxin (Lanoxin)

Using intravenous calcium with digoxin might increase the risk of fatal cardiac arrhythmias.
Hypercalcemia increases the risk of fatal cardiac arrhythmias with digoxin. However, one retrospective analysis of clinical data suggests that intravenous calcium does not increase the risk of dysrhythmias or mortality in patients receiving digoxin.

Likelihood Possible Evidence B
Diltiazem (Cardizem, Others)

Theoretically, calcium may reduce the therapeutic effects of diltiazem.
Hypercalcemia can reduce the effectiveness of verapamil in atrial fibrillation. Theoretically, calcium might increase this risk of hypercalcemia and reduce the effectiveness of diltiazem.

Likelihood Probable Evidence D
Levothyroxine (Synthroid, Others)

Calcium seems to reduce the absorption and effectiveness of levothyroxine.
Advise patients to take levothyroxine and calcium supplements at least 4 hours apart. Calcium reduces levothyroxine absorption, probably by forming insoluble complexes. Calcium carbonate supplements reduce effectiveness of levothyroxine in patients with hypothyroidism.

Likelihood Probable Evidence B
Lithium

Theoretically, concomitant use of calcium and lithium may increase this risk of hypercalcemia.
Clinical research suggests that long-term use of lithium may cause hypercalcemia in 10% to 60% of patients. Theoretically, concomitant use of lithium and calcium supplements may further increase this risk.

Likelihood Possible Evidence B
Quinolone Antibiotics

Calcium seems to reduce the absorption of quinolone antibiotics.
Advise patients to take oral quinolones at least 2 hours before or 4-6 hours after calcium supplements or calcium-fortified foods. Taking calcium at the same time as oral quinolones can reduce quinolone absorption. Calcium binds to quinolones in the gut.

Likelihood Probable Evidence B
Raltegravir (Isentress)

Calcium may reduce levels of raltegravir.
Pharmacokinetic research shows that taking a single dose of calcium carbonate 3000 mg along with raltegravir 400 mg twice daily modestly decreases the mean area under the curve of raltegravir, but the decrease does not necessitate a dose adjustment of raltegravir. However, a case of elevated HIV-1 RNA levels and documented resistance to raltegravir has been reported for a patient taking calcium carbonate 1 gram three times daily plus vitamin D3 (cholecalciferol) 400 IU three times daily in combination with raltegravir 400 mg twice daily for 11 months. It is thought that calcium reduced raltegravir levels by chelation, leading to treatment failure.

Likelihood Possible Evidence B
Sotalol (Betapace)

Calcium seems to reduce the absorption of sotalol.
Advise patients to separate doses by at least 2 hours before or 4-6 hours after calcium. Calcium appears to reduce the absorption of sotalol, probably by forming insoluble complexes.

Likelihood Possible Evidence B
Tetracycline Antibiotics

Calcium seems to reduce the absorption of tetracycline antibiotics.
Advise patients to take oral tetracyclines at least 2 hours before, or 4-6 hours after calcium supplements. Taking calcium at the same time as oral tetracyclines can reduce tetracycline absorption. Calcium binds to tetracyclines in the gut.

Likelihood Probable Evidence C
Thiazide Diuretics

Taking calcium along with thiazides might increase the risk of hypercalcemia and renal failure.
Thiazides reduce calcium excretion by the kidneys. Using thiazides along with moderately large amounts of calcium carbonate increases the risk of milk-alkali syndrome (hypercalcemia, metabolic alkalosis, renal failure). Patients may need to have their serum calcium levels and/or parathyroid function monitored regularly.

Likelihood Probable Evidence C
Verapamil (Calan, Others)

Theoretically, calcium may reduce the therapeutic effects of verapamil.
Hypercalcemia can reduce the effectiveness of verapamil in atrial fibrillation. Theoretically, use of calcium supplements may increase this risk of hypercalcemia and reduce the effectiveness of verapamil.

Likelihood Probable Evidence D
Calcium Channel Blockers

Intravenous calcium may decrease the effects of calcium channel blockers; oral calcium is unlikely to have this effect.
Intravenous calcium is used to decrease the effects of calcium channel blockers in the management of overdose. Intravenous calcium gluconate has been used before intravenous verapamil (Isoptin) to prevent or reduce the hypotensive effects without affecting the antiarrhythmic effects. But there is no evidence that dietary or supplemental calcium when taken orally interacts with calcium channel blockers.

Likelihood Unlikely Evidence D
Calcium full monograph & interactions

Whey Protein isolate4 drug types · 53 drugs

Levodopa

Theoretically, whey protein might decrease levodopa absorption.
Small clinical studies show that concomitant ingestion of protein or high doses of leucine or isoleucine (100 mg/kg) and levodopa can exacerbate tremor, rigidity, and the "on-off" syndrome in patients with Parkinson disease.

Likelihood Probable Evidence D
Bisphosphonates

Theoretically, whey protein might reduce the absorption of bisphosphonates.
Whey protein contains minerals such as calcium that bind bisphosphonates in the gut. Advise patients to take bisphosphonates at least 30 minutes before whey protein, but preferably at a different time of day.

Likelihood Probable Evidence D
Quinolone Antibiotics

Theoretically, whey protein might decrease quinolone absorption.
Whey protein contains minerals, such as calcium, that can bind to quinolones in the gut. To avoid this interaction, advise patients to take oral quinolones at least 2 hours before or 4-6 hours after whey protein.

Likelihood Probable Evidence D
Tetracycline Antibiotics

Theoretically, whey protein might decrease tetracycline absorption.
Whey protein contains minerals, such as calcium, that bind to tetracyclines in the gut. To avoid this interaction, advise patients to take oral tetracyclines at least 2 hours before or 4-6 hours after whey protein.

Likelihood Probable Evidence D
Whey Protein isolate full monograph & interactions
The maker

Brand information

Manufacturer and brand details for M-P-S Muscle Builder Orange, from the product label.

Dymatize Nutrition

See all Dymatize Nutrition products
Name
Dymatize Enterprises, LLC
City
Dallas
State
TX
ZipCode
75234
Phone Number
888-334-5326
Web Address
DYMATIZE.COM
Pharmacist Counseling Corner

M-P-S Muscle Builder Orange by Dymatize Nutrition: Common Questions

Does M-P-S Muscle Builder Orange by Dymatize Nutrition interact with any medications?
Yes. Based on its ingredients, M-P-S Muscle Builder Orange has a known interaction with 173 medications, including 12 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
M-P-S Muscle Builder Orange contains 9 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm pregnant or breastfeeding?
Calcium in pregnancy is likely safe at recommended amounts—in fact, adequate calcium is important during pregnancy. For breastfeeding, calcium needs can be met through recommended intakes. However, whey protein as a high-dose supplement hasn't been well studied in pregnancy or breastfeeding, so check with your doctor or midwife before starting.
Will this give me acne?
Whey protein has been linked in case reports to acne development or worsening in teenagers and young adults, though it's not common. Most side effects from whey are dose-related, so start with a smaller amount if you're concerned. If acne develops after starting, talk to your doctor about whether to stop or reduce the dose.
What's in the 'M-P-S MATRIX'?
The specific breakdown of that blend isn't detailed in our data, so you'd want to check the full label on the package or contact the manufacturer if you need more detail.
Does whey protein actually help with building muscle?
Whey protein shows possibly effective evidence for athletic performance, meaning there's some support for it helping with training and recovery. It's a complete protein with all amino acids your muscles need, but results depend on your training and overall diet.
What are the most common side effects?
From calcium, you might get belching, constipation, or stomach upset. From whey protein, bloating, cramps, diarrhea, nausea, and headache are common—most are dose-related and improve if you reduce the amount.
Is this product safe for people with kidney failure?
Calcium is effective for kidney failure in certain contexts, but kidney disease affects how your body handles minerals. Talk with your nephrologist or pharmacist before adding any mineral supplement if you have kidney problems, since individual tolerance varies.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

M-P-S Muscle Builder Orange label
Go deeper

The Full Monographs Behind M-P-S Muscle Builder Orange’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Calcium

Interacts with 168 drugs

Calcium is an essential mineral your body needs for strong bones, nerve signaling, and muscle function, and supplements can help fill gaps when diet falls short. Most people do best getting...

Read the full Calcium monograph → Herb & supplement monograph

Whey Protein

Interacts with 53 drugs

Whey protein is a high-quality, complete protein made from cow's milk that can help people meet protein needs and support muscle growth when combined with exercise. It is generally safe for...

Read the full Whey Protein monograph →
Sources

Sources & How We Checked

M-P-S Muscle Builder Orange's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 87 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Calcium 62 references
  1. Shils M, Olson A, Shike M. Modern Nutrition in Health and Disease. 8th ed. Philadelphia, PA: Lea and Febiger, 1994.
  2. Hernandez-Avila M, Gonzalez-Cossio T, Hernandez-Avila JE, et al. Dietary calcium supplements to lower blood lead levels in lactating women: a randomized placebo-controlled trial. Epidemiology 2003;14:206-12.. PubMed
  3. Thys-Jacobs S, Ceccarelli S, Bierman A, et al. Calcium supplementation in premenstrual syndrome: a randomized crossover trial. J Gen Intern Med 1989;4:183-9. PubMed
  4. Maton PN, Burton ME. Antacids revisited: a review of their clinical pharmacology and recommended therapeutic use. Drugs 1999;57:855-70.
  5. Clemens JD, Feinstein AR. Calcium carbonate and constipation: a historical review of medical mythopoeia. Gastroenterology 1977;72:957-61. DOI
  6. Saunders D, Sillery J, Chapman R. Effect of calcium carbonate and aluminum hydroxide on human intestinal function. Dig Dis Sci 1988;33:409-13. PubMed
  7. Friedman PA, Bushinsky DA. Diuretic effects on calcium metabolism. Semin Nephrol 1999;19:551-6.
  8. Koo WK, Walters JC, Esterlitz J, et al. Maternal calcium supplementation and fetal bone mineralization. Obstet Gynecol 1999;94:577-82. DOI
  9. Raman L, Rajalakshmi K, Krishnamachari KAVR, et al. Effect of calcium supplementation to undernourished mothers during pregnancy on the bone density of the neonates. Am J Clin Nutr 1978; 31:466-9. DOI
  10. Murry JJ, Healy MD. Drug-mineral interactions: a new responsibility for the hospital dietician. J Am Diet Assoc 1991;91:66-73.
  11. Chan JM, Giovannucci E, Andersson SO, et al. Dairy products, calcium, phosphorous, vitamin D, and risk of prostate cancer. Cancer Causes Control 1998;9:559-66.
  12. Butner LE, Fulco PP, Feldman G, et al. Calcium carbonate-induced hypothyroidism. Ann Intern Med 2000:132:595. PubMed
  13. Schneyer CR. Calcium carbonate and reduction of levothyroxine efficacy. JAMA 1998;279:750. PubMed
  14. Moser LR, Smythe MA, Tisdale JE. The use of calcium salts in the prevention and management of verapamil-induced hypotension. Ann Pharmacother 2000;34:622-9. PubMed
  15. Singh N, Singh PN, Hershman JM. Effect of calcium carbonate on the absorption of levothyroxine. JAMA 2000;283:2822-5. PubMed
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See these in context on the Whey Protein monograph →

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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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